CA3034903A1 - Detecting hepatocellular carcinoma - Google Patents
Detecting hepatocellular carcinoma Download PDFInfo
- Publication number
- CA3034903A1 CA3034903A1 CA3034903A CA3034903A CA3034903A1 CA 3034903 A1 CA3034903 A1 CA 3034903A1 CA 3034903 A CA3034903 A CA 3034903A CA 3034903 A CA3034903 A CA 3034903A CA 3034903 A1 CA3034903 A1 CA 3034903A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- methylation
- nos
- sample
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/331—Methylation site specific nuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383165P | 2016-09-02 | 2016-09-02 | |
| US62/383,165 | 2016-09-02 | ||
| PCT/US2017/049915 WO2018045322A1 (en) | 2016-09-02 | 2017-09-01 | Detecting hepatocellular carcinoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3034903A1 true CA3034903A1 (en) | 2018-03-08 |
Family
ID=61282051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3034903A Pending CA3034903A1 (en) | 2016-09-02 | 2017-09-01 | Detecting hepatocellular carcinoma |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20180066320A1 (enExample) |
| EP (2) | EP4293128A3 (enExample) |
| JP (2) | JP7293109B2 (enExample) |
| KR (2) | KR102801197B1 (enExample) |
| CN (2) | CN116064795A (enExample) |
| AU (2) | AU2017318700B2 (enExample) |
| CA (1) | CA3034903A1 (enExample) |
| ES (1) | ES2956257T3 (enExample) |
| WO (1) | WO2018045322A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| EP3126529B1 (en) | 2014-03-31 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CA3049459A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CN113811622B (zh) * | 2019-04-03 | 2024-09-17 | 梅约医学教育与研究基金会 | 在血浆中检测胰腺导管腺癌 |
| WO2020214798A1 (en) * | 2019-04-17 | 2020-10-22 | The Brigham And Women's Hospital, Inc. | Epigenetic signatures of alzheimer's disease |
| KR102155044B1 (ko) * | 2019-10-08 | 2020-09-11 | 주식회사 레피다인 | 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법 |
| KR102103885B1 (ko) * | 2019-10-08 | 2020-04-24 | 주식회사 레피다인 | 생물학적 시료의 간 조직 유래 여부를 판별하는 방법 |
| KR102472253B1 (ko) * | 2019-10-14 | 2022-11-30 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 간암 진단용 조성물 및 이의 용도 |
| CN112176419B (zh) * | 2019-10-16 | 2022-03-22 | 中国医学科学院肿瘤医院 | 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法 |
| AU2020374985A1 (en) | 2019-10-31 | 2022-05-26 | Exact Sciences Corporation | Detecting ovarian cancer |
| WO2021146570A1 (en) * | 2020-01-17 | 2021-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing hepatocellular carcinoma |
| EP4185714A1 (en) * | 2020-07-21 | 2023-05-31 | Epigenomics AG | Methods for detecting liver cancer |
| CN112011619A (zh) * | 2020-09-17 | 2020-12-01 | 山东大学深圳研究院 | Sfrp2作为标志物在乙型肝炎病毒相关肝细胞癌早期诊断中的应用及检测试剂盒 |
| CN114634981B (zh) * | 2020-12-16 | 2024-01-26 | 广州达健生物科技有限公司 | 肝癌基因甲基化检测引物探针组合及其试剂盒与应用 |
| WO2022155118A1 (en) * | 2021-01-12 | 2022-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis |
| WO2022243566A1 (en) * | 2021-05-21 | 2022-11-24 | Ophiomics - Investigação E Desenvolvimento Em Biotecnologia | Dna methylation biomarkers for hepatocellular carcinoma |
| WO2023010129A2 (en) * | 2021-07-30 | 2023-02-02 | Active Genomes Expressed Diagnostics, Corp. | Methods and compositions for treating liver cancer and liver disease |
| US20240401147A1 (en) * | 2021-10-19 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Dna methylation signature for diagnosing hepatocellular carcinoma |
| CN113897434A (zh) * | 2021-11-02 | 2022-01-07 | 北京艾克伦医疗科技有限公司 | 鉴定肝癌状态的方法和试剂盒 |
| CN113862370B (zh) * | 2021-12-02 | 2022-03-22 | 广州滴纳生物科技有限公司 | 用于筛查肝癌的引物和探针、试剂盒及其应用 |
| CN116287254B (zh) * | 2023-02-22 | 2024-04-30 | 中国人民解放军海军军医大学 | Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用 |
| CN116732175A (zh) * | 2023-03-09 | 2023-09-12 | 江苏鹍远生物技术有限公司 | 血浆游离dna甲基化标志物在肝脏肿瘤检测中的用途 |
| KR20250156776A (ko) * | 2023-03-09 | 2025-11-03 | 싱글레라 헬스 테크놀로지스 (상하이) 엘티디. | 혈장 유리 dna 메틸화 표지자의 간 종양 검출에서의 용도 |
| CN116200499B (zh) * | 2023-03-23 | 2024-01-19 | 北京和瑞精湛医学检验实验室有限公司 | 一种用于肝癌检测的基因组合与相关试剂和应用 |
| WO2024222519A1 (zh) * | 2023-04-26 | 2024-10-31 | 博尔诚（北京）科技有限公司 | 用于检测肝癌的组合物及其用途 |
| CN118685520B (zh) * | 2024-08-26 | 2024-11-26 | 湖南宏雅基因技术有限公司 | 一种肝癌基因甲基化检测的引物探针组合及试剂盒 |
| CN118834956B (zh) * | 2024-09-24 | 2024-12-06 | 上海信诺佰世医学检验有限公司 | 引物和探针组合物、试剂盒及在检测emx1、chfr基因甲基化中的应用 |
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| CN104762301B (zh) * | 2015-04-24 | 2017-12-26 | 武汉大学 | 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法 |
| KR102380690B1 (ko) * | 2016-04-14 | 2022-03-29 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 췌장 고도 이형성증의 검출방법 |
-
2017
- 2017-09-01 US US15/694,300 patent/US20180066320A1/en not_active Abandoned
- 2017-09-01 CN CN202210999151.7A patent/CN116064795A/zh active Pending
- 2017-09-01 EP EP23191397.1A patent/EP4293128A3/en active Pending
- 2017-09-01 CA CA3034903A patent/CA3034903A1/en active Pending
- 2017-09-01 JP JP2019512308A patent/JP7293109B2/ja active Active
- 2017-09-01 ES ES17847642T patent/ES2956257T3/es active Active
- 2017-09-01 EP EP17847642.0A patent/EP3507298B1/en active Active
- 2017-09-01 AU AU2017318700A patent/AU2017318700B2/en active Active
- 2017-09-01 WO PCT/US2017/049915 patent/WO2018045322A1/en not_active Ceased
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| JP7293109B2 (ja) | 2023-06-19 |
| KR20240038151A (ko) | 2024-03-22 |
| AU2022291502C1 (en) | 2025-08-21 |
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| EP4293128A2 (en) | 2023-12-20 |
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| EP3507298A4 (en) | 2021-03-10 |
| AU2022291502A1 (en) | 2023-02-09 |
| AU2017318700B2 (en) | 2022-09-22 |
| WO2018045322A1 (en) | 2018-03-08 |
| US20200115761A1 (en) | 2020-04-16 |
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| KR102648965B1 (ko) | 2024-03-18 |
| AU2017318700A2 (en) | 2020-01-16 |
| EP3507298A1 (en) | 2019-07-10 |
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