MX2015002699A - Expresion de proteinas ksac quimerica y metodo para producir proteinas solubles mediante alta presion. - Google Patents
Expresion de proteinas ksac quimerica y metodo para producir proteinas solubles mediante alta presion.Info
- Publication number
- MX2015002699A MX2015002699A MX2015002699A MX2015002699A MX2015002699A MX 2015002699 A MX2015002699 A MX 2015002699A MX 2015002699 A MX2015002699 A MX 2015002699A MX 2015002699 A MX2015002699 A MX 2015002699A MX 2015002699 A MX2015002699 A MX 2015002699A
- Authority
- MX
- Mexico
- Prior art keywords
- expression
- high pressure
- ksac protein
- soluble proteins
- producing soluble
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/015—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress or cavitation
- A23L3/0155—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress or cavitation using sub- or super-atmospheric pressures, or pressure variations transmitted by a liquid or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/008—Leishmania antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01041—Sterol 24-C-methyltransferasee (2.1.1.41)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención abarca vacunas y composiciones que comprenden la proteína KSAC quimérica que posee propiedades inmunogénicas y protectoras, y métodos de uso que incluyen la administración a un animal de la proteína KSAC antigénica misma para proteger animales. La invención también abarca métodos para hacer y producir las proteínas solubles, desagregadas, replegadas o activas de los cuerpos de inclusión producidos de las procariotas o eucariotas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261694968P | 2012-08-30 | 2012-08-30 | |
US201361830425P | 2013-06-03 | 2013-06-03 | |
PCT/US2013/057430 WO2014036349A1 (en) | 2012-08-30 | 2013-08-30 | Expression of chimeric ksac protein and method of producing soluble proteins by high pressure |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015002699A true MX2015002699A (es) | 2015-12-01 |
MX358782B MX358782B (es) | 2018-09-04 |
Family
ID=49162270
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002699A MX358782B (es) | 2012-08-30 | 2013-08-30 | Expresión de proteina ksac quimérica y método para producir proteínas solubles mediante alta presión. |
MX2015002701A MX2015002701A (es) | 2012-08-30 | 2013-08-30 | Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinates. |
MX2021004478A MX2021004478A (es) | 2012-08-30 | 2015-02-27 | Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinantes. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002701A MX2015002701A (es) | 2012-08-30 | 2013-08-30 | Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinates. |
MX2021004478A MX2021004478A (es) | 2012-08-30 | 2015-02-27 | Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinantes. |
Country Status (18)
Country | Link |
---|---|
US (3) | US9169302B2 (es) |
EP (2) | EP2890393A2 (es) |
JP (2) | JP6438396B2 (es) |
KR (1) | KR102208844B1 (es) |
CN (3) | CN104717976A (es) |
AP (1) | AP2015008331A0 (es) |
AU (4) | AU2013308623B2 (es) |
BR (1) | BR112015004463B8 (es) |
CA (2) | CA2883296A1 (es) |
EA (1) | EA031988B1 (es) |
ES (1) | ES2744709T3 (es) |
HK (2) | HK1211873A1 (es) |
MD (1) | MD4608C1 (es) |
MX (3) | MX358782B (es) |
NZ (3) | NZ705790A (es) |
PH (1) | PH12015500700B1 (es) |
RU (1) | RU2647568C2 (es) |
WO (2) | WO2014036349A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8968749B2 (en) * | 2006-07-21 | 2015-03-03 | Universidade Federal De Minas Gerais—Ufmg | Vaccine composition and immunization method |
US9169302B2 (en) * | 2012-08-30 | 2015-10-27 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
US9909114B2 (en) | 2013-03-28 | 2018-03-06 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
CN104758944B (zh) * | 2015-04-02 | 2017-11-28 | 中国科学院过程工程研究所 | 一种疫苗制剂及其制备方法和用途 |
JP2018082987A (ja) * | 2016-11-25 | 2018-05-31 | 株式会社日立製作所 | ウイルス不活化方法及びウイルス不活化装置 |
JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Vnarのリフォールディング方法およびvnarの製造方法 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CN112120012B (zh) * | 2020-09-30 | 2022-03-22 | 广东康盾创新产业集团股份公司 | 一种car-t细胞冻存方法 |
BR102021000794A2 (pt) * | 2021-01-15 | 2022-07-26 | Fundação Oswaldo Cruz | Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
