|
BE792533A
(fr)
|
1971-12-09 |
1973-06-08 |
Int Chem & Nuclear Corp |
Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
|
|
JPS5868521A
(ja)
|
1981-10-16 |
1983-04-23 |
Hitachi Ltd |
流体継手の羽根車
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5994514A
(en)
|
1991-08-14 |
1999-11-30 |
Genentech, Inc. |
Immunoglobulin variants
|
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
|
CA2143491C
(en)
|
1994-03-01 |
2011-02-22 |
Yasumasa Ishida |
A novel peptide related to human programmed cell death and dna encoding it
|
|
JP2778921B2
(ja)
|
1994-11-18 |
1998-07-23 |
三共株式会社 |
イミダゾピラゾール誘導体
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
WO2001014557A1
(en)
|
1999-08-23 |
2001-03-01 |
Dana-Farber Cancer Institute, Inc. |
Pd-1, a receptor for b7-4, and uses therefor
|
|
CA2383424C
(en)
|
1999-08-23 |
2011-02-15 |
Gordon Freeman |
Novel b7-4 molecules and uses therefor
|
|
EP1206474B1
(en)
|
1999-08-27 |
2004-05-26 |
Abbott Laboratories |
Sulfonylphenylpyrazole compounds useful as cox-2 inhibitors
|
|
IL148718A0
(en)
|
1999-09-17 |
2002-09-12 |
Abbott Gmbh & Co Kg |
Pyrazolopyrimidines as therapeutic agents
|
|
US20040038339A1
(en)
|
2000-03-24 |
2004-02-26 |
Peter Kufer |
Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
|
|
EP2264072A1
(en)
|
2000-04-13 |
2010-12-22 |
The Rockefeller University |
Enhancement of antibody-mediated cytotoxicity.
|
|
US20020094989A1
(en)
|
2000-10-11 |
2002-07-18 |
Hale Jeffrey J. |
Pyrrolidine modulators of CCR5 chemokine receptor activity
|
|
JP3871326B2
(ja)
|
2000-11-15 |
2007-01-24 |
小野薬品工業株式会社 |
Ｐｄ−１欠損マウスおよびその用途
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
ES2257461T3
(es)
|
2000-12-21 |
2006-08-01 |
Bristol-Myers Squibb Company |
Inhibidores de tiazolilo de tirosina quinasas de la familia tec.
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
KR100900176B1
(ko)
|
2001-03-07 |
2009-06-02 |
메르크 파텐트 게엠베하 |
하이브리드 이소타입 항체 부분구조를 포함하는 단백질을위한 발현 기술
|
|
ES2251582T3
(es)
|
2001-03-09 |
2006-05-01 |
Pfizer Products Inc. |
Compuestos antiinflamatorios de bencimidazol.
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
WO2003004497A1
(en)
|
2001-07-05 |
2003-01-16 |
Sumitomo Pharmaceuticals Company, Limited |
Novel heterocyclic compound
|
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
EP2206517B1
(en)
|
2002-07-03 |
2023-08-02 |
Ono Pharmaceutical Co., Ltd. |
Immunopotentiating compositions comprising anti-PD-L1 antibodies
|
|
ZA200500782B
(en)
|
2002-08-26 |
2007-10-31 |
Takeda Pharmaceutical |
Calcium receptor modulating compound and use thereof
|
|
CA2494700C
(en)
|
2002-08-26 |
2011-06-28 |
Takeda Pharmaceutical Company Limited |
Calcium receptor modulating compound and use thereof
|
|
AU2003287345A1
(en)
|
2002-10-31 |
2004-06-07 |
Genentech, Inc. |
Methods and compositions for increasing antibody production
|
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
US7563869B2
(en)
|
2003-01-23 |
2009-07-21 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to human PD-1
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
US7405295B2
(en)
|
2003-06-04 |
2008-07-29 |
Cgi Pharmaceuticals, Inc. |
Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
|
|
US20060183746A1
(en)
|
2003-06-04 |
2006-08-17 |
