JP2015509947A5 - - Google Patents
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- JP2015509947A5 JP2015509947A5 JP2014558882A JP2014558882A JP2015509947A5 JP 2015509947 A5 JP2015509947 A5 JP 2015509947A5 JP 2014558882 A JP2014558882 A JP 2014558882A JP 2014558882 A JP2014558882 A JP 2014558882A JP 2015509947 A5 JP2015509947 A5 JP 2015509947A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- isolated monoclonal
- seq
- antibody
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 30
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 28
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 5
- 239000002254 cytotoxic agent Substances 0.000 claims description 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 5
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 102000053255 human DLL3 Human genes 0.000 claims 2
- 210000005102 tumor initiating cell Anatomy 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims 1
- 201000011519 neuroendocrine tumor Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 229940127276 delta-like ligand 3 Drugs 0.000 description 23
- 239000000611 antibody drug conjugate Substances 0.000 description 7
- 229940049595 antibody-drug conjugate Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 201000005188 adrenal gland cancer Diseases 0.000 description 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603173P | 2012-02-24 | 2012-02-24 | |
| US61/603,173 | 2012-02-24 | ||
| US201261719803P | 2012-10-29 | 2012-10-29 | |
| US61/719,803 | 2012-10-29 | ||
| PCT/US2013/027391 WO2013126746A2 (en) | 2012-02-24 | 2013-02-22 | Novel modulators and methods of use |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016030269A Division JP6010241B2 (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2016030270A Division JP2016098233A (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509947A JP2015509947A (ja) | 2015-04-02 |
| JP2015509947A5 true JP2015509947A5 (OSRAM) | 2016-04-07 |
| JP6089047B2 JP6089047B2 (ja) | 2017-03-01 |
Family
ID=47790544
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558882A Expired - Fee Related JP6089047B2 (ja) | 2012-02-24 | 2013-02-22 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2016030270A Pending JP2016098233A (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2016030269A Expired - Fee Related JP6010241B2 (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2018102094A Pending JP2018162257A (ja) | 2012-02-24 | 2018-05-29 | Ｄｌｌ３モジュレーター及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016030270A Pending JP2016098233A (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2016030269A Expired - Fee Related JP6010241B2 (ja) | 2012-02-24 | 2016-02-19 | Ｄｌｌ３モジュレーター及び使用方法 |
| JP2018102094A Pending JP2018162257A (ja) | 2012-02-24 | 2018-05-29 | Ｄｌｌ３モジュレーター及び使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (31) | US9107961B2 (OSRAM) |
| EP (4) | EP2817338B1 (OSRAM) |
| JP (4) | JP6089047B2 (OSRAM) |
| KR (1) | KR20150003169A (OSRAM) |
| CN (1) | CN104520324A (OSRAM) |
| AU (3) | AU2013203459B2 (OSRAM) |
| BR (1) | BR112014020826A8 (OSRAM) |
| CA (2) | CA2865404C (OSRAM) |
| CL (2) | CL2014002240A1 (OSRAM) |
| CO (1) | CO7111274A2 (OSRAM) |
| CY (1) | CY1119590T1 (OSRAM) |
| DK (1) | DK2817338T3 (OSRAM) |
| ES (2) | ES2812849T3 (OSRAM) |
| HK (3) | HK1231488A1 (OSRAM) |
| HR (1) | HRP20171549T1 (OSRAM) |
| HU (1) | HUE037021T2 (OSRAM) |
| IL (2) | IL234155B (OSRAM) |
| LT (1) | LT2817338T (OSRAM) |
| ME (1) | ME02928B (OSRAM) |
| MX (2) | MX2014010074A (OSRAM) |
| NZ (1) | NZ628804A (OSRAM) |
| PE (2) | PE20190658A1 (OSRAM) |
| PH (1) | PH12014501876A1 (OSRAM) |
| PL (1) | PL2817338T3 (OSRAM) |
| PT (1) | PT2817338T (OSRAM) |
| RS (1) | RS56443B1 (OSRAM) |
| RU (1) | RU2014138474A (OSRAM) |
| SG (2) | SG11201405131XA (OSRAM) |
| SI (1) | SI2817338T1 (OSRAM) |
| SM (1) | SMT201700467T1 (OSRAM) |
| WO (1) | WO2013126746A2 (OSRAM) |
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2530091T3 (en) | 2010-01-29 | 2018-05-28 | Chugai Pharmaceutical Co Ltd | ANTI-DLL3 ANTIBODY |
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| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| ES2731681T3 (es) * | 2013-02-22 | 2019-11-18 | Abbvie Stemcentrx Llc | Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos |
| AU2014312215B2 (en) | 2013-08-28 | 2020-02-27 | Abbvie Stemcentrx Llc | Site-specific antibody conjugation methods and compositions |
| CN105873612A (zh) * | 2013-08-28 | 2016-08-17 | 施特姆森特克斯股份有限公司 | 改造的抗-dll3缀合物以及应用方法 |
| SG11201510740YA (en) | 2013-09-17 | 2016-01-28 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| JPWO2015068847A1 (ja) | 2013-11-11 | 2017-03-09 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子 |
| TWI700295B (zh) * | 2013-12-16 | 2020-08-01 | 馬來西亞商Ｍａｂ探索私人有限公司 | 對會感染人類之腸病毒具有專一性之抗體 |
| EP3107576A4 (en) * | 2014-02-21 | 2017-09-06 | Abbvie Stemcentrx LLC | Anti-dll3 antibodies and drug conjugates for use in melanoma |
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| US9732145B2 (en) * | 2014-07-31 | 2017-08-15 | The Israel Institute of Biological Research (IIBR) | Antibodies directed to Bacillus anthracis protective antigen |
| AU2015294834B2 (en) | 2014-07-31 | 2021-04-29 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
| EP4632120A2 (en) | 2014-11-11 | 2025-10-15 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
| MA41613A (fr) * | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
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