AU2016315924B2 - Detecting gastric neoplasm - Google Patents

Detecting gastric neoplasm Download PDF

Info

Publication number
AU2016315924B2
AU2016315924B2 AU2016315924A AU2016315924A AU2016315924B2 AU 2016315924 B2 AU2016315924 B2 AU 2016315924B2 AU 2016315924 A AU2016315924 A AU 2016315924A AU 2016315924 A AU2016315924 A AU 2016315924A AU 2016315924 B2 AU2016315924 B2 AU 2016315924B2
Authority
AU
Australia
Prior art keywords
methylation
dna
seq
sample
nos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016315924A
Other languages
English (en)
Other versions
AU2016315924A1 (en
Inventor
David A. Ahlquist
Hatim T. Allawi
John B. Kisiel
Douglas W. Mahoney
William R. Taylor
Tracy C. Yab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Mayo Clinic in Florida
Original Assignee
Mayo Foundation for Medical Education and Research
Exact Sciences Corp
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, Exact Sciences Corp, Mayo Clinic in Florida filed Critical Mayo Foundation for Medical Education and Research
Publication of AU2016315924A1 publication Critical patent/AU2016315924A1/en
Application granted granted Critical
Publication of AU2016315924B2 publication Critical patent/AU2016315924B2/en
Assigned to MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES CORPORATION reassignment MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Request for Assignment Assignors: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Priority to AU2022275451A priority Critical patent/AU2022275451B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2016315924A 2015-08-31 2016-08-31 Detecting gastric neoplasm Active AU2016315924B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022275451A AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212221P 2015-08-31 2015-08-31
US62/212,221 2015-08-31
PCT/US2016/049653 WO2017040627A1 (en) 2015-08-31 2016-08-31 Detecting gastric neoplasm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022275451A Division AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Publications (2)

Publication Number Publication Date
AU2016315924A1 AU2016315924A1 (en) 2018-02-08
AU2016315924B2 true AU2016315924B2 (en) 2022-08-25

Family

ID=58103876

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016315924A Active AU2016315924B2 (en) 2015-08-31 2016-08-31 Detecting gastric neoplasm
AU2022275451A Active AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022275451A Active AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Country Status (8)

Country Link
US (4) US10006093B2 (enExample)
EP (1) EP3344784A4 (enExample)
JP (4) JP6871926B2 (enExample)
KR (3) KR102892240B1 (enExample)
CN (2) CN114574585A (enExample)
AU (2) AU2016315924B2 (enExample)
CA (1) CA2992790A1 (enExample)
WO (1) WO2017040627A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
US10301680B2 (en) 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
AU2017244280A1 (en) * 2016-04-01 2018-10-18 Nanomed Diagnostics B.V. Detection of cancer in urine
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
KR102085669B1 (ko) * 2019-01-02 2020-03-06 한국 한의학 연구원 Cyp26c1 유전자의 메틸화 수준을 이용한 소혈관폐색증의 예측 또는 진단을 위한 정보제공방법 및 이를 위한 조성물
AU2019200359A1 (en) * 2019-01-18 2020-09-10 Clinical Genomics Pty Ltd Screening method
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
AU2020254760B2 (en) 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
CN114375340A (zh) * 2019-05-31 2022-04-19 通用诊断公司 结肠直肠癌的检测
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
WO2020254693A1 (en) * 2019-06-21 2020-12-24 Universite De Paris Detection of hypermethylated genes for diagnosing gastric cancer
CN110423814A (zh) * 2019-07-19 2019-11-08 江苏元丞生物科技有限公司 Elmo1基因甲基化检测试剂盒及其应用
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN111549129B (zh) * 2020-03-30 2023-08-29 宁波美康盛德医学检验所有限公司 用于检测胃癌的试剂盒及其应用
AU2021257479A1 (en) * 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
EP4150121A1 (en) 2020-06-30 2023-03-22 Universal Diagnostics, S.A. Systems and methods for detection of multiple cancer types
EP4284951A4 (en) * 2021-01-29 2025-05-28 Mayo Foundation for Medical Education and Research DETECTION OF THE PRESENCE OR ABSENCE OF MULTIPLE CANCERS
CN115433778B (zh) * 2021-06-02 2023-06-16 武汉艾米森生命科技有限公司 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用
CN113308544B (zh) * 2021-06-04 2022-07-05 武汉艾米森生命科技有限公司 用于dna甲基化检测的试剂及食管癌检测试剂盒
CN118272525A (zh) * 2021-11-24 2024-07-02 博尔诚（北京）科技有限公司 用于胃癌筛查的标志物、探针组合物及其应用
CN117363724A (zh) * 2022-06-29 2024-01-09 广州市基准医疗有限责任公司 用于诊断胃癌的甲基化生物标记物及其用途
CN117344010B (zh) * 2022-06-29 2024-04-26 广州市基准医疗有限责任公司 用于诊断胃癌的dna甲基化生物标记物、试剂盒及用途
CN117343992A (zh) * 2022-06-29 2024-01-05 广州市基准医疗有限责任公司 一种多基因合并荧光通道检测的方法
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
CN115976210B (zh) * 2022-12-08 2024-05-28 深圳市晋百慧生物有限公司 用于胃癌诊断和筛查的试剂盒、方法及其用途
CN117126942B (zh) * 2023-10-05 2026-01-06 上海奕谱生物科技有限公司 可用于肿瘤鉴定的新型DNA甲基化标志物TAGMe-3及其用途
CN122382202A (zh) * 2026-06-11 2026-07-14 嘉兴允英医学检验有限公司 一种检测早期胃癌的甲基化标志物组合及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) * 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2016160454A1 (en) * 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders

