JP6153135B2 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
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- JP6153135B2 JP6153135B2 JP2014521380A JP2014521380A JP6153135B2 JP 6153135 B2 JP6153135 B2 JP 6153135B2 JP 2014521380 A JP2014521380 A JP 2014521380A JP 2014521380 A JP2014521380 A JP 2014521380A JP 6153135 B2 JP6153135 B2 JP 6153135B2
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- 239000002385 cottonseed oil Substances 0.000 description 1
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 description 1
- 229940022769 d- lactic acid Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 description 1
- 229940031016 ethyl linoleate Drugs 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 229940067592 ethyl palmitate Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011086 glassine Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- JLRBNGCMXSGALP-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O.CCCCCCC(O)=O JLRBNGCMXSGALP-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 229920006270 hydrocarbon resin Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- LDHBWEYLDHLIBQ-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide;hydrate Chemical compound O.[OH-].[O-2].[Fe+3] LDHBWEYLDHLIBQ-UHFFFAOYSA-M 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940075495 isopropyl palmitate Drugs 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- 229940113915 isostearyl palmitate Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229940040102 levulinic acid Drugs 0.000 description 1
- FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- RMIODHQZRUFFFF-UHFFFAOYSA-N methoxyacetic acid Chemical group COCC(O)=O RMIODHQZRUFFFF-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000003149 muscarinic antagonist Substances 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QJQAMHYHNCADNR-UHFFFAOYSA-N n-methylpropanamide Chemical compound CCC(=O)NC QJQAMHYHNCADNR-UHFFFAOYSA-N 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000002682 neurofibrillary tangle Anatomy 0.000 description 1
- 230000016273 neuron death Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- BMQNWLUEXNQIGL-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O.CCCCCCCCC(O)=O BMQNWLUEXNQIGL-UHFFFAOYSA-N 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- 150000002889 oleic acids Chemical class 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 210000001152 parietal lobe Anatomy 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920005996 polystyrene-poly(ethylene-butylene)-polystyrene Polymers 0.000 description 1
