JP2016502504A5 - - Google Patents

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Publication number
JP2016502504A5
JP2016502504A5 JP2015536163A JP2015536163A JP2016502504A5 JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5 JP 2015536163 A JP2015536163 A JP 2015536163A JP 2015536163 A JP2015536163 A JP 2015536163A JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5
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JP
Japan
Prior art keywords
antibody
conjugate
seq
sequence
domain
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015536163A
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English (en)
Japanese (ja)
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JP2016502504A (ja
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Priority claimed from PCT/EP2013/071343 external-priority patent/WO2014057115A1/en
Publication of JP2016502504A publication Critical patent/JP2016502504A/ja
Publication of JP2016502504A5 publication Critical patent/JP2016502504A5/ja
Pending legal-status Critical Current

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JP2015536163A 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体 Pending JP2016502504A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
US201261712928P 2012-10-12 2012-10-12
US61/712,928 2012-10-12
US61/712,924 2012-10-12
US201361784233P 2013-03-14 2013-03-14
US201361784270P 2013-03-14 2013-03-14
US201361784249P 2013-03-14 2013-03-14
US61/784,233 2013-03-14
US61/784,249 2013-03-14
US61/784,270 2013-03-14
PCT/EP2013/071343 WO2014057115A1 (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepine-anti-her2 antibody conjugates

Publications (2)

Publication Number Publication Date
JP2016502504A JP2016502504A (ja) 2016-01-28
JP2016502504A5 true JP2016502504A5 (enExample) 2016-12-01

Family

ID=49552324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536163A Pending JP2016502504A (ja) 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体

Country Status (22)

Country Link
US (1) US20150273077A1 (enExample)
EP (1) EP2906252B1 (enExample)
JP (1) JP2016502504A (enExample)
KR (1) KR20150083856A (enExample)
CN (1) CN104955485B (enExample)
AU (1) AU2013328621B2 (enExample)
BR (1) BR112015008177A2 (enExample)
CA (1) CA2887896A1 (enExample)
CY (1) CY1119287T1 (enExample)
DK (1) DK2906252T3 (enExample)
ES (1) ES2640449T3 (enExample)
HR (1) HRP20171264T1 (enExample)
HU (1) HUE034505T2 (enExample)
LT (1) LT2906252T (enExample)
MX (1) MX2015004423A (enExample)
PL (1) PL2906252T3 (enExample)
PT (1) PT2906252T (enExample)
RS (1) RS56222B1 (enExample)
SI (1) SI2906252T1 (enExample)
SM (1) SMT201700444T1 (enExample)
WO (1) WO2014057115A1 (enExample)
ZA (1) ZA201502267B (enExample)

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CA2957148A1 (en) * 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201506394D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506389D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
CR20180243A (es) 2015-10-02 2018-07-31 Genentech Inc Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso
US10689458B2 (en) 2015-11-30 2020-06-23 Pfizer Inc. Site specific HER2 antibody drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
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GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN106248971B (zh) * 2016-08-19 2017-10-03 合肥瀚科迈博生物技术有限公司 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201619490D0 (en) * 2016-11-17 2017-01-04 Medimmune Ltd Pyrrolobenzodiazepine conjugates
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CA3057744A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-cd25 antibody-drug conjugate
KR20200028950A (ko) 2017-06-14 2020-03-17 에이디씨 테라퓨틱스 에스에이 항-cd25 adc의 투여를 위한 투약량 체제
SI3668874T1 (sl) 2017-08-18 2022-04-29 Medimmune Limited Pirolobenzodiazepinski konjugati
CA3177215C (en) 2017-09-29 2026-06-09 Daiichi Sankyo Company, Limited Antibody-pyrrolobenzodiazepine derivative conjugate
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
MX2020010110A (es) 2018-03-28 2020-11-06 Mitsubishi Tanabe Pharma Corp Conjugados de farmacos de agentes de union monoclonales de cmet, y usos de los mismos.
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US11141490B2 (en) * 2018-07-13 2021-10-12 Research Foundation Of The City University Of New York Antibody-drug conjugates based on gold compounds
CN113631560B (zh) 2019-03-15 2025-02-18 麦迪穆有限责任公司 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
BR112021017616A2 (pt) * 2019-03-25 2021-11-09 Daiichi Sankyo Co Ltd Conjugado de derivado de anticorpo anti-her2-pirrolobenzodiazepina
GB201908128D0 (en) 2019-06-07 2019-07-24 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
WO2021030358A1 (en) 2019-08-12 2021-02-18 Regeneron Pharmaceuticals, Inc. Macrophage stimulating 1 receptor (mst1r) variants and uses thereof
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
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US20080112961A1 (en) * 2006-10-09 2008-05-15 Macrogenics, Inc. Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
GB0819095D0 (en) * 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
WO2010151793A1 (en) * 2009-06-26 2010-12-29 Five Prime Therapeutics, Inc. Therapeutic antibody target validation and screening in vivo
CN103068405A (zh) * 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
PT2528625E (pt) * 2010-04-15 2013-10-17 Spirogen Sarl Pirrolobenzodiazepinas e conjugados das mesmas
MX368648B (es) * 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
US9586996B2 (en) * 2010-04-30 2017-03-07 Esperance Pharmaceuticals, Inc. Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use
DK2707031T3 (da) * 2011-05-08 2019-10-07 Legochem Biosciences Inc Protein-active agent conjugates and method for preparing the same
JP6104257B2 (ja) * 2011-10-14 2017-03-29 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピンおよびそのコンジュゲート
WO2013177481A1 (en) * 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof

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