Family Cites Families (377)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683890A (en) 1970-10-02 1972-08-15 Charles B Beal Carrier system for delivery of an end of an elongated member to the upper gastrointestinal tract
US4437975A (en) 1977-07-20 1984-03-20 Mobil Oil Corporation Manufacture of lube base stock oil
US4259964A (en) 1979-07-09 1981-04-07 Levine Robert A Device for obtaining stool samples
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
ATE15229T1 (de) 1981-07-16 1985-09-15 Hoffmann La Roche Verfahren zum nachweisen von okkultem humanblut in humanstuhlproben.
US4445235A (en) 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
AU529210B3 (en) 1983-02-02 1983-04-14 Australian Monoclonal Development Pty. Ltd. Monoclonal antibody in occult blood diagnosis
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4859610A (en) 1985-06-05 1989-08-22 Synbiotics Corporation Immunoassay incubation device
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4735214A (en) 1986-09-05 1988-04-05 Berman Irwin R Gastrointestinal diagnostic capsule and method of use
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5198365A (en) 1987-02-04 1993-03-30 International Immunoassay Laboratories, Inc. Fecal sample immunoassay method testing for hemoglobin
EP0281251A3 (en) 1987-02-04 1988-09-28 International Immunoassay Laboratories, Inc. A method for preparing a fecal sample composition for immunoassay testing
IE72468B1 (en) 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
ZA899593B (en) 1988-12-16 1990-09-26 Siska Diagnostics Inc Self-sustained,sequence replication system
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
JPH0874B2 (ja) 1990-07-27 1996-01-10 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
AU645915B2 (en) 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
EP0637965B1 (en) 1991-11-26 2002-10-16 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
ES2105698T3 (es) 1993-03-30 1997-10-16 Sanofi Sa Oligonucleotidos modificados con 7-deazapurina.
EP0695306A1 (en) 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
DE69417918T2 (de) 1993-11-30 2000-01-05 Mcgill University, Montreal Dna methyltransferase inhibierung
CA2188660C (en) 1994-04-25 2005-01-18 Richard G. H. Cotton Detection of mutation by resolvase cleavage
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
DE69528670T2 (de) 1994-12-23 2004-03-11 Dade Behring Inc., Deerfield Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
CA2239683A1 (en) 1995-12-22 1997-07-03 Dade Behring Marburg Gmbh Homogeneous amplification and detection of nucleic acids
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
IL116824A0 (en) 1996-01-19 1996-05-14 Huliot Plastics Ind System for the collection and transportation of a pasty material sample
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6541217B2 (en) 1996-08-27 2003-04-01 Kyowa Hakko Kogyo Co., Ltd. Hematopoietic stem cell growth factor (SCGF)
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6395524B2 (en) 1996-11-27 2002-05-28 University Of Washington Thermostable polymerases having altered fidelity and method of identifying and using same
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US20090077685A1 (en) 1998-06-16 2009-03-19 Buehler Robert E Nucleic acid molecules and other molecules associated with plants
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
DE69902996T2 (de) 1998-02-04 2003-04-30 Variagenics, Inc. Techniken zu detektion von fehlpaarungen
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
WO2000050640A1 (en) 1999-02-25 2000-08-31 Exact Laboratories, Inc. Methods for preserving dna integrity
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
AUPQ254199A0 (en) 1999-08-31 1999-09-23 University Of Western Australia, The Methods and devices for obtaining samples from hollow viscera
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US20060084054A1 (en) 1999-09-27 2006-04-20 John Alsobrook Novel proteins and nucleic acids encoding same
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6434762B2 (en) 2000-01-10 2002-08-20 Steven N. Gordon Stool collecting apparatus
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US20040033490A1 (en) 2000-03-31 2004-02-19 Laird Peter W. Epigenetic sequences for esophageal adenocarcinoma
BRPI0001536B1 (pt) 2000-04-04 2015-09-29 Fundacao Oswaldo Cruz método para diagnosticar a infecção por parasitos do genero schistosoma e kit para uso no diagnóstico da infecção por schistosoma sp
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
AU2001276371A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
DE10037769A1 (de) 2000-08-03 2002-02-21 Epigenomics Gmbh Diagnose von mit CD24 assoziierten Krankheiten
DK1423528T3 (da) 2000-09-01 2008-05-13 Epigenomics Ag Fremgangsmåde til bestemmelse af methyleringsgraden af bestemte cytosiner i genomisk DNA i sekvenskonteksten 5-CPG-3
WO2002018631A2 (de) 2000-09-01 2002-03-07 Epigenomics Ag Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen
US20050021240A1 (en) 2000-11-02 2005-01-27 Epigenomics Ag Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA
CA2428798C (en) 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
