JP2015528466A5 - - Google Patents

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Publication number
JP2015528466A5
JP2015528466A5 JP2015530070A JP2015530070A JP2015528466A5 JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5 JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5
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JP
Japan
Prior art keywords
urea
bar
inclusion body
high pressure
inclusion
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JP2015530070A
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English (en)
Japanese (ja)
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JP6405308B2 (ja
JP2015528466A (ja
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Priority claimed from PCT/US2013/057430 external-priority patent/WO2014036349A1/en
Publication of JP2015528466A publication Critical patent/JP2015528466A/ja
Publication of JP2015528466A5 publication Critical patent/JP2015528466A5/ja
Application granted granted Critical
Publication of JP6405308B2 publication Critical patent/JP6405308B2/ja
Expired - Fee Related legal-status Critical Current
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JP2015530070A 2012-08-30 2013-08-30 キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 Expired - Fee Related JP6405308B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261694968P 2012-08-30 2012-08-30
US61/694,968 2012-08-30
US201361830425P 2013-06-03 2013-06-03
US61/830,425 2013-06-03
PCT/US2013/057430 WO2014036349A1 (en) 2012-08-30 2013-08-30 Expression of chimeric ksac protein and method of producing soluble proteins by high pressure

Publications (3)

Publication Number Publication Date
JP2015528466A JP2015528466A (ja) 2015-09-28
JP2015528466A5 true JP2015528466A5 (enExample) 2016-08-12
JP6405308B2 JP6405308B2 (ja) 2018-10-17

Family

ID=49162270

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015530070A Expired - Fee Related JP6405308B2 (ja) 2012-08-30 2013-08-30 キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法
JP2015530066A Active JP6438396B2 (ja) 2012-08-30 2013-08-30 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015530066A Active JP6438396B2 (ja) 2012-08-30 2013-08-30 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法

Country Status (18)

Country Link
US (3) US9315553B2 (enExample)
EP (2) EP2890393A2 (enExample)
JP (2) JP6405308B2 (enExample)
KR (1) KR102208844B1 (enExample)
CN (3) CN104768577B (enExample)
AP (1) AP2015008331A0 (enExample)
AU (4) AU2013308627B2 (enExample)
BR (1) BR112015004463B8 (enExample)
CA (2) CA2883296A1 (enExample)
EA (1) EA031988B1 (enExample)
ES (1) ES2744709T3 (enExample)
HK (1) HK1211874A1 (enExample)
MD (1) MD4608C1 (enExample)
MX (3) MX381717B (enExample)
NZ (3) NZ705790A (enExample)
PH (1) PH12015500700B1 (enExample)
RU (1) RU2647568C2 (enExample)
WO (2) WO2014036345A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8968749B2 (en) * 2006-07-21 2015-03-03 Universidade Federal De Minas Gerais—Ufmg Vaccine composition and immunization method
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
KR102208844B1 (ko) * 2012-08-30 2021-01-27 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법
WO2014160987A2 (en) * 2013-03-28 2014-10-02 Infectious Disease Research Institute Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis
CN104758944B (zh) * 2015-04-02 2017-11-28 中国科学院过程工程研究所 一种疫苗制剂及其制备方法和用途
JP2018082987A (ja) * 2016-11-25 2018-05-31 株式会社日立製作所 ウイルス不活化方法及びウイルス不活化装置
JP2020152644A (ja) * 2019-03-18 2020-09-24 国立大学法人愛媛大学 Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN112120012B (zh) * 2020-09-30 2022-03-22 广东康盾创新产业集团股份公司 一种car-t细胞冻存方法
BR102021000794A2 (pt) * 2021-01-15 2022-07-26 Fundação Oswaldo Cruz Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
JP2743177B2 (ja) * 1987-04-24 1998-04-22 財団法人阪大微生物病研究会 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン
JP4111403B2 (ja) 1996-10-11 2008-07-02 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 免疫刺激ポリヌクレオチド／免疫調節分子複合体
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
FR2771011B1 (fr) 1997-11-17 2000-01-28 Hippocampe Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
US6489450B2 (en) 1998-07-09 2002-12-03 University Technology Corporation High pressure refolding of protein aggregates and inclusion bodies
WO2000072703A1 (en) 1999-05-28 2000-12-07 UNIVERSITé LAVAL Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure
US6645740B1 (en) 1999-06-10 2003-11-11 Merial Limited Nucleic acids encodings equine GM-CSF
IL148843A0 (en) 1999-09-25 2002-09-12 Univ Iowa Res Found Immunostimulatory nucleic acids
US7615617B2 (en) 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
WO2002056824A2 (en) 2000-08-10 2002-07-25 Boston Biomedica, Inc. Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines
US6635223B2 (en) 2000-10-25 2003-10-21 Andreas Maerz Method for inactivating micro-organisms using high pressure processing
WO2002062827A2 (en) * 2000-10-31 2002-08-15 The Regents Of The University Of Colorado, A Body Corporate Improved protein disaggregation and refolding using high pressure
AU2003245416A1 (en) 2002-06-07 2004-04-30 University Of Florida Endodontic files made using bulk metallic glasses
SE525457C2 (sv) * 2002-06-24 2005-02-22 Flow Holdings Sagl Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning
RS52507B (sr) * 2003-11-05 2013-04-30 Laboratorios Leti S.L. Primena specifičnih histona za lečenje parazitnih bolesti
US7993580B2 (en) 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
JP2009519706A (ja) 2005-11-21 2009-05-21 バロフォールド， インコーポレイテッド タンパク質の高圧リフォールディングのためのデバイスおよび方法
CN200945252Y (zh) * 2006-09-01 2007-09-12 天津市华泰森淼生物工程技术有限公司 手动开启式小型超高压生物处理设备
EP2059523A2 (en) 2006-09-15 2009-05-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
WO2008124134A2 (en) 2007-04-05 2008-10-16 Barofold, Inc. High-pressure refolding of proteins in the presence of binding partners
WO2008124139A1 (en) 2007-04-05 2008-10-16 Barofold, Inc. High pressure inclusion body solubilization in the presence of a protease
US8273561B2 (en) 2007-10-05 2012-09-25 Nuron Biotech, Inc. High pressure treatment of aggregated interferons
RU2440137C1 (ru) * 2007-12-21 2012-01-20 Пфайзер Инк. Термообработанные бактерины и эмульсионные вакцины, полученные из таких термообработанных бактеринов
BRPI0800357A2 (pt) 2008-03-10 2009-10-27 Fundacao Oswaldo Cruz método para produção de uma vacina estabilizada
US8603808B2 (en) 2008-05-08 2013-12-10 Merial Limited Leishmania vaccine using sand fly salivary immunogen
US8410258B2 (en) * 2008-05-21 2013-04-02 Infections Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
US8425919B2 (en) 2008-05-21 2013-04-23 Infectious Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
WO2009155102A2 (en) 2008-05-30 2009-12-23 Barofold, Inc. Method for derivatization of proteins using hydrostatic pressure
US20110070219A1 (en) 2009-04-27 2011-03-24 Seefeldt Matthew B High pressure protein crystallization
EP2531042A1 (en) * 2010-02-01 2012-12-12 Avure Technologies AB High-pressure arrangement with locking element preventing rotation of load basket
CN201781934U (zh) * 2010-04-14 2011-04-06 中国农业大学 一种小型框架自动式超高压设备
US8697848B2 (en) 2010-07-19 2014-04-15 The Regents Of The University Of Colorado Method for reducing immunogenicity of therapeutic protein compositions
KR102208844B1 (ko) 2012-08-30 2021-01-27 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법
ZA201501696B (en) * 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins

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