JP2019522025A5 - - Google Patents
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- Publication number
- JP2019522025A5 JP2019522025A5 JP2019504002A JP2019504002A JP2019522025A5 JP 2019522025 A5 JP2019522025 A5 JP 2019522025A5 JP 2019504002 A JP2019504002 A JP 2019504002A JP 2019504002 A JP2019504002 A JP 2019504002A JP 2019522025 A5 JP2019522025 A5 JP 2019522025A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery system
- composition
- transdermal delivery
- sodium
- memantine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037317 transdermal delivery Effects 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 43
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 claims description 38
- 229960004640 memantine Drugs 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 23
- 239000010410 layer Substances 0.000 claims description 22
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 20
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 20
- 229920001577 copolymer Polymers 0.000 claims description 18
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 14
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 14
- 239000003961 penetration enhancing agent Substances 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- -1 polypropylene Polymers 0.000 claims description 12
- 150000001447 alkali salts Chemical class 0.000 claims description 11
- 239000002585 base Substances 0.000 claims description 10
- 238000011065 in-situ storage Methods 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 8
- 239000004821 Contact adhesive Substances 0.000 claims description 8
- 229920002367 Polyisobutene Polymers 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 229920000249 biocompatible polymer Polymers 0.000 claims description 8
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229940055577 oleyl alcohol Drugs 0.000 claims description 8
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 229920000058 polyacrylate Polymers 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 6
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 6
- 239000011736 potassium bicarbonate Substances 0.000 claims description 6
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical group [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- 229920005549 butyl rubber Polymers 0.000 claims description 4
- 208000015114 central nervous system disease Diseases 0.000 claims description 4
- 239000007884 disintegrant Substances 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 4
- 229960000967 memantine hydrochloride Drugs 0.000 claims description 4
- 239000012982 microporous membrane Substances 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 235000011056 potassium acetate Nutrition 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- 235000011181 potassium carbonates Nutrition 0.000 claims description 4
- 239000001508 potassium citrate Substances 0.000 claims description 4
- 229960002635 potassium citrate Drugs 0.000 claims description 4
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 4
- 235000011082 potassium citrates Nutrition 0.000 claims description 4
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 4
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 4
- 235000011009 potassium phosphates Nutrition 0.000 claims description 4
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017550 sodium carbonate Nutrition 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- NVIFVTYDZMXWGX-UHFFFAOYSA-N sodium metaborate Chemical compound [Na+].[O-]B=O NVIFVTYDZMXWGX-UHFFFAOYSA-N 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 229960004025 sodium salicylate Drugs 0.000 claims description 4
- 229940074404 sodium succinate Drugs 0.000 claims description 4
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 claims description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229960001790 sodium citrate Drugs 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 201000004810 Vascular dementia Diseases 0.000 claims description 2
- 239000012790 adhesive layer Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000004927 clay Substances 0.000 claims description 2
- 239000011243 crosslinked material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 235000014786 phosphorus Nutrition 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 239000004584 polyacrylic acid Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229960004109 potassium acetate Drugs 0.000 claims description 2
- 229940093956 potassium carbonate Drugs 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 159000000011 group IA salts Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066862A JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367502P | 2016-07-27 | 2016-07-27 | |
| US62/367,502 | 2016-07-27 | ||
| US201662423133P | 2016-11-16 | 2016-11-16 | |
| US62/423,133 | 2016-11-16 | ||
| US201762444763P | 2017-01-10 | 2017-01-10 | |
| US201762444745P | 2017-01-10 | 2017-01-10 | |
| US62/444,745 | 2017-01-10 | ||
| US62/444,763 | 2017-01-10 | ||
| US201762457791P | 2017-02-10 | 2017-02-10 | |
| US201762457794P | 2017-02-10 | 2017-02-10 | |
| US62/457,794 | 2017-02-10 | ||
| US62/457,791 | 2017-02-10 | ||
| US201762504391P | 2017-05-10 | 2017-05-10 | |
| US62/504,391 | 2017-05-10 | ||
| PCT/US2017/044051 WO2018022818A1 (en) | 2016-07-27 | 2017-07-26 | Memantine transdermal delivery systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066862A Division JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522025A JP2019522025A (ja) | 2019-08-08 |
| JP2019522025A5 true JP2019522025A5 (enExample) | 2020-08-27 |
| JP7071958B2 JP7071958B2 (ja) | 2022-05-19 |
Family
ID=59523315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504002A Active JP7071958B2 (ja) | 2016-07-27 | 2017-07-26 | メマンチン経皮送達システム |
| JP2022066862A Pending JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066862A Pending JP2022087276A (ja) | 2016-07-27 | 2022-04-14 | メマンチン経皮送達システム |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10945968B2 (enExample) |
| EP (1) | EP3490544A1 (enExample) |
| JP (2) | JP7071958B2 (enExample) |
| KR (1) | KR102508993B1 (enExample) |
| CN (1) | CN109789113A (enExample) |
| AU (1) | AU2017301929B2 (enExample) |
| CA (1) | CA3032103A1 (enExample) |
| MX (1) | MX2019001104A (enExample) |
| RU (1) | RU2764764C2 (enExample) |
| SG (1) | SG11201900712SA (enExample) |
| WO (1) | WO2018022818A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10966936B2 (en) | 2015-12-30 | 2021-04-06 | Corium, Inc. | Systems comprising a composite backing and methods for long term transdermal administration |
| CA3028436A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| US9993466B2 (en) | 2016-07-27 | 2018-06-12 | Corium International, Inc. | Donepezil transdermal delivery system |
| WO2018160613A1 (en) * | 2017-02-28 | 2018-09-07 | Temple University-Of The Commonwealth System Of Higher Education | Novel econazole nitrate medical patch and methods of use thereof |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| WO2021005118A1 (en) * | 2019-07-09 | 2021-01-14 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising an active agent-containing layer comprising an acrylic polymer and a skin contact layer comprising a silicone gel adhesive |
| JP2023050633A (ja) * | 2021-09-30 | 2023-04-11 | 東洋インキＳｃホールディングス株式会社 | 貼付剤 |
| CN115957200A (zh) * | 2023-02-23 | 2023-04-14 | 广州新济药业科技有限公司 | 一种美金刚透皮贴剂及制备方法 |
| EP4520317A1 (en) * | 2023-09-06 | 2025-03-12 | Luye Pharma Switzerland AG | Transdermal therapeutic system of lumateperone |
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-
2017
- 2017-07-26 MX MX2019001104A patent/MX2019001104A/es unknown
- 2017-07-26 CA CA3032103A patent/CA3032103A1/en active Pending
- 2017-07-26 EP EP17749060.4A patent/EP3490544A1/en not_active Withdrawn
- 2017-07-26 CN CN201780059395.4A patent/CN109789113A/zh active Pending
- 2017-07-26 RU RU2019105280A patent/RU2764764C2/ru active
- 2017-07-26 SG SG11201900712SA patent/SG11201900712SA/en unknown
- 2017-07-26 JP JP2019504002A patent/JP7071958B2/ja active Active
- 2017-07-26 KR KR1020197005636A patent/KR102508993B1/ko active Active
- 2017-07-26 AU AU2017301929A patent/AU2017301929B2/en not_active Ceased
- 2017-07-26 US US15/660,929 patent/US10945968B2/en not_active Expired - Fee Related
- 2017-07-26 WO PCT/US2017/044051 patent/WO2018022818A1/en not_active Ceased
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2022
- 2022-04-14 JP JP2022066862A patent/JP2022087276A/ja active Pending
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