AU2016315924B2 - Detecting gastric neoplasm - Google Patents

Detecting gastric neoplasm Download PDF

Info

Publication number
AU2016315924B2
AU2016315924B2 AU2016315924A AU2016315924A AU2016315924B2 AU 2016315924 B2 AU2016315924 B2 AU 2016315924B2 AU 2016315924 A AU2016315924 A AU 2016315924A AU 2016315924 A AU2016315924 A AU 2016315924A AU 2016315924 B2 AU2016315924 B2 AU 2016315924B2
Authority
AU
Australia
Prior art keywords
methylation
dna
seq
sample
nos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016315924A
Other languages
English (en)
Other versions
AU2016315924A1 (en
Inventor
David A. Ahlquist
Hatim T. Allawi
John B. Kisiel
Douglas W. Mahoney
William R. Taylor
Tracy C. Yab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Mayo Clinic in Florida
Original Assignee
Mayo Foundation for Medical Education and Research
Exact Sciences Corp
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, Exact Sciences Corp, Mayo Clinic in Florida filed Critical Mayo Foundation for Medical Education and Research
Publication of AU2016315924A1 publication Critical patent/AU2016315924A1/en
Application granted granted Critical
Publication of AU2016315924B2 publication Critical patent/AU2016315924B2/en
Assigned to MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES CORPORATION reassignment MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Request for Assignment Assignors: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Priority to AU2022275451A priority Critical patent/AU2022275451B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2016315924A 2015-08-31 2016-08-31 Detecting gastric neoplasm Active AU2016315924B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022275451A AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212221P 2015-08-31 2015-08-31
US62/212,221 2015-08-31
PCT/US2016/049653 WO2017040627A1 (en) 2015-08-31 2016-08-31 Detecting gastric neoplasm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022275451A Division AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Publications (2)

Publication Number Publication Date
AU2016315924A1 AU2016315924A1 (en) 2018-02-08
AU2016315924B2 true AU2016315924B2 (en) 2022-08-25

Family

ID=58103876

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016315924A Active AU2016315924B2 (en) 2015-08-31 2016-08-31 Detecting gastric neoplasm
AU2022275451A Active AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022275451A Active AU2022275451B2 (en) 2015-08-31 2022-11-23 Detecting gastric neoplasm

Country Status (8)

