KR102892245B1 - 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 - Google Patents

메틸화된 dna 분석에 의한 결장 신조직형성의 검출

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Publication number
KR102892245B1
KR102892245B1 KR1020247015939A KR20247015939A KR102892245B1 KR 102892245 B1 KR102892245 B1 KR 102892245B1 KR 1020247015939 A KR1020247015939 A KR 1020247015939A KR 20247015939 A KR20247015939 A KR 20247015939A KR 102892245 B1 KR102892245 B1 KR 102892245B1
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dna
delete delete
methylation
sample
marker
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KR20240074896A (ko
Inventor
하팀 티. 알라위
마이클 더블유. 카이저
그레이엄 피. 리드가드
윌리엄 알. 테일러
타마라 제이. 샌더
아브람 엠. 바카로
Original Assignee
이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치
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KR1020247015939A 2017-01-27 2018-01-26 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 Active KR102892245B1 (ko)

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KR1020257039385A KR20250171455A (ko) 2017-01-27 2018-01-26 메틸화된 dna 분석에 의한 결장 신조직형성의 검출

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US201762451327P 2017-01-27 2017-01-27
US62/451,327 2017-01-27
US201862622107P 2018-01-25 2018-01-25
US62/622,107 2018-01-25
PCT/US2018/015535 WO2018140781A1 (en) 2017-01-27 2018-01-26 Detection of colon neoplasia by analysis of methylated dna
KR1020197021786A KR102667067B1 (ko) 2017-01-27 2018-01-26 메틸화된 dna 분석에 의한 결장 신조직형성의 검출

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KR102892245B1 true KR102892245B1 (ko) 2025-11-27

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KR1020247015939A Active KR102892245B1 (ko) 2017-01-27 2018-01-26 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
KR1020197021786A Active KR102667067B1 (ko) 2017-01-27 2018-01-26 메틸화된 dna 분석에 의한 결장 신조직형성의 검출

