JP2018515490A5 - - Google Patents
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- JP2018515490A5 JP2018515490A5 JP2017557329A JP2017557329A JP2018515490A5 JP 2018515490 A5 JP2018515490 A5 JP 2018515490A5 JP 2017557329 A JP2017557329 A JP 2017557329A JP 2017557329 A JP2017557329 A JP 2017557329A JP 2018515490 A5 JP2018515490 A5 JP 2018515490A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound
- carcinoma
- tumor
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562157902P | 2015-05-06 | 2015-05-06 | |
| US62/157,902 | 2015-05-06 | ||
| PCT/US2016/031027 WO2016179415A1 (en) | 2015-05-06 | 2016-05-05 | Solid forms of a compound modulating kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515490A JP2018515490A (ja) | 2018-06-14 |
| JP2018515490A5 true JP2018515490A5 (enExample) | 2019-06-06 |
| JP6946194B2 JP6946194B2 (ja) | 2021-10-06 |
Family
ID=56008880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557329A Active JP6946194B2 (ja) | 2015-05-06 | 2016-05-05 | キナーゼを調節する化合物の固体形態 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US9802932B2 (enExample) |
| EP (2) | EP3292123B1 (enExample) |
| JP (1) | JP6946194B2 (enExample) |
| KR (1) | KR102630889B1 (enExample) |
| CN (1) | CN107548394B (enExample) |
| AU (1) | AU2016258027B2 (enExample) |
| BR (1) | BR112017023490B1 (enExample) |
| CA (1) | CA2984910C (enExample) |
| CO (1) | CO2017011534A2 (enExample) |
| CY (1) | CY1123796T1 (enExample) |
| DK (1) | DK3292123T3 (enExample) |
| ES (1) | ES2820827T3 (enExample) |
| HR (1) | HRP20201383T1 (enExample) |
| HU (1) | HUE050506T2 (enExample) |
| IL (1) | IL255313A0 (enExample) |
| LT (1) | LT3292123T (enExample) |
| MX (1) | MX386963B (enExample) |
| MY (1) | MY192352A (enExample) |
| NZ (1) | NZ737616A (enExample) |
| PH (1) | PH12017501995A1 (enExample) |
| PT (1) | PT3292123T (enExample) |
| RS (1) | RS60731B1 (enExample) |
| RU (1) | RU2730506C2 (enExample) |
| SG (1) | SG10201912355TA (enExample) |
| SI (1) | SI3292123T1 (enExample) |
| SM (1) | SMT202000535T1 (enExample) |
| TW (1) | TWI727949B (enExample) |
| WO (1) | WO2016179415A1 (enExample) |
| ZA (1) | ZA201708007B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008276063B2 (en) | 2007-07-17 | 2013-11-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| SI2672967T1 (sl) | 2011-02-07 | 2018-12-31 | Plexxikon Inc. | Spojine in postopki za kinazno modulacijo in indikacije zanjo |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
| WO2014100620A2 (en) | 2012-12-21 | 2014-06-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2948134B1 (en) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mtor inhibitors |
| RU2680100C9 (ru) | 2013-03-15 | 2019-04-18 | Плексксикон Инк. | Гетероциклические соединения и их применения |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| MX2015015966A (es) | 2013-05-30 | 2016-04-13 | Plexxikon Inc | Compuestos para la modulacion de cinasas e indicaciones para los mismos. |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2923943T3 (es) * | 2015-05-06 | 2022-10-03 | Plexxikon Inc | Síntesis de un compuesto que modula cinasas |
| WO2016179415A1 (en) | 2015-05-06 | 2016-11-10 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| KR20180006447A (ko) | 2015-05-22 | 2018-01-17 | 플렉시콘 인코퍼레이티드 | Braf-v600-관련 질환의 치료에 사용하기 위한 plx-8394 또는 plx-7904 |
| CA2986920C (en) | 2015-05-22 | 2023-03-21 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP6863970B2 (ja) | 2015-09-21 | 2021-04-21 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ヘテロ環式化合物およびそれらの使用 |
| ES2899581T3 (es) | 2015-12-07 | 2022-03-14 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones para estos |
| EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| EP3461823B1 (en) * | 2016-06-17 | 2020-06-03 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Pexidartinib hydrochloride crystal forms, preparation method therefor and use thereof |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| EP3558991A2 (en) | 2016-12-23 | 2019-10-30 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| IL302385B2 (en) | 2017-01-06 | 2024-06-01 | Palvella Therapeutics Inc | Non-aqueous preparations of mTOR inhibitors and methods of use |
