JP2019524693A5 - - Google Patents
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- JP2019524693A5 JP2019524693A5 JP2018569033A JP2018569033A JP2019524693A5 JP 2019524693 A5 JP2019524693 A5 JP 2019524693A5 JP 2018569033 A JP2018569033 A JP 2018569033A JP 2018569033 A JP2018569033 A JP 2018569033A JP 2019524693 A5 JP2019524693 A5 JP 2019524693A5
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- Prior art keywords
- antigen
- binding
- antibody
- binding protein
- multispecific
- Prior art date
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- 239000000427 antigen Substances 0.000 claims description 97
- 102000036639 antigens Human genes 0.000 claims description 97
- 108091007433 antigens Proteins 0.000 claims description 97
- 102000025171 antigen binding proteins Human genes 0.000 claims description 81
- 108091000831 antigen binding proteins Proteins 0.000 claims description 81
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 8
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 8
- 229940126546 immune checkpoint molecule Drugs 0.000 claims description 8
- 208000023275 Autoimmune disease Diseases 0.000 claims description 6
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 208000027866 inflammatory disease Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 4
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 4
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 4
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 4
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 4
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims description 4
- -1 ICOS Proteins 0.000 claims description 4
- 102000017578 LAG3 Human genes 0.000 claims description 4
- 101150030213 Lag3 gene Proteins 0.000 claims description 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 4
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 4
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 4
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 4
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000000770 proinflammatory effect Effects 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
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- 101710185679 CD276 antigen Proteins 0.000 claims description 3
- 208000011231 Crohn disease Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 206010003246 arthritis Diseases 0.000 claims description 3
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- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 201000010536 head and neck cancer Diseases 0.000 claims description 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims description 2
- 108010065524 CD52 Antigen Proteins 0.000 claims description 2
- 102000004003 Chemokine CCL11 Human genes 0.000 claims description 2
- 108010082548 Chemokine CCL11 Proteins 0.000 claims description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010002616 Interleukin-5 Proteins 0.000 claims description 2
- 102000000743 Interleukin-5 Human genes 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 102000004889 Interleukin-6 Human genes 0.000 claims description 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims description 2
- 102000014128 RANK Ligand Human genes 0.000 claims description 2
- 108010025832 RANK Ligand Proteins 0.000 claims description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 2
- 229960002964 adalimumab Drugs 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 229960003852 atezolizumab Drugs 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229950009791 durvalumab Drugs 0.000 claims description 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 2
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims description 2
- 229960005108 mepolizumab Drugs 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 2
- 229960003301 nivolumab Drugs 0.000 claims description 2
- 229960002621 pembrolizumab Drugs 0.000 claims description 2
- 229960000575 trastuzumab Drugs 0.000 claims description 2
- 102100034608 Angiopoietin-2 Human genes 0.000 claims 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 208000003456 Juvenile Arthritis Diseases 0.000 description 3
- 208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 description 2
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 102000023732 binding proteins Human genes 0.000 description 1
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- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 201000004990 juvenile ankylosing spondylitis Diseases 0.000 description 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022120355A JP2022136261A (ja) | 2016-07-20 | 2022-07-28 | 多重特異性抗原結合タンパク質及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/090703 | 2016-07-20 | ||
| PCT/CN2016/090703 WO2018014260A1 (en) | 2016-07-20 | 2016-07-20 | Multispecific antigen binding proteins and methods of use thereof |
| PCT/CN2017/093644 WO2018014855A1 (en) | 2016-07-20 | 2017-07-20 | Multispecific antigen binding proteins and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022120355A Division JP2022136261A (ja) | 2016-07-20 | 2022-07-28 | 多重特異性抗原結合タンパク質及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524693A JP2019524693A (ja) | 2019-09-05 |
| JP2019524693A5 true JP2019524693A5 (OSRAM) | 2020-08-27 |
| JP7115991B2 JP7115991B2 (ja) | 2022-08-09 |
Family
