JP2011507838A5 - - Google Patents

Info

Publication number

JP2011507838A5

JP2011507838A5 JP2010539385A JP2010539385A JP2011507838A5 JP 2011507838 A5 JP2011507838 A5 JP 2011507838A5 JP 2010539385 A JP2010539385 A JP 2010539385A JP 2010539385 A JP2010539385 A JP 2010539385A JP 2011507838 A5 JP2011507838 A5 JP 2011507838A5

Authority

JP

Japan

Prior art keywords

drug delivery

delivery system

methyl ester

sodium salt

substance

Prior art date

2008-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000012377 drug delivery Methods 0.000 claims 17
• 150000004702 methyl esters Chemical class 0.000 claims 14
• 159000000000 sodium salts Chemical class 0.000 claims 14
• 239000002245 particle Substances 0.000 claims 13
• 239000002253 acid Substances 0.000 claims 10
• 239000000126 substance Substances 0.000 claims 9
• XVOYSCVBGLVSOL-UHFFFAOYSA-N L-cysteine sulfonic acid Natural products OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 239000013543 active substance Substances 0.000 claims 3
• 239000000463 material Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 229940123237 Taxane Drugs 0.000 claims 2
• 230000000735 allogeneic effect Effects 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 230000032823 cell division Effects 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000003018 immunosuppressive agent Substances 0.000 claims 2
• 229940124589 immunosuppressive drug Drugs 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000002105 nanoparticle Substances 0.000 claims 2
• 210000000056 organ Anatomy 0.000 claims 2
• 239000003960 organic solvent Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
• 108010036949 Cyclosporine Proteins 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
• 229960001265 ciclosporin Drugs 0.000 claims 1
• 229930182912 cyclosporin Natural products 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000001704 evaporation Methods 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
• 229960002930 sirolimus Drugs 0.000 claims 1
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
• 229960001967 tacrolimus Drugs 0.000 claims 1
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1