JP2020506680A5 - - Google Patents

Download PDF

Info

Publication number
JP2020506680A5
JP2020506680A5 JP2019537378A JP2019537378A JP2020506680A5 JP 2020506680 A5 JP2020506680 A5 JP 2020506680A5 JP 2019537378 A JP2019537378 A JP 2019537378A JP 2019537378 A JP2019537378 A JP 2019537378A JP 2020506680 A5 JP2020506680 A5 JP 2020506680A5
Authority
JP
Japan
Prior art keywords
methylation
dna
sample
nucleic acid
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019537378A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506680A (ja
JP7289264B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/015535 external-priority patent/WO2018140781A1/en
Publication of JP2020506680A publication Critical patent/JP2020506680A/ja
Publication of JP2020506680A5 publication Critical patent/JP2020506680A5/ja
Priority to JP2022193698A priority Critical patent/JP7670662B2/ja
Application granted granted Critical
Publication of JP7289264B2 publication Critical patent/JP7289264B2/ja
Priority to JP2024224826A priority patent/JP2025041764A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019537378A 2017-01-27 2018-01-26 メチル化dnaの分析による結腸腫瘍の検出 Active JP7289264B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022193698A JP7670662B2 (ja) 2017-01-27 2022-12-02 メチル化dnaの分析による腫瘍の検出
JP2024224826A JP2025041764A (ja) 2017-01-27 2024-12-20 メチル化dnaの分析による腫瘍の検出

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762451327P 2017-01-27 2017-01-27
US62/451,327 2017-01-27
US201862622107P 2018-01-25 2018-01-25
US62/622,107 2018-01-25
PCT/US2018/015535 WO2018140781A1 (en) 2017-01-27 2018-01-26 Detection of colon neoplasia by analysis of methylated dna

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022193698A Division JP7670662B2 (ja) 2017-01-27 2022-12-02 メチル化dnaの分析による腫瘍の検出

Publications (3)

Publication Number Publication Date
JP2020506680A JP2020506680A (ja) 2020-03-05
JP2020506680A5 true JP2020506680A5 (enExample) 2021-03-04
JP7289264B2 JP7289264B2 (ja) 2023-06-09

Family

ID=62978016

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019537378A Active JP7289264B2 (ja) 2017-01-27 2018-01-26 メチル化dnaの分析による結腸腫瘍の検出
JP2022193698A Active JP7670662B2 (ja) 2017-01-27 2022-12-02 メチル化dnaの分析による腫瘍の検出
JP2024224826A Pending JP2025041764A (ja) 2017-01-27 2024-12-20 メチル化dnaの分析による腫瘍の検出

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022193698A Active JP7670662B2 (ja) 2017-01-27 2022-12-02 メチル化dnaの分析による腫瘍の検出
JP2024224826A Pending JP2025041764A (ja) 2017-01-27 2024-12-20 メチル化dnaの分析による腫瘍の検出

Country Status (8)