| EP3601281B1 (en) | 2017-03-20 | 2021-09-29 | Plexxikon Inc. | CRYSTALLINE FORMS OF 4-(1-(1,1-DI(PYRIDIN-2-YL)ETHYL)-6-(3,5-DIMETHYLISOXAZOL-4-YL)-1H-
PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOIC ACID THAT INHIBITS BROMODOMAIN |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| JP7170030B2 (ja) * | 2017-07-25 | 2022-11-11 | プレキシコン インコーポレーテッド | キナーゼを調節する化合物の製剤 |
| JP7675519B2 (ja) | 2017-10-13 | 2025-05-13 | オプナ バイオ ソシエテ アノニム | キナーゼを調節するための化合物の固体形態 |
| US11103505B2 (en) | 2017-10-27 | 2021-08-31 | Plexxikon Inc. | Formulations of a compound modulating kinases |
| CN112119072A (zh) | 2018-03-20 | 2020-12-22 | 普莱希科公司 | 用于ido和tdo调节的化合物和方法，以及其适应症 |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| CA3136224A1 (en) | 2019-04-09 | 2020-10-15 | Plexxikon Inc. | Condensed azines for ep300 or cbp modulation and indications therefor |
| US12509444B2 (en) | 2019-12-06 | 2025-12-30 | Plexxikon Inc. | Compounds and methods for CD73 modulation and indications therefor |
| WO2021216898A1 (en) | 2020-04-23 | 2021-10-28 | Plexxikon Inc. | Compounds and methods for cd73 modulation and indications therefor |
| WO2021222442A1 (en) | 2020-04-29 | 2021-11-04 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| EP4178982A1 (en) | 2020-07-13 | 2023-05-17 | Precirix N.V. | Antibody fragment against folr1 |
| CN115843298B (zh) * | 2020-07-22 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型 |
| US11628176B2 (en) | 2020-08-21 | 2023-04-18 | Opna Bio SA | Combinational drug therapies |
| AU2021348592B2 (en) * | 2020-09-25 | 2024-08-08 | Jumbo Drug Bank Co., Ltd. | 1h-pyrrolo[2,3-c]pyridine compounds and application thereof |
| US20220251218A1 (en) * | 2021-02-10 | 2022-08-11 | Gnt Biotech & Medicals Corporation | Pharmaceutical combination and method for overcoming immune suppression or stimulating immune response against cancer |
| US20240189277A1 (en) * | 2021-04-16 | 2024-06-13 | The Johns Hopkins University | Ophthalmic formulations for sustained neuroprotection |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| IL318992A (en) | 2022-05-02 | 2025-04-01 | Precirix N V | Cancer treatment through advance directives |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| CN102875441A (zh) | 2003-07-17 | 2013-01-16 | 普莱希科公司 | Ppar活性化合物 |
| US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
| ES2527118T3 (es) | 2003-12-19 | 2015-01-20 | Plexxikon Inc. | Compuestos y procedimientos de desarrollo de moduladores de Ret |
| EP1742627A4 (en) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | PDE4B HEMMER AND ITS USE |
| RU2389728C2 (ru) * | 2004-07-27 | 2010-05-20 | Сгкс Фармасьютиклз, Инк. | Модуляторы киназы на основе производных пирролопиридина |
| EP1786813A2 (en) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| US7846941B2 (en) | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
| PT1893612E (pt) | 2005-06-22 | 2011-11-21 | Plexxikon Inc | Derivados de pirrolo [2,3-b]piridina como inibidores de proteína quinase |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| AU2008276063B2 (en) | 2007-07-17 | 2013-11-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| CA2727389A1 (en) | 2008-06-10 | 2009-12-17 | Prabha N. Ibrahim | 5h-pyrrolo [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor |
| US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| MX2011009489A (es) | 2009-03-11 | 2011-10-11 | Plexxikon Inc | Derivados de pirrolo [2,3-b] piridina para la inhibicion de raf cinasas. |
| JP5511942B2 (ja) | 2009-04-03 | 2014-06-04 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 組成物及びその使用 |
| EP2496086B1 (en) | 2009-11-06 | 2017-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| RU2012125070A (ru) | 2009-11-18 | 2013-12-27 | Плексксикон, Инк. | Соединения и способы модулирования киназы и показания к их применению |
| CA2784393A1 (en) | 2009-12-23 | 2011-06-30 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
