JP2019520037A5 - - Google Patents

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JP2019520037A5
JP2019520037A5 JP2018554339A JP2018554339A JP2019520037A5 JP 2019520037 A5 JP2019520037 A5 JP 2019520037A5 JP 2018554339 A JP2018554339 A JP 2018554339A JP 2018554339 A JP2018554339 A JP 2018554339A JP 2019520037 A5 JP2019520037 A5 JP 2019520037A5
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primers
seq
nos
methylation
sample
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JP2018554339A
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JP7481804B2 (ja
JP2019520037A (ja
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Priority claimed from PCT/US2017/027439 external-priority patent/WO2017180886A1/en
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Priority to JP2022131150A priority Critical patent/JP7443436B2/ja
Priority to JP2024017264A priority patent/JP2024054246A/ja
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Publication of JP7481804B2 publication Critical patent/JP7481804B2/ja
Priority to JP2025187410A priority patent/JP2026027367A/ja
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JP2018554339A 2016-04-14 2017-04-13 高度膵異形成の検出 Active JP7481804B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022131150A JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出
JP2025187410A JP2026027367A (ja) 2016-04-14 2025-11-06 高度膵異形成の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662322610P 2016-04-14 2016-04-14
US62/322,610 2016-04-14
PCT/US2017/027439 WO2017180886A1 (en) 2016-04-14 2017-04-13 Detecting pancreatic high-grade dysplasia

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JP2022131150A Division JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Division JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出

Publications (3)

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JP2019520037A JP2019520037A (ja) 2019-07-18
JP2019520037A5 true JP2019520037A5 (enExample) 2020-05-21
JP7481804B2 JP7481804B2 (ja) 2024-05-13

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JP2018554339A Active JP7481804B2 (ja) 2016-04-14 2017-04-13 高度膵異形成の検出
JP2022131150A Active JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Pending JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出
JP2025187410A Pending JP2026027367A (ja) 2016-04-14 2025-11-06 高度膵異形成の検出

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JP2022131150A Active JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Pending JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出
JP2025187410A Pending JP2026027367A (ja) 2016-04-14 2025-11-06 高度膵異形成の検出

Country Status (8)

