TR201818754T4 - Koruyucu içermeyen Brimonidin Ve Timolol Çözeltileri - Google Patents
Koruyucu içermeyen Brimonidin Ve Timolol Çözeltileri Download PDFInfo
- Publication number
- TR201818754T4 TR201818754T4 TR2018/18754T TR201818754T TR201818754T4 TR 201818754 T4 TR201818754 T4 TR 201818754T4 TR 2018/18754 T TR2018/18754 T TR 2018/18754T TR 201818754 T TR201818754 T TR 201818754T TR 201818754 T4 TR201818754 T4 TR 201818754T4
- Authority
- TR
- Turkey
- Prior art keywords
- brimonidine
- preservatives
- timolol
- solutions
- timolol solutions
- Prior art date
Links
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 title abstract 2
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003679 brimonidine Drugs 0.000 title abstract 2
- 229960004605 timolol Drugs 0.000 title abstract 2
- 239000003755 preservative agent Substances 0.000 title 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Mevcut buluş intraoküler basıncı düşürme ve glokom tedavisi için koruyucu içermeyen brimonidin ve timolol çözeltilerine yöneliktir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36868110P | 2010-07-29 | 2010-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201818754T4 true TR201818754T4 (tr) | 2019-01-21 |
Family
ID=44504227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/18754T TR201818754T4 (tr) | 2010-07-29 | 2011-07-28 | Koruyucu içermeyen Brimonidin Ve Timolol Çözeltileri |
Country Status (12)
Country | Link |
---|---|
US (3) | US10213431B2 (tr) |
EP (2) | EP2598119B1 (tr) |
AU (1) | AU2011282683B2 (tr) |
CA (1) | CA2807084C (tr) |
DK (1) | DK2598119T3 (tr) |
ES (1) | ES2709180T3 (tr) |
HU (1) | HUE040283T2 (tr) |
PL (1) | PL2598119T3 (tr) |
PT (1) | PT2598119T (tr) |
SI (1) | SI2598119T1 (tr) |
TR (1) | TR201818754T4 (tr) |
WO (1) | WO2012016000A2 (tr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Surgical (Ireland) Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
GR1008330B (el) * | 2013-10-17 | 2014-10-20 | "Φαρματεν Α.Β.Ε.Ε.", | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση εχoν βελτιωμενες φυσικες ιδιοτητες και ογκο σταγονας |
GR1008483B (el) * | 2013-12-23 | 2015-05-12 | Rafarm Α.Ε.Β.Ε., | Οφθαλμικη φαρμακευτικη συνθεση και μεθοδος για την παρασκευη αυτης |
TWI705812B (zh) | 2014-12-01 | 2020-10-01 | 奥默羅斯公司 | 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液 |
AU2016233125A1 (en) * | 2015-03-19 | 2017-09-14 | Allergan, Inc. | Fixed dose combination of bromonidine and timolol |
JP2017002035A (ja) * | 2015-06-05 | 2017-01-05 | 参天製薬株式会社 | ソフトコンタクトレンズが装用されたドライアイ患者の眼に点眼されるように用いられることを特徴とするドライアイ治療剤 |
US11541018B2 (en) * | 2016-06-23 | 2023-01-03 | Corium, Llc | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
JP7251033B2 (ja) | 2016-07-27 | 2023-04-04 | コリウム, エルエルシー | ドネペジル経皮送達システム |
AU2018392686A1 (en) | 2017-12-20 | 2020-07-09 | Corium Pharma Solutions, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
GR1010024B (el) * | 2020-05-06 | 2021-06-01 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4195085A (en) | 1975-09-26 | 1980-03-25 | Merck & Co., Inc. | Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate |
CA1334168C (en) | 1988-04-26 | 1995-01-31 | Louis M. De Santis | Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers |
US5021416A (en) | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US7030149B2 (en) * | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
CA2536061A1 (en) * | 2003-08-22 | 2005-03-17 | Edward J. Ellis | Polymeric systems for controlled drug therapy |
WO2008024846A2 (en) * | 2006-08-25 | 2008-02-28 | Allergan, Inc. | Brimonidine and timolol compositions |
MX2007010025A (es) * | 2007-08-17 | 2009-02-25 | Arturo Jimenez Bayardo | Composición farmacéutica para tratamiento de hipertensión ocular. |
PE20160904A1 (es) | 2009-12-22 | 2016-09-16 | Allergan Inc | Combinacion triple para reduccion de presion intraocular |
-
2011
- 2011-07-28 TR TR2018/18754T patent/TR201818754T4/tr unknown
- 2011-07-28 EP EP11745861.2A patent/EP2598119B1/en not_active Revoked
- 2011-07-28 ES ES11745861T patent/ES2709180T3/es active Active
- 2011-07-28 PL PL11745861T patent/PL2598119T3/pl unknown
- 2011-07-28 EP EP18194001.6A patent/EP3434257A1/en not_active Withdrawn
- 2011-07-28 SI SI201131629T patent/SI2598119T1/sl unknown
- 2011-07-28 HU HUE11745861A patent/HUE040283T2/hu unknown
- 2011-07-28 CA CA2807084A patent/CA2807084C/en active Active
- 2011-07-28 DK DK11745861.2T patent/DK2598119T3/en active
- 2011-07-28 WO PCT/US2011/045656 patent/WO2012016000A2/en active Application Filing
- 2011-07-28 US US13/812,599 patent/US10213431B2/en not_active Expired - Fee Related
- 2011-07-28 PT PT11745861T patent/PT2598119T/pt unknown
- 2011-07-28 AU AU2011282683A patent/AU2011282683B2/en not_active Ceased
-
2019
- 2019-01-10 US US16/245,026 patent/US10792288B2/en active Active
-
2020
- 2020-09-09 US US17/015,615 patent/US20210228587A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2012016000A2 (en) | 2012-02-02 |
AU2011282683A1 (en) | 2013-03-07 |
PL2598119T3 (pl) | 2019-03-29 |
ES2709180T3 (es) | 2019-04-15 |
US10213431B2 (en) | 2019-02-26 |
EP2598119B1 (en) | 2018-09-19 |
US20140148456A1 (en) | 2014-05-29 |
CA2807084A1 (en) | 2012-02-02 |
PT2598119T (pt) | 2018-12-17 |
EP2598119A2 (en) | 2013-06-05 |
WO2012016000A3 (en) | 2012-03-15 |
US20210228587A1 (en) | 2021-07-29 |
SI2598119T1 (sl) | 2019-02-28 |
EP3434257A1 (en) | 2019-01-30 |
DK2598119T3 (en) | 2019-01-07 |
US20190307759A1 (en) | 2019-10-10 |
US10792288B2 (en) | 2020-10-06 |
CA2807084C (en) | 2018-05-22 |
AU2011282683B2 (en) | 2016-12-22 |
HUE040283T2 (hu) | 2019-02-28 |
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