JP2005270108A5 - - Google Patents
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- JP2005270108A5 JP2005270108A5 JP2005120409A JP2005120409A JP2005270108A5 JP 2005270108 A5 JP2005270108 A5 JP 2005270108A5 JP 2005120409 A JP2005120409 A JP 2005120409A JP 2005120409 A JP2005120409 A JP 2005120409A JP 2005270108 A5 JP2005270108 A5 JP 2005270108A5
- Authority
- JP
- Japan
- Prior art keywords
- strand
- nucleic acid
- target strand
- primer
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/104,067 US6743605B1 (en) | 1998-06-24 | 1998-06-24 | Linear amplification of specific nucleic acid sequences |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003428482A Division JP4493330B2 (ja) | 1998-06-24 | 2003-12-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005270108A JP2005270108A (ja) | 2005-10-06 |
| JP2005270108A5 true JP2005270108A5 (enExample) | 2008-05-08 |
| JP4675141B2 JP4675141B2 (ja) | 2011-04-20 |
Family
ID=22298492
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11179056A Withdrawn JP2000037194A (ja) | 1998-06-24 | 1999-06-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
| JP2003428482A Expired - Lifetime JP4493330B2 (ja) | 1998-06-24 | 2003-12-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
| JP2005120409A Expired - Lifetime JP4675141B2 (ja) | 1998-06-24 | 2005-04-18 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11179056A Withdrawn JP2000037194A (ja) | 1998-06-24 | 1999-06-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
| JP2003428482A Expired - Lifetime JP4493330B2 (ja) | 1998-06-24 | 2003-12-24 | 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (11) | US6743605B1 (enExample) |
| EP (1) | EP0971039B1 (enExample) |
| JP (3) | JP2000037194A (enExample) |
| CA (1) | CA2273064C (enExample) |
| DE (1) | DE69943292D1 (enExample) |
| IL (1) | IL130477A (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| US6261808B1 (en) | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US8445664B2 (en) | 1998-06-24 | 2013-05-21 | Enzo Diagnostics, Inc. | Kits for amplifying and detecting nucleic acid sequences |
| US6743605B1 (en) * | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
| ES2393056T3 (es) | 1998-11-09 | 2012-12-18 | Eiken Kagaku Kabushiki Kaisha | Procedimiento de síntesis de ácido nucleico |
| JP3974441B2 (ja) * | 1998-11-09 | 2007-09-12 | 栄研化学株式会社 | 核酸の合成方法 |
| US6692918B2 (en) | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| CN1415020A (zh) | 1999-11-08 | 2003-04-30 | 荣研化学株式会社 | 检测突变和/或多态性的方法 |
| HK1052203A1 (zh) * | 1999-11-08 | 2003-09-05 | 荣研化学株式会社 | 检测突变和/或多态性的方法 |
| AU2001244677A1 (en) * | 2000-04-07 | 2001-10-23 | Eiken Kagaku Kabushiki Kaisha | Method of amplifying nucleic acid by using double-stranded nucleic acid as template |
| JP2001309785A (ja) * | 2000-05-01 | 2001-11-06 | Eiken Chem Co Ltd | 遺伝子配列間の相違検出方法 |
| WO2002000938A2 (en) | 2000-06-26 | 2002-01-03 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| EP2031058B1 (en) * | 2000-09-19 | 2012-07-18 | Eiken Kagaku Kabushiki Kaisha | Method of synthesizing polynucleotide |
| WO2002048402A2 (en) | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
| US6946251B2 (en) | 2001-03-09 | 2005-09-20 | Nugen Technologies, Inc. | Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers |
| WO2002072773A2 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| US9261460B2 (en) | 2002-03-12 | 2016-02-16 | Enzo Life Sciences, Inc. | Real-time nucleic acid detection processes and compositions |
| US9777312B2 (en) | 2001-06-30 | 2017-10-03 | Enzo Life Sciences, Inc. | Dual polarity analysis of nucleic acids |
| JP2005052002A (ja) * | 2001-07-06 | 2005-03-03 | Wakunaga Pharmaceut Co Ltd | 非環状核酸断片の増幅方法 |
| ATE425263T1 (de) | 2001-11-19 | 2009-03-15 | Parallele Bioscience Inc | Multiplex-oligonukleotidaddition und zielamplifikation |
| US20110151438A9 (en) | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
| US9353405B2 (en) | 2002-03-12 | 2016-05-31 | Enzo Life Sciences, Inc. | Optimized real time nucleic acid detection processes |
| US6815167B2 (en) | 2002-04-25 | 2004-11-09 | Geneohm Sciences | Amplification of DNA to produce single-stranded product of defined sequence and length |
