JP2019525932A5 - - Google Patents
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- JP2019525932A5 JP2019525932A5 JP2019504000A JP2019504000A JP2019525932A5 JP 2019525932 A5 JP2019525932 A5 JP 2019525932A5 JP 2019504000 A JP2019504000 A JP 2019504000A JP 2019504000 A JP2019504000 A JP 2019504000A JP 2019525932 A5 JP2019525932 A5 JP 2019525932A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- transdermal patch
- drug reservoir
- motomeko
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 52
- -1 inorganic base compound Chemical class 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 18
- 239000010410 layer Substances 0.000 claims description 14
- 239000013543 active substance Substances 0.000 claims description 13
- 239000000853 adhesive Substances 0.000 claims description 13
- 230000001070 adhesive effect Effects 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 239000004821 Contact adhesive Substances 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- 208000002193 Pain Diseases 0.000 claims description 4
- 229920002367 Polyisobutene Polymers 0.000 claims description 4
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical group O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000004014 plasticizer Substances 0.000 claims description 4
- 239000013464 silicone adhesive Substances 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229920006132 styrene block copolymer Polymers 0.000 claims description 4
- 230000037317 transdermal delivery Effects 0.000 claims description 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 4
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 3
- 230000001154 acute effect Effects 0.000 claims description 3
- 150000003839 salts Chemical group 0.000 claims description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 2
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 2
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- MUXOBHXGJLMRAB-UHFFFAOYSA-N Dimethyl succinate Chemical compound COC(=O)CCC(=O)OC MUXOBHXGJLMRAB-UHFFFAOYSA-N 0.000 claims description 2
- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
- 208000026251 Opioid-Related disease Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 2
- 208000005793 Restless legs syndrome Diseases 0.000 claims description 2
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- DRHKJLXJIQTDTD-OAHLLOKOSA-N Tamsulosine Chemical compound CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC=C(OC)C(S(N)(=O)=O)=C1 DRHKJLXJIQTDTD-OAHLLOKOSA-N 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- 206010046555 Urinary retention Diseases 0.000 claims description 2
- 150000001278 adipic acid derivatives Chemical class 0.000 claims description 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 2
- 229960001736 buprenorphine Drugs 0.000 claims description 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims description 2
- 150000001990 dicarboxylic acid derivatives Chemical class 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims description 2
- 229960003530 donepezil Drugs 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 229960002428 fentanyl Drugs 0.000 claims description 2
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 claims description 2
- 150000002314 glycerols Chemical class 0.000 claims description 2
- 239000001087 glyceryl triacetate Substances 0.000 claims description 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 2
- 150000002688 maleic acid derivatives Chemical class 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 2
- 229960004640 memantine Drugs 0.000 claims description 2
- 229960001344 methylphenidate Drugs 0.000 claims description 2
- 201000003631 narcolepsy Diseases 0.000 claims description 2
- 229940055577 oleyl alcohol Drugs 0.000 claims description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 2
- 201000005040 opiate dependence Diseases 0.000 claims description 2
- 229960005434 oxybutynin Drugs 0.000 claims description 2
- 229920006254 polymer film Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 229940026235 propylene glycol monolaurate Drugs 0.000 claims description 2
- 229960004136 rivastigmine Drugs 0.000 claims description 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims description 2
- 229960001879 ropinirole Drugs 0.000 claims description 2
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 claims description 2
- 229960003179 rotigotine Drugs 0.000 claims description 2
- 150000003329 sebacic acid derivatives Chemical class 0.000 claims description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229960002613 tamsulosin Drugs 0.000 claims description 2
- 229960002622 triacetin Drugs 0.000 claims description 2
- 239000001069 triethyl citrate Substances 0.000 claims description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000013769 triethyl citrate Nutrition 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022076575A JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367542P | 2016-07-27 | 2016-07-27 | |
| US201662367502P | 2016-07-27 | 2016-07-27 | |
| US62/367,542 | 2016-07-27 | ||
| US62/367,502 | 2016-07-27 | ||
| US201662423133P | 2016-11-16 | 2016-11-16 | |
| US62/423,133 | 2016-11-16 | ||
| US201762444763P | 2017-01-10 | 2017-01-10 | |