Country Link
US (3) US11118228B2 (enExample)
EP (1) EP3574110A4 (enExample)
JP (3) JP7289264B2 (enExample)
KR (3) KR102667067B1 (enExample)
CN (2) CN119193824A (enExample)
AU (2) AU2018211956B2 (enExample)
CA (1) CA3049459A1 (enExample)
WO (1) WO2018140781A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
US10301680B2 (en) 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6871926B2 (ja) * 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチMayo Foundation for Medical Education and Research 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
US11345949B2 (en) * 2016-07-19 2022-05-31 Exact Sciences Corporation Methylated control DNA
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
AU2020254760B2 (en) 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
CN109811035A (zh) * 2019-04-11 2019-05-28 中国人民解放军第四军医大学 一种肠道脱落细胞目标基因启动子甲基化检测的方法及试剂盒
US11396679B2 (en) * 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
CN110317874A (zh) * 2019-07-19 2019-10-11 江苏元丞生物科技有限公司 Vav3基因甲基化检测试剂盒及其应用
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN112662765A (zh) * 2020-03-17 2021-04-16 博尔诚(北京)科技有限公司 一种检测6种中国高发癌症的探针组合物
JP7801235B2 (ja) * 2020-03-20 2026-01-16 シングレラ・ヘルス・テクノロジーズ(シャンハイ)・リミテッド 結腸直腸新生物をスクリーニングするための方法およびキット
CN111961721B (zh) * 2020-04-15 2022-06-07 南方医科大学 血浆sfmbt2基因甲基化在结直肠癌中转移预测及动态监测中的应用
AU2021257479A1 (en) * 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
EP4150121A1 (en) 2020-06-30 2023-03-22 Universal Diagnostics, S.A. Systems and methods for detection of multiple cancer types
CN112430657B (zh) * 2020-10-27 2022-09-09 哈尔滨医科大学 结直肠癌相关的甲基化标志物以及用于检测结直肠癌的试剂盒
US11821045B2 (en) 2021-04-13 2023-11-21 Geninus Inc. Colorectal cancer-specific methylation biomarkers for diagnosing colorectal cancer
US20220349009A1 (en) * 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
EP4328325A4 (en) * 2021-04-23 2025-05-21 BGI Genomics Co., Limited Composition, kit, and application for detection of colorectal cancer
CN115433778B (zh) * 2021-06-02 2023-06-16 武汉艾米森生命科技有限公司 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用
WO2023017001A1 (en) * 2021-08-09 2023-02-16 Epigenomics Ag Improved methods for detecting colorectal cancer
JP2025515495A (ja) * 2022-04-27 2025-05-15 エグザクト サイエンシーズ コーポレイション 低バイアス連続マルチプレックス増幅アッセイ
IL293201B2 (en) * 2022-05-22 2023-04-01 Nucleix Ltd Preparations contain a reaction buffer for DNA amplification and sequencing
EP4582552A4 (en) * 2022-09-02 2026-08-19 Bgi Genomics Co Ltd OPLAH GENE DIFFERENTIAL METHYLATION REGION, KIT AND USE
CN119855922A (zh) * 2022-09-02 2025-04-18 深圳华大基因股份有限公司 差异性甲基化区域组合、试剂盒和用途
EP4599087A1 (en) * 2022-10-04 2025-08-13 New Day Diagnostics, LLC Multi-analyte diagnostic and prognostic assays for colorectal cancer and uses thereof
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4735214A (en) 1986-09-05 1988-04-05 Berman Irwin R Gastrointestinal diagnostic capsule and method of use
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
JPH0874B2 (ja) 1990-07-27 1996-01-10 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
AU645915B2 (en) 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
EP0637965B1 (en) 1991-11-26 2002-10-16 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
ES2105698T3 (es) 1993-03-30 1997-10-16 Sanofi Sa Oligonucleotidos modificados con 7-deazapurina.
EP0695306A1 (en) 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
DE69417918T2 (de) 1993-11-30 2000-01-05 Mcgill University, Montreal Dna methyltransferase inhibierung
CA2188660C (en) 1994-04-25 2005-01-18 Richard G. H. Cotton Detection of mutation by resolvase cleavage
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
DE69528670T2 (de) 1994-12-23 2004-03-11 Dade Behring Inc., Deerfield Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
CA2239683A1 (en) 1995-12-22 1997-07-03 Dade Behring Marburg Gmbh Homogeneous amplification and detection of nucleic acids
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US7256020B2 (en) 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6395524B2 (en) 1996-11-27 2002-05-28 University Of Washington Thermostable polymerases having altered fidelity and method of identifying and using same
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
DE69902996T2 (de) 1998-02-04 2003-04-30 Variagenics, Inc. Techniken zu detektion von fehlpaarungen
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
DK1423528T3 (da) 2000-09-01 2008-05-13 Epigenomics Ag Fremgangsmåde til bestemmelse af methyleringsgraden af bestemte cytosiner i genomisk DNA i sekvenskonteksten 5-CPG-3
CA2428798C (en) 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
US20040014067A1 (en) 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
US7482118B2 (en) * 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
CN1650033A (zh) 2002-03-07 2005-08-03 约翰霍普金斯大学医学院 针对与癌症相关的表观遗传学沉默基因的基因组筛选
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
AU2004270220B2 (en) 2003-09-05 2009-03-05 The Chinese University Of Hong Kong Method for non-invasive prenatal diagnosis
EP2088210A3 (en) 2003-10-09 2009-11-18 Epigenomics AG Improved bisulfite conversion of DNA
AU2004282593B8 (en) 2003-10-16 2008-08-28 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
WO2005042713A2 (en) * 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
AU2005200670B2 (en) 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
EP1727911B1 (en) 2004-03-26 2013-01-23 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
JP2008502890A (ja) 2004-06-18 2008-01-31 エフ.ホフマン−ラ ロシュ アーゲー 結腸直腸癌のマーカーとしてのcbp2の使用
US20070048748A1 (en) 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
JP2008518610A (ja) 2004-11-03 2008-06-05 アルマック ダイアグノスティックス リミテッド トランスクリプトームマイクロアレイ技法およびそれを使用する方法
EP1812604A4 (en) 2004-11-03 2011-02-23 Third Wave Tech Inc DETECTION ASSAY IN ONE STEP
EP2857523A1 (en) 2005-02-01 2015-04-08 Applied Biosystems, LLC Method for identifying a sequence in a polynucleotide
WO2006084078A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
ATE547537T1 (de) 2005-04-15 2012-03-15 Epigenomics Ag Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben
JP2009506759A (ja) 2005-09-01 2009-02-19 コーベット ライフ サイエンス ピーティーワイ リミテッド 核酸の増幅、定量化、及び同定の方法。
WO2007092473A2 (en) 2006-02-02 2007-08-16 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
AU2007237909A1 (en) 2006-04-19 2007-10-25 Applied Biosystems, Llc. Reagents, methods, and libraries for gel-free bead-based sequencing