US6582665B2 (en) 2001-01-25 2003-06-24 Biomedical Polymers, Inc. Universal collection and transfer system
WO2002070742A1 (en) 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
ATE324830T1 (de) 2001-05-17 2006-06-15 Faergklaemman Ab Probenentnahmevorrichtung und verfahren zur entnahme von proben von körpersubstanzen sowie verfahren zur herstellung einer probenentnahmevorrichtung
GB2375964B (en) 2001-05-31 2003-12-24 Intermark Medical Innovations A device for colonic lavage
US7402405B2 (en) 2001-06-05 2008-07-22 The Children's Hospital Of Philadelphia Methods and kits for diagnosing a pancreatic-based fat malabsorption disorder
ITPS20010019A1 (it) 2001-06-26 2002-12-26 Muretto Pietro Aurelio Gaetano Capsula endogastrica
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
US7482118B2 (en) 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
US20030157556A1 (en) 2002-02-13 2003-08-21 Maggiore Jack A. Biological fluid stabilizing composition and method of use thereof
US7781161B2 (en) 2002-03-07 2010-08-24 The Johns Hopkins University School Of Medicine Genomic screen for epigenetically silenced tumor suppressor genes
CN1650033A (zh) * 2002-03-07 2005-08-03 约翰霍普金斯大学医学院 针对与癌症相关的表观遗传学沉默基因的基因组筛选
US20030186248A1 (en) 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
ITMI20020287U1 (it) 2002-05-31 2003-12-01 Sentinel Ch S R L Tubo di estrazione per la raccolta di campioni di feci
US6921370B2 (en) 2002-07-25 2005-07-26 Alfa Scientific Designs, Inc. Specimen collection and storage and transport device and method
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
EP1554407B1 (en) 2002-10-01 2009-07-29 Epigenomics AG Method for the treatment of breast cell proliferative disorders
AU2003295511A1 (en) 2002-11-13 2004-06-03 Genentech, Inc. Methods and compositions for diagnosing dysplasia
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
WO2004067726A2 (en) 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
CA2519456A1 (en) 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
ES2335344T3 (es) 2003-03-19 2010-03-25 Hamamatsu Foundation For Science And Technology Promotion Procedimiento para detectar un marcador de cancer de colon.
US20040194206A1 (en) 2003-04-01 2004-10-07 Kieturakis Maciej J. Screening methods and kits for gastrointestinal diseases
EP2354248B1 (en) 2003-06-23 2018-01-03 Epigenomics AG Methods for analyses of colorectal cell proliferative disorders
GB0318702D0 (en) 2003-08-08 2003-09-10 Neill Ian O Method and apparatus for removing cellular material from faecal stools and container for collecting faecal stools
US7485420B2 (en) 2003-08-14 2009-02-03 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
AU2004270220B2 (en) 2003-09-05 2009-03-05 The Chinese University Of Hong Kong Method for non-invasive prenatal diagnosis
DE10345021A1 (de) 2003-09-23 2005-05-04 Univ Potsdam Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen
US20050075543A1 (en) 2003-10-03 2005-04-07 Calabrese Charles A. Method of anonymous medical testing and providing the patient with the test results
EP2088210A3 (en) 2003-10-09 2009-11-18 Epigenomics AG Improved bisulfite conversion of DNA
AU2004282593B8 (en) 2003-10-16 2008-08-28 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
US7371527B1 (en) 2003-10-21 2008-05-13 Johns Hopkins University School Of Medicine Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer
WO2005042713A2 (en) 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
AU2005200670B2 (en) 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
ES2537633T3 (es) 2004-03-02 2015-06-10 The Johns Hopkins University Mutaciones del gen de PIK3CA en cánceres humanos
JP2005304497A (ja) * 2004-03-25 2005-11-04 Joji Inasawa 特定の癌関連遺伝子を用いる癌の検出方法及び癌の抑制方法
EP1727911B1 (en) 2004-03-26 2013-01-23 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7381547B2 (en) 2004-04-28 2008-06-03 Tzam Diagnostics, Llc Methods and compositions to detect bacteria using multiplex PCR
US20080124714A1 (en) 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
JP2008502890A (ja) 2004-06-18 2008-01-31 エフ．ホフマン−ラ　ロシュ　アーゲー 結腸直腸癌のマーカーとしてのｃｂｐ２の使用
GB0415277D0 (en) 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7563598B2 (en) 2004-07-30 2009-07-21 Ambergen, Inc. Detection of truncation mutations by mass spectrometry
US20070048748A1 (en) 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US7195878B2 (en) 2004-09-30 2007-03-27 Cryo-Genomics Device and method for fecal testing
EP1812604A4 (en) 2004-11-03 2011-02-23 Third Wave Tech Inc DETECTION ASSAY IN ONE STEP
JP2008518610A (ja) 2004-11-03 2008-06-05 アルマック ダイアグノスティックス リミテッド トランスクリプトームマイクロアレイ技法およびそれを使用する方法
EP2857523A1 (en) 2005-02-01 2015-04-08 Applied Biosystems, LLC Method for identifying a sequence in a polynucleotide
WO2006084078A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
US7780915B2 (en) 2005-02-16 2010-08-24 Epitope Diagnostcs, Inc. Fecal sample test device and methods of use
WO2006094149A2 (en) 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US20060210448A1 (en) 2005-03-10 2006-09-21 Naishu Wang Fecal specimen collection, preserving and transport device and method