AU4992197A (en) | 1996-10-11 | 1998-05-11 | Regents Of The University Of California, The | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
FR2771011B1 (fr) | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
FR2776928B1 (fr) | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
WO2000002901A1 (en) | 1998-07-09 | 2000-01-20 | University Technology Corporation | High pressure refolding of protein aggregates and inclusion bodies |
WO2000072703A1 (en) | 1999-05-28 | 2000-12-07 | UNIVERSITé LAVAL | Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure |
US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
EP1700603A3 (en) | 1999-09-25 | 2007-06-13 | Coley Pharmaceutical GmbH | Immunostimulatory nucleic acids |
US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
WO2002056824A2 (en) | 2000-08-10 | 2002-07-25 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
US6635223B2 (en) * | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
CA2434045A1 (en) | 2000-10-31 | 2002-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Improved protein disaggregation and refolding using high pressure |
AU2003245416A1 (en) | 2002-06-07 | 2004-04-30 | University Of Florida | Endodontic files made using bulk metallic glasses |
SE525457C2 (sv) | 2002-06-24 | 2005-02-22 | Flow Holdings Sagl | Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning |
ES2395923T3 (es) * | 2003-11-05 | 2013-02-18 | Laboratorios Leti, S.L. | Uso de histonas específicas para el tratamiento de enfermedades parasitarias |
US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
AU2006318435A1 (en) | 2005-11-21 | 2007-05-31 | Barofold, Inc. | Devices and methods for high-pressure refolding of proteins |
CN200945252Y (zh) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | 手动开启式小型超高压生物处理设备 |
US20080161242A1 (en) * | 2006-09-15 | 2008-07-03 | Randolph Theodore W | High pressure treatment of proteins for reduced immunogenicity |
WO2008124134A2 (en) | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High-pressure refolding of proteins in the presence of binding partners |
US7829681B2 (en) | 2007-04-05 | 2010-11-09 | Barofold Inc. | High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins |
EP2207890A4 (en) | 2007-10-05 | 2010-12-15 | Barofold Inc | HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS |
AU2008348022B2 (en) * | 2007-12-21 | 2015-03-05 | Zoetis Services Llc | Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins |
BRPI0800357A2 (pt) | 2008-03-10 | 2009-10-27 | Fundacao Oswaldo Cruz | método para produção de uma vacina estabilizada |
EP2899203B1 (en) | 2008-05-08 | 2019-07-10 | Boehringer Ingelheim Animal Health USA Inc. | Leishmania vaccine using sand fly salivary immunogen |
US8410258B2 (en) * | 2008-05-21 | 2013-04-02 | Infections Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
ES2528928T3 (es) | 2008-05-21 | 2015-02-13 | Infectious Disease Research Institute | Vacunas de poliproteína recombinante para el tratamiento y diagnóstico de leishmaniosis |
WO2009155102A2 (en) | 2008-05-30 | 2009-12-23 | Barofold, Inc. | Method for derivatization of proteins using hydrostatic pressure |
US20110070219A1 (en) | 2009-04-27 | 2011-03-24 | Seefeldt Matthew B | High pressure protein crystallization |
CA2787320A1 (en) * | 2010-02-01 | 2011-08-04 | Avure Technologies Ab | High-pressure arrangement with locking element preventing rotation of load basket |
CN201781934U (zh) * | 2010-04-14 | 2011-04-06 | 中国农业大学 | 一种小型框架自动式超高压设备 |
EP2600843B9 (en) | 2010-07-19 | 2020-03-11 | Pressure BioSciences, Inc. | Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy |
US9169302B2 (en) * | 2012-08-30 | 2015-10-27 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
ZA201501696B (en) * | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
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2013
- 2013-08-30 US US14/014,434 patent/US9169302B2/en active Active
- 2013-08-30 MX MX2015002699A patent/MX358782B/es active IP Right Grant
- 2013-08-30 AU AU2013308623A patent/AU2013308623B2/en active Active
- 2013-08-30 AP AP2015008331A patent/AP2015008331A0/xx unknown
- 2013-08-30 KR KR1020157008190A patent/KR102208844B1/ko active IP Right Grant
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