| SI2672967T1 (sl) | 2011-02-07 | 2018-12-31 | Plexxikon Inc. | Spojine in postopki za kinazno modulacijo in indikacije zanjo |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| HK1199713A1 (en) | 2011-05-17 | 2015-08-14 | 普莱希科公司 | Kinase modulation and indications therefor |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
| WO2014100620A2 (en) | 2012-12-21 | 2014-06-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| RU2680100C9 (ru) | 2013-03-15 | 2019-04-18 | Плексксикон Инк. | Гетероциклические соединения и их применения |
| MX2015015966A (es) | 2013-05-30 | 2016-04-13 | Plexxikon Inc | Compuestos para la modulacion de cinasas e indicaciones para los mismos. |
| US9771369B2 (en) | 2014-03-04 | 2017-09-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US9856259B2 (en) | 2014-09-15 | 2018-01-02 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2016179415A1 (en) | 2015-05-06 | 2016-11-10 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| ES2923943T3 (es) | 2015-05-06 | 2022-10-03 | Plexxikon Inc | Síntesis de un compuesto que modula cinasas |
| KR20180006447A (ko) | 2015-05-22 | 2018-01-17 | 플렉시콘 인코퍼레이티드 | Braf-v600-관련 질환의 치료에 사용하기 위한 plx-8394 또는 plx-7904 |
| CA2986920C (en) | 2015-05-22 | 2023-03-21 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP6863970B2 (ja) | 2015-09-21 | 2021-04-21 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ヘテロ環式化合物およびそれらの使用 |
| ES2899581T3 (es) | 2015-12-07 | 2022-03-14 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones para estos |
| EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| EP3558991A2 (en) | 2016-12-23 | 2019-10-30 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| EP3601281B1 (en) | 2017-03-20 | 2021-09-29 | Plexxikon Inc. | CRYSTALLINE FORMS OF 4-(1-(1,1-DI(PYRIDIN-2-YL)ETHYL)-6-(3,5-DIMETHYLISOXAZOL-4-YL)-1H-
PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOIC ACID THAT INHIBITS BROMODOMAIN |
-
2016
- 2016-05-05 WO PCT/US2016/031027 patent/WO2016179415A1/en not_active Ceased
- 2016-05-05 SM SM20200535T patent/SMT202000535T1/it unknown
- 2016-05-05 EP EP16723225.5A patent/EP3292123B1/en active Active
- 2016-05-05 PT PT167232255T patent/PT3292123T/pt unknown
- 2016-05-05 DK DK16723225.5T patent/DK3292123T3/da active
- 2016-05-05 AU AU2016258027A patent/AU2016258027B2/en active Active
- 2016-05-05 SG SG10201912355TA patent/SG10201912355TA/en unknown
- 2016-05-05 LT LTEP16723225.5T patent/LT3292123T/lt unknown
- 2016-05-05 RS RS20201036A patent/RS60731B1/sr unknown
- 2016-05-05 ES ES16723225T patent/ES2820827T3/es active Active
- 2016-05-05 CN CN201680025494.6A patent/CN107548394B/zh active Active
- 2016-05-05 EP EP20186809.8A patent/EP3757104A1/en not_active Withdrawn
- 2016-05-05 CA CA2984910A patent/CA2984910C/en active Active
- 2016-05-05 MX MX2017013975A patent/MX386963B/es unknown
- 2016-05-05 TW TW105114053A patent/TWI727949B/zh active
- 2016-05-05 HU HUE16723225A patent/HUE050506T2/hu unknown
- 2016-05-05 SI SI201630913T patent/SI3292123T1/sl unknown
- 2016-05-05 HR HRP20201383TT patent/HRP20201383T1/hr unknown
- 2016-05-05 NZ NZ737616A patent/NZ737616A/en unknown
- 2016-05-05 MY MYPI2017704151A patent/MY192352A/en unknown
- 2016-05-05 RU RU2017141035A patent/RU2730506C2/ru active
- 2016-05-05 JP JP2017557329A patent/JP6946194B2/ja active Active
- 2016-05-05 US US15/147,692 patent/US9802932B2/en active Active
- 2016-05-05 KR KR1020177034519A patent/KR102630889B1/ko active Active
- 2016-05-05 BR BR112017023490-4A patent/BR112017023490B1/pt active IP Right Grant
-
2017
- 2017-10-04 US US15/725,197 patent/US10189833B2/en active Active
- 2017-10-29 IL IL255313A patent/IL255313A0/en active IP Right Grant
- 2017-11-02 PH PH12017501995A patent/PH12017501995A1/en unknown
- 2017-11-10 CO CONC2017/0011534A patent/CO2017011534A2/es unknown
- 2017-11-24 ZA ZA2017/08007A patent/ZA201708007B/en unknown
-
2018
- 2018-12-13 US US16/219,730 patent/US10584122B2/en active Active
-
2020
- 2020-09-24 CY CY20201100903T patent/CY1123796T1/el unknown
-
2021
- 2021-11-24 US US17/535,304 patent/US20220153737A1/en not_active Abandoned
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