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US (3) US11118228B2 (enExample)
EP (1) EP3574110A4 (enExample)
JP (3) JP7289264B2 (enExample)
KR (3) KR20250171455A (enExample)
CN (2) CN119193824A (enExample)
AU (2) AU2018211956B2 (enExample)
CA (1) CA3049459A1 (enExample)
WO (1) WO2018140781A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2522542T3 (es) 2008-02-15 2014-11-17 Mayo Foundation For Medical Education And Research Detección de neoplasia a partir de una muestra de heces
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US10301680B2 (en) 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
KR20250172724A (ko) * 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
US10704081B2 (en) 2015-10-30 2020-07-07 Exact Sciences Development Company, Llc Multiplex amplification detection assay
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
EP3452616A4 (en) 2016-05-05 2020-01-22 Exact Sciences Development Company, LLC DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA
AU2017299597B2 (en) 2016-07-19 2023-08-24 Exact Sciences Corporation Methylated control DNA
CN109642227B (zh) * 2016-07-19 2023-02-28 精密科学发展有限责任公司 来自非人类生物体的核酸对照分子
WO2018140781A1 (en) 2017-01-27 2018-08-02 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated dna
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
EP3948292A4 (en) * 2019-04-03 2023-01-18 Mayo Foundation for Medical Education and Research DETECTION OF DUCTAL PANCREATIC CARCINOMA IN PLASMA
CN109811035A (zh) * 2019-04-11 2019-05-28 中国人民解放军第四军医大学 一种肠道脱落细胞目标基因启动子甲基化检测的方法及试剂盒
US11396679B2 (en) * 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
CN110317874A (zh) * 2019-07-19 2019-10-11 江苏元丞生物科技有限公司 Vav3基因甲基化检测试剂盒及其应用
JP2022553575A (ja) 2019-10-31 2022-12-23 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN112662765A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测6种中国高发癌症的探针组合物
IL296453A (en) * 2020-03-20 2022-11-01 Singlera Health Tech Shanghai Ltd Methods and kits for screening tumors of the large intestine
CN111961721B (zh) * 2020-04-15 2022-06-07 南方医科大学 血浆sfmbt2基因甲基化在结直肠癌中转移预测及动态监测中的应用
AU2021257479A1 (en) * 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
US11530453B2 (en) 2020-06-30 2022-12-20 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
CN112430657B (zh) * 2020-10-27 2022-09-09 哈尔滨医科大学 结直肠癌相关的甲基化标志物以及用于检测结直肠癌的试剂盒
US11821045B2 (en) 2021-04-13 2023-11-21 Geninus Inc. Colorectal cancer-specific methylation biomarkers for diagnosing colorectal cancer
US20220349009A1 (en) * 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
AU2021442220B2 (en) * 2021-04-23 2025-10-16 Bgi Genomics Co., Ltd. Composition, kit, and application for detection of colorectal cancer
CN115433778B (zh) * 2021-06-02 2023-06-16 武汉艾米森生命科技有限公司 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用
WO2023017001A1 (en) * 2021-08-09 2023-02-16 Epigenomics Ag Improved methods for detecting colorectal cancer
IL293201B2 (en) * 2022-05-22 2023-04-01 Nucleix Ltd Preparations contain a reaction buffer for DNA amplification and sequencing
WO2024045160A1 (zh) * 2022-09-02 2024-03-07 深圳华大基因股份有限公司 Oplah基因的差异性甲基化区域、试剂盒和用途
WO2024045170A1 (zh) * 2022-09-02 2024-03-07 深圳华大基因股份有限公司 差异性甲基化区域组合、试剂盒和用途
WO2024075020A1 (en) * 2022-10-04 2024-04-11 Epigenomics Ag Multi-analyte diagnostic and prognostic assays for colorectal cancer and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153283A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
WO2016094839A2 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4735214A (en) 1986-09-05 1988-04-05 Berman Irwin R Gastrointestinal diagnostic capsule and method of use
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5614617A (en) 1990-07-27 1997-03-25 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
CA2074214C (en) 1991-07-23 2000-02-22 Will Bloch Improvements in the in situ pcr
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
JP3739785B2 (ja) 1991-11-26 2006-01-25 アイシス ファーマシューティカルズ，インコーポレイティド 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形
US5856097A (en) 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
HU9501963D0 (en) 1993-03-30 1995-08-28 Sterling Winthrop Inc 7-deazapurine modified oligonucleotides
EP0695306A1 (en) 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
AU1061395A (en) 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
AU693198B2 (en) 1994-04-25 1998-06-25 Avitech Diagnostics, Inc. Detection of mutation by resolvase cleavage
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
EP1260593A3 (en) 1994-12-23 2003-12-03 Dade Behring Inc. Detection of nucleic acids by nuclease-catalyzed product formation
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
CA2239683A1 (en) 1995-12-22 1997-07-03 Dade Behring Marburg Gmbh Homogeneous amplification and detection of nucleic acids
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US7256020B2 (en) 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
