JP2017537658A5 - - Google Patents
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- JP2017537658A5 JP2017537658A5 JP2017550468A JP2017550468A JP2017537658A5 JP 2017537658 A5 JP2017537658 A5 JP 2017537658A5 JP 2017550468 A JP2017550468 A JP 2017550468A JP 2017550468 A JP2017550468 A JP 2017550468A JP 2017537658 A5 JP2017537658 A5 JP 2017537658A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- primer
- strand
- template
- stranded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 238000000034 method Methods 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 11
- 230000003321 amplification Effects 0.000 claims 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 4
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 238000006073 displacement reaction Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108091093088 Amplicon Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 108010068698 spleen exonuclease Proteins 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462092102P | 2014-12-15 | 2014-12-15 | |
| US62/092,102 | 2014-12-15 | ||
| PCT/US2015/065890 WO2016100388A1 (en) | 2014-12-15 | 2015-12-15 | Exponential base-greater-than-2 nucleic acid amplification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537658A JP2017537658A (ja) | 2017-12-21 |
| JP2017537658A5 true JP2017537658A5 (enExample) | 2019-02-07 |
| JP6804462B2 JP6804462B2 (ja) | 2020-12-23 |
Family
ID=55071208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550468A Active JP6804462B2 (ja) | 2014-12-15 | 2015-12-15 | 指数関数の底が２より大きい核酸増幅 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10273534B2 (enExample) |
| EP (1) | EP3234188B1 (enExample) |
| JP (1) | JP6804462B2 (enExample) |
| CN (2) | CN114369596B (enExample) |
| AU (2) | AU2015362617B2 (enExample) |
| CA (1) | CA2971006C (enExample) |
| DK (1) | DK3234188T3 (enExample) |
| ES (1) | ES2764975T3 (enExample) |
| HK (1) | HK1247255A1 (enExample) |
| PT (1) | PT3234188T (enExample) |
| WO (1) | WO2016100388A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114369596B (zh) | 2014-12-15 | 2025-07-08 | 塞弗德公司 | 底数大于2的指数核酸扩增 |
| EP3287528A1 (de) | 2016-08-25 | 2018-02-28 | AGCT GmbH | Verfahren zur amplifikation von nukleinsäuren und kit zu dessen durchführung |
| EP3759247A1 (de) * | 2018-02-26 | 2021-01-06 | AGCT GmbH | Verfahren zur primer-verlängerungsreaktion mit verbesserter spezifität |
| WO2019162530A1 (de) * | 2018-02-26 | 2019-08-29 | Agct Gmbh | Agverfahren zur amplifikation einer nukleinsäure mit verbesserter spezifität |
| WO2019166586A1 (de) * | 2018-02-28 | 2019-09-06 | Agct Gmbh | Verfahren zur amplifikation einer nukleinsäure mit verbesserter spezifität |
| EP3874064A1 (en) * | 2018-10-29 | 2021-09-08 | Cepheid | Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers |
| US20210403981A1 (en) * | 2020-04-27 | 2021-12-30 | Cepheid | Exponential base-3 and greater nucleic acid amplification with cycling probe |
| US20230250471A1 (en) * | 2020-06-23 | 2023-08-10 | HeimBiotek, Inc. | Composition for sequential polymerase chain reaction, and gene amplification method using same |
| JP2024501832A (ja) | 2020-12-24 | 2024-01-16 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | 高忠実度ＤＮＡポリメラーゼによるｒｈＰＣＲベース増幅産物シーケンシングにおいて、プライマー二量体及びオフターゲット増幅を低減するＲＮアーゼＨ２突然変異体 |
| AU2023222749A1 (en) * | 2022-02-15 | 2024-08-29 | Cepheid | Exponential base-greater-than-base 2 nucleic acid amplification using high- and low-tm primers |
| KR20250155028A (ko) * | 2023-02-23 | 2025-10-29 | 세페이드 | 앰플리콘 폴딩 및 Tm을 감소시키기 위한 불안정화 뉴클레오타이드 삼인산의 용도 |
| WO2026019604A1 (en) * | 2024-07-19 | 2026-01-22 | Cepheid | Exponential base-x amplification with hairpin nested primers and universal flanking primers |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| AU8132994A (en) | 1993-11-05 | 1995-05-23 | Board Of Trustees Of The Leland Stanford Junior University | Nucleic acids encoding {his5, trp7, tyr8}-gnrh preprohormone and {ser8}-gnrh preprohormone and their uses |
| CA2244891C (en) | 1996-02-09 | 2008-12-30 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6312892B1 (en) | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
| US5958349A (en) | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| WO1999033559A1 (en) | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6027998A (en) | 1997-12-17 | 2000-02-22 | Advanced Micro Devices, Inc. | Method for fully planarized conductive line for a stack gate |