US7569183B2 (en) 2005-03-28 2009-08-04 Alfresa Pharma Corporation Fecal assay method and analyzer
EP1863908B1 (de) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
WO2006113671A2 (en) 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Methylation markers for diagnosis and treatment of cancers
ATE547537T1 (de) 2005-04-15 2012-03-15 Epigenomics Ag Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben
EP2345743A1 (en) 2005-05-02 2011-07-20 University of Southern California DNA methylation markers associated with the CpG island methylator phenotyp (CIMP) in human colorectal cancer
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7779489B2 (en) 2005-07-19 2010-08-24 Finell Rebecca M Potty bench with storage
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
US7288413B2 (en) 2005-08-12 2007-10-30 Beckman Coulter, Inc. Combined chemical and immunochemical fecal occult blood test
CA2621932A1 (en) 2005-09-14 2007-03-22 Human Genetic Signatures Pty Ltd Assay for hpv and methylated genomic dna targets to screen for cervical cancer
GB0521521D0 (en) 2005-10-21 2005-11-30 Medical Res Council Diagnostic methods and kits
US7514219B2 (en) 2005-11-16 2009-04-07 The Wistar Institute Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
DK1974058T3 (da) 2006-01-11 2014-09-01 Genomic Health Inc Genekspressionsmarkører til prognosticering af kolorektal cancer
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
WO2007092473A2 (en) 2006-02-02 2007-08-16 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
EP2004860A4 (en) 2006-03-29 2009-12-30 Wayne John Cancer Inst METHYLATION OF ESTROGEN RECEPTOR ALPHA AND USE
CN2902916Y (zh) * 2006-04-03 2007-05-23 漳明霖 瓦楞复合卡板托盘
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
AU2007237909A1 (en) 2006-04-19 2007-10-25 Applied Biosystems, Llc. Reagents, methods, and libraries for gel-free bead-based sequencing
ES2347485T3 (es) 2006-05-19 2010-10-29 F. Hoffmann-La Roche Ag Uso de la proteina s100a12, como marcador para el cancer colorrectal.
EP2021515A4 (en) 2006-05-26 2010-06-02 Meltzer Stephen J METHYLATED PROMOTERS AS BIOMARKERS OF COLON CANCER
WO2009035447A1 (en) 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
WO2008010975A2 (en) 2006-07-14 2008-01-24 The Johns Hopkins University Early detection and prognosis of colon cancers
EP2044215B1 (en) 2006-07-21 2015-03-25 Epigenomics AG Methods for analyses of cellular proliferative disorders of the prostate
US7492199B2 (en) 2006-07-28 2009-02-17 International Business Machines Corporation Fully synchronous DLL with architected update window
US8158356B2 (en) 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
EP2097538A4 (en) 2006-12-07 2011-11-30 Switchgear Genomics TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090203011A1 (en) 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
US20090170083A1 (en) 2007-02-02 2009-07-02 Orion Genomics Llc Gene methylation in diagnosis of melanoma
WO2008100913A2 (en) 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
EP2474628B1 (en) 2007-02-21 2015-10-28 Oslo Universitetssykehus HF New markers for cancer
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
US20080227208A1 (en) 2007-03-16 2008-09-18 Hsiao-Ching Yee Devices and Methods for Detection of Occult Blood
KR101509049B1 (ko) 2007-04-16 2015-04-06 한국생명공학연구원 위암 특이적 유전자의 조기 탐지를 위한 메틸화 바이오마커
DK3101141T3 (da) 2007-06-08 2020-02-03 Epigenomics Ag Fremgangsmåde til methyleringsanalyse
FR2919063B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal.
AU2008285557B2 (en) 2007-07-19 2014-07-03 Biomerieux Method for the assay of liver fatty acid-binding protein, ACE and CA19-9 for the in vitro diagnosis of colorectal cancer
FR2919065B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
NZ596545A (en) 2007-09-17 2013-05-31 Glaxosmithkline Biolog Sa Improved detection of mage-a expression
JP2009095262A (ja) 2007-10-15 2009-05-07 Japan Found Cancer Res Ｚｎフィンガータンパク質
JP5422108B2 (ja) 2007-10-16 2014-02-19 栄研化学株式会社 ヘムタンパク質の安定化方法及び保存溶液
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
WO2009064481A1 (en) 2007-11-14 2009-05-22 Stc.Unm Identification of novel subgroups of high-risk pediatric precursor b acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same
ES2402138T3 (es) 2007-12-28 2013-04-29 Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Terapia contra el cáncer con un parvovirus combinado con quimioterapia
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8256177B2 (en) 2008-03-12 2012-09-04 Masonite Corporation Impact resistant door skin, door including the same, and method of manufacturing an impact resistant door skin from a pre-formed door skin
US8067178B2 (en) 2008-03-14 2011-11-29 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
BRPI0908748A2 (pt) 2008-03-15 2015-07-28 Hologic Inc Composições e métodos para análise de moléculas de ácido nucleico durante reações de amplificação
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
EP2304057B1 (en) * 2008-06-17 2014-09-17 Signature Diagnostics AG Method for the detection of ovarian cancer