Currie Kevin S |
Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
|
|
WO2005005429A1
(en)
|
2003-06-30 |
2005-01-20 |
Cellular Genomics, Inc. |
Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
|
|
BRPI0413005A
(pt)
|
2003-07-29 |
2006-09-26 |
Irm Llc |
compostos e composições como inibidores da proteìna cinase
|
|
NZ545776A
(en)
|
2003-08-22 |
2009-05-31 |
Biogen Idec Inc |
Improved antibodies having altered effector function and methods for making the same
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
US20050288295A1
(en)
|
2003-11-11 |
2005-12-29 |
Currie Kevin S |
Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
|
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
GB0400440D0
(en)
|
2004-01-09 |
2004-02-11 |
Isis Innovation |
Receptor modulators
|
|
WO2006033386A1
(ja)
|
2004-09-22 |
2006-03-30 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG4抗体
|
|
EP1812442A2
(en)
|
2004-11-10 |
2007-08-01 |
CGI Pharmaceuticals, Inc. |
Imidazo[1,2-a]pyrazin-8-ylamines useful as modulators of kinase activity
|
|
EP1828186A1
(en)
|
2004-12-13 |
2007-09-05 |
Sunesis Pharmaceuticals, Inc. |
Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
|
|
EP1831168B1
(en)
|
2004-12-16 |
2014-07-02 |
Vertex Pharmaceuticals Inc. |
Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases.
|
|
TW200639163A
(en)
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
MX2007011041A
(es)
|
2005-03-10 |
2008-02-22 |
Cgi Pharmaceuticals Inc |
Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas.
|
|
ES2720160T3
(es)
|
2005-05-09 |
2019-07-18 |
Ono Pharmaceutical Co |
Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas
|
|
CN104436190A
(zh)
|
2005-06-08 |
2015-03-25 |
达纳-法伯癌症研究院公司 |
通过抑制程序性细胞死亡1(pd-1)途经治疗持续性感染和癌症的方法及组合物
|
|
EA019344B1
(ru)
|
2005-07-01 |
2014-03-31 |
МЕДАРЕКС, Эл.Эл.Си. |
Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения
|
|
JP2009506123A
(ja)
|
2005-08-29 |
2009-02-12 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
|
|
ATE548363T1
(de)
|
2005-08-29 |
2012-03-15 |
Vertex Pharma |
3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
|
|
WO2007026720A1
(ja)
|
2005-08-31 |
2007-03-08 |
Taisho Pharmaceutical Co., Ltd. |
縮環ピラゾール誘導体
|
|
US20090042856A1
(en)
|
2005-09-01 |
2009-02-12 |
Astellas Pharma Inc |
Pyridazinone derivatives used for the treatment of pain
|
|
ZA200804679B
(en)
|
2005-12-08 |
2010-02-24 |
Millenium Pharmaceuticals Inc |
Bicyclic compounds with kinase inhibitory activity
|
|
RU2008133161A
(ru)
|
2006-01-13 |
2010-02-20 |
Фармасайкликс, Инк. (Us) |
Ингибиторы тирозин киназ и их применение
|
|
PL2004688T5
(pl)
|
2006-03-23 |
2014-09-30 |
Bioarctic Neuroscience Ab |
Ulepszone przeciwciała wobec protofibryli oraz ich zastosowania
|
|
WO2007136572A2
(en)
|
2006-05-15 |
2007-11-29 |
Merck & Co., Inc. |
Antidiabetic bicyclic compounds
|
|
US8604031B2
(en)
|
2006-05-18 |
2013-12-10 |
Mannkind Corporation |
Intracellular kinase inhibitors
|
|
JO3235B1
(ar)
|
2006-05-26 |
2018-03-08 |
Astex Therapeutics Ltd |
مركبات بيررولوبيريميدين و استعمالاتها
|
|
CN101104640A
(zh)
|
2006-07-10 |
2008-01-16 |
苏州大学 |
抗人pd-l1单克隆抗体制备及应用
|
|
MX2009001913A
(es)
|
2006-08-23 |
2009-03-06 |
Pfizer Prod Inc |
Compuestos de pirimidona como inhibidores de gsk-3.