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US (3) US11078543B2 (enExample)
EP (1) EP3443089A4 (enExample)
JP (4) JP7481804B2 (enExample)
KR (2) KR102506365B1 (enExample)
CN (2) CN109153993B (enExample)
AU (3) AU2017250663B2 (enExample)
CA (1) CA3020628A1 (enExample)
WO (1) WO2017180886A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
CN106460046A (zh) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
KR20250172724A (ko) 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
KR20250073555A (ko) 2015-10-30 2025-05-27 이그잭트 사이언시즈 코포레이션 복합 증폭 검출 분석 및 혈장으로부터 dna의 분리 및 검출 방법
US11078543B2 (en) * 2016-04-14 2021-08-03 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CN116064796A (zh) 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
ES2956257T3 (es) * 2016-09-02 2023-12-18 Mayo Found Medical Education & Res Detección de carcinoma hepatocelular
JP7289264B2 (ja) 2017-01-27 2023-06-09 エグザクト サイエンシーズ コーポレーション メチル化dnaの分析による結腸腫瘍の検出
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2020154665A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
US20220162709A1 (en) * 2019-04-03 2022-05-26 Mayo Foundation For Medical Education And Research Detecting pancreatic ductal adenocarcinoma in plasma
EP3730941A1 (en) * 2019-04-23 2020-10-28 Institut Jean Paoli & Irène Calmettes Method for determining a reference tumor aggressiveness molecular gradient for a pancreatic ductal adenocarcinoma
US20220333206A1 (en) * 2019-07-29 2022-10-20 Seoul National University Hospital Biomarker for diagnosing pancreatic cancer, and use thereof
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
WO2021081498A1 (en) * 2019-10-24 2021-04-29 The Johns Hopkins University Compositions and methods for detecting and treating esophageal cancer
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
CN115867566A (zh) * 2020-05-04 2023-03-28 梅约医学教育与研究基金会 检测黑素瘤
CN115551880A (zh) * 2020-05-04 2022-12-30 梅约医学教育与研究基金会 检测胰腺神经内分泌肿瘤
CN114250298B (zh) * 2020-09-23 2024-09-24 中国医学科学院北京协和医院 胰腺导管腺癌的dna甲基化标志物及其应用
CN112176057B (zh) * 2020-09-23 2023-11-10 中国人民解放军海军军医大学第一附属医院 利用CpG位点甲基化水平检测胰腺导管腺癌的标志物及其应用
JP7684545B2 (ja) * 2020-12-04 2025-05-28 学校法人順天堂 軽度認知障害の検出方法
CN115491421A (zh) * 2021-06-18 2022-12-20 上海鹍远生物科技股份有限公司 胰腺癌诊断相关dna甲基化标志物及其应用
CN117475360B (zh) * 2023-12-27 2024-03-26 南京纳实医学科技有限公司 基于改进型mlstm-fcn的音视频特点的生物特征提取与分析方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
WO1998056952A1 (en) 1997-06-09 1998-12-17 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
DE60043896D1 (de) 1999-12-07 2010-04-08 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
AU2001276371A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
DK1423528T3 (da) 2000-09-01 2008-05-13 Epigenomics Ag Fremgangsmåde til bestemmelse af methyleringsgraden af bestemte cytosiner i genomisk DNA i sekvenskonteksten 5-CPG-3
US20020137086A1 (en) * 2001-03-01 2002-09-26 Alexander Olek Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylation status of the genes
WO2003031932A2 (en) 2001-10-05 2003-04-17 Case Western Reserve University Methods and compositions for detecting colon cancers
CA2478592A1 (en) 2002-03-07 2003-09-18 The Johns Hopkins University School Of Medicine Genomic screen for epigenetically silenced genes associated with cancer
EP1604013A4 (en) 2003-03-17 2009-02-11 Univ Johns Hopkins ANOMALALLY METHYLATED GENES IN PANCREATIC CANCER
EP1660683B1 (en) 2003-08-14 2017-04-19 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
EP2497836B1 (en) 2004-03-02 2015-01-14 The Johns Hopkins University Mutations of the PIK3CA gene in human cancers
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
WO2007140319A1 (en) 2006-05-26 2007-12-06 Meltzer Stephen J Methylated promoters as biomarkers of colon cancer
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
WO2010074924A1 (en) 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
EP2394170B1 (en) 2009-02-03 2015-04-01 MDxHealth SA Methods of detecting colorectal cancer
US20120034605A1 (en) 2009-04-03 2012-02-09 A&T Corporation Method for detection of colorectal tumor
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
US20110236916A1 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US20130012410A1 (en) 2010-03-29 2013-01-10 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
WO2012047899A2 (en) 2010-10-04 2012-04-12 The Johns Hopkins University Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
EP2655664A2 (en) 2010-12-21 2013-10-30 Sloan-Kettering Institute for Cancer Research Epigenomic markers of cancer metastasis
US10144971B2 (en) 2011-01-04 2018-12-04 The Johns Hopkins University Genes frequently altered in pancreatic neuroendocrine tumors
WO2012125721A2 (en) 2011-03-14 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
US9575073B2 (en) * 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
KR20140100938A (ko) 2011-11-30 2014-08-18 도쿠리츠교세이호진 고쿠리츠간켄큐센터 유도 악성 줄기세포
WO2013130880A1 (en) 2012-02-28 2013-09-06 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
AU2013232545A1 (en) 2012-03-15 2014-09-18 Mayo Foundation For Medical Education And Research Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease
EP2698436A1 (en) * 2012-08-14 2014-02-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Colorectal cancer markers
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
ES2859645T3 (es) * 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
EP3004387A4 (en) 2013-05-31 2017-04-12 Onconova Therapeutics, Inc. Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders
CN106460046A (zh) * 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
US20160010081A1 (en) * 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
US10184154B2 (en) * 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
WO2016160454A1 (en) * 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6877704B2 (ja) * 2015-11-16 2021-05-26 公立大学法人名古屋市立大学 膵臓癌の検出のための方法及びキット
US11078543B2 (en) * 2016-04-14 2021-08-03 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

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