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010037001A2 (en) 2008-09-26 2010-04-01 Immune Disease Institute, Inc. Selective oxidation of 5-methylcytosine by tet-family proteins
US10927415B2 (en) 2008-11-26 2021-02-23 The Johns Hopkins University Methods for identifying cancer risk
US20110318738A1 (en) 2008-12-23 2011-12-29 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
US9012723B2 (en) 2009-01-16 2015-04-21 Monsanto Technology Llc Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
WO2010089538A2 (en) 2009-02-03 2010-08-12 Oncomethylome Sciences Sa Methods of detecting colorectal cancer
IL313131A (en) 2009-02-11 2024-07-01 Caris Mpi Inc Molecular characterization of tumors
CN102292458A (zh) 2009-04-03 2011-12-21 A&T株式会社 大肠肿瘤的检测方法
JP5731488B2 (ja) 2009-05-29 2015-06-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 癌のマーカーとしてのセセルニン‐１
WO2011002029A1 (ja) * 2009-07-03 2011-01-06 国立大学法人東京大学 癌細胞の存否を判定する方法および癌患者の予後を判定する方法
CN102021233B (zh) 2009-09-22 2014-06-04 复旦大学附属华山医院 一种定量检测akap12甲基化水平的方法及其应用
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
KR101142131B1 (ko) 2009-11-05 2012-05-11 (주)지노믹트리 장암 진단을 위한 장암 특이적 메틸화 마커 유전자의 메틸화 검출방법
GB0920014D0 (en) 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
EP4350001A3 (en) 2009-11-23 2024-06-19 Genomic Health, Inc. Methods to predict clinical outcome of cancer
DE102010043541B4 (de) 2009-12-16 2012-01-26 Technische Universität Dresden Verfahren und Mittel zur Vorhersage der Überlebensdauer beim Pankreaskarzinom durch Analyse von Biomarkern
SG10201500124VA (en) 2010-01-08 2015-03-30 Agency Science Tech & Res Methods and Compositions for Treating Cancer
EP2553463B1 (en) 2010-03-26 2017-05-03 Hongzhi Zou Methods and materials for detecting colorectal neoplasm
US20130012410A1 (en) 2010-03-29 2013-01-10 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
WO2011127136A1 (en) 2010-04-06 2011-10-13 University Of Chicago Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
US20110256538A1 (en) 2010-04-15 2011-10-20 Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine Epigenomic dna modifications for tissue typing, early cancer detection, and disease management
WO2011133935A2 (en) 2010-04-22 2011-10-27 The Johns Hopkins University Methods and kits for risk assessment of barrett's neoplastic progression
WO2011139920A2 (en) 2010-04-29 2011-11-10 Life Technologies Corporation Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr)
ES2581594T3 (es) 2010-05-25 2016-09-06 The Johns Hopkins University Composiciones y métodos para detectar una neoplasia
SG10201505723UA (en) 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
CA3102758C (en) 2010-09-13 2023-09-05 Clinical Genomics Pty. Ltd. Epigenetic markers of colorectal cancers and diagnostic methods using the same
US20130237445A1 (en) 2010-09-14 2013-09-12 The University Of North Carolina At Chapel Hill Methods and kits for detecting melanoma
US9957570B2 (en) 2010-10-04 2018-05-01 The Johns Hopkins University DNA hypermethylation diagnostic biomarkers for colorectal cancer
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US20140113286A1 (en) 2010-12-21 2014-04-24 Sloan-Kettering Institute For Cancer Research Epigenomic Markers of Cancer Metastasis
EP2481813A1 (en) 2011-02-01 2012-08-01 Centro di Riferimento Oncologico - Istituto Nazionale Tumori - Aviano Markers of cutaneous melanoma and uses thereof
EP3441479B1 (en) 2011-02-02 2020-09-02 Exact Sciences Development Company, LLC Digital sequence analysis of dna methylation
US20140057262A1 (en) 2011-03-14 2014-02-27 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
US10316361B2 (en) 2011-07-15 2019-06-11 The John Hopkins University Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence
CN104024427B (zh) 2011-08-25 2018-01-02 临床基因组学私人有限公司 结直肠和乳腺癌诊断方法中的dna甲基化
US9828585B2 (en) 2011-08-30 2017-11-28 The J. David Gladstone Instututes Methods for generating cardiomyocytes
US20130129668A1 (en) 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
US9575073B2 (en) 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
WO2013058868A2 (en) 2011-10-18 2013-04-25 Exact Sciences Corporation Multiplexed kras mutation detection assay
WO2013070950A1 (en) 2011-11-08 2013-05-16 University Of Southern California Identification of a dna methylation marker for blood-based detection of ovarian cancer
GB201120162D0 (en) 2011-11-22 2012-01-04 Medical Res Council Methods for detection of benign conditions
US20140137274A1 (en) * 2011-11-30 2014-05-15 Lsip, Llc Induced malignant stem cells
US9546403B1 (en) 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
IN2014CN04935A (enExample) 2011-12-31 2015-09-18 Moni Abraham Kuriakose
AU2013207385B2 (en) 2012-01-06 2018-09-13 Exact Sciences Corporation System and method of detecting RNAs altered by cancer in peripheral blood
CA2862835A1 (en) 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists
CA3111723C (en) 2012-01-30 2026-05-19 Exact Sciences Corporation Sulfonated small dna compositions and methods for sulfonating and desulfonating small dnas
US20150126374A1 (en) 2012-02-28 2015-05-07 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
