AU2015283704A1 - Bispecific heterodimeric diabodies and uses thereof - Google Patents
Bispecific heterodimeric diabodies and uses thereof Download PDFInfo
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- AU2015283704A1 AU2015283704A1 AU2015283704A AU2015283704A AU2015283704A1 AU 2015283704 A1 AU2015283704 A1 AU 2015283704A1 AU 2015283704 A AU2015283704 A AU 2015283704A AU 2015283704 A AU2015283704 A AU 2015283704A AU 2015283704 A1 AU2015283704 A1 AU 2015283704A1
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Classifications
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- C07K16/46—Hybrid immunoglobulins
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018274919A AU2018274919A1 (en) | 2014-07-01 | 2018-12-05 | Bispecific heterodimeric diabodies and uses thereof |
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| US201462019762P | 2014-07-01 | 2014-07-01 | |
| US62/019,762 | 2014-07-01 | ||
| US201562148920P | 2015-04-17 | 2015-04-17 | |
| US62/148,920 | 2015-04-17 | ||
| PCT/IB2015/054829 WO2016001810A1 (en) | 2014-07-01 | 2015-06-26 | Bispecific heterodimeric diabodies and uses thereof |
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| AU2018274919A Division AU2018274919A1 (en) | 2014-07-01 | 2018-12-05 | Bispecific heterodimeric diabodies and uses thereof |
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| AU2015283704A1 true AU2015283704A1 (en) | 2016-12-15 |
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| AU2018274919A Abandoned AU2018274919A1 (en) | 2014-07-01 | 2018-12-05 | Bispecific heterodimeric diabodies and uses thereof |
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| AU2018274919A Abandoned AU2018274919A1 (en) | 2014-07-01 | 2018-12-05 | Bispecific heterodimeric diabodies and uses thereof |
Country Status (17)
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| US (2) | US9884921B2 (OSRAM) |
| EP (1) | EP3164417A1 (OSRAM) |
| JP (1) | JP2017520575A (OSRAM) |
| KR (1) | KR20170010863A (OSRAM) |
| CN (1) | CN106661119A (OSRAM) |
| AU (2) | AU2015283704A1 (OSRAM) |
| BR (1) | BR112016030740A2 (OSRAM) |
| CA (1) | CA2895659A1 (OSRAM) |
| CO (1) | CO2017000016A2 (OSRAM) |
| IL (1) | IL249889A0 (OSRAM) |
| MX (1) | MX2016017393A (OSRAM) |
| PE (1) | PE20170286A1 (OSRAM) |
| PH (1) | PH12016502491A1 (OSRAM) |
| RU (1) | RU2016151645A (OSRAM) |
| SG (1) | SG11201609707WA (OSRAM) |
| TW (2) | TW201936638A (OSRAM) |
| WO (1) | WO2016001810A1 (OSRAM) |
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| ES2899779T3 (es) | 2014-12-05 | 2022-03-14 | Memorial Sloan Kettering Cancer Center | Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos |
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- 2015-06-26 EP EP15741347.7A patent/EP3164417A1/en not_active Withdrawn
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- 2015-06-26 BR BR112016030740-2A patent/BR112016030740A2/pt not_active Application Discontinuation
- 2015-06-26 CA CA2895659A patent/CA2895659A1/en not_active Abandoned
- 2015-06-26 WO PCT/IB2015/054829 patent/WO2016001810A1/en not_active Ceased
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- 2015-06-26 JP JP2016575335A patent/JP2017520575A/ja active Pending
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- 2015-06-29 TW TW104120955A patent/TWI659042B/zh not_active IP Right Cessation
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| US20160002357A1 (en) | 2016-01-07 |
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| MX2016017393A (es) | 2017-09-05 |
| TWI659042B (zh) | 2019-05-11 |
| RU2016151645A (ru) | 2018-08-03 |
| PH12016502491A1 (en) | 2017-03-22 |
| PE20170286A1 (es) | 2017-03-30 |
| SG11201609707WA (en) | 2017-01-27 |
| JP2017520575A (ja) | 2017-07-27 |
| BR112016030740A2 (pt) | 2018-02-20 |
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