CA3034903A1 - Detecting hepatocellular carcinoma - Google Patents

Detecting hepatocellular carcinoma Download PDF

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Publication number
CA3034903A1
CA3034903A1 CA3034903A CA3034903A CA3034903A1 CA 3034903 A1 CA3034903 A1 CA 3034903A1 CA 3034903 A CA3034903 A CA 3034903A CA 3034903 A CA3034903 A CA 3034903A CA 3034903 A1 CA3034903 A1 CA 3034903A1
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Canada
Prior art keywords
seq
methylation
nos
sample
dna
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Pending
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CA3034903A
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English (en)
French (fr)
Inventor
William R. Taylor
David A. Ahlquist
Douglas W. Mahoney
John B. Kisiel
Tracy C. Yab
Hatim T. Allawi
Maria GIAKOUMOPOULOS
Graham P. Lidgard
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Exact Sciences Corp
Mayo Clinic in Florida
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Exact Sciences Development Co LLC
Mayo Clinic in Florida
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Publication of CA3034903A1 publication Critical patent/CA3034903A1/en
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3034903A 2016-09-02 2017-09-01 Detecting hepatocellular carcinoma Pending CA3034903A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662383165P 2016-09-02 2016-09-02
US62/383,165 2016-09-02
PCT/US2017/049915 WO2018045322A1 (en) 2016-09-02 2017-09-01 Detecting hepatocellular carcinoma

Publications (1)

Publication Number Publication Date
CA3034903A1 true CA3034903A1 (en) 2018-03-08

Family

ID=61282051

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034903A Pending CA3034903A1 (en) 2016-09-02 2017-09-01 Detecting hepatocellular carcinoma

Country Status (9)

Country Link
US (2) US20180066320A1 (enExample)
EP (2) EP3507298B1 (enExample)
JP (2) JP7293109B2 (enExample)
KR (2) KR102648965B1 (enExample)
CN (2) CN109790198B (enExample)
AU (2) AU2017318700B2 (enExample)
CA (1) CA3034903A1 (enExample)
ES (1) ES2956257T3 (enExample)
WO (1) WO2018045322A1 (enExample)

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WO2018045322A1 (en) 2018-03-08
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KR20240038151A (ko) 2024-03-22
AU2017318700A1 (en) 2019-03-14
CN109790198A (zh) 2019-05-21
AU2022291502C1 (en) 2025-08-21
AU2017318700B2 (en) 2022-09-22
KR102648965B1 (ko) 2024-03-18
US20180066320A1 (en) 2018-03-08
EP3507298A4 (en) 2021-03-10
JP7704792B2 (ja) 2025-07-08
KR20190045188A (ko) 2019-05-02
JP2019528704A (ja) 2019-10-17
US20200115761A1 (en) 2020-04-16
EP4293128A3 (en) 2024-03-20
AU2022291502B2 (en) 2025-02-20
EP3507298A1 (en) 2019-07-10
JP7293109B2 (ja) 2023-06-19
CN109790198B (zh) 2022-09-09
JP2023058645A (ja) 2023-04-25
KR102801197B1 (ko) 2025-04-29
AU2017318700A2 (en) 2020-01-16
EP3507298B1 (en) 2023-08-30
ES2956257T3 (es) 2023-12-18

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