EP2825888A4 (en) 2012-03-15 2015-09-23 Mayo Foundation METHOD AND MATERIALS FOR NONINVASIVE DETECTION OF COLORECTAL NEOPLASIA RELATED TO INFLAMMATORY ENDURANCE
EP2828405B1 (en) 2012-03-20 2017-06-28 Exact Sciences Corporation Marker panel for detecting cancer
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition
GB201208874D0 (en) 2012-05-18 2012-07-04 Medical Res Council Methods
CA2874407A1 (en) 2012-05-24 2013-11-28 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
US10106854B2 (en) 2012-06-14 2018-10-23 Aarhus Universitet Biomarkers for prostate cancer
EP2698436A1 (en) 2012-08-14 2014-02-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Colorectal cancer markers
PL2893040T3 (pl) 2012-09-04 2019-05-31 Guardant Health Inc Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
EP2899275B1 (en) 2012-09-19 2018-06-27 Sysmex Corporation Method for obtaining information about endometrial cancer, and marker and kit for obtaining information about endometrial cancer
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014051522A1 (en) 2012-09-26 2014-04-03 Agency For Science, Technology And Research Biomarkers for down syndrome prenatal diagnosis
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
WO2014062218A1 (en) 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
WO2014082067A1 (en) * 2012-11-26 2014-05-30 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
CA2892490A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
AU2013355260B2 (en) 2012-12-04 2019-07-25 Caris Mpi, Inc. Molecular profiling for cancer
TWI500770B (zh) 2013-02-20 2015-09-21 Univ Taipei Medical Hoxa9基因作為檢測肝癌生物標記的用途
JP2014161308A (ja) * 2013-02-27 2014-09-08 St Marianna Univ School Of Medicine 胃癌の検出又は胃癌発症のリスク評価のための指標を得る方法
US9809864B2 (en) 2013-03-01 2017-11-07 The Johns Hopkins University Dual sequence-capture method for quantifying trans renal HPV DNA in urine
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer
US20140322243A1 (en) 2013-04-26 2014-10-30 The Translational Genomics Research Institute Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers
US10679730B2 (en) 2013-05-28 2020-06-09 The University Of Chicago Prognostic and predictive breast cancer signature
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US20150259750A1 (en) 2013-11-26 2015-09-17 Genetic Research Institute Of The Desert Gene-gene model for estimating cancer susceptibility, risk of multiple tumor sites, and the aggressiveness of prostate cancer
WO2015095689A1 (en) 2013-12-19 2015-06-25 Exact Sciences Corporation Synthetic nucleic acid control molecules
US20160340740A1 (en) 2014-01-30 2016-11-24 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
US10301680B2 (en) * 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US9871506B2 (en) * 2014-04-16 2018-01-16 Qualcomm Incorporated Switchable decoupling capacitors
US20160010081A1 (en) 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
EP3189156B1 (en) 2014-08-08 2020-10-07 AIT Austrian Institute of Technology GmbH Thyroid cancer diagnosis by dna methylation analysis
US10292687B2 (en) 2014-08-15 2019-05-21 Covidien Lp Designs and methods to facilitate swallowing of a tethered cell collection device
AU2015318823A1 (en) 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
US10792020B2 (en) 2014-09-18 2020-10-06 Covidien Lp Tapered geometry in a compressible cell collection device
US11096677B2 (en) 2014-09-18 2021-08-24 Covidien Lp Regions of varying physical properties in a compressible cell collection device
US10751033B2 (en) 2014-09-18 2020-08-25 Covidien Lp Use of expansion-force elements in a compressible cell collection device
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016094813A1 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
CN113897432A (zh) * 2014-12-12 2022-01-07 精密科学公司 用于进行甲基化检测测定的组合物和方法
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
EP3239302A4 (en) 2014-12-26 2018-05-23 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
US20190136325A1 (en) 2014-12-31 2019-05-09 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN104762301B (zh) 2015-04-24 2017-12-26 武汉大学 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法
KR101693547B1 (ko) 2015-04-28 2017-01-06 서울대학교산학협력단 경구투여용 위장관 검체 채취 장치 및 방법
BR112016025286B1 (pt) 2015-05-08 2023-04-25 Comba Network Systems Company Limited Sistema e método para backup de sinal de unidade principal de das ativo
CN108699602B (zh) 2015-08-06 2022-01-11 犹他州立大学研究基金会 鉴定男性能育性状态和胚胎质量的方法
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
JP6877704B2 (ja) 2015-11-16 2021-05-26 公立大学法人名古屋市立大学 膵臓癌の検出のための方法及びキット
SI3408407T1 (sl) 2016-01-29 2021-04-30 Epigenomics Ag Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi
CN105648537B (zh) 2016-03-02 2018-06-29 上海易毕恩基因科技有限公司 Dna5-甲基胞嘧啶与5-羟甲基胞嘧啶基因图谱测序方法
AU2017246318B2 (en) 2016-04-07 2023-07-27 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free DNA
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
CN109153993B (zh) 2016-04-14 2023-02-17 梅约医学教育与研究基金会 检测胰腺高度异型增生
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
WO2017191274A2 (en) 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
ES2915074T3 (es) 2016-05-31 2022-06-20 Translational Genomics Res Inst Métodos de marcaje molecular y bibliotecas de secuenciación