WO2009035447A1 (en) 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090203011A1 (en) 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
WO2008100913A2 (en) 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
WO2008103761A2 (en) * 2007-02-20 2008-08-28 Sequenom, Inc. Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
KR101509049B1 (ko) 2007-04-16 2015-04-06 한국생명공학연구원 위암 특이적 유전자의 조기 탐지를 위한 메틸화 바이오마커
DK3101141T3 (da) 2007-06-08 2020-02-03 Epigenomics Ag Fremgangsmåde til methyleringsanalyse
AU2008285557B2 (en) 2007-07-19 2014-07-03 Biomerieux Method for the assay of liver fatty acid-binding protein, ACE and CA19-9 for the in vitro diagnosis of colorectal cancer
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8256177B2 (en) 2008-03-12 2012-09-04 Masonite Corporation Impact resistant door skin, door including the same, and method of manufacturing an impact resistant door skin from a pre-formed door skin
BRPI0908748A2 (pt) 2008-03-15 2015-07-28 Hologic Inc Composições e métodos para análise de moléculas de ácido nucleico durante reações de amplificação
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
US20110318738A1 (en) 2008-12-23 2011-12-29 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
WO2010089538A2 (en) 2009-02-03 2010-08-12 Oncomethylome Sciences Sa Methods of detecting colorectal cancer
GB0920014D0 (en) 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
EP4350001A3 (en) 2009-11-23 2024-06-19 Genomic Health, Inc. Methods to predict clinical outcome of cancer
EP2553463B1 (en) 2010-03-26 2017-05-03 Hongzhi Zou Methods and materials for detecting colorectal neoplasm
WO2011139920A2 (en) 2010-04-29 2011-11-10 Life Technologies Corporation Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr)
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
EP3441479B1 (en) 2011-02-02 2020-09-02 Exact Sciences Development Company, LLC Digital sequence analysis of dna methylation
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
WO2013058868A2 (en) 2011-10-18 2013-04-25 Exact Sciences Corporation Multiplexed kras mutation detection assay
WO2013070950A1 (en) 2011-11-08 2013-05-16 University Of Southern California Identification of a dna methylation marker for blood-based detection of ovarian cancer
US9546403B1 (en) 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
AU2013207385B2 (en) 2012-01-06 2018-09-13 Exact Sciences Corporation System and method of detecting RNAs altered by cancer in peripheral blood
CA3111723C (en) 2012-01-30 2026-05-19 Exact Sciences Corporation Sulfonated small dna compositions and methods for sulfonating and desulfonating small dnas
EP2828405B1 (en) 2012-03-20 2017-06-28 Exact Sciences Corporation Marker panel for detecting cancer
PL2893040T3 (pl) 2012-09-04 2019-05-31 Guardant Health Inc Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014062218A1 (en) * 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
WO2014082067A1 (en) 2012-11-26 2014-05-30 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
EP2971179B1 (en) * 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
WO2015095689A1 (en) 2013-12-19 2015-06-25 Exact Sciences Corporation Synthetic nucleic acid control molecules
US10301680B2 (en) * 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US20160010081A1 (en) 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
US10292687B2 (en) 2014-08-15 2019-05-21 Covidien Lp Designs and methods to facilitate swallowing of a tethered cell collection device
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN113897432A (zh) * 2014-12-12 2022-01-07 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2016094813A1 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
EP3239302A4 (en) 2014-12-26 2018-05-23 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
US10030272B2 (en) * 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチMayo Foundation for Medical Education and Research 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
SI3408407T1 (sl) 2016-01-29 2021-04-30 Epigenomics Ag Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
CN109153993B (zh) 2016-04-14 2023-02-17 梅约医学教育与研究基金会 检测胰腺高度异型增生
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
AU2017260630B2 (en) * 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
RU2018145532A (ru) 2016-06-21 2020-07-23 Зе Уистар Инститьют Оф Анатоми Энд Байолоджи Композиции и способы диагностирования раковых заболеваний легких с помощью профилей экспрессии генов
US11345949B2 (en) 2016-07-19 2022-05-31 Exact Sciences Corporation Methylated control DNA
US20180066320A1 (en) 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
US10934592B2 (en) 2017-02-28 2021-03-02 Mayo Foundation For Medical Education And Research Detecting prostate cancer
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
MX2021005963A (es) 2018-11-27 2021-08-24 Exact Sciences Dev Co Llc Caracterizacion de adn metilado, arn y proteinas en la deteccion de neoplasia pulmonar.
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
AU2020254760B2 (en) 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
WO2021041726A1 (en) 2019-08-27 2021-03-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
EP4031683A4 (en) 2019-09-16 2024-01-17 Exact Sciences Corporation Structure and temperature-dependent flap endonuclease substrates
KR20220092877A (ko) 2019-10-18 2022-07-04 이그잭트 사이언시즈 코포레이션 다중 분석물 분변 항원 검사
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
AU2021257479A1 (en) 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
CA3172143A1 (en) 2020-05-04 2021-11-11 David A. Ahlquist Detecting pancreatic neuroendocrine tumors
EP4146677A4 (en) 2020-05-04 2025-01-15 Mayo Foundation for Medical Education and Research Detecting melanoma
WO2022040306A1 (en) 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
EP4284951A4 (en) 2021-01-29 2025-05-28 Mayo Foundation for Medical Education and Research DETECTION OF THE PRESENCE OR ABSENCE OF MULTIPLE CANCERS
US20240052425A1 (en) 2021-03-05 2024-02-15 Mayo Foundation For Medical Education And Research Detecting cervical cancer
US20220349009A1 (en) 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
KR20240113625A (ko) 2021-11-05 2024-07-22 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 구인두암을 검출하기 위한 조성물 및 방법

