|
DE3382317D1
(de)
|
1982-03-15 |
1991-07-25 |
Schering Corp |
Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5869620A
(en)
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
WO1991001752A1
(en)
|
1989-07-27 |
1991-02-21 |
Fred Hutchinson Cancer Research Center |
Immunosuppressive monoclonal antibodies, hybridomas and methods of transplantation
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5811267A
(en)
|
1990-10-29 |
1998-09-22 |
Chiron Corporation |
Isolated nucleic acid molecules encoding antigen binding sites of antibody molecules specific for cancer antigens
|
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5844094A
(en)
|
1992-09-25 |
1998-12-01 |
Commonwealth Scientific And Industrial Research Organization |
Target binding polypeptide
|
|
WO1994012520A1
(en)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
DE69327229T2
(de)
|
1992-12-11 |
2000-03-30 |
The Dow Chemical Co., Midland |
Multivalente einkettige Antikörper
|
|
KR100310739B1
(ko)
|
1993-02-04 |
2002-05-30 |
알란 스코브 |
단백질재생을위한개선된방법
|
|
US5747654A
(en)
|
1993-06-14 |
1998-05-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant disulfide-stabilized polypeptide fragments having binding specificity
|
|
US6476198B1
(en)
|
1993-07-13 |
2002-11-05 |
The Scripps Research Institute |
Multispecific and multivalent antigen-binding polypeptide molecules
|
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
|
IT1271461B
(it)
|
1993-12-01 |
1997-05-28 |
Menarini Ricerche Sud Spa |
Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
EP0799244A1
(en)
|
1995-10-16 |
1997-10-08 |
Unilever N.V. |
A bifunctional or bivalent antibody fragment analogue
|
|
US6031072A
(en)
|
1996-07-12 |
2000-02-29 |
Mcgill University |
Compounds and methods for modulating cell adhesion
|
|
EP0938506B1
(en)
|
1996-07-16 |
2003-11-05 |
Plückthun, Andreas, Prof. Dr. |
Immunoglobulin superfamily domains and fragments with increased solubility
|
|
AU6537798A
(en)
|
1997-03-14 |
1998-10-12 |
Denise Casentini-Borocz |
Targeted cytolysis of cancer cells
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
EP1027439B1
(en)
|
1997-10-27 |
2010-03-17 |
Bac Ip B.V. |
Multivalent antigen-binding proteins
|
|
US6485910B1
(en)
|
1998-02-09 |
2002-11-26 |
Incyte Genomics, Inc. |
Ras association domain containing protein
|
|
WO1999042077A2
(en)
|
1998-02-19 |
1999-08-26 |
Xcyte Therapies, Inc. |
Compositions and methods for regulating lymphocyte activation
|
|
CZ121599A3
(cs)
|
1998-04-09 |
1999-10-13 |
Aventis Pharma Deutschland Gmbh |
Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu
|
|
US6783961B1
(en)
|
1999-02-26 |
2004-08-31 |
Genset S.A. |
Expressed sequence tags and encoded human proteins
|
|
JP4169478B2
(ja)
|
1998-04-21 |
2008-10-22 |
マイクロメット アーゲー |
Ｃｄ１９×ｃｄ３特異的ポリペプチドおよびその使用
|
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
|
GB9812545D0
(en)
|
1998-06-10 |
1998-08-05 |
Celltech Therapeutics Ltd |
Biological products
|
|
ES2207278T3
(es)
|
1998-07-28 |
2004-05-16 |
Micromet Ag |
Heterominicuerpos.