RU2018145532A (ru) 2016-06-21 2020-07-23 Зе Уистар Инститьют Оф Анатоми Энд Байолоджи Композиции и способы диагностирования раковых заболеваний легких с помощью профилей экспрессии генов
US11345949B2 (en) 2016-07-19 2022-05-31 Exact Sciences Corporation Methylated control DNA
US20180066320A1 (en) 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
US20180087113A1 (en) 2016-09-27 2018-03-29 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
HUE059194T2 (hu) 2016-12-16 2022-10-28 Eurofins Genomics Europe Sequencing GmbH Epigenetikai markerek és a kapcsolódó eljárások, valamint eszközök a petefészekrák kimutatására és kezelésére
AU2018211956B2 (en) * 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
US11298010B2 (en) 2017-01-31 2022-04-12 University Of Kansas Imaging and collection device and related systems and methods
US10934592B2 (en) 2017-02-28 2021-03-02 Mayo Foundation For Medical Education And Research Detecting prostate cancer
WO2019010429A1 (en) 2017-07-07 2019-01-10 The Trustees Of The University Of Pennsylvania METHODS OF DIAGNOSING PANCREATIC CANCER
KR20250047324A (ko) 2017-08-07 2025-04-03 더 존스 홉킨스 유니버시티 암을 평가하고 치료하기 위한 방법 및 재료
WO2019035100A2 (en) 2017-08-18 2019-02-21 University Of Southern California PROGNOSTIC MARKERS OF CANCER RECIDIVE
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US12071660B2 (en) 2018-01-08 2024-08-27 Ludwig Institute For Cancer Research Ltd. Bisulfite-free, base-resolution identification of cytosine modifications
US20230272474A1 (en) 2018-01-19 2023-08-31 The University Of North Carolina At Chapel Hill Methylation markers for melanoma and uses thereof
RU2020127753A (ru) 2018-01-22 2022-02-24 Джонсон энд Джонсон Консьюмер Инк. Перфорированные капсулы
CA3302676A1 (en) 2018-04-02 2026-05-13 Grail, Inc. Methylation markers and targeted methylation probe panels
US20200071767A1 (en) 2018-04-09 2020-03-05 The Trustees Of Columbia University In The City Of New York Barrett's esophagus progression to cancer gene panel and methods of use thereof
CN113748215B (zh) 2018-11-04 2024-07-23 Pfs基因组学公司 用于乳腺癌的预后和预测来自辅助放射疗法的益处的方法和基因组分类器
MX2021005963A (es) 2018-11-27 2021-08-24 Exact Sciences Dev Co Llc Caracterizacion de adn metilado, arn y proteinas en la deteccion de neoplasia pulmonar.
AU2019392939A1 (en) 2018-12-08 2021-06-24 Decipher Biosciences, Inc. Transcriptomic profiling for prognosis of breast cancer
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
AU2020254760B2 (en) 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
WO2020214778A1 (en) 2019-04-16 2020-10-22 The Johns Hopkins University Methods for detecting and treating esophageal cancer
WO2020236939A2 (en) 2019-05-23 2020-11-26 Paradigm Diagnostics Tissue preparation using nuclease
JP2022535747A (ja) 2019-05-28 2022-08-10 ケース ウエスタン リザーブ ユニバーシティ Ｄｎａのメチル化を保存するための組成物および方法
GB201908624D0 (en) 2019-06-17 2019-07-31 Vib Vzw Predicting age using dna methylation signatures
WO2020264220A1 (en) 2019-06-25 2020-12-30 The Translational Genomics Research Institute Detection and treatment of residual disease using circulating tumor dna analysis
WO2021041726A1 (en) 2019-08-27 2021-03-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
EP4031683A4 (en) 2019-09-16 2024-01-17 Exact Sciences Corporation Structure and temperature-dependent flap endonuclease substrates
KR20220092877A (ko) 2019-10-18 2022-07-04 이그잭트 사이언시즈 코포레이션 다중 분석물 분변 항원 검사
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
AU2021217238B2 (en) 2020-02-07 2026-08-06 Nimble Science Ltd. Ingestible apparatus and method for collecting samples in the gastrointestinal tract and/or delivering health-related substance thereto
AU2021257479A1 (en) 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
EP4146677A4 (en) 2020-05-04 2025-01-15 Mayo Foundation for Medical Education and Research Detecting melanoma
CA3172143A1 (en) 2020-05-04 2021-11-11 David A. Ahlquist Detecting pancreatic neuroendocrine tumors
EP4189086B1 (en) 2020-07-29 2026-03-11 Exact Sciences Corporation Purification of sulfonated dna
WO2022040306A1 (en) 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
EP4284951A4 (en) 2021-01-29 2025-05-28 Mayo Foundation for Medical Education and Research DETECTION OF THE PRESENCE OR ABSENCE OF MULTIPLE CANCERS
CA3210617A1 (en) 2021-03-01 2022-09-09 S. Laura Chang Methods and genomic classifiers for prognosis of breast cancer and identifying subjects not likely to benefit from radiotherapy
US20240052425A1 (en) 2021-03-05 2024-02-15 Mayo Foundation For Medical Education And Research Detecting cervical cancer
US20220349009A1 (en) 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
KR20240113625A (ko) 2021-11-05 2024-07-22 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 구인두암을 검출하기 위한 조성물 및 방법
TW202417642A (zh) 2022-09-16 2024-05-01 大陸商江蘇鵾遠生物科技股份有限公司 鑑別癌症的甲基化標誌物及應用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) * 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2014159652A2 (en) * 2013-03-14 2014-10-02 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2016160454A1 (en) * 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders

