JP2016502504A5 - - Google Patents

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Publication number
JP2016502504A5
JP2016502504A5 JP2015536163A JP2015536163A JP2016502504A5 JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5 JP 2015536163 A JP2015536163 A JP 2015536163A JP 2015536163 A JP2015536163 A JP 2015536163A JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5
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JP
Japan
Prior art keywords
antibody
conjugate
seq
sequence
domain
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015536163A
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English (en)
Japanese (ja)
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JP2016502504A (ja
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Priority claimed from PCT/EP2013/071343 external-priority patent/WO2014057115A1/en
Publication of JP2016502504A publication Critical patent/JP2016502504A/ja
Publication of JP2016502504A5 publication Critical patent/JP2016502504A5/ja
Pending legal-status Critical Current

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JP2015536163A 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体 Pending JP2016502504A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
US201261712928P 2012-10-12 2012-10-12
US61/712,928 2012-10-12
US61/712,924 2012-10-12
US201361784233P 2013-03-14 2013-03-14
US201361784270P 2013-03-14 2013-03-14
US201361784249P 2013-03-14 2013-03-14
US61/784,270 2013-03-14
US61/784,249 2013-03-14
US61/784,233 2013-03-14
PCT/EP2013/071343 WO2014057115A1 (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepine-anti-her2 antibody conjugates

Publications (2)

Publication Number Publication Date
JP2016502504A JP2016502504A (ja) 2016-01-28
JP2016502504A5 true JP2016502504A5 (enExample) 2016-12-01

Family

ID=49552324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536163A Pending JP2016502504A (ja) 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体

Country Status (22)

Country Link
US (1) US20150273077A1 (enExample)
EP (1) EP2906252B1 (enExample)
JP (1) JP2016502504A (enExample)
KR (1) KR20150083856A (enExample)
CN (1) CN104955485B (enExample)
AU (1) AU2013328621B2 (enExample)
BR (1) BR112015008177A2 (enExample)
CA (1) CA2887896A1 (enExample)
CY (1) CY1119287T1 (enExample)
DK (1) DK2906252T3 (enExample)
ES (1) ES2640449T3 (enExample)
HR (1) HRP20171264T1 (enExample)
HU (1) HUE034505T2 (enExample)
LT (1) LT2906252T (enExample)
MX (1) MX2015004423A (enExample)
PL (1) PL2906252T3 (enExample)
PT (1) PT2906252T (enExample)
RS (1) RS56222B1 (enExample)
SI (1) SI2906252T1 (enExample)
SM (1) SMT201700444T1 (enExample)
WO (1) WO2014057115A1 (enExample)
ZA (1) ZA201502267B (enExample)

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BR112014009055B1 (pt) 2011-10-14 2021-12-14 Seattle Genetics, Inc. Compostos pirrolobenzodiazepinas, conjugados alvos, ligante de fármaco e uso dos ditos conjugados para tratar uma doença proliferativa
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AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
EA031585B1 (ru) 2012-12-21 2019-01-31 Медимьюн Лимитед Пирролобензодиазепины и их конъюгаты
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
JP6445519B2 (ja) 2013-03-13 2018-12-26 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン及びそのコンジュゲート
CN105142674B (zh) 2013-03-13 2018-11-13 麦迪穆有限责任公司 吡咯并苯并二氮杂卓和其结合物
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
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GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3197500A1 (en) * 2014-09-17 2017-08-02 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
EP3223854A1 (en) 2014-11-25 2017-10-04 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201506389D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506394D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
TWI727380B (zh) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 位點專一性her2抗體藥物共軛體
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
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GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN106248971B (zh) * 2016-08-19 2017-10-03 合肥瀚科迈博生物技术有限公司 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途
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BR112019021680A2 (pt) 2017-04-20 2020-05-12 Adc Therapeutics Sa Terapia de combinação com conjugado anticorpo-fármaco anti-cd25??
PL3612234T3 (pl) 2017-04-20 2024-09-02 Adc Therapeutics Sa Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek
CA3064681A1 (en) 2017-06-14 2018-12-20 Adc Therapeutics Sa Dosage regimes for the administration of an anti-cd25 adc
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
WO2019065964A1 (ja) 2017-09-29 2019-04-04 第一三共株式会社 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
MX2020010110A (es) 2018-03-28 2020-11-06 Mitsubishi Tanabe Pharma Corp Conjugados de farmacos de agentes de union monoclonales de cmet, y usos de los mismos.
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US11141490B2 (en) * 2018-07-13 2021-10-12 Research Foundation Of The City University Of New York Antibody-drug conjugates based on gold compounds
AU2020242747B2 (en) 2019-03-15 2025-09-18 Medimmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
US20220177601A1 (en) * 2019-03-25 2022-06-09 Daiichi Sankyo Company, Limited Anti-her2 antibody-pyrrolobenzodiazepine derivative conjugate
GB201908128D0 (en) * 2019-06-07 2019-07-24 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
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GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
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GB0508084D0 (en) * 2005-04-21 2005-06-01 Spirogen Ltd Pyrrolobenzodiazepines
US20080112961A1 (en) * 2006-10-09 2008-05-15 Macrogenics, Inc. Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
GB0819095D0 (en) * 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
US20120183477A1 (en) * 2009-06-26 2012-07-19 Five Prime Therapeutics, Inc. Therapeutic Antibody Target Validation and Screening In Vivo
CN102971329B (zh) * 2010-04-15 2016-06-29 麦迪穆有限责任公司 用于治疗增殖性疾病的吡咯并苯并二氮杂卓
MX2012011900A (es) * 2010-04-15 2013-03-21 Seattle Genetics Inc Conjugados de pirrolobenzodiazepina diana.
JP5972864B2 (ja) * 2010-04-15 2016-08-17 メディミューン リミテッド ピロロベンゾジアゼピン及びそれらのコンジュゲート
JP2013531474A (ja) * 2010-04-30 2013-08-08 エスペランス ファーマシューティカルズ, インコーポレイテッド 溶解性ペプチド−Her2/neu(ヒト上皮成長因子レセプター2)リガンド結合体およびその使用方法
CN103648530B (zh) * 2011-05-08 2017-02-08 乐高化学生物科学股份有限公司 蛋白质‑活性剂缀合物及其制备方法
US11135303B2 (en) * 2011-10-14 2021-10-05 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
WO2013177481A1 (en) * 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof

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