JP2017534604A5 - - Google Patents
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- JP2017534604A5 JP2017534604A5 JP2017518487A JP2017518487A JP2017534604A5 JP 2017534604 A5 JP2017534604 A5 JP 2017534604A5 JP 2017518487 A JP2017518487 A JP 2017518487A JP 2017518487 A JP2017518487 A JP 2017518487A JP 2017534604 A5 JP2017534604 A5 JP 2017534604A5
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- JP
- Japan
- Prior art keywords
- composition
- composition according
- sirolimus
- carrier
- micrograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060988P | 2014-10-07 | 2014-10-07 | |
| US62/060,988 | 2014-10-07 | ||
| US201562144145P | 2015-04-07 | 2015-04-07 | |
| US62/144,145 | 2015-04-07 | ||
| PCT/US2015/054550 WO2016057712A1 (en) | 2014-10-07 | 2015-10-07 | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534604A JP2017534604A (ja) | 2017-11-24 |
| JP2017534604A5 true JP2017534604A5 (enExample) | 2018-11-08 |
| JP6679584B2 JP6679584B2 (ja) | 2020-04-15 |
Family
ID=54360545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518487A Active JP6679584B2 (ja) | 2014-10-07 | 2015-10-07 | 肺高血圧症を処置するための吸入可能なラパマイシン配合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20170304276A1 (enExample) |
| EP (1) | EP3209330B1 (enExample) |
| JP (1) | JP6679584B2 (enExample) |
| KR (1) | KR20170095807A (enExample) |
| CN (1) | CN107249576A (enExample) |
| AU (1) | AU2015330905B2 (enExample) |
| BR (1) | BR112017006842A2 (enExample) |
| CA (1) | CA2963085C (enExample) |
| IL (1) | IL251385B (enExample) |
| MX (1) | MX389399B (enExample) |
| RU (1) | RU2732908C2 (enExample) |
| WO (1) | WO2016057712A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6529012B2 (ja) | 2013-10-08 | 2019-06-12 | エイアイ・セラピューティクス・インコーポレーテッド | リンパ脈管筋腫症の処置のためのラパマイシン |
| NZ724756A (en) | 2014-04-04 | 2023-07-28 | Ai Therapeutics Inc | An inhalable rapamycin formulation for treating age-related conditions |
| AU2015330905B2 (en) | 2014-10-07 | 2021-02-25 | AI Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| PL3505157T3 (pl) * | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| IL277402B1 (en) | 2018-03-20 | 2026-04-01 | Abraxis Bioscience Llc | Methods for treating central nervous system disorders using administration of MTOR inhibitor nanoparticles and albumin |
| SG11202011462SA (en) * | 2018-05-22 | 2020-12-30 | Abraxis Bioscience Llc | Methods and compositions for treating pulmonary hypertension |
| EP3941551A4 (en) * | 2019-03-19 | 2023-01-18 | Abraxis BioScience, LLC | SUBCUTANEOUS ADMINISTRATION OF NANOPARTICLES WITH AN MTOR INHIBITOR AND ALBUMIN FOR THE TREATMENT OF DISEASES |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| CN113444730A (zh) * | 2021-03-17 | 2021-09-28 | 昆明市延安医院 | 一种原发性肝细胞klotho基因转导干细胞筛选构建方法 |
| TW202541834A (zh) * | 2024-04-16 | 2025-11-01 | 南韓商韓美藥品股份有限公司 | 吸入用組成物 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2517482A (en) | 1949-04-09 | 1950-08-01 | Sharp & Dohme Inc | Inhaler |
| GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| DE3345722A1 (de) | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Inhalator |
| GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
| DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| AU688782B2 (en) | 1993-09-30 | 1998-03-19 | Wyeth | Rapamycin formulations for oral administration |
| KR970705979A (ko) | 1994-09-29 | 1997-11-03 | 디 히스 | 치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles) |
| US5635161A (en) | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
| DE19523516C1 (de) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| US6258823B1 (en) | 1996-07-12 | 2001-07-10 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| BR9713661A (pt) | 1996-12-30 | 2000-10-24 | Battelle Memorial Institute | Formulação e método para o tratamento de neoplasmas por inalação |
