JP2018515490A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018515490A5 JP2018515490A5 JP2017557329A JP2017557329A JP2018515490A5 JP 2018515490 A5 JP2018515490 A5 JP 2018515490A5 JP 2017557329 A JP2017557329 A JP 2017557329A JP 2017557329 A JP2017557329 A JP 2017557329A JP 2018515490 A5 JP2018515490 A5 JP 2018515490A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound
- carcinoma
- tumor
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562157902P | 2015-05-06 | 2015-05-06 | |
| US62/157,902 | 2015-05-06 | ||
| PCT/US2016/031027 WO2016179415A1 (en) | 2015-05-06 | 2016-05-05 | Solid forms of a compound modulating kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515490A JP2018515490A (ja) | 2018-06-14 |
| JP2018515490A5 true JP2018515490A5 (enExample) | 2019-06-06 |
| JP6946194B2 JP6946194B2 (ja) | 2021-10-06 |
Family
ID=56008880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557329A Active JP6946194B2 (ja) | 2015-05-06 | 2016-05-05 | キナーゼを調節する化合物の固体形態 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US9802932B2 (enExample) |
| EP (2) | EP3292123B1 (enExample) |
| JP (1) | JP6946194B2 (enExample) |
| KR (1) | KR102630889B1 (enExample) |
| CN (1) | CN107548394B (enExample) |
| AU (1) | AU2016258027B2 (enExample) |
| BR (1) | BR112017023490B1 (enExample) |
| CA (1) | CA2984910C (enExample) |
| CO (1) | CO2017011534A2 (enExample) |
| CY (1) | CY1123796T1 (enExample) |
| DK (1) | DK3292123T3 (enExample) |
| ES (1) | ES2820827T3 (enExample) |
| HR (1) | HRP20201383T1 (enExample) |
| HU (1) | HUE050506T2 (enExample) |
| IL (1) | IL255313A0 (enExample) |
| LT (1) | LT3292123T (enExample) |
| MX (1) | MX386963B (enExample) |
| MY (1) | MY192352A (enExample) |
| NZ (1) | NZ737616A (enExample) |
| PH (1) | PH12017501995A1 (enExample) |
| PT (1) | PT3292123T (enExample) |
| RS (1) | RS60731B1 (enExample) |
| RU (1) | RU2730506C2 (enExample) |
| SG (1) | SG10201912355TA (enExample) |
| SI (1) | SI3292123T1 (enExample) |
| SM (1) | SMT202000535T1 (enExample) |
| TW (1) | TWI727949B (enExample) |
| WO (1) | WO2016179415A1 (enExample) |
| ZA (1) | ZA201708007B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| CN104981247A (zh) | 2012-09-06 | 2015-10-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| SMT201800230T1 (it) | 2012-12-21 | 2018-07-17 | Plexxikon Inc | Composti e metodi per la modulazione della chinasi e loro indicazioni |
| WO2014117035A1 (en) | 2013-01-24 | 2014-07-31 | Transderm, Inc. | COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS |
| HRP20181392T1 (hr) | 2013-03-15 | 2018-10-19 | Plexxikon Inc. | Heterociklični spojevi i njihova uporaba |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| AU2014274093B2 (en) | 2013-05-30 | 2018-11-08 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2923943T3 (es) | 2015-05-06 | 2022-10-03 | Plexxikon Inc | Síntesis de un compuesto que modula cinasas |
| JP6946194B2 (ja) | 2015-05-06 | 2021-10-06 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼを調節する化合物の固体形態 |
| CN113893253A (zh) | 2015-05-22 | 2022-01-07 | 普莱希科公司 | 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP4071149A3 (en) | 2015-09-21 | 2023-01-25 | Opna Immuno Oncology, SA | Heterocyclic compounds and uses thereof |