|
|
DK1124568T3
(da)
|
1998-10-21 |
2008-01-02 |
Altor Bioscience Corp |
Polyspecifikke bindingsmolekyler og anvendelser deraf
|
|
WO2001057188A2
(en)
|
2000-02-03 |
2001-08-09 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
|
US20020142000A1
(en)
|
1999-01-15 |
2002-10-03 |
Digan Mary Ellen |
Anti-CD3 immunotoxins and therapeutic uses therefor
|
|
DE19905048A1
(de)
|
1999-02-08 |
2000-08-10 |
Gsf Forschungszentrum Umwelt |
Verwendung depletorisch oder mitogen wirkender Antikörper in der Immuntherapie
|
|
SI2857516T1
(sl)
|
2000-04-11 |
2017-09-29 |
Genentech, Inc. |
Multivalentna protitelesa in njihove uporabe
|
|
EP1284752A4
(en)
|
2000-04-26 |
2004-08-18 |
Elusys Therapeutics Inc |
BISPECIFIC MOLECULES AND USES THEREOF
|
|
US20040047854A1
(en)
|
2001-07-27 |
2004-03-11 |
Black Roy A. |
Human disintegrin protein
|
|
GB0025307D0
(en)
|
2000-10-16 |
2000-11-29 |
Celltech Chiroscience Ltd |
Biological products
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
AU2002327164A1
(en)
|
2001-01-29 |
2002-12-09 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
|
US20040053245A1
(en)
|
2001-02-05 |
2004-03-18 |
Tang Y. Tom |
Novel nucleic acids and polypeptides
|
|
WO2002072141A2
(en)
|
2001-03-09 |
2002-09-19 |
William Herman |
Targeted ligands
|
|
AU2002247826A1
(en)
|
2001-03-13 |
2002-09-24 |
University College London |
Specific binding members
|
|
CA2445611A1
(en)
|
2001-05-31 |
2002-12-05 |
Chiron Corporation |
P-cadherin as a target for anti-cancer therapy
|
|
US7189507B2
(en)
|
2001-06-18 |
2007-03-13 |
Pdl Biopharma, Inc. |
Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
|
|
DE60237282D1
(de)
|
2001-06-28 |
2010-09-23 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
|
WO2003022987A2
(en)
|
2001-07-26 |
2003-03-20 |
Eos Biotechnology, Inc. |
Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
EP1293514B1
(en)
|
2001-09-14 |
2006-11-29 |
Affimed Therapeutics AG |
Multimeric single chain tandem Fv-antibodies
|
|
US20040142325A1
(en)
|
2001-09-14 |
2004-07-22 |
Liat Mintz |
Methods and systems for annotating biomolecular sequences
|
|
EP2075256A2
(en)
|
2002-01-14 |
2009-07-01 |
William Herman |
Multispecific binding molecules
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
WO2003087163A1
(en)
|
2002-04-15 |
2003-10-23 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
|
EP1354600A1
(en)
|
2002-04-19 |
2003-10-22 |
Affimed Therapeutics AG |
Antibody combination useful for tumor therapy
|
|
US20040018493A1
(en)
|
2002-07-12 |
2004-01-29 |
Anastasio Alison E. |
Haplotypes of the CD3E gene
|
|
US20060172344A1
(en)
|
2002-07-18 |
2006-08-03 |
Yaeta Endo |
Single chain antibody and use thereof
|
|
MXPA05001933A
(es)
|
2002-08-19 |
2005-04-28 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores.
