JP2018526029A5 - - Google Patents
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- JP2018526029A5 JP2018526029A5 JP2018530661A JP2018530661A JP2018526029A5 JP 2018526029 A5 JP2018526029 A5 JP 2018526029A5 JP 2018530661 A JP2018530661 A JP 2018530661A JP 2018530661 A JP2018530661 A JP 2018530661A JP 2018526029 A5 JP2018526029 A5 JP 2018526029A5
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- JP
- Japan
- Prior art keywords
- seq
- nos
- primer pair
- primers
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000011987 methylation Effects 0.000 claims 30
- 238000007069 methylation reaction Methods 0.000 claims 30
- 108091029430 CpG site Proteins 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 12
- 239000012472 biological sample Substances 0.000 claims 12
- 239000000523 sample Substances 0.000 claims 9
- 102100029233 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Human genes 0.000 claims 8
- 102100036013 Antigen-presenting glycoprotein CD1d Human genes 0.000 claims 8
- 102100032528 C-type lectin domain family 11 member A Human genes 0.000 claims 8
- 102100036324 Cytochrome P450 26C1 Human genes 0.000 claims 8
- 102100027118 Engulfment and cell motility protein 1 Human genes 0.000 claims 8
- 101000634075 Homo sapiens Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Proteins 0.000 claims 8
- 101000716121 Homo sapiens Antigen-presenting glycoprotein CD1d Proteins 0.000 claims 8
- 101000942297 Homo sapiens C-type lectin domain family 11 member A Proteins 0.000 claims 8
- 101000875398 Homo sapiens Cytochrome P450 26C1 Proteins 0.000 claims 8
- 101001057862 Homo sapiens Engulfment and cell motility protein 1 Proteins 0.000 claims 8
- 101000964762 Homo sapiens Zinc finger protein 569 Proteins 0.000 claims 8
- 101000665140 Homo sapiens Scm-like with four MBT domains protein 2 Proteins 0.000 claims 7
- 101001032478 Homo sapiens cAMP-dependent protein kinase inhibitor alpha Proteins 0.000 claims 7
- 102100038691 Scm-like with four MBT domains protein 2 Human genes 0.000 claims 7
- 102100040654 Zinc finger protein 569 Human genes 0.000 claims 7
- 102100038086 cAMP-dependent protein kinase inhibitor alpha Human genes 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 6
- 101000752241 Homo sapiens Rho guanine nucleotide exchange factor 4 Proteins 0.000 claims 6
- 102100021709 Rho guanine nucleotide exchange factor 4 Human genes 0.000 claims 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 6
- 206010017758 gastric cancer Diseases 0.000 claims 6
- 238000007855 methylation-specific PCR Methods 0.000 claims 6
- 201000011549 stomach cancer Diseases 0.000 claims 6
- -1 GRN2D Proteins 0.000 claims 5
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 4
- 102100038781 Carbohydrate sulfotransferase 2 Human genes 0.000 claims 4
- 102100035316 Doublesex- and mab-3-related transcription factor A2 Human genes 0.000 claims 4
- 102100035292 Fibroblast growth factor 14 Human genes 0.000 claims 4
- 102100030334 Friend leukemia integration 1 transcription factor Human genes 0.000 claims 4
- 102100022374 Homeobox protein DLX-4 Human genes 0.000 claims 4
- 102100023823 Homeobox protein EMX1 Human genes 0.000 claims 4
- 101000762375 Homo sapiens Bone morphogenetic protein 3 Proteins 0.000 claims 4
- 101000883009 Homo sapiens Carbohydrate sulfotransferase 2 Proteins 0.000 claims 4
- 101000949728 Homo sapiens Doublesex- and mab-3-related transcription factor A2 Proteins 0.000 claims 4
- 101000878181 Homo sapiens Fibroblast growth factor 14 Proteins 0.000 claims 4
- 101001062996 Homo sapiens Friend leukemia integration 1 transcription factor Proteins 0.000 claims 4
- 101000901614 Homo sapiens Homeobox protein DLX-4 Proteins 0.000 claims 4
- 101001048956 Homo sapiens Homeobox protein EMX1 Proteins 0.000 claims 4