- 150000003097 polyterpenes Chemical class 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 210000002442 prefrontal cortex Anatomy 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000010734 process oil Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- XEIOPEQGDSYOIH-MURFETPASA-N propan-2-yl (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(C)C XEIOPEQGDSYOIH-MURFETPASA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960004323 rivastigmine tartrate Drugs 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000007507 senile plaque formation Effects 0.000 description 1
- 208000022288 senile plaque formation Diseases 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical class O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 150000003377 silicon compounds Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- REFMEZARFCPESH-UHFFFAOYSA-M sodium;heptane-1-sulfonate Chemical compound [Na+].CCCCCCCS([O-])(=O)=O REFMEZARFCPESH-UHFFFAOYSA-M 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical group 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical compound Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical class OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
また、薬物の安定性の観点から、薬物との相互作用の少ないゴム系粘着剤を用いた貼付剤が提案されている(特許文献4〜6)。
[1] 支持体上に薬物を保持する粘着剤層が形成された貼付剤であって、
前記粘着剤層は、
熱可塑性エラストマー、
該エラストマー100重量部に対して50重量部を超え、800重量部以下の不揮発性炭化水素油、および
リバスチグミンまたはその塩を含み、
前記粘着剤層は、さらに粘着付与剤を含んでいてもよく、該粘着付与剤の粘着剤層中の含有量が10重量%以下である、貼付剤。
[2] 粘着剤層中の不揮発性炭化水素油の含有量が23.5重量%以上、88重量%以下である、上記[1]に記載の貼付剤。
[3] 粘着剤層中の不揮発性炭化水素油の含有量が、熱可塑性エラストマー100重量部に対して、150重量部を超え、250重量部以下である、上記[1]または[2]に記載の貼付剤。
[4] 粘着剤層中の不揮発性炭化水素油の含有量が50重量%以上、70重量%以下である、上記[1]〜[3]のいずれかに記載の貼付剤。
[5] 不揮発性炭化水素油が流動パラフィンである、上記[1]〜[4]のいずれかに記載の貼付剤。
[6] 不揮発性炭化水素油の40℃における動粘度が、80mm2/s以上である、上記[1]〜[5]のいずれかに記載の貼付剤。
[7] 熱可塑性エラストマーがスチレン系ブロック共重合体である、上記[1]〜[6]のいずれかに記載の貼付剤。
[8] スチレン系ブロック共重合体がスチレン−イソプレン−スチレンブロック共重合体である、上記[7]に記載の貼付剤。
[9] スチレン系ブロック共重合体がスチレン−イソプレン−スチレンブロック共重合体とスチレン‐イソプレンブロック共重合体との混合物である、上記[7]に記載の貼付剤。
[10] 粘着剤層中に粘着付与剤を含まない、上記[1]〜[9]のいずれかに記載の貼付剤。
[11] 粘着剤層中に抗酸化剤を含まない、上記[1]〜[10]のいずれかに記載の貼付剤。
[12] 支持体上に薬物を保持する貯蔵層および粘着剤層が形成された貼付剤であって、
前記貯蔵層はリバスチグミンまたはその塩を含み、
前記粘着剤層は、
熱可塑性エラストマー、および
該エラストマー100重量部に対して50重量部を超え、800重量部以下の不揮発性炭化水素油を含み、
前記粘着剤層は、さらに粘着付与剤を含んでいてもよく、該粘着付与剤の粘着剤層中の含有量が10重量%以下である、貼付剤。
[13] 粘着剤層中の不揮発性炭化水素油の含有量が23.5重量%以上、88重量%以下である、上記[12]に記載の貼付剤。
市販品としては、たとえば、KRATON POLYMERS社製の「KRATON D1161」、「KRATON D1163」、「KRATON D1113」、「KRATON D1119」、JSR社製の「JSR SIS5229」、「JSR SIS5403」、「JSR SIS5505」等が挙げられる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
本発明においては、必要に応じて、上記したものから1種または2種以上を選択して用いることができる。
かかる貼付剤では、薬物を保持する貯蔵層(以下、「薬物貯蔵層」とも略称する)がリバスチグミンまたはその塩を含み、粘着剤層が、熱可塑性エラストマーおよび該エラストマー100重量部に対して50重量部を超え、800重量部以下の不揮発性炭化水素油を含む。また、粘着剤層は粘着付与剤を含んでいてもよく、該粘着付与剤の粘着剤層中の含有量が10重量%以下である。