| US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| ATE302263T1 (de) | 1999-05-28 | 2005-09-15 | Cepheid | Anlage zum brechen von zellen |
| US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
| US6262490B1 (en) | 1999-11-05 | 2001-07-17 | Advanced Semiconductor Engineering, Inc. | Substrate strip for use in packaging semiconductor chips |
| RU2252964C2 (ru) * | 1999-11-08 | 2005-05-27 | Эйкен Кагаку Кабусики Кайся | Способ и набор для синтеза нуклеиновой кислоты, имеющей нуклеотидную последовательность, где в одной цепи попеременно связаны комплементарные нуклеотидные последовательности |
| US6403037B1 (en) | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
| CA2410950A1 (en) | 2000-05-30 | 2001-12-06 | Hans-Michael Wenz | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| WO2002090538A1 (en) * | 2001-05-08 | 2002-11-14 | Eiken Kagaku Kabushiki Kaisha | Method of synthesizing nucleic acid |
| ATE408711T1 (de) | 2002-03-01 | 2008-10-15 | Integrated Dna Tech Inc | Polynomiale amplifikation von nukleinsäuren |
| DE10253337B4 (de) * | 2002-11-14 | 2005-10-20 | November Ag Molekulare Medizin | Verfahren zum Nachweis einer Nukleinsäure |
| WO2004068112A2 (en) | 2003-01-28 | 2004-08-12 | Gorilla Genomics, Inc. | Hairpin primer amplification |
| US8871469B1 (en) | 2004-11-13 | 2014-10-28 | Steven Albert Benner | Self-avoiding molecular recognition systems in DNA priming |
| JP2008029335A (ja) * | 2006-07-03 | 2008-02-14 | Fujifilm Corp | 新規遺伝子増幅法に用いられるプライマーセットおよびキット |
| JP2008048648A (ja) * | 2006-08-23 | 2008-03-06 | Institute Of Physical & Chemical Research | 核酸増幅用プライマーセット及び核酸の増幅方法 |
| US8252558B2 (en) | 2006-10-09 | 2012-08-28 | Oxitec Limited | Methods for amplifying and detecting nucleic acid sequences |
| CN101631796B (zh) * | 2007-03-09 | 2013-08-07 | 独立行政法人理化学研究所 | 具有由单核苷或单核苷酸衍生的结构的化合物、核酸、标记物以及核酸检测方法和试剂盒 |
| CA2734868C (en) * | 2008-08-26 | 2019-09-10 | Fluidigm Corporation | Assay methods for increased throughput of samples and/or targets |
| WO2010133972A1 (en) * | 2009-05-22 | 2010-11-25 | Population Genetics Technologies Ltd | Sorting asymmetrically tagged nucleic acids by selective primer extension |
| CN102559928A (zh) * | 2011-12-28 | 2012-07-11 | 中国海洋大学 | 特异性引物组、包含其的试剂盒、使用方法及检测方法 |
| KR20130107881A (ko) * | 2012-03-23 | 2013-10-02 | 삼성테크윈 주식회사 | 클라미디아 및 임균 유래의 표적 유전자를 동시에 증폭하고 검출하기 위한 멀티 플렉스 키트 및 이를 이용한 진단 방법 |
| US9074249B2 (en) * | 2012-06-04 | 2015-07-07 | New England Biolabs, Inc. | Detection of amplification products |
| EP2971106B1 (en) | 2013-03-11 | 2020-02-26 | ELITechGroup, Inc. | Methods for true isothermal strand displacement amplification |
| CN114369596B (zh) | 2014-12-15 | 2025-07-08 | 塞弗德公司 | 底数大于2的指数核酸扩增 |
| EP3759247A1 (de) | 2018-02-26 | 2021-01-06 | AGCT GmbH | Verfahren zur primer-verlängerungsreaktion mit verbesserter spezifität |
| EP3874064A1 (en) | 2018-10-29 | 2021-09-08 | Cepheid | Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers |
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2015
- 2015-12-15 CN CN202111433266.1A patent/CN114369596B/zh active Active
- 2015-12-15 CA CA2971006A patent/CA2971006C/en active Active
- 2015-12-15 WO PCT/US2015/065890 patent/WO2016100388A1/en not_active Ceased
- 2015-12-15 PT PT158207563T patent/PT3234188T/pt unknown
- 2015-12-15 AU AU2015362617A patent/AU2015362617B2/en active Active
- 2015-12-15 ES ES15820756T patent/ES2764975T3/es active Active
- 2015-12-15 DK DK15820756.3T patent/DK3234188T3/da active
- 2015-12-15 HK HK18106922.0A patent/HK1247255A1/zh unknown
- 2015-12-15 JP JP2017550468A patent/JP6804462B2/ja active Active
- 2015-12-15 US US15/535,009 patent/US10273534B2/en active Active
- 2015-12-15 EP EP15820756.3A patent/EP3234188B1/en active Active
- 2015-12-15 CN CN201580076131.0A patent/CN107429292B/zh active Active
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2019
- 2019-03-20 US US16/359,947 patent/US11028434B2/en active Active
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2021
- 2021-05-03 US US17/306,761 patent/US11952621B2/en active Active
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2022
- 2022-05-25 AU AU2022203553A patent/AU2022203553B2/en active Active