| CN108368110A (zh) | 2015-12-07 | 2018-08-03 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
| EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| WO2017215521A1 (zh) * | 2016-06-17 | 2017-12-21 | 苏州科睿思制药有限公司 | Plx3397的盐酸盐晶型及其制备方法和用途 |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| AU2017395023B2 (en) | 2016-12-23 | 2022-04-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| AU2018205253B2 (en) | 2017-01-06 | 2022-01-13 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| JP2020511467A (ja) | 2017-03-20 | 2020-04-16 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ブロモドメインを阻害する４−（１−（１，１−ジ（ピリジン−２−イル）エチル）−６−（３，５−ジメチルイソオキサゾール−４−イル）−１Ｈ−ピロロ［３，２−ｂ］ピリジン−３−イル）安息香酸の結晶形 |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| WO2019023198A1 (en) | 2017-07-25 | 2019-01-31 | Plexxikon Inc. | FORMULATION OF A COMPOUND MODULATING KINASES |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| TWI803530B (zh) | 2017-10-27 | 2023-06-01 | 美商普雷辛肯公司 | 調節激酶之化合物之調配物 |
| US11149011B2 (en) | 2018-03-20 | 2021-10-19 | Plexxikon Inc. | Compounds and methods for IDO and TDO modulation, and indications therefor |
| EP3817743A4 (en) | 2018-07-02 | 2022-07-06 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF MTOR INHIBITORS AND METHODS OF USE |
| WO2020210366A1 (en) | 2019-04-09 | 2020-10-15 | Plexxikon Inc. | Condensed azines for ep300 or cbp modulation and indications therefor |
| US12509444B2 (en) | 2019-12-06 | 2025-12-30 | Plexxikon Inc. | Compounds and methods for CD73 modulation and indications therefor |
| TW202206422A (zh) | 2020-04-23 | 2022-02-16 | 美商普雷辛肯公司 | 用於ｃｄ７３調節之化合物及方法及其適應症 |
| BR112022021920A2 (pt) | 2020-04-29 | 2023-01-17 | Plexxikon Inc | Síntese de compostos heterocíclicos |
| WO2022013225A1 (en) | 2020-07-13 | 2022-01-20 | Precirix N.V. | Antibody fragment against folr1 |
| US20230271958A1 (en) * | 2020-07-22 | 2023-08-31 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE |
| CA3192047A1 (en) | 2020-08-21 | 2022-02-24 | Plexxikon Inc. | Combinational drug anticancer therapies |
| US12552789B2 (en) | 2020-09-25 | 2026-02-17 | Jumbo Drug Bank Co., Ltd. | 1H-pyrrolo[2,3-c]pyridine compounds and application thereof |
| US20220251218A1 (en) * | 2021-02-10 | 2022-08-11 | Gnt Biotech & Medicals Corporation | Pharmaceutical combination and method for overcoming immune suppression or stimulating immune response against cancer |
| WO2022221537A1 (en) * | 2021-04-16 | 2022-10-20 | The Johns Hopkins University | Ophthalmic formulations for sustained neuroprotection |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101415503B1 (ko) | 2003-07-17 | 2014-07-04 | 플렉시콘, 인코퍼레이티드 | Ｐｐａｒ 활성 화합물 |
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| PL1696920T3 (pl) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
| US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
| JP2008503446A (ja) | 2004-05-06 | 2008-02-07 | プレキシコン，インコーポレーテッド | Ｐｄｅ４ｂ阻害剤及びその使用 |
| RU2389728C2 (ru) * | 2004-07-27 | 2010-05-20 | Сгкс Фармасьютиклз, Инк. | Модуляторы киназы на основе производных пирролопиридина |
