DK0396964T3 - Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner - Google Patents

Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner

Info

Publication number
DK0396964T3
DK0396964T3 DK90107892.3T DK90107892T DK0396964T3 DK 0396964 T3 DK0396964 T3 DK 0396964T3 DK 90107892 T DK90107892 T DK 90107892T DK 0396964 T3 DK0396964 T3 DK 0396964T3
Authority
DK
Denmark
Prior art keywords
mutants
bordetella strains
pertussis toxin
development
producing
Prior art date
Application number
DK90107892.3T
Other languages
English (en)
Inventor
Luciano Nencioni
Mariagrazia Pizza
Antonello Covacci
Rino Rappuoli
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26327122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0396964(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8920341A external-priority patent/IT1230139B/it
Priority claimed from IT01928690A external-priority patent/IT1238007B/it
Application filed by Sclavo Spa filed Critical Sclavo Spa
Application granted granted Critical
Publication of DK0396964T3 publication Critical patent/DK0396964T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
DK90107892.3T 1989-04-28 1990-04-25 Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner DK0396964T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920341A IT1230139B (it) 1989-04-28 1989-04-28 Ceppi di bordetella utili come vaccini antipertosse
IT01928690A IT1238007B (it) 1990-02-07 1990-02-07 Mutanti della tossina della pertosse, ceppi di bordetella capaci di produrre detti mutanti e loro impiego per lo sviluppo di vaccini antipertosse

Publications (1)

Publication Number Publication Date
DK0396964T3 true DK0396964T3 (da) 1995-10-30

Family

ID=26327122

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90107892.3T DK0396964T3 (da) 1989-04-28 1990-04-25 Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner

Country Status (10)

Country Link
US (2) US7427404B1 (da)
EP (1) EP0396964B1 (da)
JP (2) JP2655583B2 (da)
AT (1) ATE127347T1 (da)
CA (1) CA2015677C (da)
DE (1) DE69022106T2 (da)
DK (1) DK0396964T3 (da)
ES (1) ES2078258T3 (da)
GR (1) GR3018285T3 (da)
HK (1) HK17096A (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
EP0396964B1 (en) * 1989-04-28 1995-09-06 SCLAVO S.p.A. Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
DE4113385A1 (de) * 1991-04-24 1992-10-29 Biotechnolog Forschung Gmbh Hybridtransposon mit pt-operon, plasmide und bakterienstaemme dafuer
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
GB9513371D0 (en) 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
DE69434000T3 (de) * 1993-10-05 2008-11-06 UCB Pharma Ltd., Slough Impfstoffzusammensetzungen
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
AU2001271495A1 (en) * 2000-06-26 2002-01-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A high yield pertussis vaccine production strain and method for making same
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
BRPI0402630B8 (pt) * 2004-07-05 2021-05-25 Fund Butantan processo de obtenção de vacina pertussis celular menos reatogênica
CA2759681C (en) * 2009-04-24 2019-09-17 Kathleen M. Tatti Selective detection of bordetella species
US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
KR20130072201A (ko) 2010-03-30 2013-07-01 피페넥스 인크. 재조합 독소 단백질의 고수준 발현
EP2802646B1 (en) * 2011-12-21 2017-05-10 Bionet-Asia Co. Ltd Modified bordetella pertussis strains
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP6440619B2 (ja) 2012-10-12 2018-12-19 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 混合ワクチン用の架橋されていない無細胞百日咳抗原
PE20151720A1 (es) 2013-03-08 2015-12-10 Crucell Holland Bv Vacuna acelular contra pertussis
EP3492097A1 (en) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
AU2016248452B2 (en) 2015-04-16 2018-05-31 Inventprise, Inc. Bordetella pertussis immunogenic vaccine compositions
MX2021005303A (es) 2018-11-06 2021-07-07 Glaxosmithkline Biologicals Sa Composiciones inmunogenicas.
EP3799884A1 (en) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogenic compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
IT1223334B (it) * 1987-11-02 1990-09-19 Sclavo Spa Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
US6713072B1 (en) * 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5221618A (en) 1987-11-24 1993-06-22 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine
EP0396964B1 (en) * 1989-04-28 1995-09-06 SCLAVO S.p.A. Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines

Also Published As

Publication number Publication date
CA2015677C (en) 2005-06-21
JPH09163978A (ja) 1997-06-24
HK17096A (en) 1996-02-09
CA2015677A1 (en) 1990-10-28
US7666436B1 (en) 2010-02-23
DE69022106T2 (de) 1996-02-15
ATE127347T1 (de) 1995-09-15
JPH03169825A (ja) 1991-07-23
ES2078258T3 (es) 1995-12-16
GR3018285T3 (en) 1996-03-31
EP0396964A1 (en) 1990-11-14
EP0396964B1 (en) 1995-09-06
JP2852025B2 (ja) 1999-01-27
US7427404B1 (en) 2008-09-23
DE69022106D1 (de) 1995-10-12
JP2655583B2 (ja) 1997-09-24

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