表1に示す処方に従って、粘着剤層を構成する各成分を秤取した。まず、スチレン−イソプレン−スチレンブロック共重合体(SIS)/スチレン-イソプレンブロック共重合体(SI)混合物(クレイトン社製「KRAYTON D1119」(重量平均分子量:207,500)、JSR社製「JSR SIS5505」、「JSR SIS5229」)を、当該混合物100重量部に対し、230重量部のトルエンに溶解した。前記溶解液に、流動パラフィン(ソネボーン社製の「KAYDOL」、「Hydrobrite 550PO」、「Hydrobrite HV」)、リバスチグミンを加えて混合撹拌し、粘着剤層形成用の塗液を調製した。
なお、上記塗液をシリコーン処理したポリエチレンテレフタレート(PET)製フィルム(剥離ライナー)に塗布し、乾燥後の粘着剤層中のリバスチグミン含有量が1.8mg/cm2となるように調製した。80℃のオーブンにて1時間乾燥後、該粘着剤層の表面にPET製フィルム(支持体)をラミネートし、15cm×30cmの大きさに裁断して、目的の貼付剤を得た。なお、表中のSIS/SI比は重量比である。
表1の実施例1の処方において、スチレン−イソプレン−スチレンブロック共重合体/スチレン-イソプレンブロック共重合体混合物に代えて、市販の熱硬化性感圧性アクリル系粘着剤(「Duro tak 87−2194」、ヘンケル社製、固形分含有量=40重量%)を、固形分含有量が表1の熱可塑性エラストマー含有量と同じになるように秤取して流動パラフィンを添加し、リバスチグミンを溶解して加えて混合撹拌し、粘着剤層形成用の塗液を調製した。
該塗液をシリコーン処理したPET製フィルム(剥離ライナー)に塗布し、乾燥後の粘着剤層重量が100g/m2となるように調製し、80℃のオーブンにて60分乾燥したが硬化せず、貼付剤は得られなかった。
表2に示す処方に従って、粘着剤層を構成する各成分を秤取し、実施例1と同様に貼付剤を調整したが、比較例2に関しては、十分な粘着性が得られず、比較例3に関しては粘着剤層が維持できず、評価できなかった。
<剥離強度>
25mm×300mmに裁断した貼付剤をステンレス(SUS304)板に貼付し、180°方向に300mm/minのスピードで剥離した際の応力を測定した。
<ボールタック>
100mm幅で裁断した貼付剤を貼付した傾斜角30°の斜面において、100mmの助走路を経て1/32インチ〜1インチのボールを転がして、貼付剤上で5秒以上留まった最大のボールの呼び径を測定した。
<保持力>
25mm×300mmに裁断した貼付剤をステンレス(SUS304)板に貼付し、90°方向に25gの荷重を60分間掛け、剥離した距離を測定した。
<はみ出し>
実施例および比較例で調整した貼付剤の端部を、支持体の上から指先で圧縮し、はみ出しの度合いを下記基準に従って評価した。
A:圧縮しても、粘着層は全くはみ出さない。
B:圧縮しても、粘着層がほとんどはみ出さない。
C:圧縮時、粘着層が変形して支持体からはみ出すが、圧縮を開放すると元に戻る。
D:圧縮時、粘着層が変形して支持体からはみ出し、圧縮を開放しても元に戻りにくい。
<入浴時剥離の程度>
実施例および比較例で調整した貼付剤を直径36mmの円形に打抜き、健常ボランティア5名の胸部に貼付し、入浴時の剥離の度合いを下記基準に従って評価した。
A:5名とも剥離しない。
B:1〜2名に端部の剥離が見られるものの、脱落はしない。
C:1〜2名で貼付剤が脱落。
D:3名以上で脱落。
国際公開第2006/093139号パンフレットに記載された方法に準じて、Wister系雄性ラット(5週齢)の腹部抽出皮膚を縦型フランツ拡散セルに装着した。実施例1〜3の各貼付剤および支持体上に薬物層および粘着剤層を形成してなる市販のリバスチグミン含有貼付剤(リバスチグミン含有量=1.8mg/cm2)をそれぞれ面積1.0cm2の円形に打ち抜いて試料とし、拡散セルのラット皮膚上に貼付した(n=3)。レセプター側には10体積%エタノール生理食塩水を用いて、経時的にレセプター溶液中のリバスチグミン含有量を、高速液体クロマトグラフィー(HPLC)により定量した。HPLCの測定条件を以下に示す。
<HPLC測定条件>
HPLCシステム:高速液体クロマトグラフ(LC2010C) 株式会社島津製作所製
カラム:ODS、4.6mmφ×15cm、5μm
カラム温度:25℃、
移動相:緩衝液/メタノール=50/50、
(緩衝液;5.0mM 1−ヘプタンスルホン酸ナトリウム、1体積%リン酸)
検出波長:220nm、
流量:0.8mL/min.
貼付開始日の3日前にkbs:JW雌性家兎(17週齢)の背部被毛を電気バリカンで毛刈りし、実施例1の貼付剤と市販のリバスチグミン含有貼付剤をそれぞれ2.5cm角に裁断して皮膚に貼付した(n=3)。貼付場所を覆うように油紙を載せ、胸部から腹部全体にかけてアンダーラップテープ(ニチバン株式会社製)で覆うように巻き付け、さらに家兎用ジャケット(BJ03、バイオリサーチセンター株式会社製)を装着した。24時間固定後、試料を除去し、除去後1時間目、24時間目、48時間目、および72時間目にJ.Pharmacol.Exp.Ther.82,377−390(1944)に記載の方法に基づき、皮膚刺激反応の程度を評価した。
[紅斑および痂皮の形成]
紅斑を認めない;0点
非常に軽度な(かろうじて識別できる程度の)紅斑を認める;1点
明確な紅斑を認める;2点
中等度ないし高度の紅斑を認める;3点
高度の紅斑から紅斑の採点を妨げる程度の痂皮の形成を認める;4点
[浮腫の形成]
浮腫を認めない;0点
非常に軽度な(かろうじて識別できる程度の)浮腫を認める;1点
軽度の浮腫を認める(はっきりした膨隆による明確な縁が識別できる);2点
中等度の浮腫(約1mmの膨隆)を認める;3点
高度の浮腫(1mm以上の膨隆と曝露範囲を超えた広がり)を認める;4点
市販のリバスチグミン製剤と同じ包材中に、実施例1および9で得られた製剤を封入し、市販のリバスチグミン製剤とともに40℃、75%RHにて保管した。初期および保管後(1ヶ月後と3ヶ月後)の製剤から粘着剤層をTHFに溶解し、HPLCにてリバスチグミン含量を定量、初期値に対する保管後の薬物残存率を比較した
