JP2008506407A5 - - Google Patents
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- JP2008506407A5 JP2008506407A5 JP2007521881A JP2007521881A JP2008506407A5 JP 2008506407 A5 JP2008506407 A5 JP 2008506407A5 JP 2007521881 A JP2007521881 A JP 2007521881A JP 2007521881 A JP2007521881 A JP 2007521881A JP 2008506407 A5 JP2008506407 A5 JP 2008506407A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- detecting
- group
- distinguishing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 210000000481 breast Anatomy 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 5
- 230000011987 methylation Effects 0.000 claims 5
- 238000007069 methylation reaction Methods 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- 108091029430 CpG site Proteins 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016926 | 2004-07-18 | ||
| PCT/EP2005/007830 WO2006008128A2 (en) | 2004-07-18 | 2005-07-18 | Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008506407A JP2008506407A (ja) | 2008-03-06 |
| JP2008506407A5 true JP2008506407A5 (enExample) | 2008-09-25 |
Family
ID=35462310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521881A Pending JP2008506407A (ja) | 2004-07-18 | 2005-07-18 | 乳房細胞増殖性疾患を検出するためのエピジェネティックな方法および核酸 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090298054A1 (enExample) |
| EP (4) | EP1961827A3 (enExample) |
| JP (1) | JP2008506407A (enExample) |
| WO (1) | WO2006008128A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130021400A (ko) | 2005-04-15 | 2013-03-05 | 에피제노믹스 아게 | 세포 증식 질환을 분석하기 위한 방법 및 핵산 |
| JP2007267700A (ja) * | 2006-03-31 | 2007-10-18 | Kochi Univ | Ｈｏｘｂ１３遺伝子のメチル化を指標とする腎細胞癌を含む悪性腫瘍の判定方法 |
| EP2484778A3 (en) * | 2006-04-17 | 2012-10-10 | Epigenomics AG | Methods and nucleic acids for the detection of colorectal cell proliferative disorders |
| US20090317810A1 (en) * | 2006-04-17 | 2009-12-24 | Epigenomics Ag | Methods and nucleic acids for the detection of colorectal cell proliferative disorders |
| ES2599816T3 (es) * | 2006-07-21 | 2017-02-03 | Epigenomics Ag | Métodos relacionados con el gen GLI3 para la detección de cáncer colorrectal |
| US9939441B2 (en) * | 2006-07-21 | 2018-04-10 | Epigenomics Ag | Methods and nucleic acids for analyses for cellular proliferative disorders |
| AU2008207110B2 (en) * | 2007-01-19 | 2013-10-17 | Epigenomics Ag | Methods and nucleic acids for analyses of cell proliferative disorders |
| US9096849B2 (en) * | 2007-05-21 | 2015-08-04 | The United States Of America, As Represented By The Secretary Of The Navy | Solid phase for capture of nucleic acids |
| WO2009037635A2 (en) * | 2007-09-17 | 2009-03-26 | Koninklijke Philips Electronics N. V. | Method for the analysis of breast cancer disorders |
| CA2708163A1 (en) * | 2007-12-11 | 2009-06-18 | Epigenomics Ag | Methods and nucleic acids for analyses of cell proliferative disorders |
| WO2009074364A1 (en) * | 2007-12-13 | 2009-06-18 | Edgar Dahl | Novel prognostic breast cancer marker |
| CA2718092C (en) | 2008-03-21 | 2019-03-19 | Oncomethylome Sciences S.A. | Detection and prognosis of cervical cancer |
| JP2009247260A (ja) * | 2008-04-04 | 2009-10-29 | Sumitomo Chemical Co Ltd | Ｄｎａメチル化測定方法 |
| US20100112643A1 (en) * | 2008-11-04 | 2010-05-06 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Method for direct capture of ribonucleic acid |
| KR20110113642A (ko) * | 2009-01-30 | 2011-10-17 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 유방 종양의 하위분류 방법 |
| EP2428584A4 (en) * | 2009-04-03 | 2012-10-10 | A & T Corp | COLORECTAL TUMOR DETECTION METHOD |
| WO2010118782A1 (en) * | 2009-04-17 | 2010-10-21 | Universite Libre De Bruxelles | Methods and tools for predicting the efficiency of anthracyclines in cancer |
| WO2011002024A1 (ja) * | 2009-06-30 | 2011-01-06 | シスメックス株式会社 | 生体試料中の上皮性癌由来の細胞の存否を判定するための方法、分子マーカー及びキット |
| GB201000688D0 (en) * | 2010-01-15 | 2010-03-03 | Diagenic Asa | Product and method |
| JPWO2011105570A1 (ja) | 2010-02-26 | 2013-06-20 | シスメックス株式会社 | 生体試料中の癌細胞の存否を判定する方法、判定用分子マーカーおよびキット |
| JP5636611B2 (ja) * | 2010-02-26 | 2014-12-10 | 株式会社明治 | 消化管癌に対する発癌リスク抑制効果の評価方法 |
| US9410188B2 (en) * | 2010-05-28 | 2016-08-09 | Biomerieux | Method and kit for discriminating between breast cancer and benign breast disease |