| US6451784B1 (en) | 1996-12-30 | 2002-09-17 | Battellepharma, Inc. | Formulation and method for treating neoplasms by inhalation |
| US5989591A (en) | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US20040039047A1 (en) | 1998-08-11 | 2004-02-26 | Mark Zamoyski | Compositions and methods for treating lung cancers |
| DK1104760T3 (da) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
| US20040018228A1 (en) | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| CA2457148A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| CA2456746A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Method for treating lung cancers |
| CA2486622A1 (en) | 2002-05-20 | 2003-12-04 | Research Development Foundation | Aerosol drug inhibition of lung metastases |
| US20050070567A1 (en) | 2002-08-12 | 2005-03-31 | The Regents Of The University Of Michigan | Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway |
| ATE520405T1 (de) * | 2002-08-21 | 2011-09-15 | Norton Healthcare Ltd | Inhalationszusammensetzung |
| EP1585548B1 (en) | 2002-12-09 | 2018-06-27 | Abraxis BioScience, LLC | Compositions and methods of delivery of pharmacological agents |
| UA83484C2 (uk) | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| US20050119330A1 (en) | 2003-03-17 | 2005-06-02 | Kao Peter N. | Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases |
| AR043504A1 (es) | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
| AR050374A1 (es) | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
| US20060094744A1 (en) | 2004-09-29 | 2006-05-04 | Maryanoff Cynthia A | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| FR2882366B1 (fr) | 2005-02-18 | 2008-04-18 | Coletica Sa | Polymere reticule de carbohydrate, notamment a base de polysaccharides et/ou de polyols |
| EP1853612A1 (en) | 2005-03-02 | 2007-11-14 | Wyeth | Purification of rapamycin |
| JP2008532953A (ja) * | 2005-03-08 | 2008-08-21 | ライフサイクル ファーマ エー／エス | シロリムスおよび／またはその類縁物質を含む医薬組成物 |
| AU2006227623B2 (en) | 2005-03-17 | 2011-10-20 | Elan Pharma International Limited | Injectable compositions of nanoparticulate immunosuppressive compounds |
| CN1883474A (zh) | 2005-06-22 | 2006-12-27 | 华北制药集团新药研究开发有限责任公司 | 一种含大环内酯类化合物和多孔水不溶性亲水性载体的组合物 |
| US7446096B2 (en) | 2005-12-19 | 2008-11-04 | Industrial Technology Research Institute | Glutathione based delivery system |
| EP1962819A1 (en) | 2005-12-20 | 2008-09-03 | Wyeth | Control of cci-779 dosage form stability through control of drug substance impurities |
| PT1983984T (pt) | 2006-02-02 | 2018-06-14 | Novartis Ag | Tratamento da esclerosa tuberosa |
| GB0602123D0 (en) | 2006-02-02 | 2006-03-15 | Novartis Ag | Organic compounds |
| RU2010104916A (ru) | 2006-08-16 | 2011-08-20 | Михаил В. Благосклонный (US) | Способ профилактики и лечения возрастных заболеваний |
| EP2079748A4 (en) | 2006-11-10 | 2011-05-04 | Biocon Ltd | PURE FORM OF RAPAMYCIN AND ITS RECOVERY AND PURIFICATION PROCESS |
| EP2241342A3 (en) | 2006-11-20 | 2011-01-12 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| US20080138405A1 (en) | 2006-12-06 | 2008-06-12 | Raheja Praveen | Sirolimus nanodispersion |
| EP1952807A1 (en) | 2007-01-24 | 2008-08-06 | LEK Pharmaceuticals D.D. | Sirolimus formulation |
| RU2478387C2 (ru) | 2007-02-20 | 2013-04-10 | Новартис Аг | ИМИДАЗОХИНОЛИНЫ В КАЧЕСТВЕ ДВОЙНЫХ ИНГИБИТОРОВ ЛИПИДКИНАЗЫ И mTOR |
| US20100166869A1 (en) * | 2007-05-03 | 2010-07-01 | Desai Neil P | Methods and compositions for treating pulmonary hypertension |
| CA2723314C (en) | 2008-02-13 | 2017-01-10 | The Board Of Regents, The University Of Texas System | Templated open flocs of anisotropic particles for enhanced pulmonary delivery |
| JP5705112B2 (ja) * | 2008-07-30 | 2015-04-22 | エスティーシー．ユーエヌエム | ドライパウダー吸入エアロゾル用の大径キャリア粒子を含む製剤 |
| PT2365802T (pt) * | 2008-11-11 | 2017-11-14 | Univ Texas | Microcápsulas de rapamicina e utilização para o tratamento de cancro |