|
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
|
US9701754B1
(en)
|
2002-10-23 |
2017-07-11 |
City Of Hope |
Covalent disulfide-linked diabodies and uses thereof
|
|
AU2003304203A1
(en)
|
2002-10-29 |
2005-01-04 |
Pharmacia Corporation |
Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
|
|
WO2004044000A2
(en)
|
2002-11-14 |
2004-05-27 |
Adherex Technologies, Inc. |
Compounds and methods for modulating functions of classical cadherins
|
|
EP2314676A1
(en)
|
2002-11-26 |
2011-04-27 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
EP1623017B1
(en)
|
2003-05-08 |
2010-09-15 |
Life Technologies Corporation |
Generation and isolation of antigen-specific t cells
|
|
US8784821B1
(en)
|
2003-05-31 |
2014-07-22 |
Amgen Research (Munich) Gmbh |
Human-anti-human cd3 binding molecules
|
|
WO2004106381A1
(en)
|
2003-05-31 |
2004-12-09 |
Micromet Ag |
Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
|
|
EP1636266A2
(en)
|
2003-06-11 |
2006-03-22 |
Wyeth a Corporation of the State of Delaware |
Platelet glycoprotein ib alpha variant fusion polypeptides and methods of use thereof
|
|
US20050163782A1
(en)
|
2003-06-27 |
2005-07-28 |
Biogen Idec Ma Inc. |
Modified binding molecules comprising connecting peptides
|
|
DK1639011T3
(da)
|
2003-06-30 |
2009-02-16 |
Domantis Ltd |
Pegylerede enkelt-domæne antistoffer (dAb)
|
|
US7754209B2
(en)
|
2003-07-26 |
2010-07-13 |
Trubion Pharmaceuticals |
Binding constructs and methods for use thereof
|
|
US20070037204A1
(en)
|
2003-08-08 |
2007-02-15 |
Hiroyuki ABURANTAI |
Gene overexpressed in cancer
|
|
WO2005019258A2
(en)
|
2003-08-11 |
2005-03-03 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
WO2005028507A1
(en)
|
2003-09-24 |
2005-03-31 |
Monash University |
CRYSTAL STRUCTURE OF CD3ϵϜ/OKT3 COMPLEX
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
EP1593690B1
(en)
|
2004-05-05 |
2009-07-01 |
Micromet AG |
Preparation of ScFv antibody fragments
|
|
EP1753783B1
(en)
|
2004-06-03 |
2014-08-06 |
Novimmune SA |
Anti-cd3 antibodies and methods of use thereof
|
|
EP1786918A4
(en)
|
2004-07-17 |
2009-02-11 |
Imclone Systems Inc |
NEW BISPECIFIC ANTIBODY TETRAVALENT
|
|
JP2008511337A
(ja)
|
2004-09-02 |
2008-04-17 |
ジェネンテック・インコーポレーテッド |
ヘテロ多量体分子
|
|
EP2028193B1
(en)
|
2005-01-05 |
2012-03-07 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
|
CN101175862A
(zh)
|
2005-02-10 |
2008-05-07 |
肿瘤疗法科学股份有限公司 |
诊断膀胱癌的方法
|
|
US20120237442A1
(en)
|
2005-04-06 |
2012-09-20 |
Ibc Pharmaceuticals, Inc. |
Design and Construction of Novel Multivalent Antibodies
|
|
WO2006113665A2
(en)
*
|
2005-04-15 |
2006-10-26 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9963510B2
(en)
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
KR101203328B1
(ko)
|
2005-04-26 |
2012-11-20 |
화이자 인코포레이티드 |
Ｐ-카드헤린 항체
|
|
JP2008540340A
(ja)
|
2005-04-28 |
2008-11-20 |
マクギル ユニバーシティー |
カドヘリン介在過程を調節する化合物及び方法
|
|
CN101262885B
(zh)
|
2005-06-10 |
2015-04-01 |
中外制药株式会社 |
含有sc(Fv)2的药物组合物
|
|
JP2006345852A
(ja)
|
2005-06-16 |
2006-12-28 |
Virxsys Corp |
抗体複合体
|
|
BRPI0615745A2
(pt)
|
2005-09-12 |
2011-05-24 |
Novimmune Sa |
formulação de anticorpo anti-cd3
|
|
WO2007042261A2
(en)
|
2005-10-11 |
2007-04-19 |
