JP2014097057A5 - - Google Patents

Info

Publication number

JP2014097057A5

JP2014097057A5 JP2013255691A JP2013255691A JP2014097057A5 JP 2014097057 A5 JP2014097057 A5 JP 2014097057A5 JP 2013255691 A JP2013255691 A JP 2013255691A JP 2013255691 A JP2013255691 A JP 2013255691A JP 2014097057 A5 JP2014097057 A5 JP 2014097057A5

Authority

JP

Japan

Prior art keywords

oligonucleotide

temperature

solution

composition

seq

Prior art date

2013-12-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 36
• 108091034117 Oligonucleotide Proteins 0.000 claims 26
• 101710132601 Capsid protein Proteins 0.000 claims 13
• 101710094648 Coat protein Proteins 0.000 claims 13
• 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 13
• 101710125418 Major capsid protein Proteins 0.000 claims 13
• 101710141454 Nucleoprotein Proteins 0.000 claims 13
• 101710083689 Probable capsid protein Proteins 0.000 claims 13
• 239000002245 particle Substances 0.000 claims 9
• 241001515965 unidentified phage Species 0.000 claims 7
• 241001534160 Escherichia virus Qbeta Species 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 4
• 210000000234 capsid Anatomy 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 claims 3
• MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 2
• NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229940029575 guanosine Drugs 0.000 claims 2
• 239000012528 membrane Substances 0.000 claims 2
• 150000007523 nucleic acids Chemical group 0.000 claims 2
• 238000001338 self-assembly Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
• 230000004931 aggregating effect Effects 0.000 claims 1
• 238000004220 aggregation Methods 0.000 claims 1
• 230000002776 aggregation Effects 0.000 claims 1
• 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
• 239000004202 carbamide Substances 0.000 claims 1
• 239000003638 chemical reducing agent Substances 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 238000010494 dissociation reaction Methods 0.000 claims 1
• 230000005593 dissociations Effects 0.000 claims 1
• PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims 1
• 239000007800 oxidant agent Substances 0.000 claims 1
• 239000011734 sodium Substances 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1