JP2019528704A5 - - Google Patents
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- JP2019528704A5 JP2019528704A5 JP2019512308A JP2019512308A JP2019528704A5 JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5 JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nos
- methylation
- measuring
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000011987 methylation Effects 0.000 claims 23
- 238000007069 methylation reaction Methods 0.000 claims 23
- 108091029430 CpG site Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 11
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 9
- 102100028571 Disabled homolog 2-interacting protein Human genes 0.000 claims 7
- 102100023823 Homeobox protein EMX1 Human genes 0.000 claims 7
- 102100030309 Homeobox protein Hox-A1 Human genes 0.000 claims 7
- 101000915396 Homo sapiens Disabled homolog 2-interacting protein Proteins 0.000 claims 7
- 101001048956 Homo sapiens Homeobox protein EMX1 Proteins 0.000 claims 7
- 101001083156 Homo sapiens Homeobox protein Hox-A1 Proteins 0.000 claims 7
- 101000658628 Homo sapiens Testis-specific Y-encoded-like protein 5 Proteins 0.000 claims 7
- 102100034914 Testis-specific Y-encoded-like protein 5 Human genes 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 238000007855 methylation-specific PCR Methods 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 3
- 108010076804 DNA Restriction Enzymes Proteins 0.000 claims 2
- 238000009585 enzyme analysis Methods 0.000 claims 2
- 238000012175 pyrosequencing Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023019916A JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383165P | 2016-09-02 | 2016-09-02 | |
| US62/383,165 | 2016-09-02 | ||
| PCT/US2017/049915 WO2018045322A1 (en) | 2016-09-02 | 2017-09-01 | Detecting hepatocellular carcinoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019916A Division JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528704A JP2019528704A (ja) | 2019-10-17 |
| JP2019528704A5 true JP2019528704A5 (enExample) | 2020-03-05 |
| JP7293109B2 JP7293109B2 (ja) | 2023-06-19 |
Family
ID=61282051
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512308A Active JP7293109B2 (ja) | 2016-09-02 | 2017-09-01 | 肝細胞癌の検出 |
| JP2023019916A Active JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019916A Active JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20180066320A1 (enExample) |
| EP (2) | EP4293128A3 (enExample) |
| JP (2) | JP7293109B2 (enExample) |
| KR (2) | KR102801197B1 (enExample) |
| CN (2) | CN116064795A (enExample) |
| AU (2) | AU2017318700B2 (enExample) |
| CA (1) | CA3034903A1 (enExample) |
| ES (1) | ES2956257T3 (enExample) |
| WO (1) | WO2018045322A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| EP3126529B1 (en) | 2014-03-31 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CA3049459A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CN113811622B (zh) * | 2019-04-03 | 2024-09-17 | 梅约医学教育与研究基金会 | 在血浆中检测胰腺导管腺癌 |
| WO2020214798A1 (en) * | 2019-04-17 | 2020-10-22 | The Brigham And Women's Hospital, Inc. | Epigenetic signatures of alzheimer's disease |
| KR102155044B1 (ko) * | 2019-10-08 | 2020-09-11 | 주식회사 레피다인 | 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법 |
| KR102103885B1 (ko) * | 2019-10-08 | 2020-04-24 | 주식회사 레피다인 | 생물학적 시료의 간 조직 유래 여부를 판별하는 방법 |
| KR102472253B1 (ko) * | 2019-10-14 | 2022-11-30 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 간암 진단용 조성물 및 이의 용도 |
| CN112176419B (zh) * | 2019-10-16 | 2022-03-22 | 中国医学科学院肿瘤医院 | 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法 |
| AU2020374985A1 (en) | 2019-10-31 | 2022-05-26 | Exact Sciences Corporation | Detecting ovarian cancer |
| WO2021146570A1 (en) * | 2020-01-17 | 2021-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing hepatocellular carcinoma |