| EP1786813A2 (en) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| CA2608733A1 (en) | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| DK2395004T3 (en) | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| WO2008063888A2 (en) * | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| US8119637B2 (en) | 2008-06-10 | 2012-02-21 | Plexxikon Inc. | Substituted pyrrolo[2,3-b]pyrazines and methods for kinase modulation, and indications therefor |
| US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| TW201036973A (en) | 2009-03-11 | 2010-10-16 | Plexxikon Inc | Compounds and uses thereof |
| HUE027598T2 (en) | 2009-04-03 | 2016-10-28 | Hoffmann La Roche | Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses |
| ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
| JP2013511541A (ja) | 2009-11-18 | 2013-04-04 | プレキシコン インコーポレーテッド | キナーゼ調節のための化合物および方法、ならびにその適応 |
| KR20120112623A (ko) | 2009-12-23 | 2012-10-11 | 플렉시콘, 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| EP2709622A4 (en) | 2011-05-17 | 2015-03-04 | Plexxikon Inc | CINEMA MODULATION AND INDICATIONS THEREFOR |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| CN104981247A (zh) | 2012-09-06 | 2015-10-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| SMT201800230T1 (it) | 2012-12-21 | 2018-07-17 | Plexxikon Inc | Composti e metodi per la modulazione della chinasi e loro indicazioni |
| HRP20181392T1 (hr) | 2013-03-15 | 2018-10-19 | Plexxikon Inc. | Heterociklični spojevi i njihova uporaba |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| AU2014274093B2 (en) | 2013-05-30 | 2018-11-08 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2016044067A1 (en) | 2014-09-15 | 2016-03-24 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2923943T3 (es) | 2015-05-06 | 2022-10-03 | Plexxikon Inc | Síntesis de un compuesto que modula cinasas |
| JP6946194B2 (ja) | 2015-05-06 | 2021-10-06 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼを調節する化合物の固体形態 |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| CN113893253A (zh) | 2015-05-22 | 2022-01-07 | 普莱希科公司 | 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 |
| WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP4071149A3 (en) | 2015-09-21 | 2023-01-25 | Opna Immuno Oncology, SA | Heterocyclic compounds and uses thereof |
| CN108368110A (zh) | 2015-12-07 | 2018-08-03 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
| EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| AU2017395023B2 (en) | 2016-12-23 | 2022-04-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| JP2020511467A (ja) | 2017-03-20 | 2020-04-16 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ブロモドメインを阻害する４−（１−（１，１−ジ（ピリジン−２−イル）エチル）−６−（３，５−ジメチルイソオキサゾール−４−イル）−１Ｈ−ピロロ［３，２−ｂ］ピリジン−３−イル）安息香酸の結晶形 |
-
2016
- 2016-05-05 JP JP2017557329A patent/JP6946194B2/ja active Active
- 2016-05-05 SM SM20200535T patent/SMT202000535T1/it unknown
- 2016-05-05 HR HRP20201383TT patent/HRP20201383T1/hr unknown
- 2016-05-05 KR KR1020177034519A patent/KR102630889B1/ko active Active
- 2016-05-05 EP EP16723225.5A patent/EP3292123B1/en active Active
- 2016-05-05 WO PCT/US2016/031027 patent/WO2016179415A1/en not_active Ceased
- 2016-05-05 EP EP20186809.8A patent/EP3757104A1/en not_active Withdrawn
- 2016-05-05 CN CN201680025494.6A patent/CN107548394B/zh active Active
- 2016-05-05 US US15/147,692 patent/US9802932B2/en active Active
- 2016-05-05 ES ES16723225T patent/ES2820827T3/es active Active
