JP2017537658A5 - - Google Patents
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- JP2017537658A5 JP2017537658A5 JP2017550468A JP2017550468A JP2017537658A5 JP 2017537658 A5 JP2017537658 A5 JP 2017537658A5 JP 2017550468 A JP2017550468 A JP 2017550468A JP 2017550468 A JP2017550468 A JP 2017550468A JP 2017537658 A5 JP2017537658 A5 JP 2017537658A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- primer
- strand
- template
- stranded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004707 nucleic acids Proteins 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 238000000034 method Methods 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 11
- 230000003321 amplification Effects 0.000 claims 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 4
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 238000006073 displacement reaction Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108091093088 Amplicon Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 108010068698 spleen exonuclease Proteins 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462092102P | 2014-12-15 | 2014-12-15 | |
| US62/092,102 | 2014-12-15 | ||
| PCT/US2015/065890 WO2016100388A1 (en) | 2014-12-15 | 2015-12-15 | Exponential base-greater-than-2 nucleic acid amplification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537658A JP2017537658A (ja) | 2017-12-21 |
| JP2017537658A5 true JP2017537658A5 (enExample) | 2019-02-07 |
| JP6804462B2 JP6804462B2 (ja) | 2020-12-23 |
Family
ID=55071208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550468A Active JP6804462B2 (ja) | 2014-12-15 | 2015-12-15 | 指数関数の底が２より大きい核酸増幅 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10273534B2 (enExample) |
| EP (1) | EP3234188B1 (enExample) |
| JP (1) | JP6804462B2 (enExample) |
| CN (2) | CN114369596B (enExample) |
| AU (2) | AU2015362617B2 (enExample) |
| CA (1) | CA2971006C (enExample) |
| DK (1) | DK3234188T3 (enExample) |
| ES (1) | ES2764975T3 (enExample) |
| HK (1) | HK1247255A1 (enExample) |
| PT (1) | PT3234188T (enExample) |
| WO (1) | WO2016100388A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3234188B1 (en) | 2014-12-15 | 2019-10-23 | Cepheid | Exponential base-greater-than-2 nucleic acid amplification |
| EP3287528A1 (de) * | 2016-08-25 | 2018-02-28 | AGCT GmbH | Verfahren zur amplifikation von nukleinsäuren und kit zu dessen durchführung |
| CN112074612A (zh) * | 2018-02-26 | 2020-12-11 | Agct有限公司 | 一种具有更高特异性的核酸扩增方法 |
| US20210071243A1 (en) * | 2018-02-26 | 2021-03-11 | Agct Gmbh | Method for primer extension reaction with improved specificity |
| EP3759246A1 (de) * | 2018-02-28 | 2021-01-06 | AGCT GmbH | Verfahren zur amplifikation einer nukleinsäure mit verbesserter spezifität |
| CN113227398B (zh) | 2018-10-29 | 2025-03-14 | 塞弗德公司 | 在减少的扩增时间下使用巢式重叠引物的指数基数-3核酸扩增 |
| US20210403981A1 (en) * | 2020-04-27 | 2021-12-30 | Cepheid | Exponential base-3 and greater nucleic acid amplification with cycling probe |
| WO2021261928A1 (ko) * | 2020-06-23 | 2021-12-30 | (주)하임바이오텍 | 순차적 중합효소 연쇄 반응용 조성물 및 이를 이용한 유전자 증폭 방법 |
| US12024742B2 (en) | 2020-12-24 | 2024-07-02 | Integrated Dna Technologies, Inc. | RNASE H2 mutants that reduce primer dimers and off-target amplification in RHPCR-based amplicon sequencing with high-fidelity DNA polymerases |
| KR20240152864A (ko) * | 2022-02-15 | 2024-10-22 | 세페이드 | 고- 및 저-Tm 프라이머를 사용하는 베이스 2 초과의 지수적 베이스의 핵산 증폭 |
| AU2024225975A1 (en) * | 2023-02-23 | 2025-08-14 | Cepheid | Use of destabilizing nucleotide triphosphates to reduce amplicon folding and tm |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| AU8132994A (en) | 1993-11-05 | 1995-05-23 | Board Of Trustees Of The Leland Stanford Junior University | Nucleic acids encoding {his5, trp7, tyr8}-gnrh preprohormone and {ser8}-gnrh preprohormone and their uses |
| EP2573101B1 (en) | 1996-02-09 | 2016-04-20 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| WO1997045559A1 (en) | 1996-05-29 | 1997-12-04 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6312892B1 (en) | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
| US5958349A (en) | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6027998A (en) | 1997-12-17 | 2000-02-22 | Advanced Micro Devices, Inc. | Method for fully planarized conductive line for a stack gate |