Also Published As

Publication number Publication date
AU2016315924A1 (en) 2018-02-08
KR20180081042A (ko) 2018-07-13
JP2021118711A (ja) 2021-08-12
JP2018526029A (ja) 2018-09-13
JP2023113723A (ja) 2023-08-16
US20180251859A1 (en) 2018-09-06
AU2022275451A1 (en) 2023-01-19
CN108138235B (zh) 2022-04-15
KR20250172724A (ko) 2025-12-09
US10597733B2 (en) 2020-03-24
KR102892240B1 (ko) 2025-11-27
US20240191308A1 (en) 2024-06-13
JP7771126B2 (ja) 2025-11-17
US10006093B2 (en) 2018-06-26
CN114574585A (zh) 2022-06-03
US12601011B2 (en) 2026-04-14
KR102688282B1 (ko) 2024-07-26
AU2022275451B2 (en) 2025-05-08
JP2025081468A (ja) 2025-05-27
US20170058356A1 (en) 2017-03-02
KR20240118890A (ko) 2024-08-05
US20200299778A1 (en) 2020-09-24
EP3344784A1 (en) 2018-07-11
US11859254B2 (en) 2024-01-02
JP6871926B2 (ja) 2021-05-19
CN108138235A (zh) 2018-06-08
WO2017040627A1 (en) 2017-03-09
CA2992790A1 (en) 2017-03-09
EP3344784A4 (en) 2019-07-10

Similar Documents

Publication Publication Date Title
AU2022275451B2 (en) Detecting gastric neoplasm
AU2022291502B2 (en) Detecting hepatocellular carcinoma
US20230028856A1 (en) Detecting gastrointestinal neoplasms
AU2020254760B2 (en) Detecting pancreatic ductal adenocarcinoma in plasma
AU2018229294B2 (en) Detecting prostate cancer
US20190360058A1 (en) Detecting colorectal neoplasia
WO2019108626A1 (en) Detecting breast cancer
HK40103516A (en) Detecting hepatocellular carcinoma

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Owner name: EXACT SCIENCES CORPORATION

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

FGA Letters patent sealed or granted (standard patent)