JP2015528466A5 - - Google Patents
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- Publication number
- JP2015528466A5 JP2015528466A5 JP2015530070A JP2015530070A JP2015528466A5 JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5 JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015530070 A JP2015530070 A JP 2015530070A JP 2015528466 A5 JP2015528466 A5 JP 2015528466A5
- Authority
- JP
- Japan
- Prior art keywords
- urea
- bar
- inclusion body
- high pressure
- inclusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003000 inclusion body Anatomy 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 5
- 239000004202 carbamide Substances 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694968P | 2012-08-30 | 2012-08-30 | |
| US61/694,968 | 2012-08-30 | ||
| US201361830425P | 2013-06-03 | 2013-06-03 | |
| US61/830,425 | 2013-06-03 | ||
| PCT/US2013/057430 WO2014036349A1 (en) | 2012-08-30 | 2013-08-30 | Expression of chimeric ksac protein and method of producing soluble proteins by high pressure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528466A JP2015528466A (ja) | 2015-09-28 |
| JP2015528466A5 true JP2015528466A5 (enExample) | 2016-08-12 |
| JP6405308B2 JP6405308B2 (ja) | 2018-10-17 |
Family
ID=49162270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9169302B2 (enExample) |
| EP (2) | EP2890392B1 (enExample) |
| JP (2) | JP6405308B2 (enExample) |
| KR (1) | KR102208844B1 (enExample) |
| CN (3) | CN104717976A (enExample) |
| AP (1) | AP2015008331A0 (enExample) |
| AU (4) | AU2013308623B2 (enExample) |
| BR (1) | BR112015004463B8 (enExample) |
| CA (2) | CA2883303A1 (enExample) |
| EA (1) | EA031988B1 (enExample) |
| ES (1) | ES2744709T3 (enExample) |
| HK (1) | HK1211874A1 (enExample) |
| MD (1) | MD4608C1 (enExample) |
| MX (3) | MX358782B (enExample) |
| NZ (3) | NZ715459A (enExample) |
| PH (1) | PH12015500700B1 (enExample) |
| RU (1) | RU2647568C2 (enExample) |
| WO (2) | WO2014036349A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968749B2 (en) * | 2006-07-21 | 2015-03-03 | Universidade Federal De Minas Gerais—Ufmg | Vaccine composition and immunization method |
| ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| MX358782B (es) | 2012-08-30 | 2018-09-04 | Merial Inc | Expresión de proteina ksac quimérica y método para producir proteínas solubles mediante alta presión. |
| EP2978447B1 (en) * | 2013-03-28 | 2019-05-08 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
| CN104758944B (zh) | 2015-04-02 | 2017-11-28 | 中国科学院过程工程研究所 | 一种疫苗制剂及其制备方法和用途 |
| JP2018082987A (ja) * | 2016-11-25 | 2018-05-31 | 株式会社日立製作所 | ウイルス不活化方法及びウイルス不活化装置 |
| JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN112120012B (zh) * | 2020-09-30 | 2022-03-22 | 广东康盾创新产业集团股份公司 | 一种car-t细胞冻存方法 |
| BR102021000794A2 (pt) * | 2021-01-15 | 2022-07-26 | Fundação Oswaldo Cruz | Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
| US6610661B1 (en) | 1996-10-11 | 2003-08-26 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| FR2771011B1 (fr) | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| FR2776928B1 (fr) | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
| AU4975699A (en) | 1998-07-09 | 2000-02-01 | University Technology Corporation | High pressure refolding of protein aggregates and inclusion bodies |
| EP1180945A1 (en) | 1999-05-28 | 2002-02-27 | Universite Laval | Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure |
| US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
| AU780979B2 (en) | 1999-09-25 | 2005-04-28 | Coley Pharmaceutical Gmbh | Immunostimulatory nucleic acids |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| AU2002246493A1 (en) | 2000-08-10 | 2002-07-30 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
| US6635223B2 (en) | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
| DE60133426T2 (de) * | 2000-10-31 | 2008-11-13 | BaroFold, Inc., Boulder | Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks |
| AU2003245416A1 (en) | 2002-06-07 | 2004-04-30 | University Of Florida | Endodontic files made using bulk metallic glasses |
| SE525457C2 (sv) * | 2002-06-24 | 2005-02-22 | Flow Holdings Sagl | Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning |
| WO2005044301A2 (en) * | 2003-11-05 | 2005-05-19 | C.B.F. Leti, S.L. Unipersonal | Use of specific histones for the treatment of parasitic diseases |
| US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| AU2006318435A1 (en) | 2005-11-21 | 2007-05-31 | Barofold, Inc. | Devices and methods for high-pressure refolding of proteins |