- 2016-05-05 HU HUE16723225A patent/HUE050506T2/hu unknown
- 2016-05-05 SG SG10201912355TA patent/SG10201912355TA/en unknown
- 2016-05-05 TW TW105114053A patent/TWI727949B/zh active
- 2016-05-05 CA CA2984910A patent/CA2984910C/en active Active
- 2016-05-05 AU AU2016258027A patent/AU2016258027B2/en active Active
- 2016-05-05 DK DK16723225.5T patent/DK3292123T3/da active
- 2016-05-05 BR BR112017023490-4A patent/BR112017023490B1/pt active IP Right Grant
- 2016-05-05 RU RU2017141035A patent/RU2730506C2/ru active
- 2016-05-05 MY MYPI2017704151A patent/MY192352A/en unknown
- 2016-05-05 SI SI201630913T patent/SI3292123T1/sl unknown
- 2016-05-05 PT PT167232255T patent/PT3292123T/pt unknown
- 2016-05-05 LT LTEP16723225.5T patent/LT3292123T/lt unknown
- 2016-05-05 NZ NZ737616A patent/NZ737616A/en unknown
- 2016-05-05 MX MX2017013975A patent/MX386963B/es unknown
- 2016-05-05 RS RS20201036A patent/RS60731B1/sr unknown
-
2017
- 2017-10-04 US US15/725,197 patent/US10189833B2/en active Active
- 2017-10-29 IL IL255313A patent/IL255313A0/en active IP Right Grant
- 2017-11-02 PH PH12017501995A patent/PH12017501995A1/en unknown
- 2017-11-10 CO CONC2017/0011534A patent/CO2017011534A2/es unknown
- 2017-11-24 ZA ZA2017/08007A patent/ZA201708007B/en unknown
-
2018
- 2018-12-13 US US16/219,730 patent/US10584122B2/en active Active
-
2020
- 2020-09-24 CY CY20201100903T patent/CY1123796T1/el unknown
-
2021
- 2021-11-24 US US17/535,304 patent/US20220153737A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20201383T1 (hr) | Kruti oblici spoja za moduliranje kinaza | |
| JP7189956B2 (ja) | Ｓｏｓ１阻害剤としての新規なベンジルアミノ置換ピリドピリミジノンおよび誘導体 | |
| JP6965360B2 (ja) | ｏ−アミノヘテロアリールアルキニル基含有化合物およびその製造方法と用途 | |
| AU2018267622B2 (en) | Alkyne substituted quinazoline compound and methods of use | |
| IL283184B2 (en) | Crystal polymorph of (7s,13r)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10] benzoxatriazacyclotridecin–4(5h)–one for the treatment of cancer | |
| JP6781150B2 (ja) | 癌の治療に有用な縮合二環式（ヘテロ）芳香族化合物 | |
| JP2017520612A (ja) | 抗がん剤としての官能化され置換されたインドール | |
| WO2001083456A1 (en) | Condensed heteroaryl derivatives | |
| KR20090127307A (ko) | 히스타민 ｈ３ 수용체 조절제로서의 테트라하이드로이소퀴놀린 화합물 | |
| KR102142797B1 (ko) | 피리디닐아미노피리미딘 유도체의 메실레이트 염의 결정질 형태, 그의 제조 방법, 및 그의 용도 | |
| JP2016513704A5 (enExample) | ||
| JP2014524476A5 (enExample) | ||
| WO2016008010A1 (en) | Functionalised and substituted carbazoles as anti-cancer agents | |
| EP1599202A1 (en) | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | |
| WO2025209490A1 (en) | Macrocyclic compound, preparation methods and medicinal uses thereof | |
| JP2023544173A5 (enExample) | ||
| KR20230163335A (ko) | 헤테로아릴 유도체 화합물 및 이의 용도 | |
| TWI755418B (zh) | 聯芳組成物和調控激酶級聯之方法 | |
| AU2011318875A1 (en) | Antagonist for mutated androgen receptor | |
| JP2023544732A5 (enExample) | ||
| TWI374880B (en) | A pharmaceutically acceptable salt and solvate of n-[3-[[[2-[(2,3-dihydro-2-oxo-1h-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-n-methylmethanesulfonamide and uses thereof | |
| CN103626761B (zh) | 苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用 | |
| JP7110335B2 (ja) | プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 | |
| CN110066236B (zh) | 1h-吡咯衍生物、其制备方法、药物组合物及应用 | |
| JP2022537385A (ja) | 大環状キナーゼ阻害剤の多形 |