|
|
EP2061761A1
(en)
|
2006-09-07 |
2009-05-27 |
Millennium Pharmaceuticals, Inc. |
Phenethylamide derivatives with kinase inhibitory activity
|
|
AR063706A1
(es)
|
2006-09-11 |
2009-02-11 |
Cgi Pharmaceuticals Inc |
Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
|
|
AR063946A1
(es)
|
2006-09-11 |
2009-03-04 |
Cgi Pharmaceuticals Inc |
Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
|
|
AR063707A1
(es)
|
2006-09-11 |
2009-02-11 |
Cgi Pharmaceuticals Inc |
Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
|
|
EP2270200A3
(en)
|
2006-09-11 |
2011-07-13 |
CGI Pharmaceuticals, Inc. |
Kinase inhibitors, and methods of using and identifying kinase inhibitors
|
|
EA018573B1
(ru)
|
2006-09-22 |
2013-09-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
WO2008045627A2
(en)
|
2006-10-06 |
2008-04-17 |
Irm Llc |
Protein kinase inhibitors and methods for using thereof
|
|
WO2008054827A2
(en)
|
2006-11-03 |
2008-05-08 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
WO2008116064A2
(en)
|
2007-03-21 |
2008-09-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases
|
|
CN101687854A
(zh)
|
2007-05-04 |
2010-03-31 |
Irm责任有限公司 |
作为c-kit和pdgfr激酶抑制剂的化合物和组合物
|
|
WO2008144253A1
(en)
|
2007-05-14 |
2008-11-27 |
Irm Llc |
Protein kinase inhibitors and methods for using thereof
|
|
EP2666787B1
(en)
|
2007-05-31 |
2022-02-09 |
Genmab A/S |
STABLE IgG4 ANTIBODIES
|
|
JP5191537B2
(ja)
|
2007-06-18 |
2013-05-08 |
エム・エス・ディー・オス・ベー・フェー |
ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体
|
|
WO2009024531A1
(en)
|
2007-08-17 |
2009-02-26 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for treating and diagnosing hematologic malignancies
|
|
CL2008002793A1
(es)
|
2007-09-20 |
2009-09-04 |
Cgi Pharmaceuticals Inc |
Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
EP2214486A4
(en)
|
2007-10-19 |
2011-03-09 |
Avila Therapeutics Inc |
HETEROARYL COMPOUNDS AND ITS USES
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
EP2205564B1
(en)
|
2007-10-23 |
2014-07-30 |
F. Hoffmann-La Roche AG |
Novel kinase inhibitors
|
|
JP5643105B2
(ja)
|
2007-12-14 |
2014-12-17 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
新規イミダゾ［１，２−ａ］ピリジン及びイミダゾ［１，２−ｂ］ピリダジン誘導体
|
|
WO2009098144A1
(en)
|
2008-02-05 |
2009-08-13 |
F. Hoffmann-La Roche Ag |
Novel pyridinones and pyridazinones
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
US8426424B2
(en)
|
2008-05-06 |
2013-04-23 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
SG10201510696RA
(en)
|
2008-06-27 |
2016-01-28 |
Celgene Avilomics Res Inc |
Heteroaryl compounds and uses thereof
|
|
AU2009265813B2
(en)
|
2008-07-02 |
2014-04-10 |
F. Hoffmann-La Roche Ag |
Novel phenylpyrazinones as kinase inhibitors
|
|
EP2307413B1
(en)
|
2008-07-15 |
2015-09-09 |
F. Hoffmann-La Roche AG |
Novel phenyl-imidazopyridines and pyridazines
|
|
CN105362277A
(zh)
|
2008-07-16 |
2016-03-02 |
药品循环有限公司 |
用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
|
|
WO2010006970A1
(en)
|
2008-07-18 |
2010-01-21 |
F. Hoffmann-La Roche Ag |
Novel phenylimidazopyrazines
|
|
CN102164604A
(zh)
|
2008-07-24 |
2011-08-24 |
百时美施贵宝公司 |
用作激酶调节剂的稠合杂环化合物
|
|
EP2328920A2
(en)
|
2008-08-25 |
2011-06-08 |
Amplimmune, Inc. |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
|
MY156789A
(en)
|
2008-09-05 |
2016-03-31 |
Celgene Avilomics Res Inc |
Algorithm for designing irreversible inhibitors
|
|
AU2009290543B2
(en)
|
