JP2013542263A5 - - Google Patents

Info

Publication number

JP2013542263A5

JP2013542263A5 JP2013538937A JP2013538937A JP2013542263A5 JP 2013542263 A5 JP2013542263 A5 JP 2013542263A5 JP 2013538937 A JP2013538937 A JP 2013538937A JP 2013538937 A JP2013538937 A JP 2013538937A JP 2013542263 A5 JP2013542263 A5 JP 2013542263A5

Authority

JP

Japan

Prior art keywords

use according

taxane

formula

pharmaceutically acceptable

acceptable salt

Prior art date

2011-11-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229940123237 Taxane Drugs 0.000 claims 9
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 9
• 150000003839 salts Chemical class 0.000 claims 8
• 150000001875 compounds Chemical class 0.000 claims 6
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
• 229960003668 docetaxel Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229930012538 Paclitaxel Natural products 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 231100000682 maximum tolerated dose Toxicity 0.000 claims 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
• 229960001592 paclitaxel Drugs 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
• 238000004108 freeze drying Methods 0.000 description 4
• 0 *CC(NC1=O)=Nc2c1nc(CNc(cc1)ccc1C(N[C@@](CCC=O)C(O)=O)=O)cn2 Chemical compound *CC(NC1=O)=Nc2c1nc(CNc(cc1)ccc1C(N[C@@](CCC=O)C(O)=O)=O)cn2 0.000 description 3
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 229910052786 argon Inorganic materials 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1