Country Link
US (4) US10006093B2 (enExample)
EP (1) EP3344784A4 (enExample)
JP (4) JP6871926B2 (enExample)
KR (2) KR102688282B1 (enExample)
CN (2) CN108138235B (enExample)
AU (2) AU2016315924B2 (enExample)
CA (1) CA2992790A1 (enExample)
WO (1) WO2017040627A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2812753T3 (es) 2014-03-31 2021-03-18 Mayo Found Medical Education & Res Detección de neoplasma colorectal
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
EP3436604A1 (en) * 2016-04-01 2019-02-06 NanoMed Diagnostics B.V. Detection of cancer in urine
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN110475875B (zh) 2017-01-27 2024-06-25 精密科学公司 通过分析甲基化dna检测结肠瘤形成
CN111655869B (zh) 2017-11-30 2024-06-28 梅约医学教育与研究基金会 检测乳腺癌
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
KR102085669B1 (ko) * 2019-01-02 2020-03-06 한국 한의학 연구원 Cyp26c1 유전자의 메틸화 수준을 이용한 소혈관폐색증의 예측 또는 진단을 위한 정보제공방법 및 이를 위한 조성물
AU2019200359A1 (en) * 2019-01-18 2020-09-10 Clinical Genomics Pty Ltd Screening method
US20220162709A1 (en) * 2019-04-03 2022-05-26 Mayo Foundation For Medical Education And Research Detecting pancreatic ductal adenocarcinoma in plasma
AU2020285322A1 (en) * 2019-05-31 2021-12-16 Universal Diagnostics, S.A. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US20230033016A1 (en) * 2019-06-21 2023-02-02 Universite De Paris Detection of hypermethylated genes for diagnosing gastric cancer
CN110423814A (zh) * 2019-07-19 2019-11-08 江苏元丞生物科技有限公司 Elmo1基因甲基化检测试剂盒及其应用
KR20220092561A (ko) 2019-10-31 2022-07-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 난소암 검출
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN111549129B (zh) * 2020-03-30 2023-08-29 宁波美康盛德医学检验所有限公司 用于检测胃癌的试剂盒及其应用
CN115605138A (zh) * 2020-04-17 2023-01-13 精密科学公司(Us) 可摄取取样装置
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
AU2022213409A1 (en) * 2021-01-29 2023-08-17 Exact Sciences Corporation Detecting the presence or absence of multiple types of cancer
CN115433778B (zh) * 2021-06-02 2023-06-16 武汉艾米森生命科技有限公司 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用
CN113308544B (zh) * 2021-06-04 2022-07-05 武汉艾米森生命科技有限公司 用于dna甲基化检测的试剂及食管癌检测试剂盒
CN114317740B (zh) * 2021-11-24 2024-01-23 博尔诚(北京)科技有限公司 用于胃癌筛查的标志物、探针组合物及其应用
CN118389691A (zh) * 2022-06-29 2024-07-26 广州市基准医疗有限责任公司 用于诊断胃癌的甲基化生物标记物组合、试剂盒及用途
CN115976210B (zh) * 2022-12-08 2024-05-28 深圳市晋百慧生物有限公司 用于胃癌诊断和筛查的试剂盒、方法及其用途
CN117126942A (zh) * 2023-10-05 2023-11-28 上海奕谱生物科技有限公司 可用于肿瘤鉴定的新型DNA甲基化标志物TAGMe-3及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) * 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2016160454A1 (en) * 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
EP1238113B1 (en) 1999-12-07 2010-02-24 EXACT Sciences Corporation Detection of lung neoplasms in stool
AU2001277521A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Diagnosis of diseases associated with cell signalling
MXPA03001834A (es) 2000-09-01 2003-08-01 Epigenomics Ag Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'.
WO2003031932A2 (en) 2001-10-05 2003-04-17 Case Western Reserve University Methods and compositions for detecting colon cancers
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med GENOMIC SCREEN ON EPIGENETIC MUTED CANCER ASSOCIATED GENES
US20030186248A1 (en) 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
CA2519456A1 (en) 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
EP1636386B1 (en) 2003-06-23 2015-08-05 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
WO2005017207A2 (en) 2003-08-14 2005-02-24 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
ES2537633T3 (es) 2004-03-02 2015-06-10 The Johns Hopkins University Mutaciones del gen de PIK3CA en cánceres humanos
JP2005304497A (ja) * 2004-03-25 2005-11-04 Joji Inasawa 特定の癌関連遺伝子を用いる癌の検出方法及び癌の抑制方法
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
CN2902916Y (zh) * 2006-04-03 2007-05-23 漳明霖 瓦楞复合卡板托盘
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
EP2021515A4 (en) 2006-05-26 2010-06-02 Meltzer Stephen J METHYLATED PROMOTERS AS BIOMARKERS OF COLON CANCER
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2009153667A2 (en) * 2008-06-17 2009-12-23 Occure Gmbh Method for the detection of ovarian cancer
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
US20110318738A1 (en) 2008-12-23 2011-12-29 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
US20120164238A1 (en) 2009-02-03 2012-06-28 Mdxhealth Sa Methods of detecting colorectal cancer
JPWO2010113529A1 (ja) 2009-04-03 2012-10-04 株式会社エイアンドティー 大腸腫瘍の検出方法
JP5757572B2 (ja) * 2009-07-03 2015-07-29 国立大学法人 東京大学 癌細胞の存否を判定する方法および癌患者の予後を判定する方法
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US20130012410A1 (en) 2010-03-29 2013-01-10 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
KR20130041961A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
US9957570B2 (en) 2010-10-04 2018-05-01 The Johns Hopkins University DNA hypermethylation diagnostic biomarkers for colorectal cancer
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
WO2012088298A2 (en) 2010-12-21 2012-06-28 Sloan-Kettering Institute For Cancer Research Epigenomic markers of cancer metastasis
US20140057262A1 (en) 2011-03-14 2014-02-27 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US20130065228A1 (en) 2011-06-01 2013-03-14 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
WO2012174256A2 (en) * 2011-06-17 2012-12-20 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
EP2749642A4 (en) 2011-11-30 2015-03-04 Nat Cancer Ct INDUCED MALIGNE STEM CELLS
WO2013130880A1 (en) 2012-02-28 2013-09-06 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
EP2825888A4 (en) 2012-03-15 2015-09-23 Mayo Foundation METHOD AND MATERIALS FOR NONINVASIVE DETECTION OF COLORECTAL NEOPLASIA RELATED TO INFLAMMATORY ENDURANCE
EP2900835B1 (en) 2012-09-27 2025-04-30 Population Bio, Inc. Method for screening and treating developmental disorders
US10648035B2 (en) * 2012-11-26 2020-05-12 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
JP2014161308A (ja) * 2013-02-27 2014-09-08 St Marianna Univ School Of Medicine 胃癌の検出又は胃癌発症のリスク評価のための指標を得る方法
US20140322243A1 (en) 2013-04-26 2014-10-30 The Translational Genomics Research Institute Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
ES2812753T3 (es) 2014-03-31 2021-03-18 Mayo Found Medical Education & Res Detección de neoplasma colorectal
US9871506B2 (en) * 2014-04-16 2018-01-16 Qualcomm Incorporated Switchable decoupling capacitors
WO2016041010A1 (en) 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
EP3230476B1 (en) * 2014-12-12 2020-02-05 Exact Sciences Development Company, LLC Zdhhc1 for normalizing methylation detection assays
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
CA2972782A1 (en) 2014-12-31 2016-07-07 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
WO2017192221A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated dna
CN110475875B (zh) * 2017-01-27 2024-06-25 精密科学公司 通过分析甲基化dna检测结肠瘤形成
CN111655869B (zh) 2017-11-30 2024-06-28 梅约医学教育与研究基金会 检测乳腺癌

