KR102208844B1 - 고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법 - Google Patents

고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법 Download PDF

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KR102208844B1
KR102208844B1 KR1020157008190A KR20157008190A KR102208844B1 KR 102208844 B1 KR102208844 B1 KR 102208844B1 KR 1020157008190 A KR1020157008190 A KR 1020157008190A KR 20157008190 A KR20157008190 A KR 20157008190A KR 102208844 B1 KR102208844 B1 KR 102208844B1
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니꼴라 피에르 이브 까르부레
질다 메리앙
르네 라바뛰
리오넬 제랑뜨
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뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드
토프 앵뒤스뜨리 에스.에이.에스.
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KR1020157008190A 2012-08-30 2013-08-30 고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법 Active KR102208844B1 (ko)

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US201261694968P 2012-08-30 2012-08-30
US61/694,968 2012-08-30
US201361830425P 2013-06-03 2013-06-03
US61/830,425 2013-06-03
PCT/US2013/057426 WO2014036345A2 (en) 2012-08-30 2013-08-30 Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins

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KR20150063403A KR20150063403A (ko) 2015-06-09
KR102208844B1 true KR102208844B1 (ko) 2021-01-27

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AU (4) AU2013308623B2 (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8968749B2 (en) * 2006-07-21 2015-03-03 Universidade Federal De Minas Gerais—Ufmg Vaccine composition and immunization method
MX381717B (es) 2012-08-30 2025-03-13 Merial Inc Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinates.
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
ES2728865T3 (es) * 2013-03-28 2019-10-29 Infectious Disease Res Inst Vacunas que comprenden polipéptidos de Leishmania para el tratamiento y el diagnóstico de la leishmaniasis
CN104758944B (zh) * 2015-04-02 2017-11-28 中国科学院过程工程研究所 一种疫苗制剂及其制备方法和用途
JP2018082987A (ja) * 2016-11-25 2018-05-31 株式会社日立製作所 ウイルス不活化方法及びウイルス不活化装置
JP2020152644A (ja) * 2019-03-18 2020-09-24 国立大学法人愛媛大学 Vnarのリフォールディング方法およびvnarの製造方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
CN112120012B (zh) * 2020-09-30 2022-03-22 广东康盾创新产业集团股份公司 一种car-t细胞冻存方法
BR102021000794A2 (pt) * 2021-01-15 2022-07-26 Fundação Oswaldo Cruz Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004530651A (ja) 2000-10-31 2004-10-07 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド, ア ボディー コーポレイト 高圧を使用する、改善されたタンパク質脱凝集およびリフォールディング
WO2009143006A1 (en) 2008-05-21 2009-11-26 Infectious Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
JP2743177B2 (ja) * 1987-04-24 1998-04-22 財団法人阪大微生物病研究会 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン
US6610661B1 (en) 1996-10-11 2003-08-26 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
FR2771011B1 (fr) 1997-11-17 2000-01-28 Hippocampe Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
WO2000002901A1 (en) 1998-07-09 2000-01-20 University Technology Corporation High pressure refolding of protein aggregates and inclusion bodies
AU4906200A (en) 1999-05-28 2000-12-18 Universite Laval Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure
US6645740B1 (en) 1999-06-10 2003-11-11 Merial Limited Nucleic acids encodings equine GM-CSF
PL354997A1 (en) 1999-09-25 2004-03-22 University Of Iowa Research Foundation Immunostimulatory nucleic acids
US7615617B2 (en) 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
AU2002246493A1 (en) 2000-08-10 2002-07-30 Boston Biomedica, Inc. Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines
US6635223B2 (en) 2000-10-25 2003-10-21 Andreas Maerz Method for inactivating micro-organisms using high pressure processing
WO2004024027A2 (en) 2002-06-07 2004-03-25 University Of Florida Endodontic files made using bulk metallic glasses
SE525457C2 (sv) 2002-06-24 2005-02-22 Flow Holdings Sagl Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning
PT1687023E (pt) * 2003-11-05 2013-01-23 Leti Sl Lab Uso de histonas específicas para o tratamento de doenças parasitárias
US7993580B2 (en) 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
US20090215998A1 (en) 2005-11-21 2009-08-27 Barofoid, Inc. Devices and methods for high-pressure refolding of proteins
CN200945252Y (zh) * 2006-09-01 2007-09-12 天津市华泰森淼生物工程技术有限公司 手动开启式小型超高压生物处理设备
JP2010503683A (ja) 2006-09-15 2010-02-04 バロフォールド, インコーポレイテッド 免疫原性低下のためのタンパク質の高圧処理
US20080249286A1 (en) 2007-04-05 2008-10-09 Seefeldt Matthew B High-pressure refolding of proteins in the presence of binding partners
WO2008124139A1 (en) 2007-04-05 2008-10-16 Barofold, Inc. High pressure inclusion body solubilization in the presence of a protease
EP2207890A4 (en) 2007-10-05 2010-12-15 Barofold Inc HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS
CN101903041A (zh) * 2007-12-21 2010-12-01 辉瑞大药厂 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗
BRPI0800357A2 (pt) 2008-03-10 2009-10-27 Fundacao Oswaldo Cruz método para produção de uma vacina estabilizada
WO2009137577A2 (en) 2008-05-08 2009-11-12 Merial Limited Leishmania vaccine using sand fly salivary immunogen
US8410258B2 (en) * 2008-05-21 2013-04-02 Infections Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
US20100112660A1 (en) 2008-05-30 2010-05-06 Barofold, Inc. Method for Derivatization of Proteins Using Hydrostatic Pressure
US20110070219A1 (en) 2009-04-27 2011-03-24 Seefeldt Matthew B High pressure protein crystallization
WO2011091860A1 (en) * 2010-02-01 2011-08-04 Avure Technologies Ab High-pressure arrangement with locking element preventing rotation of load basket
CN201781934U (zh) * 2010-04-14 2011-04-06 中国农业大学 一种小型框架自动式超高压设备
ES2749977T3 (es) 2010-07-19 2020-03-24 Pressure Biosciences Inc Composiciones de proteínas terapéuticas que tienen inmunogenia reducida y/o eficacia mejorada
ZA201501696B (en) * 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
MX381717B (es) * 2012-08-30 2025-03-13 Merial Inc Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinates.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004530651A (ja) 2000-10-31 2004-10-07 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド, ア ボディー コーポレイト 高圧を使用する、改善されたタンパク質脱凝集およびリフォールディング
WO2009143006A1 (en) 2008-05-21 2009-11-26 Infectious Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SAIZ A. HERNANDO et al., Advances in design for successful commercial high pressure food processing, Volume: 60 Issue: 4 Page: 154-156 Publication year: Apr. 2008

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