JP2019523270A5 - - Google Patents
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- Publication number
- JP2019523270A5 JP2019523270A5 JP2019504001A JP2019504001A JP2019523270A5 JP 2019523270 A5 JP2019523270 A5 JP 2019523270A5 JP 2019504001 A JP2019504001 A JP 2019504001A JP 2019504001 A JP2019504001 A JP 2019504001A JP 2019523270 A5 JP2019523270 A5 JP 2019523270A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- layer
- drug reservoir
- donepezil
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 43
- 239000010410 layer Substances 0.000 claims description 40
- 229940079593 drug Drugs 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 29
- 229960003530 donepezil Drugs 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 20
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 18
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 18
- 239000001069 triethyl citrate Substances 0.000 claims description 18
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 18
- 235000013769 triethyl citrate Nutrition 0.000 claims description 18
- 229920001577 copolymer Polymers 0.000 claims description 16
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims description 16
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 16
- 239000000853 adhesive Substances 0.000 claims description 15
- 230000001070 adhesive effect Effects 0.000 claims description 15
- 239000002585 base Substances 0.000 claims description 14
- 239000004821 Contact adhesive Substances 0.000 claims description 13
- 230000037317 transdermal delivery Effects 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 238000011065 in-situ storage Methods 0.000 claims description 10
- 239000012982 microporous membrane Substances 0.000 claims description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 8
- 150000001447 alkali salts Chemical class 0.000 claims description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 5
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 5
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229920002367 Polyisobutene Polymers 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 2
- 239000003522 acrylic cement Substances 0.000 claims description 2
- 239000012790 adhesive layer Substances 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 229920001083 polybutene Polymers 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 2
- 239000002356 single layer Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 229960001790 sodium citrate Drugs 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229960004025 sodium salicylate Drugs 0.000 claims description 2
- 229940074404 sodium succinate Drugs 0.000 claims description 2
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 2
- 238000012385 systemic delivery Methods 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 2
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 2
- 159000000011 group IA salts Chemical class 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022106083A JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367502P | 2016-07-27 | 2016-07-27 | |
| US201662367542P | 2016-07-27 | 2016-07-27 | |
| US62/367,502 | 2016-07-27 | ||
| US62/367,542 | 2016-07-27 | ||
| US201662423133P | 2016-11-16 | 2016-11-16 | |
| US62/423,133 | 2016-11-16 | ||
| US201762444763P | 2017-01-10 | 2017-01-10 | |
| US201762444745P | 2017-01-10 | 2017-01-10 | |
| US62/444,745 | 2017-01-10 | ||
| US62/444,763 | 2017-01-10 | ||
| US201762457794P | 2017-02-10 | 2017-02-10 | |
| US62/457,794 | 2017-02-10 | ||
| US201762504408P | 2017-05-10 | 2017-05-10 | |
| US201762504391P | 2017-05-10 | 2017-05-10 | |
| US62/504,391 | 2017-05-10 | ||
| US62/504,408 | 2017-05-10 | ||
| PCT/US2017/044050 WO2018022817A1 (en) | 2016-07-27 | 2017-07-26 | Donepezil transdermal delivery system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106083A Division JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523270A JP2019523270A (ja) | 2019-08-22 |
| JP2019523270A5 true JP2019523270A5 (enExample) | 2020-08-20 |
| JP7251033B2 JP7251033B2 (ja) | 2023-04-04 |
Family
ID=59523314
