CN109790198B - 检测肝细胞癌 - Google Patents

检测肝细胞癌 Download PDF

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CN109790198B
CN109790198B CN201780053034.9A CN201780053034A CN109790198B CN 109790198 B CN109790198 B CN 109790198B CN 201780053034 A CN201780053034 A CN 201780053034A CN 109790198 B CN109790198 B CN 109790198B
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seq
primer set
nos
methylation
dna
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CN109790198A (zh
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威廉·R·泰勒
大卫·A·阿尔奎斯特
道格拉斯·W·马奥尼
约翰·B·基谢尔
特蕾西·C·亚卜
哈特姆·T·阿拉维
玛丽亚·贾库莫普洛斯
格雷厄姆·P·利德加德
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Exact Sciences Corp
Mayo Clinic in Florida
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Exact Sciences Development Co LLC
Mayo Clinic in Florida
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201780053034.9A 2016-09-02 2017-09-01 检测肝细胞癌 Active CN109790198B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210999151.7A CN116064795A (zh) 2016-09-02 2017-09-01 确定差异甲基化区域的甲基化状态的方法和试剂盒

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US201662383165P 2016-09-02 2016-09-02
US62/383,165 2016-09-02
PCT/US2017/049915 WO2018045322A1 (en) 2016-09-02 2017-09-01 Detecting hepatocellular carcinoma

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EP (2) EP3507298B1 (enExample)
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KR (2) KR102801197B1 (enExample)
CN (2) CN109790198B (enExample)
AU (2) AU2017318700B2 (enExample)
CA (1) CA3034903A1 (enExample)
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CN111655869B (zh) 2017-11-30 2024-06-28 梅约医学教育与研究基金会 检测乳腺癌
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KR102155044B1 (ko) * 2019-10-08 2020-09-11 주식회사 레피다인 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법
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CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
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CN113897434A (zh) * 2021-11-02 2022-01-07 北京艾克伦医疗科技有限公司 鉴定肝癌状态的方法和试剂盒
CN113862370B (zh) * 2021-12-02 2022-03-22 广州滴纳生物科技有限公司 用于筛查肝癌的引物和探针、试剂盒及其应用
CN116287254B (zh) * 2023-02-22 2024-04-30 中国人民解放军海军军医大学 Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用
KR20250156776A (ko) * 2023-03-09 2025-11-03 싱글레라 헬스 테크놀로지스 (상하이) 엘티디. 혈장 유리 dna 메틸화 표지자의 간 종양 검출에서의 용도
CN116732175A (zh) * 2023-03-09 2023-09-12 江苏鹍远生物技术有限公司 血浆游离dna甲基化标志物在肝脏肿瘤检测中的用途
CN116200499B (zh) * 2023-03-23 2024-01-19 北京和瑞精湛医学检验实验室有限公司 一种用于肝癌检测的基因组合与相关试剂和应用
WO2024222519A1 (zh) * 2023-04-26 2024-10-31 博尔诚（北京）科技有限公司 用于检测肝癌的组合物及其用途
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EP3507298B1 (en) 2023-08-30
CN109790198A (zh) 2019-05-21
WO2018045322A1 (en) 2018-03-08
AU2017318700A1 (en) 2019-03-14
KR20190045188A (ko) 2019-05-02
JP2019528704A (ja) 2019-10-17
AU2022291502B2 (en) 2025-02-20
CA3034903A1 (en) 2018-03-08
AU2017318700B2 (en) 2022-09-22
EP3507298A1 (en) 2019-07-10
EP4293128A2 (en) 2023-12-20
KR102648965B1 (ko) 2024-03-18
US20180066320A1 (en) 2018-03-08
KR20240038151A (ko) 2024-03-22
JP2023058645A (ja) 2023-04-25
EP3507298A4 (en) 2021-03-10
KR102801197B1 (ko) 2025-04-29
AU2022291502A1 (en) 2023-02-09
US20200115761A1 (en) 2020-04-16
AU2017318700A2 (en) 2020-01-16
AU2022291502C1 (en) 2025-08-21
ES2956257T3 (es) 2023-12-18
CN116064795A (zh) 2023-05-05
JP7293109B2 (ja) 2023-06-19
EP4293128A3 (en) 2024-03-20
JP7704792B2 (ja) 2025-07-08

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