| US201762444745P | 2017-01-10 | 2017-01-10 | |
| US62/444,763 | 2017-01-10 | ||
| US62/444,745 | 2017-01-10 | ||
| US201762457794P | 2017-02-10 | 2017-02-10 | |
| US62/457,794 | 2017-02-10 | ||
| US201762504391P | 2017-05-10 | 2017-05-10 | |
| US201762504408P | 2017-05-10 | 2017-05-10 | |
| US62/504,408 | 2017-05-10 | ||
| US62/504,391 | 2017-05-10 | ||
| PCT/US2017/044049 WO2018022816A1 (en) | 2016-07-27 | 2017-07-26 | Sodium bicarbonate in situ conversion driven transdermal delivery of amine drug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076575A Division JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525932A JP2019525932A (ja) | 2019-09-12 |
| JP2019525932A5 true JP2019525932A5 (enExample) | 2020-08-27 |
| JP7071330B2 JP7071330B2 (ja) | 2022-05-18 |
Family
ID=59523314
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504000A Active JP7071330B2 (ja) | 2016-07-27 | 2017-07-26 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2019504001A Active JP7251033B2 (ja) | 2016-07-27 | 2017-07-26 | ドネペジル経皮送達システム |
| JP2019503974A Active JP7153010B2 (ja) | 2016-07-27 | 2017-07-26 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
| JP2022076575A Pending JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2022106083A Pending JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
| JP2022124683A Pending JP2022140751A (ja) | 2016-07-27 | 2022-08-04 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504001A Active JP7251033B2 (ja) | 2016-07-27 | 2017-07-26 | ドネペジル経皮送達システム |
| JP2019503974A Active JP7153010B2 (ja) | 2016-07-27 | 2017-07-26 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
| JP2022076575A Pending JP2022093707A (ja) | 2016-07-27 | 2022-05-06 | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| JP2022106083A Pending JP2022121629A (ja) | 2016-07-27 | 2022-06-30 | ドネペジル経皮送達システム |
| JP2022124683A Pending JP2022140751A (ja) | 2016-07-27 | 2022-08-04 | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (13) | US9993466B2 (enExample) |
| EP (3) | EP3490540A1 (enExample) |
| JP (6) | JP7071330B2 (enExample) |
| KR (9) | KR20230109782A (enExample) |
| CN (5) | CN116270551A (enExample) |
| AU (7) | AU2017302306A1 (enExample) |
| CA (3) | CA3031945C (enExample) |
| MX (2) | MX394249B (enExample) |
| SG (1) | SG11201900692WA (enExample) |
| WO (3) | WO2018022816A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170110083A (ko) | 2014-12-23 | 2017-10-10 | 인털렉츄얼 프라퍼티 어쏘시에이츠, 엘엘씨 | 경피 투여를 위한 방법 및 제형 |
| WO2017083920A1 (en) * | 2015-11-18 | 2017-05-26 | Commonwealth Scientific And Industrial Research Organisation | Rice grain with thickened aleurone |
| IL303255A (en) | 2015-12-30 | 2023-07-01 | Corium Inc | Systems and methods for long term transdermal administration |
| KR102419767B1 (ko) | 2016-06-23 | 2022-07-12 | 코리움, 인크. | 친수성 및 소수성 도메인 및 치료제가 포함된 접착성 매트릭스 |
| US10945968B2 (en) | 2016-07-27 | 2021-03-16 | Corium, Inc. | Memantine transdermal delivery systems |
| CA3031945C (en) | 2016-07-27 | 2025-09-23 | Corium Int Inc | Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs by in situ salt-to-neutral drug conversion of salt drug |
| EP3658127A1 (en) * | 2017-07-26 | 2020-06-03 | Corium, Inc. | Transdermal delivery system with a microporous membrane having solvent-filled pores |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| CA3086163A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| KR102710072B1 (ko) * | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102823139B1 (ko) * | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102115102B1 (ko) | 2018-12-21 | 2020-05-26 | 동아에스티 주식회사 | 안정화된 도네페질 함유 경피 흡수제제 |
| US11101101B2 (en) * | 2019-05-15 | 2021-08-24 | Fei Company | Laser-based phase plate image contrast manipulation |
| KR102372630B1 (ko) * | 2019-05-15 | 2022-03-14 | 주식회사 대웅제약 | 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제 |
| EP4048247B1 (en) * | 2019-10-24 | 2024-04-03 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system for the transdermal administration of fingolimod |
| KR20220084145A (ko) * | 2019-11-26 | 2022-06-21 | 히사미쓰 세이야꾸 가부시키가이샤 | 로피니롤 함유 첩부제의 점착제층 유지력 향상 방법, 및 로피니롤 함유 유지력 개선 첩부제 |
| WO2021127092A1 (en) * | 2019-12-18 | 2021-06-24 | Pioneer Hi-Bred International, Inc. | Compositions and methods for improving grain yield in plants |
| MX2022012841A (es) * | 2020-04-14 | 2022-12-02 | Glanis Pharmaceuticals Inc | Sistema de entrega transdérmica y/o tópica que comprende hidroxicloroquina y/o cloroquina. |
| JP2022044038A (ja) * | 2020-09-04 | 2022-03-16 | 株式会社大石膏盛堂 | ドネペジル含有経皮吸収液剤およびその製造方法 |
| CN112656778A (zh) * | 2020-12-28 | 2021-04-16 | 广东红珊瑚药业有限公司 | 一种压敏胶基质以及一种贴剂 |
| US12270039B2 (en) * | 2021-05-14 | 2025-04-08 | Board Of Trustees Of Southern Illinois University | Compositions and methods to increase oleic acid content in soybeans |
| US12270040B2 (en) * | 2021-05-27 | 2025-04-08 | Board Of Trustees Of Southern Illinois University | Soybean lines with low saturated fatty acid and high oleic acid contents |
| CR20240001A (es) * | 2021-07-08 | 2024-05-22 | Monsanto Technology Llc | Proteínas inhibidoras de insectos novedosas |
| WO2025103446A1 (zh) * | 2023-11-16 | 2025-05-22 | 宜昌人福药业有限责任公司 | 含有多奈哌齐的透皮贴剂及其制备方法 |
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