JP2016505546A5 - - Google Patents

Info

Publication number

JP2016505546A5

JP2016505546A5 JP2015545453A JP2015545453A JP2016505546A5 JP 2016505546 A5 JP2016505546 A5 JP 2016505546A5 JP 2015545453 A JP2015545453 A JP 2015545453A JP 2015545453 A JP2015545453 A JP 2015545453A JP 2016505546 A5 JP2016505546 A5 JP 2016505546A5

Authority

JP

Japan

Prior art keywords

kabat

cdr

vegf

seq

variant

Prior art date

2013-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 32
• 230000035772 mutation Effects 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 206010061289 metastatic neoplasm Diseases 0.000 claims 4
• 241000282412 Homo Species 0.000 claims 3
• 206010064930 age-related macular degeneration Diseases 0.000 claims 3
• 208000002780 macular degeneration Diseases 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 208000026278 immune system disease Diseases 0.000 claims 2
• 230000001394 metastastic effect Effects 0.000 claims 2
• 208000011645 metastatic carcinoma Diseases 0.000 claims 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
• 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Chemical group CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• 206010030113 Oedema Diseases 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 201000011190 diabetic macular edema Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 230000000306 recurrent effect Effects 0.000 claims 1
• 230000002207 retinal effect Effects 0.000 claims 1
• 208000004644 retinal vein occlusion Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1