| EP2505665A1 (en) * | 2011-03-31 | 2012-10-03 | Queen Mary And Westfield College, University Of London | Cancer markers |
| US20130309667A1 (en) * | 2012-05-15 | 2013-11-21 | Anthony P. Shuber | Primers for analyzing methylated sequences and methods of use thereof |
| CA2876393A1 (en) | 2012-06-13 | 2013-12-19 | King Abdullah University Of Science And Technology | Methylation biomarkers for breast cancer |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CN105473742A (zh) | 2013-06-24 | 2016-04-06 | 米尔纳疗法公司 | miR-34活性的生物标志物 |
| PL3029150T3 (pl) * | 2014-12-05 | 2019-03-29 | Epiontis Gmbh | Epigenetyczny sposób identyfikacji folikularnych pomocniczych limfocytów T (TFH) |
| JP2017090103A (ja) * | 2015-11-05 | 2017-05-25 | 和光純薬工業株式会社 | 非浸潤性乳癌の判定法 |
| JP2017090102A (ja) * | 2015-11-05 | 2017-05-25 | 和光純薬工業株式会社 | 浸潤性乳癌の判定法 |
| EP3481296A1 (en) | 2016-07-08 | 2019-05-15 | Ontolead, Inc. | Relationship analysis utilizing biofeedback information |
| CN110225984A (zh) * | 2016-09-07 | 2019-09-10 | 科技研究局 | 鉴别癌症风险的方法和治疗选择 |
| CN107267597A (zh) * | 2017-03-10 | 2017-10-20 | 王建华 | Hic1在肿瘤诊断、治疗、预后和预测复发中的应用 |
| WO2019005722A1 (en) * | 2017-06-26 | 2019-01-03 | The Research Foundation For The State University Of New York | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIA FOR VIRTUAL PANCREATOGRAPHY |
| JP7072825B2 (ja) * | 2017-09-13 | 2022-05-23 | 三菱電機ソフトウエア株式会社 | コピー数計測装置、コピー数計測プログラムおよびコピー数計測方法 |
| EP3828289A4 (en) * | 2018-07-26 | 2022-06-08 | Excellen Medical Technology Co., Ltd. | METHOD AND KIT FOR IDENTIFYING A GASTRONIC CANCER CONDITION |
| CN112585282A (zh) * | 2018-07-26 | 2021-03-30 | 北京艾克伦医疗科技有限公司 | 鉴定乳腺癌状态的方法和试剂盒 |
| CN110055330B (zh) * | 2019-04-30 | 2022-10-11 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物stamp-ep9及其应用 |
| WO2020252721A1 (en) * | 2019-06-20 | 2020-12-24 | The Johns Hopkins University | Dna methylation markers and their use in differentiation of suspected cancerous lymph node biopsy samples |
| KR102637032B1 (ko) * | 2020-01-28 | 2024-02-15 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도 |
| WO2025212993A1 (en) * | 2024-04-05 | 2025-10-09 | Encoded Therapeutics, Inc. | Materials and methods for trangene expression in neural cells |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5245022A (en) | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
| US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| DE69417918T2 (de) | 1993-11-30 | 2000-01-05 | Mcgill University, Montreal | Dna methyltransferase inhibierung |
| US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US5514758A (en) | 1994-09-30 | 1996-05-07 | The Goodyear Tire & Rubber Company | Process for making latex for high performance masking tape |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6251594B1 (en) | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US5958773A (en) | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US6331393B1 (en) | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| WO2002002806A2 (en) * | 2000-06-30 | 2002-01-10 | Epigenomics Ag | Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics |
| DK1423528T3 (da) * | 2000-09-01 | 2008-05-13 | Epigenomics Ag | Fremgangsmåde til bestemmelse af methyleringsgraden af bestemte cytosiner i genomisk DNA i sekvenskonteksten 5-CPG-3 |
| DE10112515B4 (de) | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| EP1540014A2 (en) * | 2002-08-27 | 2005-06-15 | Epigenomics AG | Method and nucleic acids for the analysis of breast cell proliferative disorders |
| EP1692316A2 (en) * | 2003-12-11 | 2006-08-23 | Epigenomics AG | Method and nucleic acids for the improved treatment of breast cell proliferative disorders |
-
2005
- 2005-07-18 EP EP08009974A patent/EP1961827A3/en not_active Withdrawn
- 2005-07-18 JP JP2007521881A patent/JP2008506407A/ja active Pending
- 2005-07-18 US US11/632,824 patent/US20090298054A1/en not_active Abandoned
- 2005-07-18 EP EP10174924A patent/EP2302073A1/en not_active Withdrawn
- 2005-07-18 EP EP10174950A patent/EP2281902A1/en not_active Withdrawn
- 2005-07-18 WO PCT/EP2005/007830 patent/WO2006008128A2/en not_active Ceased
- 2005-07-18 EP EP05768093A patent/EP1769086A2/en not_active Withdrawn
-
2011
- 2011-02-10 US US13/025,099 patent/US20110269126A1/en not_active Abandoned
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