| EP4185714A1 (en) * | 2020-07-21 | 2023-05-31 | Epigenomics AG | Methods for detecting liver cancer |
| CN112011619A (zh) * | 2020-09-17 | 2020-12-01 | 山东大学深圳研究院 | Sfrp2作为标志物在乙型肝炎病毒相关肝细胞癌早期诊断中的应用及检测试剂盒 |
| CN114634981B (zh) * | 2020-12-16 | 2024-01-26 | 广州达健生物科技有限公司 | 肝癌基因甲基化检测引物探针组合及其试剂盒与应用 |
| WO2022155118A1 (en) * | 2021-01-12 | 2022-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis |
| WO2022243566A1 (en) * | 2021-05-21 | 2022-11-24 | Ophiomics - Investigação E Desenvolvimento Em Biotecnologia | Dna methylation biomarkers for hepatocellular carcinoma |
| WO2023010129A2 (en) * | 2021-07-30 | 2023-02-02 | Active Genomes Expressed Diagnostics, Corp. | Methods and compositions for treating liver cancer and liver disease |
| US20240401147A1 (en) * | 2021-10-19 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Dna methylation signature for diagnosing hepatocellular carcinoma |
| CN113897434A (zh) * | 2021-11-02 | 2022-01-07 | 北京艾克伦医疗科技有限公司 | 鉴定肝癌状态的方法和试剂盒 |
| CN113862370B (zh) * | 2021-12-02 | 2022-03-22 | 广州滴纳生物科技有限公司 | 用于筛查肝癌的引物和探针、试剂盒及其应用 |
| CN116287254B (zh) * | 2023-02-22 | 2024-04-30 | 中国人民解放军海军军医大学 | Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用 |
| CN116732175A (zh) * | 2023-03-09 | 2023-09-12 | 江苏鹍远生物技术有限公司 | 血浆游离dna甲基化标志物在肝脏肿瘤检测中的用途 |
| KR20250156776A (ko) * | 2023-03-09 | 2025-11-03 | 싱글레라 헬스 테크놀로지스 (상하이) 엘티디. | 혈장 유리 dna 메틸화 표지자의 간 종양 검출에서의 용도 |
| CN116200499B (zh) * | 2023-03-23 | 2024-01-19 | 北京和瑞精湛医学检验实验室有限公司 | 一种用于肝癌检测的基因组合与相关试剂和应用 |
| WO2024222519A1 (zh) * | 2023-04-26 | 2024-10-31 | 博尔诚（北京）科技有限公司 | 用于检测肝癌的组合物及其用途 |
| CN118685520B (zh) * | 2024-08-26 | 2024-11-26 | 湖南宏雅基因技术有限公司 | 一种肝癌基因甲基化检测的引物探针组合及试剂盒 |
| CN118834956B (zh) * | 2024-09-24 | 2024-12-06 | 上海信诺佰世医学检验有限公司 | 引物和探针组合物、试剂盒及在检测emx1、chfr基因甲基化中的应用 |
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| EP2899274A4 (en) * | 2012-09-19 | 2016-06-01 | Sysmex Corp | METHOD FOR OBTAINING INFORMATION ON HEPATOCELLULAR CARCINOMAS AND MARKERS AND KIT FOR OBTAINING INFORMATION ON HEPATOCELLULAR CARCINOMAS |
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| US20160340740A1 (en) * | 2014-01-30 | 2016-11-24 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| US10184154B2 (en) * | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3034624A1 (en) * | 2014-12-18 | 2016-06-22 | Hospital Clínic de Barcelona | Method for the prognosis of hepatocellular carcinoma |
| EP3274440A4 (en) * | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CN104762301B (zh) * | 2015-04-24 | 2017-12-26 | 武汉大学 | 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法 |
| KR102380690B1 (ko) * | 2016-04-14 | 2022-03-29 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 췌장 고도 이형성증의 검출방법 |
-
2017
- 2017-09-01 US US15/694,300 patent/US20180066320A1/en not_active Abandoned
- 2017-09-01 CN CN202210999151.7A patent/CN116064795A/zh active Pending
- 2017-09-01 EP EP23191397.1A patent/EP4293128A3/en active Pending
- 2017-09-01 CA CA3034903A patent/CA3034903A1/en active Pending
- 2017-09-01 JP JP2019512308A patent/JP7293109B2/ja active Active
- 2017-09-01 ES ES17847642T patent/ES2956257T3/es active Active
- 2017-09-01 EP EP17847642.0A patent/EP3507298B1/en active Active
- 2017-09-01 AU AU2017318700A patent/AU2017318700B2/en active Active
- 2017-09-01 WO PCT/US2017/049915 patent/WO2018045322A1/en not_active Ceased
- 2017-09-01 KR KR1020247008512A patent/KR102801197B1/ko active Active
- 2017-09-01 CN CN201780053034.9A patent/CN109790198B/zh active Active
- 2017-09-01 KR KR1020197005873A patent/KR102648965B1/ko active Active
-
2019
- 2019-10-08 US US16/596,513 patent/US20200115761A1/en active Pending
-
2022
- 2022-12-21 AU AU2022291502A patent/AU2022291502C1/en active Active
-
2023
- 2023-02-13 JP JP2023019916A patent/JP7704792B2/ja active Active
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