JP3898228B2 (ja) 1996-04-12 2007-03-28 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 検出プローブ、キット及びアッセイ
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998023733A2 (en) 1996-11-27 1998-06-04 University Of Washington Thermostable polymerases having altered fidelity
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
WO1999040222A1 (en) 1998-02-04 1999-08-12 Variagenics, Inc. Mismatch detection techniques
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
DK1423528T3 (da) * 2000-09-01 2008-05-13 Epigenomics Ag Fremgangsmåde til bestemmelse af methyleringsgraden af bestemte cytosiner i genomisk DNA i sekvenskonteksten 5-CPG-3
WO2002070755A2 (en) 2000-11-15 2002-09-12 Third Wave Technologies, Inc. Fen endonucleases
US20040014067A1 (en) 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
US7482118B2 (en) * 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med GENOMIC SCREEN ON EPIGENETIC MUTED CANCER ASSOCIATED GENES
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
EP2194147B1 (en) 2002-12-04 2015-07-22 Applied Biosystems, LLC Multiplex amplification of polynucleotides
US20060147955A1 (en) 2004-11-03 2006-07-06 Third Wave Technologies, Inc. Single step detection assay
WO2005023091A2 (en) 2003-09-05 2005-03-17 The Trustees Of Boston University Method for non-invasive prenatal diagnosis
EP2292797B1 (en) 2003-10-09 2013-07-24 Epigenomics AG Improved bisulfite conversion of DNA
US20050186588A1 (en) 2003-10-16 2005-08-25 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
EP1692264A2 (en) * 2003-10-28 2006-08-23 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
AU2005200670B2 (en) 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
AU2005230936B2 (en) 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
CA2565405A1 (en) 2004-06-18 2005-12-29 F. Hoffmann-La Roche Ag Use of protein cbp2 as a marker for colorectal cancer
US20070048748A1 (en) 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
WO2006048291A2 (en) 2004-11-03 2006-05-11 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
US20080003571A1 (en) 2005-02-01 2008-01-03 Mckernan Kevin Reagents, methods, and libraries for bead-based sequencing
US20060171952A1 (en) 2005-02-02 2006-08-03 Mather Jennie P JAM-3 and antibodies that bind thereto
ES2313143T3 (es) 2005-04-06 2009-03-01 Maurice Stroun Metodo para el diagnostico de cancer mediante la deteccion de adn y arn circulantes.
SI1871912T1 (sl) 2005-04-15 2012-06-29 Epigenomics Ag Postopek za določitev DNA metilacije v vzorcih krvi ali urina
EP1937834B1 (en) 2005-09-01 2014-06-11 AusDiagnostics Pty Ltd. Methods for the amplification, quantitation and identification of nucleic acids
EP2423334A3 (en) 2006-02-02 2012-04-18 The Board of Trustees of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
US20080026390A1 (en) 2006-06-14 2008-01-31 Roland Stoughton Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090203011A1 (en) 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
JP2010517582A (ja) * 2007-02-12 2010-05-27 ザ・ジョンズ・ホプキンス・ユニバーシティー 結腸癌の早期検出および予後診断の方法
WO2008103763A2 (en) * 2007-02-20 2008-08-28 Sequenom, Inc. Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
WO2009034481A2 (en) 2007-04-16 2009-03-19 Korea Research Institute Of Bioscience And Biotechnology Methylation biomarker for early detection of gastric cancer
US8623599B2 (en) 2007-06-08 2014-01-07 Epigenomics Ag Method for methylation analysis
AU2008285557B2 (en) 2007-07-19 2014-07-03 Biomerieux Method for the assay of liver fatty acid-binding protein, ACE and CA19-9 for the in vitro diagnosis of colorectal cancer
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
ES2522542T3 (es) 2008-02-15 2014-11-17 Mayo Foundation For Medical Education And Research Detección de neoplasia a partir de una muestra de heces
US8256177B2 (en) 2008-03-12 2012-09-04 Masonite Corporation Impact resistant door skin, door including the same, and method of manufacturing an impact resistant door skin from a pre-formed door skin
KR101419980B1 (ko) 2008-03-15 2014-07-15 홀로직, 인크. 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
WO2010074924A1 (en) 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
DK2394170T3 (en) 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
US20110287424A1 (en) 2009-03-27 2011-11-24 Life Technologies Corporation Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr)
GB0920014D0 (en) 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
ES2735993T3 (es) 2009-11-23 2019-12-23 Genomic Health Inc Métodos para predecir el resultado clínico del cáncer
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) * 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
CN110129436A (zh) 2011-02-02 2019-08-16 精密科学公司 Dna甲基化的数字序列分析
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
AU2012253345B2 (en) 2011-05-12 2016-10-20 Exact Sciences Corporation Isolation of nucleic acids