Micromet Ag |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
PL1976880T3
(pl)
|
2005-12-21 |
2017-01-31 |
Amgen Research (Munich) Gmbh |
Kompozycje farmaceutyczne odporne na rozpuszczalny cea
|
|
WO2007075672A2
(en)
|
2005-12-23 |
2007-07-05 |
Lankenau Institute For Medical Research |
Prognostic cancer markers
|
|
JP2009528257A
(ja)
|
2006-02-28 |
2009-08-06 |
オンコセラピー・サイエンス株式会社 |
抗ｃｄｈ３抗体のエフェクター機能を用いて細胞を障害する方法
|
|
WO2007106507A2
(en)
|
2006-03-14 |
2007-09-20 |
Petrie Howard T |
Detection of gene expression in mixed sample or tissue
|
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
|
EP1999154B1
(en)
|
2006-03-24 |
2012-10-24 |
Merck Patent GmbH |
Engineered heterodimeric protein domains
|
|
US8535677B2
(en)
|
2006-06-06 |
2013-09-17 |
Oxford Biotherapeutics, Ltd. |
Antibody drug conjugate treatment of colorectal cancer
|
|
TWI610939B
(zh)
|
2007-02-21 |
2018-01-11 |
腫瘤療法 科學股份有限公司 |
表現腫瘤相關抗原之癌症的胜肽疫苗
|
|
CN109456410B
(zh)
|
2007-04-03 |
2022-01-28 |
安进研发（慕尼黑）股份有限公司 |
跨物种特异性CD3-ε结合结构域
|
|
CN103694350B
(zh)
*
|
2007-04-03 |
2018-04-24 |
安进研发（慕尼黑）股份有限公司 |
跨物种特异性CD3-ε结合结构域
|
|
WO2008124858A2
(en)
|
2007-04-11 |
2008-10-23 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. |
Targeted receptor
|
|
EP2164508B1
(en)
|
2007-06-04 |
2014-01-08 |
Rappaport Family Institute for Research in the Medical Sciences |
Agents for the treatment of inflammatory diseases and methods of using same
|
|
US20090155275A1
(en)
|
2007-07-31 |
2009-06-18 |
Medimmune, Llc |
Multispecific epitope binding proteins and uses thereof
|
|
WO2009021754A2
(en)
|
2007-08-15 |
2009-02-19 |
Bayer Schering Pharma Aktiengesellschaft |
Monospecific and multispecific antibodies and method of use
|
|
CN101827936B
(zh)
|
2007-08-20 |
2014-12-10 |
肿瘤疗法科学股份有限公司 |
Cdh3肽以及含有cdh3肽的药剂
|
|
CA2700714C
(en)
|
2007-09-26 |
2018-09-11 |
Ucb Pharma S.A. |
Dual specificity antibody fusions
|
|
CA2740310A1
(en)
|
2007-11-01 |
2009-05-07 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Altered cadherin processing in tumor cells
|
|
DE112008003232T5
(de)
|
2007-11-30 |
2011-02-24 |
Glaxo Group Limited, Greenford |
Antigen-Bindungskonstrukte
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
EP2080812A1
(en)
|
2008-01-18 |
2009-07-22 |
Transmedi SA |
Compositions and methods of detecting post-stop peptides
|
|
CA2722466A1
(en)
|
2008-04-29 |
2009-11-05 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
|
EP2313504B1
(en)
*
|
2008-06-30 |
2015-01-07 |
Oncotherapy Science, Inc. |
Anti-cdh3 antibodies labeled with radioisotope label and uses thereof
|
|
TW201008574A
(en)
|
2008-08-19 |
2010-03-01 |
Oncotherapy Science Inc |
INHBB epitope peptides and vaccines containing the same
|
|
EP4180458A1
(en)
|
2008-10-01 |
2023-05-17 |
Amgen Research (Munich) GmbH |
Cross-species-specific psma x cd3 bispecific single chain antibody
|
|
AU2009299791B2
(en)
|
2008-10-01 |
2016-02-25 |
Amgen Research (Munich) Gmbh |
Cross-species-specific PSCAxCD3, CD19xCD3, C-METxCD3, EndosialinxCD3, EpCAMxC D3, IGF-1RxCD3 or FAPalpha xCD3 bispecific single chain antibody
|
|
ES2582603T5
(es)
|
2008-10-01 |
2022-12-02 |
Amgen Res Munich Gmbh |
Anticuerpos biespecíficos de cadena sencilla con especificidad por antígenos diana de alto peso molecular
