JP2016502504A5 - - Google Patents

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Publication number
JP2016502504A5
JP2016502504A5 JP2015536163A JP2015536163A JP2016502504A5 JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5 JP 2015536163 A JP2015536163 A JP 2015536163A JP 2015536163 A JP2015536163 A JP 2015536163A JP 2016502504 A5 JP2016502504 A5 JP 2016502504A5
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JP
Japan
Prior art keywords
antibody
conjugate
seq
sequence
domain
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015536163A
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English (en)
Japanese (ja)
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JP2016502504A (ja
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Priority claimed from PCT/EP2013/071343 external-priority patent/WO2014057115A1/en
Publication of JP2016502504A publication Critical patent/JP2016502504A/ja
Publication of JP2016502504A5 publication Critical patent/JP2016502504A5/ja
Pending legal-status Critical Current

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JP2015536163A 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体 Pending JP2016502504A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
US201261712928P 2012-10-12 2012-10-12
US61/712,928 2012-10-12
US61/712,924 2012-10-12
US201361784249P 2013-03-14 2013-03-14
US201361784233P 2013-03-14 2013-03-14
US201361784270P 2013-03-14 2013-03-14
US61/784,270 2013-03-14
US61/784,249 2013-03-14
US61/784,233 2013-03-14
PCT/EP2013/071343 WO2014057115A1 (en) 2012-10-12 2013-10-11 Pyrrolobenzodiazepine-anti-her2 antibody conjugates

Publications (2)

Publication Number Publication Date
JP2016502504A JP2016502504A (ja) 2016-01-28
JP2016502504A5 true JP2016502504A5 (enExample) 2016-12-01

Family

ID=49552324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536163A Pending JP2016502504A (ja) 2012-10-12 2013-10-11 ピロロベンゾジアゼピン−抗体結合体

Country Status (22)

Country Link
US (1) US20150273077A1 (enExample)
EP (1) EP2906252B1 (enExample)
JP (1) JP2016502504A (enExample)
KR (1) KR20150083856A (enExample)
CN (1) CN104955485B (enExample)
AU (1) AU2013328621B2 (enExample)
BR (1) BR112015008177A2 (enExample)
CA (1) CA2887896A1 (enExample)
CY (1) CY1119287T1 (enExample)
DK (1) DK2906252T3 (enExample)
ES (1) ES2640449T3 (enExample)
HR (1) HRP20171264T1 (enExample)
HU (1) HUE034505T2 (enExample)
LT (1) LT2906252T (enExample)
MX (1) MX2015004423A (enExample)
PL (1) PL2906252T3 (enExample)
PT (1) PT2906252T (enExample)
RS (1) RS56222B1 (enExample)
SI (1) SI2906252T1 (enExample)
SM (1) SMT201700444T1 (enExample)
WO (1) WO2014057115A1 (enExample)
ZA (1) ZA201502267B (enExample)

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WO2013041606A1 (en) 2011-09-20 2013-03-28 Spirogen Sàrl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
MX358757B (es) 2011-10-14 2018-09-03 Seattle Genetics Inc Pirrolobenzodiazepinas y conjugados dirigidos.
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HRP20190366T1 (hr) 2012-10-12 2019-04-19 Medimmune Limited Pirolobenzodiazepini i njihovi konjugati
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CN105246894A (zh) 2012-12-21 2016-01-13 斯皮罗根有限公司 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
AU2013366493B2 (en) 2012-12-21 2017-08-24 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
WO2014140862A2 (en) 2013-03-13 2014-09-18 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
JP6445519B2 (ja) 2013-03-13 2018-12-26 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン及びそのコンジュゲート
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
WO2016044396A1 (en) * 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
US10780096B2 (en) 2014-11-25 2020-09-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US9504694B2 (en) * 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201506394D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506389D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
NZ741261A (en) 2015-10-02 2019-11-29 Genentech Inc Pyrrolobenzodiazepine antibody drug conjugates and methods of use
TWI726942B (zh) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 位點專一性her2抗體藥物共軛體
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN106248971B (zh) * 2016-08-19 2017-10-03 合肥瀚科迈博生物技术有限公司 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途
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UA125198C2 (uk) * 2017-02-08 2022-01-26 Ейдісі Терапьютікс Са Кон'югати піролобензодіазепін-антитіло
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WO2018229218A1 (en) 2017-06-14 2018-12-20 Adc Therapeutics Sa Dosage regimes for the administration of an anti-cd25 adc
BR112020003003A2 (pt) * 2017-08-18 2020-08-11 Medimmune Limited conjugados de pirrolobenzodiazepina
CN117003875A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
MX2020010110A (es) 2018-03-28 2020-11-06 Mitsubishi Tanabe Pharma Corp Conjugados de farmacos de agentes de union monoclonales de cmet, y usos de los mismos.
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US11141490B2 (en) * 2018-07-13 2021-10-12 Research Foundation Of The City University Of New York Antibody-drug conjugates based on gold compounds
MX2021010477A (es) 2019-03-15 2021-10-01 Medimmune Ltd Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer.
SG11202109860VA (en) * 2019-03-25 2021-10-28 Daiichi Sankyo Co Ltd Anti-her2 antibody-pyrrolobenzodiazepine derivative conjugate
GB201908128D0 (en) * 2019-06-07 2019-07-24 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP4013494A1 (en) 2019-08-12 2022-06-22 Regeneron Pharmaceuticals, Inc. Macrophage stimulating 1 receptor (mst1r) variants and uses thereof
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
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US20080112961A1 (en) * 2006-10-09 2008-05-15 Macrogenics, Inc. Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
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AU2010265934B2 (en) * 2009-06-26 2015-04-23 Five Prime Therapeutics, Inc. Therapeutic antibody target validation and screening in vivo
ES2623057T3 (es) * 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
WO2011130598A1 (en) * 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
KR101772354B1 (ko) * 2010-04-15 2017-08-28 시애틀 지네틱스, 인크. 표적화된 피롤로벤조디아제핀 접합체
US9586996B2 (en) * 2010-04-30 2017-03-07 Esperance Pharmaceuticals, Inc. Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use
SMT201900500T1 (it) * 2011-05-08 2019-11-13 Legochem Biosciences Inc Coniugati di agente protettivo-proteina e metodo per preparare i medesimi
WO2013055987A1 (en) * 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
WO2013177481A1 (en) * 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof

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