JP2017534604A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017534604A5 JP2017534604A5 JP2017518487A JP2017518487A JP2017534604A5 JP 2017534604 A5 JP2017534604 A5 JP 2017534604A5 JP 2017518487 A JP2017518487 A JP 2017518487A JP 2017518487 A JP2017518487 A JP 2017518487A JP 2017534604 A5 JP2017534604 A5 JP 2017534604A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- sirolimus
- carrier
- micrograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 105
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 28
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 28
- 229960002930 sirolimus Drugs 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 10
- 210000004072 lung Anatomy 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- 239000000969 carrier Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000011859 microparticle Substances 0.000 claims description 4
- 239000008249 pharmaceutical aerosol Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 229940127293 prostanoid Drugs 0.000 claims description 4
- 150000003814 prostanoids Chemical class 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 3
- 230000002685 pulmonary effect Effects 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 102000002045 Endothelin Human genes 0.000 claims description 2
- 108050009340 Endothelin Proteins 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 2
- 125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 claims description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims description 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 2
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 150000003815 prostacyclins Chemical class 0.000 claims description 2
- 150000003180 prostaglandins Chemical class 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 150000003595 thromboxanes Chemical class 0.000 claims description 2
- 238000001238 wet grinding Methods 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 description 10
- 239000002552 dosage form Substances 0.000 description 9
- 239000002775 capsule Substances 0.000 description 6
- 239000011888 foil Substances 0.000 description 3
- 208000002815 pulmonary hypertension Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 description 1
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 239000004503 fine granule Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060988P | 2014-10-07 | 2014-10-07 | |
| US62/060,988 | 2014-10-07 | ||
| US201562144145P | 2015-04-07 | 2015-04-07 | |
| US62/144,145 | 2015-04-07 | ||
| PCT/US2015/054550 WO2016057712A1 (en) | 2014-10-07 | 2015-10-07 | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534604A JP2017534604A (ja) | 2017-11-24 |
| JP2017534604A5 true JP2017534604A5 (enExample) | 2018-11-08 |
| JP6679584B2 JP6679584B2 (ja) | 2020-04-15 |
Family
ID=54360545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518487A Active JP6679584B2 (ja) | 2014-10-07 | 2015-10-07 | 肺高血圧症を処置するための吸入可能なラパマイシン配合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20170304276A1 (enExample) |
| EP (1) | EP3209330B1 (enExample) |
| JP (1) | JP6679584B2 (enExample) |
| KR (1) | KR20170095807A (enExample) |
| CN (1) | CN107249576A (enExample) |
| AU (1) | AU2015330905B2 (enExample) |
| BR (1) | BR112017006842A2 (enExample) |
| CA (1) | CA2963085C (enExample) |
| IL (1) | IL251385B (enExample) |
| MX (1) | MX389399B (enExample) |
| RU (1) | RU2732908C2 (enExample) |
| WO (1) | WO2016057712A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015054280A1 (en) | 2013-10-08 | 2015-04-16 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| RU2718583C2 (ru) | 2014-04-04 | 2020-04-08 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Рапамицин-содержащая композиция, вводимая путем ингаляции для лечения возрастных заболеваний |