- 101001017833 Homo sapiens Leucine-rich repeat-containing protein 4 Proteins 0.000 claims 4
- 101001059535 Homo sapiens Megakaryocyte-associated tyrosine-protein kinase Proteins 0.000 claims 4
- 101000735360 Homo sapiens Poly(rC)-binding protein 3 Proteins 0.000 claims 4
- 101000974747 Homo sapiens Potassium channel subfamily K member 12 Proteins 0.000 claims 4
- 101000994669 Homo sapiens Potassium voltage-gated channel subfamily A member 3 Proteins 0.000 claims 4
- 101000995332 Homo sapiens Protein NDRG4 Proteins 0.000 claims 4
- 101000983140 Homo sapiens Protein associated with UVRAG as autophagy enhancer Proteins 0.000 claims 4
- 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 claims 4
- 101001051767 Homo sapiens Protein kinase C beta type Proteins 0.000 claims 4
- 101000783373 Homo sapiens Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Proteins 0.000 claims 4
- 101000976579 Homo sapiens Zinc finger protein 132 Proteins 0.000 claims 4
- 101000964764 Homo sapiens Zinc finger protein 568 Proteins 0.000 claims 4
- 102100033304 Leucine-rich repeat-containing protein 4 Human genes 0.000 claims 4
- 102100028905 Megakaryocyte-associated tyrosine-protein kinase Human genes 0.000 claims 4
- 102100034955 Poly(rC)-binding protein 3 Human genes 0.000 claims 4
- 102100022801 Potassium channel subfamily K member 12 Human genes 0.000 claims 4
- 102100034355 Potassium voltage-gated channel subfamily A member 3 Human genes 0.000 claims 4
- 102100034432 Protein NDRG4 Human genes 0.000 claims 4
- 102100026827 Protein associated with UVRAG as autophagy enhancer Human genes 0.000 claims 4
- 102100024923 Protein kinase C beta type Human genes 0.000 claims 4
- 102100036140 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Human genes 0.000 claims 4
- 102100036395 Transcription factor Sp9 Human genes 0.000 claims 4
- 102100023572 Zinc finger protein 132 Human genes 0.000 claims 4
- 102100040655 Zinc finger protein 568 Human genes 0.000 claims 4
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 3
- 108010076804 DNA Restriction Enzymes Proteins 0.000 claims 3
- 102100032050 Elongation of very long chain fatty acids protein 2 Human genes 0.000 claims 3
- 101000921368 Homo sapiens Elongation of very long chain fatty acids protein 2 Proteins 0.000 claims 3
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 3
- 239000013068 control sample Substances 0.000 claims 3
- 238000009585 enzyme analysis Methods 0.000 claims 3
- 238000012268 genome sequencing Methods 0.000 claims 3
- 238000012175 pyrosequencing Methods 0.000 claims 3
- 101000642459 Homo sapiens Transcription factor Sp9 Proteins 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 102100030346 Antigen peptide transporter 1 Human genes 0.000 claims 1
- 108010023335 Member 2 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102000050611 human ZNF569 Human genes 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021069789A JP2021118711A (ja) | 2015-08-31 | 2021-04-16 | 胃の新生物を検出すること |
| JP2023085323A JP7771126B2 (ja) | 2015-08-31 | 2023-05-24 | 胃の新生物を検出すること |
| JP2025023534A JP2025081468A (ja) | 2015-08-31 | 2025-02-17 | 胃の新生物を検出すること |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562212221P | 2015-08-31 | 2015-08-31 | |
| US62/212,221 | 2015-08-31 | ||
| PCT/US2016/049653 WO2017040627A1 (en) | 2015-08-31 | 2016-08-31 | Detecting gastric neoplasm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069789A Division JP2021118711A (ja) | 2015-08-31 | 2021-04-16 | 胃の新生物を検出すること |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526029A JP2018526029A (ja) | 2018-09-13 |
| JP2018526029A5 true JP2018526029A5 (enExample) | 2019-08-08 |
| JP6871926B2 JP6871926B2 (ja) | 2021-05-19 |
Family
ID=58103876
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530661A Active JP6871926B2 (ja) | 2015-08-31 | 2016-08-31 | 胃の新生物を検出すること |