|
|
US10981998B2
(en)
|
2008-10-01 |
2021-04-20 |
Amgen Research (Munich) Gmbh |
Cross-species-specific single domain bispecific single chain antibody
|
|
WO2010040545A1
(en)
|
2008-10-06 |
2010-04-15 |
Novoplant Gmbh |
Proteolytically stable antibody formats
|
|
AU2009303318B2
(en)
|
2008-10-10 |
2016-06-30 |
Aptevo Research And Development Llc |
TCR complex immunotherapeutics
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
US8455249B2
(en)
|
2009-05-01 |
2013-06-04 |
The University Of Tokyo |
Highly effective anti-cadherin antibody for induction of antibody-dependent cellular cytotoxicity in vivo
|
|
PE20120540A1
(es)
|
2009-05-27 |
2012-05-09 |
Hoffmann La Roche |
Anticuerpos triespecificos o tetraespecificos
|
|
US8703132B2
(en)
|
2009-06-18 |
2014-04-22 |
Hoffmann-La Roche, Inc. |
Bispecific, tetravalent antigen binding proteins
|
|
RU2012112550A
(ru)
|
2009-09-01 |
2013-10-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
WO2011031833A2
(en)
|
2009-09-09 |
2011-03-17 |
Theraclone Sciences, Inc. |
Human anti-cancer antibodies
|
|
EP2475682B1
(en)
|
2009-09-10 |
2018-01-31 |
UCB Biopharma SPRL |
Multivalent antibodies
|
|
CN102597775A
(zh)
|
2009-09-25 |
2012-07-18 |
佐马技术有限公司 |
筛选方法
|
|
US20120269826A1
(en)
|
2009-10-20 |
2012-10-25 |
Mckee Charlotte |
Anti-cd3 antibody dosing in autoimmune disease
|
|
WO2011056997A1
(en)
|
2009-11-04 |
2011-05-12 |
Fabrus Llc |
Methods for affinity maturation-based antibody optimization
|
|
GB0920127D0
(en)
|
2009-11-17 |
2009-12-30 |
Ucb Pharma Sa |
Antibodies
|
|
WO2011071541A2
(en)
|
2009-12-11 |
2011-06-16 |
The Scripps Research Institute |
Cadherin modulatory agents
|
|
CN102939303A
(zh)
|
2009-12-22 |
2013-02-20 |
诺瓦提斯公司 |
四价cd47-抗体恒定区融合蛋白用于治疗
|
|
US20110165161A1
(en)
|
2009-12-23 |
2011-07-07 |
Shih-Yao Lin |
Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
|
|
DK2519542T3
(en)
|
2009-12-28 |
2019-01-14 |
Onco Therapy Science Inc |
ANTI-CDH3 ANTIBODIES AND APPLICATIONS THEREOF.
|
|
CN102014475B
(zh)
|
2010-01-08 |
2012-01-04 |
华为技术有限公司 |
资源映射、码分复用方法及装置
|
|
WO2011085178A1
(en)
|
2010-01-11 |
2011-07-14 |
Trustees Of Dartmouth College |
Monomeric bi-specific fusion protein
|
|
PT2535358T
(pt)
|
2010-02-10 |
2018-02-23 |
Perseus Proteomics Inc |
Anticorpo anti-caderina marcado com metal radioativo
|
|
PT2361936T
(pt)
|
2010-02-25 |
2016-07-15 |
Affimed Gmbh |
Molécula que se liga a antigénio e utilizações desta
|
|
WO2011109588A1
(en)
|
2010-03-03 |
2011-09-09 |
Health Research Inc. |
Novel cd3 epsilon immunogens and antibodies
|
|
TWI653333B
(zh)
|
2010-04-01 |
2019-03-11 |
安進研究（慕尼黑）有限責任公司 |
跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
|
|
BR112012028010A2
(pt)
|
2010-05-03 |
2017-09-26 |
Genentech Inc |
anticorpo isolado, célula, ácido nucleíco isolado, método de identificação de um primeiro anticorpo que se liga a um epítopo antigênico tat425 ligado or um anticorpo, métodos de inibir o crescimento de uma célula, de tratamento terapêutico de determinação da presença de uma proteína de tat425 e de diagnóstico da presença de um tumor em um mamífero
|
|
MX339622B
(es)
*
|
2010-08-02 |
2016-06-02 |
Macrogenics Inc |
Diacuerpos covalentes y sus usos.