2008-09-12 |
2015-09-03 |
Oxford University Innovation Limited |
PD-1 specific antibodies and uses thereof
|
|
US8927697B2
(en)
|
2008-09-12 |
2015-01-06 |
Isis Innovation Limited |
PD-1 specific antibodies and uses thereof
|
|
BRPI0919377A2
(pt)
|
2008-09-26 |
2016-09-27 |
Dana Farber Cancer Inst Inc |
anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento
|
|
KR101050829B1
(ko)
|
2008-10-02 |
2011-07-20 |
서울대학교산학협력단 |
항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제
|
|
RU2539568C2
(ru)
|
2008-10-31 |
2015-01-20 |
Дженентек, Инк. |
Пиразолопиримидиновые соединения-ингибиторы jak и способы
|
|
US20120028981A1
(en)
|
2008-11-05 |
2012-02-02 |
Principia Biopharma Inc. |
Kinase Knockdown Via Electrophilically Enhanced Inhibitors
|
|
US8598174B2
(en)
|
2008-11-12 |
2013-12-03 |
Genetech, Inc. |
Pyridazinones, method of making, and method of use thereof
|
|
EP2370593B1
(en)
|
2008-11-28 |
2016-03-30 |
Emory University |
Methods for determining the efficacy of pd-1 antagonists
|
|
US8426428B2
(en)
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
HUE065752T2
(hu)
|
2008-12-09 |
2024-06-28 |
Hoffmann La Roche |
Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
|
|
WO2010068810A2
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted amides, method of making, and method of use thereof
|
|
WO2010068806A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
|
|
WO2010068788A1
(en)
|
2008-12-10 |
2010-06-17 |
Cgi Pharmaceuticals, Inc. |
Heterocyclic amides as btk inhibitors
|
|
BRPI0922565A2
(pt)
|
2008-12-19 |
2015-12-15 |
Bristol Myers Squibb Co |
compostos de carbazol carboxamida úteis como inibidores de cinase
|
|
US20100197924A1
(en)
*
|
2008-12-22 |
2010-08-05 |
Millennium Pharmaceuticals, Inc. |
Preparation of aminotetralin compounds
|
|
EP2379559B1
(en)
|
2009-01-06 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
|
|
ES2629337T3
(es)
|
2009-02-09 |
2017-08-08 |
Inserm - Institut National De La Santé Et De La Recherche Médicale |
Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos
|
|
US8299077B2
(en)
|
2009-03-02 |
2012-10-30 |
Roche Palo Alto Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
CA2748414A1
(en)
|
2009-04-24 |
2010-10-28 |
F. Hoffmann-La Roche Ag |
Inhibitors of bruton's tyrosine kinase
|
|
JP5656976B2
(ja)
|
2009-04-29 |
2015-01-21 |
ローカス ファーマシューティカルズ インコーポレイテッド |
ピロロトリアジン化合物
|
|
EP2440204B1
(en)
|
2009-06-12 |
2013-12-18 |
Bristol-Myers Squibb Company |
Nicotinamide compounds useful as kinase modulators
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
EP2789615B1
(en)
|
2009-08-11 |
2017-05-03 |
Bristol-Myers Squibb Company |
Azaindazoles as Btk kinase modulators and use thereof
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CA2771822C
(en)
|
2009-09-04 |
2020-08-11 |
Daniel A. Erlanson |
Bruton's tyrosine kinase inhibitors
|
|
EP2485589A4
(en)
|
2009-09-04 |
2013-02-06 |
Biogen Idec Inc |
HETEROARYL-BTK INHIBITORS
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
US8389689B2
(en)
|
2009-10-28 |
2013-03-05 |
Janssen Biotech, Inc. |
Anti-GLP-1R antibodies and their uses
|
|
US10053513B2
(en)
|
2009-11-30 |
2018-08-21 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
HUE050768T2
(hu)
|
2010-02-19 |
2021-01-28 |
Xencor Inc |
Új CTLA4-IG immunadhezinek
|
|
MX341925B
(es)
|
2010-03-29 |
2016-09-07 |
Zymeworks Inc |
Anticuerpos con funcion efectora suprimida o mejorada.