ID=60992747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018569033A Active JP7115991B2 (ja) | 2016-07-20 | 2017-07-20 | 多重特異性抗原結合タンパク質及びその使用方法 |
| JP2022120355A Withdrawn JP2022136261A (ja) | 2016-07-20 | 2022-07-28 | 多重特異性抗原結合タンパク質及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022120355A Withdrawn JP2022136261A (ja) | 2016-07-20 | 2022-07-28 | 多重特異性抗原結合タンパク質及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11447573B2 (OSRAM) |
| EP (1) | EP3487887A4 (OSRAM) |
| JP (2) | JP7115991B2 (OSRAM) |
| KR (1) | KR20190040483A (OSRAM) |
| CN (1) | CN109476762A (OSRAM) |
| AU (1) | AU2017300349A1 (OSRAM) |
| BR (1) | BR112019000970A2 (OSRAM) |
| CA (1) | CA3030933A1 (OSRAM) |
| EA (1) | EA201990331A1 (OSRAM) |
| IL (1) | IL264211A (OSRAM) |
| MX (1) | MX2019000730A (OSRAM) |
| SG (1) | SG11201811640SA (OSRAM) |
| WO (2) | WO2018014260A1 (OSRAM) |
| ZA (1) | ZA201900181B (OSRAM) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| TW202515920A (zh) | 2017-04-11 | 2025-04-16 | 美商因荷布瑞克斯生物科學公司 | 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法 |
| KR102758346B1 (ko) | 2017-08-04 | 2025-01-24 | 젠맵 에이/에스 | Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도 |
| AU2018387829B2 (en) | 2017-12-22 | 2024-12-19 | Argenx Bvba | Bispecific antigen binding construct |
| CN109970860A (zh) * | 2017-12-27 | 2019-07-05 | 信达生物制药(苏州)有限公司 | 三链抗体、其制备方法及其用途 |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| JP7369127B2 (ja) | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Ｔｉｇｉｔに対する単一ドメイン抗体及びその変異体 |
| WO2019134710A1 (en) * | 2018-01-08 | 2019-07-11 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| KR102839330B1 (ko) | 2018-01-15 | 2025-07-30 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-1에 대한 단일-도메인 항체 및 이의 변이체 |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
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| KR20210006913A (ko) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | 제한된 ｃｄ3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
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| CN110835375B (zh) * | 2018-08-16 | 2021-04-06 | 上海洛启生物医药技术有限公司 | 一种抗pd-1/egfr双特异性抗体及其用途 |
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| CN111196856A (zh) * | 2018-11-19 | 2020-05-26 | 三生国健药业（上海）股份有限公司 | 抗her2/pd1双特异性抗体 |
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| CN111378044B (zh) * | 2018-12-28 | 2022-07-15 | 长春金赛药业有限责任公司 | 抗体融合蛋白、制备方法及其应用 |
| TWI793395B (zh) * | 2019-01-25 | 2023-02-21 | 大陸商信達生物製藥（蘇州）有限公司 | 結合ｐｄ-ｌ１和ｏｘ４０的雙特異性抗體 |
| TWI756621B (zh) * | 2019-01-25 | 2022-03-01 | 大陸商信達生物製藥（蘇州）有限公司 | 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體 |
| US20220185875A1 (en) * | 2019-03-18 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific antibody specifically bound to vegf and ang2 |
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| US20170239351A1 (en) | 2014-08-11 | 2017-08-24 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, a PD-1 Inhibitor, and/or a PD-L1 Inhibitor |
| CN114920840A (zh) | 2014-10-14 | 2022-08-19 | 诺华股份有限公司 | 针对pd-l1的抗体分子及其用途 |
| KR102122463B1 (ko) | 2014-10-14 | 2020-06-15 | 할로자임, 아이엔씨 | 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법 |
| SG10201807625PA (en) * | 2014-11-17 | 2018-10-30 | Genentech Inc | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| KR20190080992A (ko) | 2015-05-21 | 2019-07-08 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
| CN105754990A (zh) * | 2016-01-29 | 2016-07-13 | 深圳精准医疗科技有限公司 | 一种pd-1/ctla-4双特异性抗体的制备方法及其应用 |
| EP3419667A4 (en) | 2016-02-26 | 2019-10-23 | Imunexus Pty Ltd | MULTISPECIFIC MOLECULES |
| WO2017165681A1 (en) | 2016-03-24 | 2017-09-28 | Gensun Biopharma Inc. | Trispecific inhibitors for cancer treatment |
| CN107400166A (zh) | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | 针对ctla4的单域抗体及其衍生蛋白 |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| WO2019134710A1 (en) * | 2018-01-08 | 2019-07-11 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
-
2016
- 2016-07-20 WO PCT/CN2016/090703 patent/WO2018014260A1/en not_active Ceased
-
2017
- 2017-07-20 MX MX2019000730A patent/MX2019000730A/es unknown
- 2017-07-20 JP JP2018569033A patent/JP7115991B2/ja active Active
- 2017-07-20 CA CA3030933A patent/CA3030933A1/en active Pending
- 2017-07-20 CN CN201780044843.3A patent/CN109476762A/zh active Pending
- 2017-07-20 WO PCT/CN2017/093644 patent/WO2018014855A1/en not_active Ceased
- 2017-07-20 BR BR112019000970-1A patent/BR112019000970A2/pt not_active IP Right Cessation
- 2017-07-20 US US16/319,224 patent/US11447573B2/en active Active
- 2017-07-20 EA EA201990331A patent/EA201990331A1/ru unknown
- 2017-07-20 SG SG11201811640SA patent/SG11201811640SA/en unknown
- 2017-07-20 KR KR1020197004517A patent/KR20190040483A/ko not_active Abandoned
- 2017-07-20 AU AU2017300349A patent/AU2017300349A1/en not_active Abandoned
- 2017-07-20 EP EP17830489.5A patent/EP3487887A4/en not_active Withdrawn
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2019
- 2019-01-10 ZA ZA2019/00181A patent/ZA201900181B/en unknown
- 2019-01-13 IL IL264211A patent/IL264211A/en unknown
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2022
- 2022-07-28 JP JP2022120355A patent/JP2022136261A/ja not_active Withdrawn
- 2022-08-10 US US17/818,942 patent/US20230059836A1/en not_active Abandoned
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