|
|
AR082686A1
(es)
|
2010-08-13 |
2012-12-26 |
Baylor Res Inst |
Adyuvantes de vacuna que direccionan a los adyuvantes de anticuerpos directamente hacia las celulas presentadoras de antigenos
|
|
EP3533803B1
(en)
|
2010-08-14 |
2021-10-27 |
AbbVie Inc. |
Anti-amyloid-beta antibodies
|
|
PL2606064T3
(pl)
|
2010-08-16 |
2015-07-31 |
Novimmune Sa |
Sposoby wytwarzania wieloswoistych i wielowartościowych przeciwciał
|
|
SG189313A1
(en)
|
2010-10-08 |
2013-05-31 |
John C Williams |
A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
|
|
EP3708586A1
(en)
|
2010-10-29 |
2020-09-16 |
Perseus Proteomics Inc. |
Anti-cdh3 antibody having high internalization capacity
|
|
JP2014015396A
(ja)
|
2010-10-29 |
2014-01-30 |
Perseus Proteomics Inc |
高い親和性を有する抗ｃｄｈ３抗体
|
|
MX349057B
(es)
|
2010-11-30 |
2017-07-07 |
Chugai Pharmaceutical Co Ltd |
Agente terapeutico que induce citotoxicidad.
|
|
US20120201746A1
(en)
|
2010-12-22 |
2012-08-09 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
US20120195900A1
(en)
|
2010-12-22 |
2012-08-02 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
TW201247706A
(en)
|
2011-03-08 |
2012-12-01 |
Baylor Res Inst |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
|
|
EP2683735A1
(en)
|
2011-03-10 |
2014-01-15 |
HCO Antibody, Inc. |
Bispecific three-chain antibody-like molecules
|
|
AU2012229048B2
(en)
|
2011-03-16 |
2016-01-21 |
Amgen Inc |
Fc variants
|
|
AU2012228100B2
(en)
|
2011-03-17 |
2016-09-08 |
The University Of Birmingham |
Re-directed immunotherapy
|
|
CN103429619B
(zh)
|
2011-03-17 |
2017-07-28 |
雷蒙特亚特特拉维夫大学有限公司 |
双特异性和单特异性、不对称抗体和其制备方法
|
|
EP2688591A4
(en)
|
2011-03-22 |
2014-10-01 |
Baylor Res Inst |
TARGETING DENDRITIC CELLS FOR A TUBERCULOSIS VACCINE
|
|
WO2012135132A1
(en)
|
2011-03-25 |
2012-10-04 |
Baylor Research Institute |
Compositions and methods to immunize against hepatitis c virus
|
|
TWI743461B
(zh)
|
2011-03-28 |
2021-10-21 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
CA2830972C
(en)
|
2011-04-19 |
2018-11-20 |
Pfizer Inc. |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
|
EP2699596A4
(en)
|
2011-04-22 |
2015-01-14 |
Emergent Product Dev Seattle |
PROSTATE-SPECIFIC MEMBRANE-BINDING PROTEINS AND COMPOSITIONS AND METHOD THEREFOR
|
|
WO2012158818A2
(en)
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
EP2714079B2
(en)
|
2011-05-21 |
2019-08-28 |
MacroGenics, Inc. |
Deimmunized serum-binding domains and their use for extending serum half-life
|
|
EA033677B1
(ru)
|
2011-05-21 |
2019-11-15 |
Macrogenics Inc |