| JP2021069789A Pending JP2021118711A (ja) | 2015-08-31 | 2021-04-16 | 胃の新生物を検出すること |
| JP2023085323A Active JP7771126B2 (ja) | 2015-08-31 | 2023-05-24 | 胃の新生物を検出すること |
| JP2025023534A Pending JP2025081468A (ja) | 2015-08-31 | 2025-02-17 | 胃の新生物を検出すること |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069789A Pending JP2021118711A (ja) | 2015-08-31 | 2021-04-16 | 胃の新生物を検出すること |
| JP2023085323A Active JP7771126B2 (ja) | 2015-08-31 | 2023-05-24 | 胃の新生物を検出すること |
| JP2025023534A Pending JP2025081468A (ja) | 2015-08-31 | 2025-02-17 | 胃の新生物を検出すること |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10006093B2 (enExample) |
| EP (1) | EP3344784A4 (enExample) |
| JP (4) | JP6871926B2 (enExample) |
| KR (2) | KR102688282B1 (enExample) |
| CN (2) | CN108138235B (enExample) |
| AU (2) | AU2016315924B2 (enExample) |
| CA (1) | CA2992790A1 (enExample) |
| WO (1) | WO2017040627A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| EP3126529B1 (en) | 2014-03-31 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| JP2019516397A (ja) * | 2016-04-01 | 2019-06-20 | ナノメド ダイアグノスティックス べー．フェー．Ｎａｎｏｍｅｄ Ｄｉａｇｎｏｓｔｉｃｓ Ｂ．Ｖ． | 尿における癌の検出 |
| US10370726B2 (en) * | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| CA3049459A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| KR102085669B1 (ko) * | 2019-01-02 | 2020-03-06 | 한국 한의학 연구원 | Cyp26c1 유전자의 메틸화 수준을 이용한 소혈관폐색증의 예측 또는 진단을 위한 정보제공방법 및 이를 위한 조성물 |
| AU2019200359A1 (en) * | 2019-01-18 | 2020-09-10 | Clinical Genomics Pty Ltd | Screening method |
| CN113811622B (zh) * | 2019-04-03 | 2024-09-17 | 梅约医学教育与研究基金会 | 在血浆中检测胰腺导管腺癌 |
| JP7540735B2 (ja) * | 2019-05-31 | 2024-08-27 | ユニバーサル ダイアグノスティクス，エセ．アー | 大腸がんの検出 |
| US11001898B2 (en) | 2019-05-31 | 2021-05-11 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| US11396679B2 (en) | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| US20230033016A1 (en) * | 2019-06-21 | 2023-02-02 | Universite De Paris | Detection of hypermethylated genes for diagnosing gastric cancer |
| CN110423814A (zh) * | 2019-07-19 | 2019-11-08 | 江苏元丞生物科技有限公司 | Elmo1基因甲基化检测试剂盒及其应用 |
| AU2020374985A1 (en) | 2019-10-31 | 2022-05-26 | Exact Sciences Corporation | Detecting ovarian cancer |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| CN111549129B (zh) * | 2020-03-30 | 2023-08-29 | 宁波美康盛德医学检验所有限公司 | 用于检测胃癌的试剂盒及其应用 |
| AU2021257479A1 (en) * | 2020-04-17 | 2022-11-10 | Exact Sciences Corporation | Ingestible sampling device |
| WO2021228418A1 (en) | 2020-05-15 | 2021-11-18 | Universal Diagnostics, S.L. | Methods and systems for identifying methylation biomarkers |
| WO2022002424A1 (en) | 2020-06-30 | 2022-01-06 | Universal Diagnostics, S.L. | Systems and methods for detection of multiple cancer types |
| CA3206781A1 (en) * | 2021-01-29 | 2022-08-04 | John B. Kisiel | Detecting the presence or absence of multiple types of cancer |
| CN115433778B (zh) * | 2021-06-02 | 2023-06-16 | 武汉艾米森生命科技有限公司 | 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用 |
| CN113308544B (zh) * | 2021-06-04 | 2022-07-05 | 武汉艾米森生命科技有限公司 | 用于dna甲基化检测的试剂及食管癌检测试剂盒 |
| CN114317740B (zh) * | 2021-11-24 | 2024-01-23 | 博尔诚（北京）科技有限公司 | 用于胃癌筛查的标志物、探针组合物及其应用 |
| CN118389691A (zh) * | 2022-06-29 | 2024-07-26 | 广州市基准医疗有限责任公司 | 用于诊断胃癌的甲基化生物标记物组合、试剂盒及用途 |
| CN115976210B (zh) * | 2022-12-08 | 2024-05-28 | 深圳市晋百慧生物有限公司 | 用于胃癌诊断和筛查的试剂盒、方法及其用途 |
| CN117126942A (zh) * | 2023-10-05 | 2023-11-28 | 上海奕谱生物科技有限公司 | 可用于肿瘤鉴定的新型DNA甲基化标志物TAGMe-3及其用途 |
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| EP3034624A1 (en) | 2014-12-18 | 2016-06-22 | Hospital Clínic de Barcelona | Method for the prognosis of hepatocellular carcinoma |
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| US10385406B2 (en) | 2016-05-05 | 2019-08-20 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated DNA |
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