表8に示す処方に従って、薬物貯蔵層を構成する各成分を秤取した。まず、スチレン−イソプレン−スチレンブロック共重合体(SIS)/スチレン-イソプレンブロック共重合体(SI)混合物(クレイトン社製「KRAYTON D1119」(重量平均分子量:207,500))を、当混合物100重量部に対し、230重量部のトルエンに溶解した。前記溶解液に、流動パラフィン(ソネボーン社製「Hydrobrite HV」)、リバスチグミンを加えて混合撹拌し、薬物貯蔵層形成用の塗液を調製した。
上記塗液をシリコーン処理したポリエチレンテレフタレート(PET)製フィルム(剥離ライナー)に塗布し、乾燥後の薬物貯蔵層中のリバスチグミン含有量が1.8mg/cm2となるように調製した。80℃のオーブンにて1時間乾燥後、該薬物貯蔵層の表面にPET製フィルム(支持体)をラミネートし目的の薬物貯蔵層を得た。
一方、表8に示す処方に従って、粘着剤層を構成する各成分を秤取した。まず、スチレン−イソプレン−スチレンブロック共重合体(SIS)/スチレン-イソプレンブロック共重合体(SI)混合物(クレイトン社製「KRAYTON D1119」(重量平均分子量:207,500))を、当該混合物100重量部に対し、230重量部のトルエンに溶解した。前記溶解液に、流動パラフィン(ソネボーン社製「Hydrobrite HV」)を加えて混合撹拌し、粘着剤層形成用の塗液を調製した。
上記塗液をシリコーン処理したポリエチレンテレフタレート(PET)製フィルム(剥離ライナー)に塗布し、乾燥後の粘着剤層重量が100g/m2となるように調製した。80℃のオーブンにて1時間乾燥後、該粘着剤層の表面に薬物貯蔵層をラミネートし、15cm×30cmの大きさに裁断して、目的の貼付剤を得た。
Claims (8)
- 支持体上に薬物を保持する粘着剤層が形成された貼付剤であって、
前記粘着剤層は、
熱可塑性エラストマー、
該エラストマー100重量部に対して50重量部を超え、800重量部以下の不揮発性炭化水素油、および
リバスチグミンまたはその塩を含み、
前記熱可塑性エラストマーが、スチレン−イソプレン−スチレンブロック共重合体とスチレン−イソプレンブロック共重合体とが、10/90〜82/18(重量比)の混合比率で混合された混合物からなり、
前記不揮発性炭化水素油が炭素数が20〜40の鎖式飽和炭化水素または炭素数20〜40の鎖式不飽和炭化水素であり、
前記粘着剤層は、さらに粘着付与剤を含んでいてもよく、該粘着付与剤の粘着剤層中の含有量が5重量%以下である、貼付剤。 - 粘着剤層中の不揮発性炭化水素油の含有量が23.5重量%以上、88重量%以下である、請求項1に記載の貼付剤。
- 粘着剤層中の不揮発性炭化水素油の含有量が、熱可塑性エラストマー100重量部に対して、150重量部を超え、250重量部以下である、請求項1または2に記載の貼付剤。
- 粘着剤層中の不揮発性炭化水素油の含有量が50重量%以上、70重量%以下である、請求項1〜3のいずれか1項に記載の貼付剤。
- 不揮発性炭化水素油が流動パラフィンである、請求項1〜4のいずれか1項に記載の貼付剤。
- 不揮発性炭化水素油の40℃における動粘度が、80mm2/s以上である請求項1〜5のいずれか1項に記載の貼付剤。
- 粘着剤層中に粘着付与剤を含まない、請求項1〜6のいずれか1項に記載の貼付剤。
- 粘着剤層中に抗酸化剤を含まない、請求項1〜7のいずれか1項に記載の貼付剤。
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2013
- 2013-06-12 EP EP13803993.8A patent/EP2859892B1/en active Active
- 2013-06-12 CN CN201380009075.XA patent/CN104114167B/zh active Active
- 2013-06-12 WO PCT/JP2013/066273 patent/WO2013187451A1/ja active Application Filing
- 2013-06-12 PL PL13803993.8T patent/PL2859892T3/pl unknown
- 2013-06-12 JP JP2014521380A patent/JP6153135B2/ja active Active
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Cited By (1)
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JP2017137363A (ja) * | 2012-06-12 | 2017-08-10 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
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JP2017137363A (ja) | 2017-08-10 |
EP2859892C0 (en) | 2023-06-07 |
PL2859892T3 (pl) | 2023-10-16 |
US20150224063A1 (en) | 2015-08-13 |
CN104114167B (zh) | 2017-05-17 |
CN104114167A (zh) | 2014-10-22 |
JPWO2013187451A1 (ja) | 2016-02-08 |
EP2859892B1 (en) | 2023-06-07 |
EP2859892A4 (en) | 2015-11-18 |
EP2859892A1 (en) | 2015-04-15 |
WO2013187451A1 (ja) | 2013-12-19 |
JP6467726B2 (ja) | 2019-02-13 |
US10758494B2 (en) | 2020-09-01 |
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