JP2016502504A5 - - Google Patents

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Publication number
JP2016502504A5
JP2016502504A5 JP2015536163A JP2015536163A JP2016502504A5 JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5 JP 2015536163 A JP2015536163 A JP 2015536163A JP 2015536163 A JP2015536163 A JP 2015536163A JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5
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JP
Japan
Prior art keywords
antibody
conjugate
seq
sequence
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015536163A
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English (en)
Japanese (ja)
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JP2016502504A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2013/071343 external-priority patent/WO2014057115A1/en
Publication of JP2016502504A publication Critical patent/JP2016502504A/ja
Publication of JP2016502504A5 publication Critical patent/JP2016502504A5/ja
Pending legal-status Critical Current

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JP2015536163A 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体 Pending JP2016502504A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
US201261712928P 2012-10-12 2012-10-12
US61/712,928 2012-10-12
US61/712,924 2012-10-12
US201361784249P 2013-03-14 2013-03-14
US201361784233P 2013-03-14 2013-03-14
US201361784270P 2013-03-14 2013-03-14
US61/784,233 2013-03-14
US61/784,270 2013-03-14
US61/784,249 2013-03-14
PCT/EP2013/071343 WO2014057115A1 (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepine-anti-her2 antibody conjugates

Publications (2)

Publication Number Publication Date
JP2016502504A JP2016502504A (ja) 2016-01-28
JP2016502504A5 true JP2016502504A5 (enExample) 2016-12-01

Family

ID=49552324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536163A Pending JP2016502504A (ja) 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体

Country Status (22)

Country Link
US (1) US20150273077A1 (enExample)
EP (1) EP2906252B1 (enExample)
JP (1) JP2016502504A (enExample)
KR (1) KR20150083856A (enExample)
CN (1) CN104955485B (enExample)
AU (1) AU2013328621B2 (enExample)
BR (1) BR112015008177A2 (enExample)
CA (1) CA2887896A1 (enExample)
CY (1) CY1119287T1 (enExample)
DK (1) DK2906252T3 (enExample)
ES (1) ES2640449T3 (enExample)
HR (1) HRP20171264T1 (enExample)
HU (1) HUE034505T2 (enExample)
LT (1) LT2906252T (enExample)
MX (1) MX2015004423A (enExample)
PL (1) PL2906252T3 (enExample)
PT (1) PT2906252T (enExample)
RS (1) RS56222B1 (enExample)
SI (1) SI2906252T1 (enExample)
SM (1) SMT201700444T1 (enExample)
WO (1) WO2014057115A1 (enExample)
ZA (1) ZA201502267B (enExample)

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EP2558475A1 (en) 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
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CN103998449A (zh) 2011-10-14 2014-08-20 斯皮罗根有限公司 吡咯并苯并二氮杂卓
CN103987384A (zh) 2011-10-14 2014-08-13 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
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CN103997893B (zh) 2011-10-14 2019-04-12 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
CA2885340C (en) 2012-10-12 2016-11-08 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
JP6367204B2 (ja) 2012-10-12 2018-08-01 メドイミューン・リミテッドMedImmune Limited 結合用のピロロベンゾジアゼピン誘導体の合成および中間体
PT3470086T (pt) 2012-10-12 2021-02-01 Medimmune Ltd Pirrolobenzodiazepinas e conjugados das mesmas
BR112015014669B1 (pt) 2012-12-21 2023-09-26 Medimmune Limited Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa
AU2013366490B9 (en) 2012-12-21 2018-02-01 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
EA027910B1 (ru) 2013-03-13 2017-09-29 Медимьюн Лимитед Пирролобензодиазепины и их конъюгаты
CN105142674B (zh) 2013-03-13 2018-11-13 麦迪穆有限责任公司 吡咯并苯并二氮杂卓和其结合物
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
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GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
ES2830385T3 (es) 2014-09-12 2021-06-03 Genentech Inc Anticuerpos e inmunoconjugados anti-HER2
HK1243629A1 (zh) * 2014-09-17 2018-07-20 基因泰克公司 包含抗her2抗体和吡咯并苯并二氮杂䓬的免疫缀合物
CA2968447A1 (en) 2014-11-25 2016-06-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms
US9504694B2 (en) * 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201506389D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506394D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
TWI778491B (zh) 2015-11-30 2022-09-21 美商輝瑞股份有限公司 位點專一性her2抗體藥物共軛體
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
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CN106248971B (zh) * 2016-08-19 2017-10-03 合肥瀚科迈博生物技术有限公司 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途
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TWI885539B (zh) 2017-09-29 2025-06-01 日商第一三共股份有限公司 抗體-吡咯并苯二氮呯衍生物複合體
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CN120586086A (zh) 2018-03-28 2025-09-05 田边三菱制药株式会社 cMET单克隆结合剂的药物缀合物及其用途
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US11141490B2 (en) * 2018-07-13 2021-10-12 Research Foundation Of The City University Of New York Antibody-drug conjugates based on gold compounds
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AU2020246448A1 (en) * 2019-03-25 2021-10-14 Daiichi Sankyo Company, Limited Anti-HER2 antibody-pyrrolobenzodiazepine derivative conjugate
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CN119486758A (zh) 2022-06-30 2025-02-18 东丽株式会社 癌的治疗和/或预防用药物组合物

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EP2558475A1 (en) * 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
US9586996B2 (en) * 2010-04-30 2017-03-07 Esperance Pharmaceuticals, Inc. Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use
PT2707031T (pt) * 2011-05-08 2019-09-05 Legochem Biosciences Inc Conjugados de proteína e agente ativo e processo para a sua preparação
PL2750713T3 (pl) * 2011-10-14 2016-03-31 Medimmune Ltd Pirolobenzodiazepiny i ich koniugaty
WO2013177481A1 (en) * 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof

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