JP2018523682A5 - - Google Patents

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Publication number

JP2018523682A5

JP2018523682A5 JP2018508674A JP2018508674A JP2018523682A5 JP 2018523682 A5 JP2018523682 A5 JP 2018523682A5 JP 2018508674 A JP2018508674 A JP 2018508674A JP 2018508674 A JP2018508674 A JP 2018508674A JP 2018523682 A5 JP2018523682 A5 JP 2018523682A5

Authority

JP

Japan

Prior art keywords

solution

hours

subject

optionally

pharmaceutical composition

Prior art date

2016-08-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 24
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 18
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 18
• 238000002360 preparation method Methods 0.000 claims 11
• 239000001103 potassium chloride Substances 0.000 claims 9
• 235000011164 potassium chloride Nutrition 0.000 claims 9
• 239000011780 sodium chloride Substances 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 208000017442 Retinal disease Diseases 0.000 claims 6
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 5
• 239000008121 dextrose Substances 0.000 claims 5
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 4
• 239000001509 sodium citrate Substances 0.000 claims 4
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
• 239000001110 calcium chloride Substances 0.000 claims 2
• 229960002713 calcium chloride Drugs 0.000 claims 2
• 229910001628 calcium chloride Inorganic materials 0.000 claims 2
• 150000004683 dihydrates Chemical class 0.000 claims 2
• 150000004687 hexahydrates Chemical class 0.000 claims 2
• 229960002337 magnesium chloride Drugs 0.000 claims 2
• 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
• 229960000999 sodium citrate dihydrate Drugs 0.000 claims 2
• 230000004083 survival effect Effects 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims 2
• 230000035899 viability Effects 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 229920001353 Dextrin Polymers 0.000 claims 1
• 239000004375 Dextrin Substances 0.000 claims 1
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
• 201000003533 Leber congenital amaurosis Diseases 0.000 claims 1
• 208000034461 Progressive cone dystrophy Diseases 0.000 claims 1
• 201000007737 Retinal degeneration Diseases 0.000 claims 1
• 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
• 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
• 208000027073 Stargardt disease Diseases 0.000 claims 1
• LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 claims 1
• 229940052299 calcium chloride dihydrate Drugs 0.000 claims 1
• 230000004656 cell transport Effects 0.000 claims 1
• 201000008615 cone dystrophy Diseases 0.000 claims 1
• 235000019425 dextrin Nutrition 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 238000002513 implantation Methods 0.000 claims 1
• 208000002780 macular degeneration Diseases 0.000 claims 1
• 229940050906 magnesium chloride hexahydrate Drugs 0.000 claims 1
• DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 claims 1
• 210000000608 photoreceptor cell Anatomy 0.000 claims 1
• 239000002244 precipitate Substances 0.000 claims 1
• 238000001556 precipitation Methods 0.000 claims 1
• 230000004258 retinal degeneration Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000001632 sodium acetate Substances 0.000 claims 1
• 235000017281 sodium acetate Nutrition 0.000 claims 1
• 229940010747 sodium hyaluronate Drugs 0.000 claims 1
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1