|
|
CN110818724B
(zh)
|
2010-05-07 |
2020-11-13 |
吉利德康涅狄格有限公司 |
吡啶酮和氮杂吡啶酮化合物及使用方法
|
|
WO2011152351A1
(ja)
|
2010-05-31 |
2011-12-08 |
小野薬品工業株式会社 |
プリノン誘導体
|
|
CA3007787C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
EP2582668B1
(en)
|
2010-06-16 |
2016-01-13 |
Bristol-Myers Squibb Company |
Carboline carboxamide compounds useful as kinase inhibitors
|
|
MX342164B
(es)
|
2010-06-23 |
2016-09-19 |
Hanmi Science Co Ltd |
Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa.
|
|
US20120053189A1
(en)
|
2010-06-28 |
2012-03-01 |
Pharmacyclics, Inc. |
Btk inhibitors for the treatment of immune mediated conditions
|
|
US20120100166A1
(en)
|
2010-07-15 |
2012-04-26 |
Zyngenia, Inc. |
Ang-2 Binding Complexes and Uses Thereof
|
|
MY160734A
(en)
|
2010-08-10 |
2017-03-15 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
AR082590A1
(es)
|
2010-08-12 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
JP5842004B2
(ja)
|
2010-09-01 |
2016-01-13 |
ジーアイリード コネチカット インコーポレーテッドＧｉｌｅａｄ Ｃｏｎｎｅｃｔｉｃｕｔ，Ｉｎｃ． |
ピリダジノン、その製造方法及びその使用方法
|
|
US9249123B2
(en)
|
2010-09-01 |
2016-02-02 |
Genentech, Inc. |
Pyridinones/pyrazinones, method of making, and method of use thereof
|
|
JP6147670B2
(ja)
|
2010-12-22 |
2017-06-14 |
テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド |
改善された半減期を有する修飾された抗体
|
|
BR112013024574B1
(pt)
|
2011-03-29 |
2022-08-09 |
Roche Glycart Ag |
Anticorpo e uso do anticorpo
|
|
CA2830806C
(en)
|
2011-03-31 |
2020-05-12 |
Merck Sharp & Dohme Corp. |
Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments
|
|
WO2012135801A1
(en)
|
2011-04-01 |
2012-10-04 |
University Of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
CA2760174A1
(en)
|
2011-12-01 |
2013-06-01 |
Pharmascience Inc. |
Protein kinase inhibitors and uses thereof
|
|
US20140038989A1
(en)
|
2011-04-20 |
2014-02-06 |
Glaxo Group Limited |
Tetrahydropyrazolo [1,5-a] pyrimidine as anti-tuberculosis compounds
|
|
JP6072771B2
(ja)
|
2011-04-20 |
2017-02-01 |
メディミューン，エルエルシー |
Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子
|
|
US8962831B2
(en)
|
2011-05-17 |
2015-02-24 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
CA2834077A1
(en)
|
2011-05-17 |
2012-11-22 |
F. Hoffmann-La Roche Ag |
Inhibitors of bruton's tyrosine kinase
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
US20140107151A1
(en)
|
2011-05-17 |
2014-04-17 |
Principia Biophama Inc. |
Tyrosine kinase inhibitors
|
|
CN103596982B
(zh)
|
2011-06-06 |
2016-11-02 |
诺沃—诺迪斯克有限公司 |
治疗性抗体
|
|
LT2718270T
(lt)
|
2011-06-10 |
2022-08-10 |
Merck Patent Gmbh |
Pirimidino ir piridino junginių, turinčių btk inhibitorinį aktyvumą, kompozicijos ir gamybos būdai
|
|
WO2012175692A1
(en)
|
2011-06-22 |
2012-12-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-axl antibodies and uses thereof
