JP6946194B2 - キナーゼを調節する化合物の固体形態 - Google Patents

キナーゼを調節する化合物の固体形態 Download PDF

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JP6946194B2
JP6946194B2 JP2017557329A JP2017557329A JP6946194B2 JP 6946194 B2 JP6946194 B2 JP 6946194B2 JP 2017557329 A JP2017557329 A JP 2017557329A JP 2017557329 A JP2017557329 A JP 2017557329A JP 6946194 B2 JP6946194 B2 JP 6946194B2
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compound
cancer
disease
crystalline
treatment
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JP2018515490A5 (enExample
JP2018515490A (ja
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プラブハ・エヌ・イブラヒム
ゲイリー・コンラッド・バイザー
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Plexxikon Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017557329A 2015-05-06 2016-05-05 キナーゼを調節する化合物の固体形態 Active JP6946194B2 (ja)

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Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
US62/157,902 2015-05-06
PCT/US2016/031027 WO2016179415A1 (en) 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases

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JP2018515490A JP2018515490A (ja) 2018-06-14
JP2018515490A5 JP2018515490A5 (enExample) 2019-06-06
JP6946194B2 true JP6946194B2 (ja) 2021-10-06

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US (4) US9802932B2 (enExample)
EP (2) EP3292123B1 (enExample)
JP (1) JP6946194B2 (enExample)
KR (1) KR102630889B1 (enExample)
CN (1) CN107548394B (enExample)
AU (1) AU2016258027B2 (enExample)
BR (1) BR112017023490B1 (enExample)
CA (1) CA2984910C (enExample)
CO (1) CO2017011534A2 (enExample)
CY (1) CY1123796T1 (enExample)
DK (1) DK3292123T3 (enExample)
ES (1) ES2820827T3 (enExample)
HR (1) HRP20201383T1 (enExample)
HU (1) HUE050506T2 (enExample)
IL (1) IL255313A0 (enExample)
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MX (1) MX386963B (enExample)
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NZ (1) NZ737616A (enExample)
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PT (1) PT3292123T (enExample)
RS (1) RS60731B1 (enExample)
RU (1) RU2730506C2 (enExample)
SG (1) SG10201912355TA (enExample)
SI (1) SI3292123T1 (enExample)
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TW (1) TWI727949B (enExample)
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TWI803530B (zh) 2017-10-27 2023-06-01 美商普雷辛肯公司 調節激酶之化合物之調配物
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