JP2009533066A5 - - Google Patents

Info

Publication number

JP2009533066A5

JP2009533066A5 JP2009505769A JP2009505769A JP2009533066A5 JP 2009533066 A5 JP2009533066 A5 JP 2009533066A5 JP 2009505769 A JP2009505769 A JP 2009505769A JP 2009505769 A JP2009505769 A JP 2009505769A JP 2009533066 A5 JP2009533066 A5 JP 2009533066A5

Authority

JP

Japan

Prior art keywords

seq

nucleic acid

sequence

cell proliferative

group

Prior art date

2007-04-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 29
• 210000004027 cell Anatomy 0.000 claims 17
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
• 108020004707 nucleic acids Proteins 0.000 claims 15
• 102000039446 nucleic acids Human genes 0.000 claims 15
• 150000007523 nucleic acids Chemical class 0.000 claims 15
• 230000002062 proliferating effect Effects 0.000 claims 15
• 230000000295 complement effect Effects 0.000 claims 12
• 230000003321 amplification Effects 0.000 claims 11
• 238000003199 nucleic acid amplification method Methods 0.000 claims 11
• 230000011987 methylation Effects 0.000 claims 10
• 238000007069 methylation reaction Methods 0.000 claims 10
• 108020004414 DNA Proteins 0.000 claims 9
• 239000012472 biological sample Substances 0.000 claims 9
• 239000003153 chemical reaction reagent Substances 0.000 claims 9
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 9
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
• 239000002773 nucleotide Substances 0.000 claims 7
• 125000003729 nucleotide group Chemical group 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 108091034117 Oligonucleotide Proteins 0.000 claims 6
• 108091093037 Peptide nucleic acid Proteins 0.000 claims 6
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 6
• 238000009396 hybridization Methods 0.000 claims 6
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 4
• 108091029430 CpG site Proteins 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 102000004190 Enzymes Human genes 0.000 claims 3
• 108090000790 Enzymes Proteins 0.000 claims 3
• 102000012060 Septin 9 Human genes 0.000 claims 3
• 108050002584 Septin 9 Proteins 0.000 claims 3
• 229940104302 cytosine Drugs 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 229940035893 uracil Drugs 0.000 claims 3
• 102100033798 Homeobox protein aristaless-like 4 Human genes 0.000 claims 2
• 101000779608 Homo sapiens Homeobox protein aristaless-like 4 Proteins 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• 238000003018 immunoassay Methods 0.000 claims 2
• 230000003211 malignant effect Effects 0.000 claims 2
• 238000003752 polymerase chain reaction Methods 0.000 claims 2
• 108091008146 restriction endonucleases Proteins 0.000 claims 2
• 101150054887 ALX4 gene Proteins 0.000 claims 1
• 108010076804 DNA Restriction Enzymes Proteins 0.000 claims 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
• 238000002965 ELISA Methods 0.000 claims 1
• 108060002716 Exonuclease Proteins 0.000 claims 1
• 238000001574 biopsy Methods 0.000 claims 1
• 210000000601 blood cell Anatomy 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 230000000112 colonic effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000001976 enzyme digestion Methods 0.000 claims 1
• 102000013165 exonuclease Human genes 0.000 claims 1
• 210000003608 fece Anatomy 0.000 claims 1
• -1 isolated blood cell Substances 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 238000003127 radioimmunoassay Methods 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 238000012163 sequencing technique Methods 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 239000007790 solid phase Substances 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 238000001262 western blot Methods 0.000 claims 1