|
|
WO2013008095A1
(en)
|
2011-07-08 |
2013-01-17 |
Novartis Ag |
Novel pyrrolo pyrimidine derivatives
|
|
EA026924B1
(ru)
|
2011-08-01 |
2017-05-31 |
Дженентек, Инк. |
Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek
|
|
KR101981873B1
(ko)
|
2011-11-28 |
2019-05-23 |
메르크 파텐트 게엠베하 |
항-ｐｄ-ｌ1 항체 및 그의 용도
|
|
HUE029656T2
(en)
|
2011-12-31 |
2017-03-28 |
Beigene Ltd |
Condensed tricyclic compounds as RAF kinase inhibitors
|
|
JP6226752B2
(ja)
|
2012-02-09 |
2017-11-08 |
中外製薬株式会社 |
抗体のＦｃ領域改変体
|
|
WO2013165690A1
(en)
|
2012-04-30 |
2013-11-07 |
Medimmune, Llc |
Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
|
|
US9212224B2
(en)
|
2012-05-15 |
2015-12-15 |
Bristol-Myers Squibb Company |
Antibodies that bind PD-L1 and uses thereof
|
|
CN104736168B
(zh)
|
2012-05-31 |
2018-09-21 |
索伦托治疗有限公司 |
与pd-l1结合的抗原结合蛋白
|
|
MX2014015744A
(es)
|
2012-07-03 |
2015-06-05 |
Janssen Sciences Ireland Uc |
Anticuerpos a-beta de epítopo de terminal c y central.
|
|
CA2886433C
(en)
|
2012-10-04 |
2022-01-04 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-pd-l1 antibodies and methods of use
|
|
EP2934577A1
(en)
|
2012-12-19 |
2015-10-28 |
Adimab, LLC |
Multivalent antibody analogs, and methods of their preparation and use
|
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
|
TWI635098B
(zh)
|
2013-02-01 |
2018-09-11 |
再生元醫藥公司 |
含嵌合恆定區之抗體
|
|
LT2840892T
(lt)
|
2013-02-20 |
2018-07-25 |
Regeneron Pharmaceuticals, Inc. |
Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis
|
|
KR20150127591A
(ko)
|
2013-03-15 |
2015-11-17 |
리제너론 파아마슈티컬스, 인크. |
Il-33 길항제 및 이의 용도
|
|
SG11201506764WA
(en)
|
2013-04-25 |
2015-09-29 |
Beigene Ltd |
Fused heterocyclic compounds as protein kinase inhibitors
|
|
JP6720075B2
(ja)
*
|
2013-05-31 |
2020-07-08 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
癌のための併用療法
|
|
US9676853B2
(en)
|
2013-05-31 |
2017-06-13 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind PD-1
|
|
JP6623353B2
(ja)
|
2013-09-13 |
2019-12-25 |
ベイジーン スウィッツァーランド ゲーエムベーハー |
抗ｐｄ−１抗体並びにその治療及び診断のための使用
|
|
WO2015061752A1
(en)
|
2013-10-25 |
2015-04-30 |
Pharmacyclics, Inc. |
Treatment using bruton's tyrosine kinase inhibitors and immunotherapy
|
|
ES2716685T3
(es)
|
2014-01-24 |
2019-06-14 |
Dana Farber Cancer Inst Inc |
Moléculas de anticuerpo para PD-1 y usos de las mismas
|
|
KR102003754B1
(ko)
|
2014-07-03 |
2019-07-25 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
|
TW201607930A
(zh)
|
2014-07-18 |
2016-03-01 |
百濟神州有限公司 |
作為ｔ７９０ｍ／ｗｔ－ｅｇｆｒ的選擇性和不可逆的激酶抑制劑的５－氨基－４－氨甲醯基－吡唑化合物及其用途
|
|
SI3179992T1
(sl)
|
2014-08-11 |
2022-09-30 |
Acerta Pharma B.V. |
Terapevtske kombinacije zaviralca BTK, zaviralca PD-1 in/ali zaviralca PD-L1
|
|
EP3180343A1
(en)
|
2014-08-14 |
2017-06-21 |
Assia Chemical Industries Ltd. |