| US8889213B2 (en) | 2009-01-26 | 2014-11-18 | Teva Pharmaceutical Industries Ltd. | Processes for coating a carrier with microparticles |
| US20100196483A1 (en) | 2009-02-04 | 2010-08-05 | Activaero Gmbh Research & Development | Method for treatmentof severe and uncontrollable asthma |
| GB0905818D0 (en) | 2009-04-06 | 2009-05-20 | Airbus Uk Ltd | Coupling assembly |
| KR20130128018A (ko) | 2009-04-10 | 2013-11-25 | 하이얀 치 | 새로운 노화 방지 물질 및 그 확인 방법 |
| GB0908129D0 (en) | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| US9248110B2 (en) * | 2010-03-18 | 2016-02-02 | Steven Lehrer | Compositions and methods of treating and preventing lung cancer and lymphangioleiomyomatosis |
| PT105058B (pt) * | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
| WO2011163600A2 (en) | 2010-06-25 | 2011-12-29 | Apt Pharmaceuticals, Inc. | Tacrolimus compositions for aerosol administration |
| US20140037548A1 (en) * | 2010-06-28 | 2014-02-06 | The Board Of Trustees Of The Leland Standford Junior University | Treatment and prevention of diffuse parenchymal lung disease by selective active-site mTOR inhibitors |
| WO2012047674A2 (en) | 2010-09-27 | 2012-04-12 | Microdose Therapeutx, Inc. | Methods and compositions for disease treatment using inhalation |
| CN102670518B (zh) * | 2011-03-14 | 2014-08-20 | 齐鲁制药有限公司 | 一种难溶性药物球形颗粒的制备方法 |
| US20140067548A1 (en) | 2012-08-31 | 2014-03-06 | Sap Ag | Saving on device functionality for business calendar |
| EP3721784B1 (en) | 2013-03-28 | 2023-12-20 | EndoChoice, Inc. | Compact multi-viewing element endoscope system |
| JP6529012B2 (ja) | 2013-10-08 | 2019-06-12 | エイアイ・セラピューティクス・インコーポレーテッド | リンパ脈管筋腫症の処置のためのラパマイシン |
| MX2016010373A (es) | 2014-02-11 | 2016-11-30 | Lam Therapeutics Inc | Rapamicina para el tratamiento de linfangioleiomiomatosis. |
| US10307371B2 (en) | 2014-02-11 | 2019-06-04 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| NZ724756A (en) * | 2014-04-04 | 2023-07-28 | Ai Therapeutics Inc | An inhalable rapamycin formulation for treating age-related conditions |
| DE102014005466A1 (de) | 2014-04-12 | 2015-10-15 | Klaus Düring | Verfahren zur Gewinnung von Napin und Cruciferin oder einem Gemisch davon aus Raps |
| AU2015330905B2 (en) | 2014-10-07 | 2021-02-25 | AI Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
| MA40910A (fr) * | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | Poudres de rapamycine pour administration pulmonaire |
| WO2016130645A1 (en) | 2015-02-10 | 2016-08-18 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| CN108039392A (zh) | 2017-11-06 | 2018-05-15 | 北京汉能薄膜发电技术有限公司 | 铜铟镓硒化合物、油墨及其薄膜吸收层制备方法 |
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2015
- 2015-10-07 AU AU2015330905A patent/AU2015330905B2/en active Active
- 2015-10-07 KR KR1020177010965A patent/KR20170095807A/ko not_active Ceased
- 2015-10-07 JP JP2017518487A patent/JP6679584B2/ja active Active
- 2015-10-07 CN CN201580066403.9A patent/CN107249576A/zh active Pending
- 2015-10-07 CA CA2963085A patent/CA2963085C/en active Active
- 2015-10-07 MX MX2017004440A patent/MX389399B/es unknown
- 2015-10-07 US US15/516,219 patent/US20170304276A1/en not_active Abandoned
- 2015-10-07 BR BR112017006842A patent/BR112017006842A2/pt not_active Application Discontinuation
- 2015-10-07 WO PCT/US2015/054550 patent/WO2016057712A1/en not_active Ceased
- 2015-10-07 EP EP15787076.7A patent/EP3209330B1/en active Active
- 2015-10-07 RU RU2017115990A patent/RU2732908C2/ru active
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2017
- 2017-03-26 IL IL251385A patent/IL251385B/en unknown
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2019
- 2019-12-27 US US16/728,615 patent/US11491143B2/en active Active
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2022
- 2022-10-14 US US17/965,859 patent/US12611398B2/en active Active
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