Similar Documents

Publication Publication Date Title
JP2025041764A5 (enExample)
JP2023025184A5 (ja) メチル化dnaの分析による腫瘍の検出
JP2024123233A5 (enExample)
EP2417270B1 (en) Digital quantification of dna methylation
JP2022513658A5 (enExample)
CN100354298C (zh) 使用单核苷酸多态性组分析受损样品的方法和组合物
AU2020243694A1 (en) Methods and systems for detecting methylation changes in DNA samples
US20100240549A1 (en) Specific amplification of tumor specific dna sequences
Trouchet et al. Digital PCR: from early developments to its future application in clinics
JP2022553575A5 (enExample)
KR102223014B1 (ko) 전암병변의 검출방법
US20180143198A1 (en) Method for detecting differentially methylated cpg islands associated with abnormal state of human body
JP2008506407A5 (enExample)
JP2022526415A5 (enExample)
JP2019520037A5 (enExample)
JP2014519310A5 (enExample)
US7425415B2 (en) Method for detecting methylated CpG islands
CN103703173A (zh) Dna甲基化的数字序列分析
US20160355885A1 (en) Gene methylation based colorectal cancer diagnosis
US20140045180A1 (en) Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis
JP2018528780A (ja) 短いホモポリマー反復の改良された検出
KR20100105770A (ko) 전립선암에서 gstp1 과메틸화의 검출
Zhang et al. On-chip oligonucleotide ligation assay using one-dimensional microfluidic beads array for the detection of low-abundant DNA point mutations
JP5258760B2 (ja) メチル化核酸又は非メチル化核酸を増幅する方法
KR101683086B1 (ko) 유전자의 발현량 및 메틸화 프로필을 활용한 돼지의 산자수 예측방법