Solid state forms of ibrutinib
|
|
TW201625304A
(zh)
|
2014-10-24 |
2016-07-16 |
美國禮來大藥廠 |
泌尿上皮癌之療法
|
|
WO2016087994A1
(en)
|
2014-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
EA036269B1
(ru)
|
2014-12-18 |
2020-10-21 |
Принсипиа Биофарма Инк. |
Лечение пузырчатки
|
|
JP6687248B2
(ja)
|
2014-12-24 |
2020-04-22 |
プリンシピア バイオファーマ インコーポレイテッド |
回腸−空腸薬物送達用組成物
|
|
US9139653B1
(en)
|
2015-04-30 |
2015-09-22 |
Kymab Limited |
Anti-human OX40L antibodies and methods of treatment
|
|
CA2981746C
(en)
|
2015-04-15 |
2023-08-01 |
Beigene, Ltd. |
Maleate salts of a b-raf kinase inhibitor, crystalline forms, methods of preparation, and uses therefore
|
|
KR20250151554A
(ko)
|
2015-05-29 |
2025-10-21 |
제넨테크, 인크. |
암에 대한 치료 및 진단 방법
|
|
WO2017024465A1
(en)
|
2015-08-10 |
2017-02-16 |
Innovent Biologics (Suzhou) Co., Ltd. |
Pd-1 antibodies
|
|
US20190022092A1
(en)
|
2015-09-15 |
2019-01-24 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
|
|
TW201725044A
(zh)
|
2015-10-01 |
2017-07-16 |
基利科學股份有限公司 |
用於治療癌症之btk抑制劑及查核點抑制劑之組合
|
|
WO2017165491A1
(en)
*
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Use of a pd-1 antagonist and a raf inhibitor in the treatment of cancer
|
|
NZ749997A
(en)
|
2016-07-05 |
2022-11-25 |
Beigene Ltd |
Combination of a pd-l antagonist and a raf inhibitor for treating cancer
|
|
KR102604975B1
(ko)
|
2016-08-16 |
2023-11-24 |
베이진 스위찰랜드 게엠베하 |
(s)-7-(1-아크릴로일피페리딘-4-일)-2-(4-페녹시페닐)-4,5,6,7-테트라-하이드로피라졸로 [1,5-a] 피리미딘-3-카르복스아미드의 제조 및 그 용도
|
|
EP3500299B1
(en)
|
2016-08-19 |
2023-12-13 |
BeiGene Switzerland GmbH |
Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
|
|
BR112019003976A2
(pt)
|
2016-08-26 |
2019-05-28 |
Beigene, Ltd. |
anticorpos anti-tim-3 e seu uso
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
US11202782B2
(en)
|
2016-09-27 |
2021-12-21 |
Beigene, Ltd. |
Treatment cancers using a combination comprising PARP inhibitors
|
|
PE20240950A1
(es)
|
2016-10-14 |
2024-05-06 |
Xencor Inc |
PROTEINAS DE FUSION FC HETERODIMERICAS IL 15/IL 15R(alfa)
|
|
WO2018137681A1
(en)
|
2017-01-25 |
2018-08-02 |
Beigene, Ltd. |
Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof
|
|
BR112019021822A2
(pt)
|
2017-04-20 |
2020-05-26 |
Adc Therapeutics Sa |
Terapia de combinação
|
|
KR102757960B1
(ko)
|
2017-06-26 |
2025-01-22 |
베이진 엘티디 |
간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료
|
|
CN110997677A
(zh)
|
2017-08-12 |
2020-04-10 |
百济神州有限公司 |
具有改进的双重选择性的Btk抑制剂
|
|
WO2019108795A1
(en)
|
2017-11-29 |
2019-06-06 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
|
|
US20210040213A1
(en)
|
2018-02-09 |
2021-02-11 |
Beigene, Ltd. |
Immunomonotherapy for urothelial carcinoma
|
|
GB201803746D0
(en)
|
2018-03-08 |
2018-04-25 |
Ultrahuman Eight Ltd |
PD1 binding agents
|