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274748A1 (en) * 2013-03-14 2014-09-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2014159652A2 (en) * 2013-03-14 2014-10-02 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2016160454A1 (en) * 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders

Also Published As

Publication number Publication date
US20200299778A1 (en) 2020-09-24
WO2017040627A1 (en) 2017-03-09
CN108138235B (zh) 2022-04-15
EP3344784A1 (en) 2018-07-11
AU2022275451B2 (en) 2025-05-08
US20240191308A1 (en) 2024-06-13
JP2023113723A (ja) 2023-08-16
US20180251859A1 (en) 2018-09-06
US11859254B2 (en) 2024-01-02
AU2022275451A1 (en) 2023-01-19
JP2025081468A (ja) 2025-05-27
JP2018526029A (ja) 2018-09-13
AU2016315924A1 (en) 2018-02-08
CA2992790A1 (en) 2017-03-09
CN114574585A (zh) 2022-06-03
US10006093B2 (en) 2018-06-26
US20170058356A1 (en) 2017-03-02
JP6871926B2 (ja) 2021-05-19
CN108138235A (zh) 2018-06-08
KR20240118890A (ko) 2024-08-05
KR20180081042A (ko) 2018-07-13
JP7771126B2 (ja) 2025-11-17
KR102688282B1 (ko) 2024-07-26
JP2021118711A (ja) 2021-08-12
KR102892240B1 (ko) 2025-11-27
US10597733B2 (en) 2020-03-24
EP3344784A4 (en) 2019-07-10

Similar Documents

Publication Publication Date Title
AU2022275451B2 (en) Detecting gastric neoplasm
AU2022291502B2 (en) Detecting hepatocellular carcinoma
US20230028856A1 (en) Detecting gastrointestinal neoplasms
US11542557B2 (en) Detecting colorectal neoplasia
AU2018229294B2 (en) Detecting prostate cancer
AU2020254760B2 (en) Detecting pancreatic ductal adenocarcinoma in plasma
WO2019108626A1 (en) Detecting breast cancer
KR20250172724A (ko) 위 신생물 검출 방법

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Owner name: EXACT SCIENCES CORPORATION

Free format text: FORMER APPLICANT(S): MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; EXACT SCIENCES DEVELOPMENT COMPANY, LLC

FGA Letters patent sealed or granted (standard patent)