Cd3-связывающие молекулы, способные к связыванию с cd3 человека и cd3, не являющимся человеческим
|
|
ES2704038T3
(es)
|
2011-05-24 |
2019-03-13 |
Zyngenia Inc |
Complejos multiespecíficos multivalentes y monovalentes y sus usos
|
|
WO2012162583A1
(en)
|
2011-05-26 |
2012-11-29 |
Ibc Pharmaceuticals, Inc. |
Design and construction of novel multivalent antibodies
|
|
HUE061692T2
(hu)
|
2011-05-27 |
2023-08-28 |
Hoffmann La Roche |
Kettõs célzás
|
|
US20140193408A1
(en)
|
2011-06-16 |
2014-07-10 |
Novartis Ag |
Soluble proteins for use as therapeutics
|
|
JPWO2012176765A1
(ja)
|
2011-06-24 |
2015-02-23 |
株式会社ペルセウスプロテオミクス |
抗ヒトｐ−カドへリン（ｃｄｈ３）遺伝子組み換え抗体
|
|
US20140242081A1
(en)
|
2011-07-18 |
2014-08-28 |
Micromet Ag |
Dosing regimens for treatment of cea-expressing cancers
|
|
CA2842649C
(en)
|
2011-07-22 |
2020-01-21 |
Affimed Therapeutics Ag |
Multivalent antigen-binding fv molecule
|
|
ES2686327T3
(es)
|
2011-08-23 |
2018-10-17 |
Roche Glycart Ag |
Moléculas de unión a antígeno biespecíficas
|
|
US20130058936A1
(en)
|
2011-08-23 |
2013-03-07 |
Peter Bruenker |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
|
PE20141521A1
(es)
|
2011-08-23 |
2014-10-25 |
Roche Glycart Ag |
Moleculas biespecificas de union a antigeno activadoras de celulas t
|
|
KR101723273B1
(ko)
|
2011-08-23 |
2017-04-04 |
로슈 글리카트 아게 |
2 개의 ｆａｂ 단편을 포함하는 fc-부재 항체 및 이용 방법
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
WO2013041865A1
(en)
|
2011-09-22 |
2013-03-28 |
Immunocore Limited |
T cell receptors
|
|
WO2013041687A1
(en)
|
2011-09-23 |
2013-03-28 |
Amgen Research (Munich) Gmbh |
Bispecific binding molecules for 5t4 and cd3
|
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對ｂｃｍａ之e3以及ｃｄ３的結合分子
|
|
BR112014015018A2
(pt)
|
2011-12-19 |
2020-10-27 |
Synimmune Gmbh |
moléculas de anticorpo biespecífico e seu método de produção, bem como composição farmacêutica e molécula de ácido nucleico
|
|
GB201203442D0
(en)
|
2012-02-28 |
2012-04-11 |
Univ Birmingham |
Immunotherapeutic molecules and uses
|
|
US20150037334A1
(en)
|
2012-03-01 |
2015-02-05 |
Amgen Research (Munich) Gmbh |
Long life polypeptide binding molecules
|
|
HK1206386A1
(en)
|
2012-04-04 |
2016-01-08 |
Perseus Proteomics Inc. |
Conjugate of anti-cdh3 (p-cadherin) antibody and drug
|
|
RU2673153C2
(ru)
|
2012-04-20 |
2018-11-22 |
АПТЕВО РИСЁРЧ ЭНД ДИВЕЛОПМЕНТ ЭлЭлСи |
Полипептиды, связывающиеся с cd3
|
|
EA039663B1
(ru)
*
|
2012-05-03 |
2022-02-24 |
Амген Инк. |
Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
|
|
US10647756B2
(en)
*
|
2015-05-18 |
2020-05-12 |
Pfizer Inc. |
Humanized antibodies
|