| CN200945252Y (zh) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | 手动开启式小型超高压生物处理设备 |
| US20080161242A1 (en) | 2006-09-15 | 2008-07-03 | Randolph Theodore W | High pressure treatment of proteins for reduced immunogenicity |
| US7829681B2 (en) | 2007-04-05 | 2010-11-09 | Barofold Inc. | High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins |
| WO2008124134A2 (en) | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High-pressure refolding of proteins in the presence of binding partners |
| WO2009045553A1 (en) | 2007-10-05 | 2009-04-09 | Barofold, Inc. | High pressure treatment of aggregated interferons |
| AU2008348022B2 (en) * | 2007-12-21 | 2015-03-05 | Zoetis Services Llc | Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins |
| BRPI0800357A2 (pt) | 2008-03-10 | 2009-10-27 | Fundacao Oswaldo Cruz | método para produção de uma vacina estabilizada |
| EP2283035B1 (en) | 2008-05-08 | 2015-07-29 | Merial Limited | Leishmania vaccine using sand fly salivary immunogen |
| US8410258B2 (en) * | 2008-05-21 | 2013-04-02 | Infections Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
| EP2300051B1 (en) | 2008-05-21 | 2014-11-12 | Infectious Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
| WO2009155102A2 (en) | 2008-05-30 | 2009-12-23 | Barofold, Inc. | Method for derivatization of proteins using hydrostatic pressure |
| US20110070219A1 (en) | 2009-04-27 | 2011-03-24 | Seefeldt Matthew B | High pressure protein crystallization |
| CA2787320A1 (en) | 2010-02-01 | 2011-08-04 | Avure Technologies Ab | High-pressure arrangement with locking element preventing rotation of load basket |
| CN201781934U (zh) * | 2010-04-14 | 2011-04-06 | 中国农业大学 | 一种小型框架自动式超高压设备 |
| EP2600843B9 (en) | 2010-07-19 | 2020-03-11 | Pressure BioSciences, Inc. | Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy |
| MX358782B (es) * | 2012-08-30 | 2018-09-04 | Merial Inc | Expresión de proteina ksac quimérica y método para producir proteínas solubles mediante alta presión. |
| ZA201501696B (en) * | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
-
2013
- 2013-08-30 MX MX2015002699A patent/MX358782B/es active IP Right Grant
- 2013-08-30 NZ NZ715459A patent/NZ715459A/en unknown
- 2013-08-30 ES ES13760212T patent/ES2744709T3/es active Active
- 2013-08-30 CN CN201380053720.8A patent/CN104717976A/zh active Pending
- 2013-08-30 AU AU2013308623A patent/AU2013308623B2/en active Active
- 2013-08-30 AU AU2013308627A patent/AU2013308627B2/en not_active Ceased
- 2013-08-30 US US14/014,434 patent/US9169302B2/en active Active
- 2013-08-30 CA CA2883303A patent/CA2883303A1/en not_active Abandoned
- 2013-08-30 NZ NZ705790A patent/NZ705790A/en unknown
- 2013-08-30 EP EP13760212.4A patent/EP2890392B1/en not_active Not-in-force
- 2013-08-30 US US14/014,437 patent/US9315553B2/en active Active
- 2013-08-30 JP JP2015530070A patent/JP6405308B2/ja not_active Expired - Fee Related
- 2013-08-30 CN CN201380054922.4A patent/CN104768577B/zh active Active
- 2013-08-30 MX MX2015002701A patent/MX381717B/es unknown
- 2013-08-30 NZ NZ706288A patent/NZ706288A/en not_active IP Right Cessation
- 2013-08-30 WO PCT/US2013/057430 patent/WO2014036349A1/en not_active Ceased
- 2013-08-30 CN CN201810318137.XA patent/CN108578679A/zh active Pending
- 2013-08-30 JP JP2015530066A patent/JP6438396B2/ja active Active
- 2013-08-30 AP AP2015008331A patent/AP2015008331A0/xx unknown
- 2013-08-30 CA CA2883296A patent/CA2883296A1/en not_active Abandoned
- 2013-08-30 BR BR112015004463A patent/BR112015004463B8/pt active IP Right Grant
- 2013-08-30 MD MDA20150031A patent/MD4608C1/ro not_active IP Right Cessation
- 2013-08-30 EA EA201500275A patent/EA031988B1/ru unknown
- 2013-08-30 WO PCT/US2013/057426 patent/WO2014036345A2/en not_active Ceased
- 2013-08-30 RU RU2015111255A patent/RU2647568C2/ru active
- 2013-08-30 EP EP13766420.7A patent/EP2890393A2/en active Pending
- 2013-08-30 KR KR1020157008190A patent/KR102208844B1/ko active Active
- 2013-08-30 HK HK16100050.9A patent/HK1211874A1/xx unknown
-
2015
- 2015-02-27 MX MX2021004478A patent/MX2021004478A/es unknown
- 2015-03-27 PH PH12015500700A patent/PH12015500700B1/en unknown
-
2016
- 2016-02-05 US US15/017,486 patent/US10364274B2/en active Active
-
2017
- 2017-01-17 AU AU2017200301A patent/AU2017200301A1/en not_active Abandoned
- 2017-03-14 AU AU2017201724A patent/AU2017201724B2/en active Active
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