CN101903041A - 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 - Google Patents
经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 Download PDFInfo
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- CN101903041A CN101903041A CN2008801217140A CN200880121714A CN101903041A CN 101903041 A CN101903041 A CN 101903041A CN 2008801217140 A CN2008801217140 A CN 2008801217140A CN 200880121714 A CN200880121714 A CN 200880121714A CN 101903041 A CN101903041 A CN 101903041A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
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- A—HUMAN NECESSITIES
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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Abstract
Description
储存温度(12小时) | 4℃ | 37℃ | 45℃ | 56℃ | 65℃ | 80℃ |
原始脂酶活性百分比 | 100% | 55.4% | 32.5% | 15.7% | 10.8% | 8.4% |
取样时间(小时) | 起始 | 2 | 4 | 6 | 8 |
原始脂酶活性百分比 | 100% | 41% | 34% | 28% | 24% |
组分 | 组分浓度/剂量 |
犬钩端螺旋体 | 1200NU/2ml剂量 |
出血黄疸钩端螺旋体 | 1200NU/2ml剂量 |
感冒伤寒型钩端螺旋体 | 1200NU/2ml剂量 |
哈德焦钩端螺旋体 | 2400NU/2ml剂量 |
波摩那钩端螺旋体 | 1200NU/2ml剂量 |
布拉迪斯拉发钩端螺旋体 | 1200NU/2ml剂量 |
猪红斑丹毒丝菌 | 14OU/2ml剂量 |
猪细小病毒 | 17,920HA/.05ml |
Claims (6)
Priority Applications (1)
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CN201610981429.2A CN106562927A (zh) | 2007-12-21 | 2008-12-04 | 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 |
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US1571807P | 2007-12-21 | 2007-12-21 | |
US61/015,718 | 2007-12-21 | ||
PCT/IB2008/003369 WO2009090461A1 (en) | 2007-12-21 | 2008-12-04 | Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins |
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CN201610981429.2A Division CN106562927A (zh) | 2007-12-21 | 2008-12-04 | 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 |
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CN101903041A true CN101903041A (zh) | 2010-12-01 |
Family
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CN2008801217140A Pending CN101903041A (zh) | 2007-12-21 | 2008-12-04 | 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 |
CN201610981429.2A Pending CN106562927A (zh) | 2007-12-21 | 2008-12-04 | 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 |
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CN201610981429.2A Pending CN106562927A (zh) | 2007-12-21 | 2008-12-04 | 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗 |
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US (2) | US20090162397A1 (zh) |
EP (1) | EP2224951B1 (zh) |
JP (2) | JP5890096B2 (zh) |
KR (1) | KR101254848B1 (zh) |
CN (2) | CN101903041A (zh) |
AR (1) | AR070675A1 (zh) |
AU (1) | AU2008348022B2 (zh) |
BR (1) | BRPI0819938B1 (zh) |
CA (1) | CA2710186C (zh) |
CL (1) | CL2008003845A1 (zh) |
CO (1) | CO6290700A2 (zh) |
DK (1) | DK2224951T3 (zh) |
ES (1) | ES2763395T3 (zh) |
LT (1) | LT2224951T (zh) |
NZ (1) | NZ585877A (zh) |
PT (1) | PT2224951T (zh) |
RU (1) | RU2440137C1 (zh) |
TW (1) | TWI419702B (zh) |
UY (1) | UY31557A1 (zh) |
WO (1) | WO2009090461A1 (zh) |
ZA (1) | ZA201005178B (zh) |
Cited By (4)
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CN105879023A (zh) * | 2016-05-28 | 2016-08-24 | 青岛易邦生物工程有限公司 | 一种猪细小病毒和猪流行性腹泻二联灭活疫苗 |