| RU2732908C2 (ru) | 2014-10-07 | 2020-09-24 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Ингаляционная лекарственная форма рапамицина для лечения легочной гипертензии |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| HUE058320T2 (hu) * | 2017-12-29 | 2022-07-28 | Celon Pharma Sa | Száraz por alakú ketamin készítmény pulmonáris adagolásra kezelésnek ellenálló depresszió esetén |
| KR102837015B1 (ko) | 2018-03-20 | 2025-07-23 | 아브락시스 바이오사이언스, 엘엘씨 | mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법 |
| WO2019226685A1 (en) * | 2018-05-22 | 2019-11-28 | Abraxis Bioscience, Llc | Methods and compositions for treating pulmonary hypertension |
| CA3133988A1 (en) * | 2019-03-19 | 2020-09-24 | Abraxis Bioscience, Llc | Subcutaneous administration of nanoparticles comprising an mtor inhibitor and albumin for treatment of diseases |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| CN113444730A (zh) * | 2021-03-17 | 2021-09-28 | 昆明市延安医院 | 一种原发性肝细胞klotho基因转导干细胞筛选构建方法 |
| WO2025220834A1 (ko) * | 2024-04-16 | 2025-10-23 | 한미약품 주식회사 | 흡입제 조성물 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2517482A (en) | 1949-04-09 | 1950-08-01 | Sharp & Dohme Inc | Inhaler |
| GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| DE3345722A1 (de) | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Inhalator |
| GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
| DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| AU688782B2 (en) | 1993-09-30 | 1998-03-19 | Wyeth | Rapamycin formulations for oral administration |
| JPH10506406A (ja) | 1994-09-29 | 1998-06-23 | アンダリス、リミテッド | 治療用ビヒクルとしての噴霧乾燥させた微細粒子 |
| US5635161A (en) | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
| DE19523516C1 (de) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| AU735648B2 (en) | 1996-07-12 | 2001-07-12 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| US6471943B1 (en) | 1996-12-30 | 2002-10-29 | Battelle Pulmonary Therapeutics, Inc. | Formulation and method for treating neoplasms by inhalation |
| US6451784B1 (en) | 1996-12-30 | 2002-09-17 | Battellepharma, Inc. | Formulation and method for treating neoplasms by inhalation |
| US5989591A (en) | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US20040039047A1 (en) | 1998-08-11 | 2004-02-26 | Mark Zamoyski | Compositions and methods for treating lung cancers |
| DE60001623T2 (de) * | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| US20040018228A1 (en) | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| WO2003015521A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| CA2456746A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Method for treating lung cancers |
| EP1506032A1 (en) | 2002-05-20 | 2005-02-16 | Research Development Foundation | Aerosol drug inhibition of lung metastases |
| US20050070567A1 (en) | 2002-08-12 | 2005-03-31 | The Regents Of The University Of Michigan | Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway |
| MXPA05001903A (es) * | 2002-08-21 | 2005-04-28 | Norton Healthcare Ltd | Composicion para inhalacion. |
| EP1585548B1 (en) | 2002-12-09 | 2018-06-27 | Abraxis BioScience, LLC | Compositions and methods of delivery of pharmacological agents |
| UA83484C2 (uk) | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| US20050119330A1 (en) | 2003-03-17 | 2005-06-02 | Kao Peter N. | Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases |
| AR043504A1 (es) | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
| AR050374A1 (es) | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
| EP1809247A1 (en) | 2004-09-29 | 2007-07-25 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| FR2882366B1 (fr) | 2005-02-18 | 2008-04-18 | Coletica Sa | Polymere reticule de carbohydrate, notamment a base de polysaccharides et/ou de polyols |
| AU2006218918A1 (en) | 2005-03-02 | 2006-09-08 | Wyeth | Purification of rapamycin |