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504000A Active JP7071330B2 (ja) | 2016-07-27 | 2017-07-26 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2019503974A Active JP7153010B2 (ja) | 2016-07-27 | 2017-07-26 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
| JP2019504001A Active JP7251033B2 (ja) | 2016-07-27 | 2017-07-26 | ドネペジル経皮送達システム |
| JP2022076575A Pending JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2022106083A Pending JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
| JP2022124683A Pending JP2022140751A (ja) | 2016-07-27 | 2022-08-04 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504000A Active JP7071330B2 (ja) | 2016-07-27 | 2017-07-26 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2019503974A Active JP7153010B2 (ja) | 2016-07-27 | 2017-07-26 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076575A Pending JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2022106083A Pending JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
| JP2022124683A Pending JP2022140751A (ja) | 2016-07-27 | 2022-08-04 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (13) | US9993466B2 (enExample) |
| EP (3) | EP3490558A1 (enExample) |
| JP (6) | JP7071330B2 (enExample) |
| KR (9) | KR102555208B1 (enExample) |
| CN (5) | CN109789133A (enExample) |
| AU (7) | AU2017302306A1 (enExample) |
| CA (3) | CA3032044C (enExample) |
| MX (2) | MX394249B (enExample) |
| SG (1) | SG11201900692WA (enExample) |
| WO (3) | WO2018022817A1 (enExample) |
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| AU2016355920B2 (en) * | 2015-11-18 | 2020-11-12 | Commonwealth Scientific And Industrial Research Organisation | Rice grain with thickened aleurone |
| US10966936B2 (en) | 2015-12-30 | 2021-04-06 | Corium, Inc. | Systems comprising a composite backing and methods for long term transdermal administration |
| CA3028436A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| US9993466B2 (en) | 2016-07-27 | 2018-06-12 | Corium International, Inc. | Donepezil transdermal delivery system |
| CN111132669A (zh) * | 2017-07-26 | 2020-05-08 | 考里安公司 | 具有带溶剂填充孔的微孔膜的透皮递送系统 |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| KR102823139B1 (ko) * | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102710072B1 (ko) * | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102115102B1 (ko) | 2018-12-21 | 2020-05-26 | 동아에스티 주식회사 | 안정화된 도네페질 함유 경피 흡수제제 |
| KR102372630B1 (ko) * | 2019-05-15 | 2022-03-14 | 주식회사 대웅제약 | 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제 |
| US11101101B2 (en) * | 2019-05-15 | 2021-08-24 | Fei Company | Laser-based phase plate image contrast manipulation |
| BR112022007369A2 (pt) * | 2019-10-24 | 2022-07-05 | Lts Lohmann Therapie Systeme Ag | Sistema terapêutico transdérmico para a administração transdérmica de fingolimode |
| EP4066829A4 (en) * | 2019-11-26 | 2023-12-27 | Hisamitsu Pharmaceutical Co., Inc. | Method for improving holding power of adhesive agent layer in ropinirole-containing transdermal patch, and ropinirole-containing transdermal patch having improved holding power |
| WO2021127092A1 (en) * | 2019-12-18 | 2021-06-24 | Pioneer Hi-Bred International, Inc. | Compositions and methods for improving grain yield in plants |
| CN115397402A (zh) * | 2020-04-14 | 2022-11-25 | 格兰尼斯制药公司 | 包含羟氯喹和/或氯喹的经皮和/或局部递送系统 |
| JP2022044038A (ja) * | 2020-09-04 | 2022-03-16 | 株式会社大石膏盛堂 | ドネペジル含有経皮吸収液剤およびその製造方法 |
| CN112656778A (zh) * | 2020-12-28 | 2021-04-16 | 广东红珊瑚药业有限公司 | 一种压敏胶基质以及一种贴剂 |
| US12270039B2 (en) * | 2021-05-14 | 2025-04-08 | Board Of Trustees Of Southern Illinois University | Compositions and methods to increase oleic acid content in soybeans |
| US12270040B2 (en) * | 2021-05-27 | 2025-04-08 | Board Of Trustees Of Southern Illinois University | Soybean lines with low saturated fatty acid and high oleic acid contents |
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- 2025-05-30 US US19/223,763 patent/US20250375396A1/en active Pending
- 2025-07-08 AU AU2025205205A patent/AU2025205205A1/en not_active Abandoned
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