CN106039304A (zh) * | 2016-05-28 | 2016-10-26 | 青岛易邦生物工程有限公司 | 一种猪细小病毒、猪流行性腹泻、大肠埃希氏菌三联疫苗 |
CN107496913A (zh) * | 2017-09-15 | 2017-12-22 | 天津瑞普生物技术股份有限公司 | 猪丹毒、猪细小病毒、猪流感病毒三联灭活疫苗制备方法 |
CN111658611A (zh) * | 2020-04-13 | 2020-09-15 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
Families Citing this family (4)
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CA2710186C (en) * | 2007-12-21 | 2015-11-03 | Pfizer Inc. | Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins |
AP2015008331A0 (en) * | 2012-08-30 | 2015-03-31 | Top Ind Sas | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
JP2016512841A (ja) | 2013-03-15 | 2016-05-09 | ゾエティス・サービシーズ・エルエルシー | 多価ワクチンによるb.トレハロシ感染に対するウシの干渉効果 |
CN112941091A (zh) * | 2021-03-17 | 2021-06-11 | 吉林大学 | 一种猪血凝性脑脊髓炎dna疫苗及其制备方法 |
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AU2002951692A0 (en) * | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
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CA2710186C (en) * | 2007-12-21 | 2015-11-03 | Pfizer Inc. | Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins |
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- 2008-12-04 AU AU2008348022A patent/AU2008348022B2/en active Active
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Patent Citations (1)
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CN101516393A (zh) * | 2006-09-11 | 2009-08-26 | 辉瑞产品公司 | 热处理菌苗和由该热处理菌苗制备的乳液疫苗 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105879023A (zh) * | 2016-05-28 | 2016-08-24 | 青岛易邦生物工程有限公司 | 一种猪细小病毒和猪流行性腹泻二联灭活疫苗 |
CN106039304A (zh) * | 2016-05-28 | 2016-10-26 | 青岛易邦生物工程有限公司 | 一种猪细小病毒、猪流行性腹泻、大肠埃希氏菌三联疫苗 |
CN105879023B (zh) * | 2016-05-28 | 2020-11-27 | 青岛易邦生物工程有限公司 | 一种猪细小病毒和猪流行性腹泻二联灭活疫苗 |
CN106039304B (zh) * | 2016-05-28 | 2021-02-05 | 青岛易邦生物工程有限公司 | 一种猪细小病毒、猪流行性腹泻、大肠埃希氏菌三联疫苗 |
CN107496913A (zh) * | 2017-09-15 | 2017-12-22 | 天津瑞普生物技术股份有限公司 | 猪丹毒、猪细小病毒、猪流感病毒三联灭活疫苗制备方法 |
CN111658611A (zh) * | 2020-04-13 | 2020-09-15 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
Also Published As
Publication number | Publication date |
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CN106562927A (zh) | 2017-04-19 |
UY31557A1 (es) | 2009-08-03 |
KR20100092022A (ko) | 2010-08-19 |
CA2710186A1 (en) | 2009-07-23 |
ES2763395T3 (es) | 2020-05-28 |
EP2224951B1 (en) | 2019-10-30 |
PT2224951T (pt) | 2020-01-10 |
JP2011507827A (ja) | 2011-03-10 |
CL2008003845A1 (es) | 2010-09-24 |
TWI419702B (zh) | 2013-12-21 |
LT2224951T (lt) | 2020-01-10 |
JP5890096B2 (ja) | 2016-03-22 |
BRPI0819938B1 (pt) | 2019-02-26 |
KR101254848B1 (ko) | 2013-04-15 |
AU2008348022B2 (en) | 2015-03-05 |
BRPI0819938A2 (pt) | 2015-05-26 |
CA2710186C (en) | 2015-11-03 |
JP2014237698A (ja) | 2014-12-18 |
TW200940088A (en) | 2009-10-01 |
AU2008348022A1 (en) | 2009-07-23 |
US9289482B2 (en) | 2016-03-22 |
US20090162397A1 (en) | 2009-06-25 |
DK2224951T3 (da) | 2020-01-06 |
RU2440137C1 (ru) | 2012-01-20 |
NZ585877A (en) | 2012-06-29 |
AR070675A1 (es) | 2010-04-28 |
ZA201005178B (en) | 2011-03-30 |
WO2009090461A1 (en) | 2009-07-23 |
CO6290700A2 (es) | 2011-06-20 |
US20100285057A1 (en) | 2010-11-11 |
EP2224951A1 (en) | 2010-09-08 |
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