| BRPI0608573A2 (pt) * | 2005-03-08 | 2017-07-25 | Lifecycle Pharma As | Composição farmacêutica, e, método para a preparação de uma composição farmacêutica. |
| CN101175481A (zh) | 2005-03-17 | 2008-05-07 | 伊兰制药国际有限公司 | 纳米颗粒免疫抑制化合物的可注射的组合物 |
| CN1883474A (zh) | 2005-06-22 | 2006-12-27 | 华北制药集团新药研究开发有限责任公司 | 一种含大环内酯类化合物和多孔水不溶性亲水性载体的组合物 |
| US7446096B2 (en) | 2005-12-19 | 2008-11-04 | Industrial Technology Research Institute | Glutathione based delivery system |
| AR058561A1 (es) | 2005-12-20 | 2008-02-13 | Wyeth Corp | Control de la estabilidad de la forma de dosificacion de cci -779 a traves del control de impurezas de sustancias de farmaco |
| CA2637255C (en) | 2006-02-02 | 2018-06-12 | Novartis Ag | 40-o-(2-hydroxyethyl)-rapamycin for treating tuberous sclerosis disorders |
| GB0602123D0 (en) | 2006-02-02 | 2006-03-15 | Novartis Ag | Organic compounds |
| US20100081681A1 (en) | 2006-08-16 | 2010-04-01 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
| BRPI0621967A2 (pt) | 2006-11-10 | 2011-12-27 | Biocon Ltd | forma pura de rapamicina e um processo para recuperaÇço e purificaÇço da mesma |
| US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| WO2008063576A2 (en) | 2006-11-20 | 2008-05-29 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080138405A1 (en) | 2006-12-06 | 2008-06-12 | Raheja Praveen | Sirolimus nanodispersion |
| EP1952807A1 (en) | 2007-01-24 | 2008-08-06 | LEK Pharmaceuticals D.D. | Sirolimus formulation |
| CA2676786C (en) | 2007-02-20 | 2015-01-27 | Novartis Ag | Imidazoquinolines as dual lipid kinase and mtor inhibitors |
| CA2686736A1 (en) * | 2007-05-03 | 2008-11-13 | Abraxis Bioscience, Llc | Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension |
| WO2009103035A2 (en) | 2008-02-13 | 2009-08-20 | Board Of Regents, The University Of Texas System | Templated open flocs of anisotropic particles for enhanced pulmonary delivery |
| ES2645692T3 (es) * | 2008-11-11 | 2017-12-07 | The Board Of Regents,The University Of Texas System | Microcápsulas de rapamicina y su uso para el tratamiento del cáncer |
| CA2750711C (en) | 2009-01-26 | 2015-07-07 | Teva Pharmaceutical Industries Ltd. | Processes for coating a carrier with microparticles |
| US20100196483A1 (en) | 2009-02-04 | 2010-08-05 | Activaero Gmbh Research & Development | Method for treatmentof severe and uncontrollable asthma |
| GB0905818D0 (en) | 2009-04-06 | 2009-05-20 | Airbus Uk Ltd | Coupling assembly |
| KR20130128018A (ko) | 2009-04-10 | 2013-11-25 | 하이얀 치 | 새로운 노화 방지 물질 및 그 확인 방법 |
| GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| US9248110B2 (en) * | 2010-03-18 | 2016-02-02 | Steven Lehrer | Compositions and methods of treating and preventing lung cancer and lymphangioleiomyomatosis |
| PT105058B (pt) * | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
| WO2011163600A2 (en) | 2010-06-25 | 2011-12-29 | Apt Pharmaceuticals, Inc. | Tacrolimus compositions for aerosol administration |
| US20140037548A1 (en) * | 2010-06-28 | 2014-02-06 | The Board Of Trustees Of The Leland Standford Junior University | Treatment and prevention of diffuse parenchymal lung disease by selective active-site mTOR inhibitors |
| WO2012047674A2 (en) | 2010-09-27 | 2012-04-12 | Microdose Therapeutx, Inc. | Methods and compositions for disease treatment using inhalation |
| CN102670518B (zh) * | 2011-03-14 | 2014-08-20 | 齐鲁制药有限公司 | 一种难溶性药物球形颗粒的制备方法 |
| US20140067548A1 (en) | 2012-08-31 | 2014-03-06 | Sap Ag | Saving on device functionality for business calendar |
| JP2016522006A (ja) | 2013-03-28 | 2016-07-28 | エンドチョイス インコーポレイテッドＥｎｄｏｃｈｏｉｃｅ， Ｉｎｃ． | 小型マルチビュー素子内視鏡システム |
| WO2015054280A1 (en) * | 2013-10-08 | 2015-04-16 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| US10307371B2 (en) | 2014-02-11 | 2019-06-04 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| WO2015123219A1 (en) * | 2014-02-11 | 2015-08-20 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| RU2718583C2 (ru) | 2014-04-04 | 2020-04-08 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Рапамицин-содержащая композиция, вводимая путем ингаляции для лечения возрастных заболеваний |
