JP2018505177A5 - - Google Patents
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- JP2018505177A5 JP2018505177A5 JP2017540245A JP2017540245A JP2018505177A5 JP 2018505177 A5 JP2018505177 A5 JP 2018505177A5 JP 2017540245 A JP2017540245 A JP 2017540245A JP 2017540245 A JP2017540245 A JP 2017540245A JP 2018505177 A5 JP2018505177 A5 JP 2018505177A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 108091008324 binding proteins Proteins 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 101001042104 Homo sapiens Inducible T-cell costimulator Proteins 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 102000043396 human ICOS Human genes 0.000 claims description 7
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000000556 agonist Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000003308 immunostimulating effect Effects 0.000 claims description 3
- 229940034982 antineoplastic agent Drugs 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000002519 immonomodulatory effect Effects 0.000 claims description 2
- 239000002955 immunomodulating agent Substances 0.000 claims description 2
- 230000002584 immunomodulator Effects 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 102000023732 binding proteins Human genes 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- ICLAYQQKWJGHBV-XJZMHMBSSA-N (2s)-2-[[(3r)-3-decoxytetradecanoyl]amino]-3-[(2r,3r,4r,5s,6r)-3-[[(3r)-3-decoxytetradecanoyl]amino]-4-[(3r)-3-decoxytetradecanoyl]oxy-6-(hydroxymethyl)-5-phosphonooxyoxan-2-yl]oxypropanoic acid Chemical group CCCCCCCCCCC[C@@H](OCCCCCCCCCC)CC(=O)N[C@H](C(O)=O)CO[C@@H]1O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCCCCCC)[C@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OCCCCCCCCCC ICLAYQQKWJGHBV-XJZMHMBSSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000016396 cytokine production Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 description 17
- 208000025865 Ulcer Diseases 0.000 description 5
- 230000036269 ulceration Effects 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 description 2
- 241000699800 Cricetinae Species 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 102100030385 Granzyme B Human genes 0.000 description 1
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 description 1
- 102100034980 ICOS ligand Human genes 0.000 description 1
- 101710093458 ICOS ligand Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101001009604 Mus musculus Granzyme B(G,H) Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562108605P | 2015-01-28 | 2015-01-28 | |
| US62/108,605 | 2015-01-28 | ||
| US201562192331P | 2015-07-14 | 2015-07-14 | |
| US62/192,331 | 2015-07-14 | ||
| US201562247355P | 2015-10-28 | 2015-10-28 | |
| US62/247,355 | 2015-10-28 | ||
| PCT/IB2016/050383 WO2016120789A1 (en) | 2015-01-28 | 2016-01-26 | Agonistic icos binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019092997A Division JP6653782B2 (ja) | 2015-01-28 | 2019-05-16 | アゴニスト性ｉｃｏｓ結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505177A JP2018505177A (ja) | 2018-02-22 |
| JP2018505177A5 true JP2018505177A5 (OSRAM) | 2019-03-22 |
| JP6553197B2 JP6553197B2 (ja) | 2019-07-31 |
Family
ID=55262868
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540245A Active JP6553197B2 (ja) | 2015-01-28 | 2016-01-26 | アゴニスト性ｉｃｏｓ結合タンパク質 |
| JP2019092997A Active JP6653782B2 (ja) | 2015-01-28 | 2019-05-16 | アゴニスト性ｉｃｏｓ結合タンパク質 |
| JP2020011111A Active JP7062704B2 (ja) | 2015-01-28 | 2020-01-27 | アゴニスト性ｉｃｏｓ結合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019092997A Active JP6653782B2 (ja) | 2015-01-28 | 2019-05-16 | アゴニスト性ｉｃｏｓ結合タンパク質 |
| JP2020011111A Active JP7062704B2 (ja) | 2015-01-28 | 2020-01-27 | アゴニスト性ｉｃｏｓ結合タンパク質 |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US9771424B2 (OSRAM) |
| EP (3) | EP3572432A1 (OSRAM) |
| JP (3) | JP6553197B2 (OSRAM) |
| KR (1) | KR102315160B1 (OSRAM) |
| CN (1) | CN107667117B (OSRAM) |
| AU (3) | AU2016210867B2 (OSRAM) |
| BR (1) | BR112017016336A2 (OSRAM) |
| CA (1) | CA2974910A1 (OSRAM) |
| CL (1) | CL2017001921A1 (OSRAM) |
| CO (1) | CO2017007665A2 (OSRAM) |
| CR (1) | CR20170351A (OSRAM) |
| DO (1) | DOP2017000171A (OSRAM) |
| EA (1) | EA036335B1 (OSRAM) |
| ES (1) | ES2913871T3 (OSRAM) |
| IL (1) | IL253508B (OSRAM) |
| JO (1) | JO3745B1 (OSRAM) |
| MA (3) | MA41414A (OSRAM) |
| MX (1) | MX2017009758A (OSRAM) |
| MY (1) | MY185845A (OSRAM) |
| PE (1) | PE20180120A1 (OSRAM) |
| PH (1) | PH12017501347B1 (OSRAM) |
| SG (1) | SG11201705829TA (OSRAM) |
| TW (1) | TWI717332B (OSRAM) |
| UA (1) | UA124613C2 (OSRAM) |
| UY (1) | UY36539A (OSRAM) |
| WO (1) | WO2016120789A1 (OSRAM) |
| ZA (1) | ZA201704818B (OSRAM) |
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| WO2014151763A1 (en) | 2013-03-14 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of detecting donor-specific antibodies and systems for practicing the same |
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