| EP1179585B1 (en) | 1997-12-24 | 2008-07-09 | Cepheid | Device and method for lysis |
| US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| WO2000073412A2 (en) | 1999-05-28 | 2000-12-07 | Cepheid | Apparatus and method for analyzing a fluid sample |
| US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
| US6262490B1 (en) | 1999-11-05 | 2001-07-17 | Advanced Semiconductor Engineering, Inc. | Substrate strip for use in packaging semiconductor chips |
| BR0015382B1 (pt) * | 1999-11-08 | 2014-04-29 | Eiken Chemical | Processos e kits para sintetizacao e amplificação do acido nucleico bem como, processos para detectar uma sequencia de nucleotideo alvo e de uma mutacao da dita sequencia |
| US6403037B1 (en) | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
| JP2004507226A (ja) | 2000-05-30 | 2004-03-11 | ピーイー コーポレイション （エヌワイ） | ライゲーションおよび増幅の組み合わせを用いて標的核酸を検出するための方法 |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| JPWO2002090538A1 (ja) * | 2001-05-08 | 2004-08-26 | 栄研化学株式会社 | 核酸を合成する方法 |
| WO2003074724A2 (en) | 2002-03-01 | 2003-09-12 | Integrated Dna Technologies, Inc. | Polynomial amplification of nucleic acids |
| DE10253337B4 (de) * | 2002-11-14 | 2005-10-20 | November Ag Molekulare Medizin | Verfahren zum Nachweis einer Nukleinsäure |
| US20040259116A1 (en) | 2003-01-28 | 2004-12-23 | Gorilla Genomics, Inc. | Hairpin primer amplification |
| US8871469B1 (en) | 2004-11-13 | 2014-10-28 | Steven Albert Benner | Self-avoiding molecular recognition systems in DNA priming |
| JP2008029335A (ja) * | 2006-07-03 | 2008-02-14 | Fujifilm Corp | 新規遺伝子増幅法に用いられるプライマーセットおよびキット |
| JP2008048648A (ja) * | 2006-08-23 | 2008-03-06 | Institute Of Physical & Chemical Research | 核酸増幅用プライマーセット及び核酸の増幅方法 |
| WO2008043987A2 (en) | 2006-10-09 | 2008-04-17 | Oxitec Limited | Methods for amplifying and detecting nucleic acid sequences |
| CN101631796B (zh) * | 2007-03-09 | 2013-08-07 | 独立行政法人理化学研究所 | 具有由单核苷或单核苷酸衍生的结构的化合物、核酸、标记物以及核酸检测方法和试剂盒 |
| WO2010027870A2 (en) * | 2008-08-26 | 2010-03-11 | Fluidigm Corporation | Assay methods for increased throughput of samples and/or targets |
| EP2432899A1 (en) * | 2009-05-22 | 2012-03-28 | Population Genetics Technologies LTD. | Sorting asymmetrically tagged nucleic acids by selective primer extension |
| CN102559928A (zh) * | 2011-12-28 | 2012-07-11 | 中国海洋大学 | 特异性引物组、包含其的试剂盒、使用方法及检测方法 |
| KR20130107881A (ko) * | 2012-03-23 | 2013-10-02 | 삼성테크윈 주식회사 | 클라미디아 및 임균 유래의 표적 유전자를 동시에 증폭하고 검출하기 위한 멀티 플렉스 키트 및 이를 이용한 진단 방법 |
| US9074249B2 (en) * | 2012-06-04 | 2015-07-07 | New England Biolabs, Inc. | Detection of amplification products |
| WO2014164479A1 (en) | 2013-03-11 | 2014-10-09 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
| EP3234188B1 (en) | 2014-12-15 | 2019-10-23 | Cepheid | Exponential base-greater-than-2 nucleic acid amplification |
| US20210071243A1 (en) | 2018-02-26 | 2021-03-11 | Agct Gmbh | Method for primer extension reaction with improved specificity |
| CN113227398B (zh) | 2018-10-29 | 2025-03-14 | 塞弗德公司 | 在减少的扩增时间下使用巢式重叠引物的指数基数-3核酸扩增 |
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2015
- 2015-12-15 EP EP15820756.3A patent/EP3234188B1/en active Active
- 2015-12-15 ES ES15820756T patent/ES2764975T3/es active Active
- 2015-12-15 US US15/535,009 patent/US10273534B2/en active Active
- 2015-12-15 CN CN202111433266.1A patent/CN114369596B/zh active Active
- 2015-12-15 HK HK18106922.0A patent/HK1247255A1/zh unknown
- 2015-12-15 CN CN201580076131.0A patent/CN107429292B/zh active Active
- 2015-12-15 DK DK15820756.3T patent/DK3234188T3/da active
- 2015-12-15 JP JP2017550468A patent/JP6804462B2/ja active Active
- 2015-12-15 CA CA2971006A patent/CA2971006C/en active Active
- 2015-12-15 AU AU2015362617A patent/AU2015362617B2/en active Active
- 2015-12-15 WO PCT/US2015/065890 patent/WO2016100388A1/en not_active Ceased
- 2015-12-15 PT PT158207563T patent/PT3234188T/pt unknown
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2019
- 2019-03-20 US US16/359,947 patent/US11028434B2/en active Active
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2021
- 2021-05-03 US US17/306,761 patent/US11952621B2/en active Active
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2022
- 2022-05-25 AU AU2022203553A patent/AU2022203553B2/en active Active