| DE102014005466A1 (de) | 2014-04-12 | 2015-10-15 | Klaus Düring | Verfahren zur Gewinnung von Napin und Cruciferin oder einem Gemisch davon aus Raps |
| RU2732908C2 (ru) | 2014-10-07 | 2020-09-24 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Ингаляционная лекарственная форма рапамицина для лечения легочной гипертензии |
| MA40910A (fr) * | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | Poudres de rapamycine pour administration pulmonaire |
| WO2016130645A1 (en) | 2015-02-10 | 2016-08-18 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| CN108039392A (zh) | 2017-11-06 | 2018-05-15 | 北京汉能薄膜发电技术有限公司 | 铜铟镓硒化合物、油墨及其薄膜吸收层制备方法 |
-
2015
- 2015-10-07 RU RU2017115990A patent/RU2732908C2/ru active
- 2015-10-07 JP JP2017518487A patent/JP6679584B2/ja active Active
- 2015-10-07 MX MX2017004440A patent/MX389399B/es unknown
- 2015-10-07 CA CA2963085A patent/CA2963085C/en active Active
- 2015-10-07 AU AU2015330905A patent/AU2015330905B2/en active Active
- 2015-10-07 BR BR112017006842A patent/BR112017006842A2/pt not_active Application Discontinuation
- 2015-10-07 CN CN201580066403.9A patent/CN107249576A/zh active Pending
- 2015-10-07 EP EP15787076.7A patent/EP3209330B1/en active Active
- 2015-10-07 US US15/516,219 patent/US20170304276A1/en not_active Abandoned
- 2015-10-07 KR KR1020177010965A patent/KR20170095807A/ko not_active Ceased
- 2015-10-07 WO PCT/US2015/054550 patent/WO2016057712A1/en not_active Ceased
-
2017
- 2017-03-26 IL IL251385A patent/IL251385B/en unknown
-
2019
- 2019-12-27 US US16/728,615 patent/US11491143B2/en active Active
-
2022
- 2022-10-14 US US17/965,859 patent/US20230255944A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017534604A5 (enExample) | ||
| RU2016136348A (ru) | Рапамицин для лечения лимфангиолейомиоматоза | |
| RU2016117764A (ru) | Рапамицин для лечения лимфангиолейомиоматоза | |
| RU2017115990A (ru) | Ингаляционная лекарственная форма рапамицина для лечения легочной гипертензии | |
| RU2016143365A (ru) | Рапамицин-содержащая композиция, вводимая путем ингаляции для лечения возрастных заболеваний | |
| JP2017509684A5 (enExample) | ||
| JP2016532672A5 (enExample) | ||
| US20150272874A1 (en) | Pulmonary disease-specific therapeutic agent | |
| CN103002877A (zh) | 作为缓解疾病的抗风湿性药（dmard）和抗癌药剂的甲氨蝶呤的持续释放制剂 | |
| US20170246118A1 (en) | Long acting pharmaceutical compositions | |
| Rawal et al. | Dry-powder inhaler formulation of rifampicin: an improved targeted delivery system for alveolar tuberculosis | |
| JP2018150339A (ja) | パーキンソン病の迅速な軽減のためのレボドパ製剤 | |
| EP3307236A1 (en) | Process for the preparation of porous microparticles | |
| CN113271960A (zh) | 干粉吸入配制品及其用于治疗肺的用途 | |
| WO2016055544A1 (en) | Composition comprising at least one dry powder obtained by spray drying to increase the stability of the formulation | |
| AU2013248242A1 (en) | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration | |
| JP7654544B2 (ja) | ベダキリンの組成物、それらを含む組み合わせ、それらを調製するための方法、それらを含む使用及び治療方法 | |
| CN117940128A (zh) | 异丁司特用于防止眼癌转移 | |
| WO2021195580A1 (en) | Prevention and treatment of coronavirus-associated diseases using an apelin peptide and formulations thereof | |
| ES2973119T3 (es) | Combinación de ibudilast e interferón-beta y métodos de uso | |
| CN116916889A (zh) | 用于肺高压领域的吸入式伊马替尼 | |
| KR20150101993A (ko) | 레보도파 혈장 농도의 환자간 변산도의 감소 | |
| CN112533664A (zh) | 使用气雾剂诊断Brugada综合征的方法 | |
| Saigal et al. | Controlled release inhalable polymeric microspheres for treatment of pulmonary arterial hypertension | |
| PATIL et al. | LIPOSOMAL DRY POWDER INHALER: NOVEL PULMONARY TARGETED DRUG DELIVERY SYSTEM FOR THE TREATMENT OF LUNG CANCER |