WO2013058868A2 (en) 2011-10-18 2013-04-25 Exact Sciences Corporation Multiplexed kras mutation detection assay
WO2013070950A1 (en) 2011-11-08 2013-05-16 University Of Southern California Identification of a dna methylation marker for blood-based detection of ovarian cancer
US9546403B1 (en) 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
JP2015503356A (ja) 2012-01-06 2015-02-02 バイオミクス, インコーポレイテッドViomics, Inc. 末梢血中で、がんによって変化したｒｎａを検出するシステムおよび方法
CA2863215C (en) 2012-01-30 2021-05-04 Exact Sciences Corporation Modification of dna on magnetic beads
EP2828405B1 (en) 2012-03-20 2017-06-28 Exact Sciences Corporation Marker panel for detecting cancer
ES2769241T5 (es) 2012-09-04 2023-05-30 Guardant Health Inc Sistemas y métodos para detectar variación en el número de copias
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
WO2014062218A1 (en) * 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
WO2014082067A1 (en) 2012-11-26 2014-05-30 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
US9994911B2 (en) 2013-03-14 2018-06-12 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
EP3084004A4 (en) 2013-12-19 2017-08-16 Exact Sciences Corporation Synthetic nucleic acid control molecules
US20160010081A1 (en) 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
US10292687B2 (en) 2014-08-15 2019-05-21 Covidien Lp Designs and methods to facilitate swallowing of a tethered cell collection device
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3889611A1 (en) 2014-12-12 2021-10-06 Exact Sciences Development Company, LLC Compositions and methods for performing methylation detection assays
US20180143198A1 (en) 2014-12-26 2018-05-24 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
US10030272B2 (en) * 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
KR20250172724A (ko) 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
US10704081B2 (en) 2015-10-30 2020-07-07 Exact Sciences Development Company, Llc Multiplex amplification detection assay
DK3408407T3 (da) * 2016-01-29 2021-02-08 Epigenomics Ag Fremgangsmåder til påvisning af cpg-methylering af tumorafledt dna i blodprøver
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
US20190085406A1 (en) 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer
EP3452616A4 (en) 2016-05-05 2020-01-22 Exact Sciences Development Company, LLC DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
EP3472361A4 (en) 2016-06-21 2020-02-19 The Wistar Institute Of Anatomy And Biology COMPOSITIONS AND METHODS FOR DIAGNOSING LUNG CANCER USING GENE EXPRESSION PROFILES
AU2017299597B2 (en) 2016-07-19 2023-08-24 Exact Sciences Corporation Methylated control DNA
KR102648965B1 (ko) 2016-09-02 2024-03-18 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 간세포 암종 검출
WO2018140781A1 (en) 2017-01-27 2018-08-02 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated dna
KR102747156B1 (ko) 2017-02-28 2024-12-26 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 전립선 암의 검출
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
MX2021005963A (es) 2018-11-27 2021-08-24 Exact Sciences Dev Co Llc Caracterizacion de adn metilado, arn y proteinas en la deteccion de neoplasia pulmonar.
AU2020211461A1 (en) 2019-01-24 2021-08-19 Exact Sciences Corporation Detecting endometrial cancer
EP3948292A4 (en) 2019-04-03 2023-01-18 Mayo Foundation for Medical Education and Research DETECTION OF DUCTAL PANCREATIC CARCINOMA IN PLASMA
US20220403471A1 (en) 2019-08-27 2022-12-22 Exact Sciences Corporation Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
US20230046033A1 (en) 2019-09-16 2023-02-16 Exact Sciences Corporation Structure and temperature-dependent flap endonuclease substrates
CN115038968A (zh) 2019-10-18 2022-09-09 精密科学公司 多种分析物粪便抗原测试
JP2022553575A (ja) 2019-10-31 2022-12-23 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
AU2021257479A1 (en) 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
CN115551880A (zh) 2020-05-04 2022-12-30 梅约医学教育与研究基金会 检测胰腺神经内分泌肿瘤
EP4146677A4 (en) 2020-05-04 2025-01-15 Mayo Foundation for Medical Education and Research Detecting melanoma
EP4200445A4 (en) 2020-08-19 2025-08-27 Mayo Found Medical Education & Res DETECTION OF NON-HODGKIN'S LYMPHOMA
EP4284951A4 (en) 2021-01-29 2025-05-28 Mayo Foundation for Medical Education and Research DETECTION OF THE PRESENCE OR ABSENCE OF MULTIPLE CANCERS
KR20230154433A (ko) 2021-03-05 2023-11-08 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 자궁경부암의 검출
US20220349009A1 (en) 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
WO2023081796A1 (en) 2021-11-05 2023-05-11 Mayo Foundation For Medical Education And Research Compositions and methods for detecting oropharyngeal cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015153283A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
WO2016094839A2 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Genome Biol, 16(1): 17 (2015.01.29.)
PLoS One, 7(9): e46000 (2012.09.25.)

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