JP2019527728A5 - - Google Patents
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- JP2019527728A5 JP2019527728A5 JP2019522611A JP2019522611A JP2019527728A5 JP 2019527728 A5 JP2019527728 A5 JP 2019527728A5 JP 2019522611 A JP2019522611 A JP 2019522611A JP 2019522611 A JP2019522611 A JP 2019522611A JP 2019527728 A5 JP2019527728 A5 JP 2019527728A5
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- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- tautomer
- solvate
- isomer
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- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000005101 LEOPARD Syndrome Diseases 0.000 claims 1
- 206010062901 Multiple lentigines syndrome Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010029748 Noonan syndrome Diseases 0.000 claims 1
- 208000010708 Noonan syndrome with multiple lentigines Diseases 0.000 claims 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 0 C*(C)CC[C@@]1OCC(CC2)(CCN2c(nc2C)c(CO)nc2Sc2cccc(Cl)c2Cl)[C@@]1N Chemical compound C*(C)CC[C@@]1OCC(CC2)(CCN2c(nc2C)c(CO)nc2Sc2cccc(Cl)c2Cl)[C@@]1N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021116788A JP7416740B2 (ja) | 2016-07-12 | 2021-07-15 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
| JP2023177195A JP2024009957A (ja) | 2016-07-12 | 2023-10-13 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662361249P | 2016-07-12 | 2016-07-12 | |
| US62/361,249 | 2016-07-12 | ||
| US201762449523P | 2017-01-23 | 2017-01-23 | |
| US62/449,523 | 2017-01-23 | ||
| PCT/US2017/041577 WO2018013597A1 (en) | 2016-07-12 | 2017-07-11 | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021116788A Division JP7416740B2 (ja) | 2016-07-12 | 2021-07-15 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527728A JP2019527728A (ja) | 2019-10-03 |
| JP2019527728A5 true JP2019527728A5 (cg-RX-API-DMAC7.html) | 2021-07-26 |
| JP6916279B2 JP6916279B2 (ja) | 2021-08-11 |
Family
ID=59383648
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522611A Active JP6916279B2 (ja) | 2016-07-12 | 2017-07-11 | アロステリックｓｈｐ２阻害剤としての２，５−二置換３−メチルピラジンおよび２，５，６−三置換３−メチルピラジン |
| JP2021116788A Active JP7416740B2 (ja) | 2016-07-12 | 2021-07-15 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
| JP2023177195A Pending JP2024009957A (ja) | 2016-07-12 | 2023-10-13 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021116788A Active JP7416740B2 (ja) | 2016-07-12 | 2021-07-15 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
| JP2023177195A Pending JP2024009957A (ja) | 2016-07-12 | 2023-10-13 | アロステリックｓｈｐ２阻害剤としての２，５－二置換３－メチルピラジンおよび２，５，６－三置換３－メチルピラジン |
Country Status (22)
Families Citing this family (139)
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