| AU2003253651C1 (en) | 2002-06-14 | 2010-06-03 | Gen-Probe Incorporated | Compositions and methods for detecting hepatitis B virus |
| GB0218215D0 (en) * | 2002-08-06 | 2002-09-11 | Tepnel Medical Ltd | Amplification of nucleic acids |
| US7803579B2 (en) | 2002-10-29 | 2010-09-28 | Riken | Process for amplifying nucleic acid |
| US7402386B2 (en) | 2003-04-14 | 2008-07-22 | Nugen Technologies, Inc. | Global amplification using random priming by a composite primer |
| US8206902B2 (en) | 2003-12-25 | 2012-06-26 | Riken | Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same |
| US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
| CA2476030A1 (en) * | 2004-06-09 | 2005-12-09 | Wilsun Xu | A power signaling based technique for detecting islanding conditions in electric power distribution systems |
| US8124334B2 (en) * | 2004-07-06 | 2012-02-28 | Enzo Biochem, Inc. | Selective detection of oncogenic HPV |
| WO2006034387A1 (en) * | 2004-09-21 | 2006-03-30 | Applera Corporation | TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (miRNAs) |
| EP1696040A1 (en) * | 2005-02-28 | 2006-08-30 | Eurofins Viralliance, Inc. | Method of genotyping and phenotyping hepatitis B viruses resistant to antiviral molecules |
| WO2006108423A2 (en) | 2005-04-12 | 2006-10-19 | In Situ Rcp A/S Under Founding | Methods for production of oligonucleotides |
| WO2006108422A2 (en) * | 2005-04-12 | 2006-10-19 | In Situ Rcp A/S Under Founding | Methods for production of oligonucleotides |
| CA2610294C (en) | 2005-05-09 | 2023-10-03 | Theranos, Inc. | Point-of-care fluidic systems and uses thereof |
| ATE550441T1 (de) * | 2005-09-06 | 2012-04-15 | Gen Probe Inc | Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren |
| WO2007030759A2 (en) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
| EP1954298A4 (en) * | 2005-11-28 | 2012-10-31 | Imaginot Pty Ltd | DISPENSING SYSTEM FOR ORAL THERAPEUTIC CONNECTION |
| JP4580875B2 (ja) | 2006-01-20 | 2010-11-17 | 株式会社東芝 | 核酸検出法のためのプライマーの設計方法 |
| US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
| US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
| US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
| US7501254B2 (en) | 2006-07-20 | 2009-03-10 | Ghc Technologies, Inc. | Methods and compositions for amplification and capture of nucleic acid sequences |
| US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
| US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
| AU2008206221A1 (en) * | 2007-01-17 | 2008-07-24 | Meridian Bioscience, Inc. | Stable reagents and kits useful in loop-mediated isothermal amplification (LAMP) |
| US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
| CN108333379B (zh) | 2007-10-02 | 2021-09-07 | 拉布拉多诊断有限责任公司 | 模块化现场护理装置及其应用 |
| US8420323B2 (en) * | 2007-11-14 | 2013-04-16 | Fujifilm Corporation | Nucleic acid amplification method |
| US20090162845A1 (en) | 2007-12-20 | 2009-06-25 | Elazar Rabbani | Affinity tag nucleic acid and protein compositions, and processes for using same |
| US20090203531A1 (en) * | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| WO2009117698A2 (en) | 2008-03-21 | 2009-09-24 | Nugen Technologies, Inc. | Methods of rna amplification in the presence of dna |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| CA2750879C (en) | 2009-01-30 | 2018-05-22 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| US9393564B2 (en) | 2009-03-30 | 2016-07-19 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| EP2272980A1 (en) * | 2009-07-09 | 2011-01-12 | Bioesplora SRL | Molecular probes for target nucleic acid detection and quantification |
| WO2011014811A1 (en) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| CA3081708C (en) | 2009-10-19 | 2023-10-03 | Theranos Ip Company, Llc | Integrated health data capture and analysis system |
| US8916362B2 (en) | 2009-11-23 | 2014-12-23 | Swift Biosciences, Inc. | Devices comprising a polynucleotide to extend single stranded target molecules |
| CN106248582B (zh) | 2011-01-21 | 2020-10-20 | 拉布拉多诊断有限责任公司 | 样品使用最大化的系统和方法 |
| US9957560B2 (en) | 2011-07-25 | 2018-05-01 | Oxford Nanopore Technologies Ltd. | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| US9109226B2 (en) * | 2011-09-01 | 2015-08-18 | New England Biolabs, Inc. | Synthetic nucleic acids for polymerization reactions |
| US9416153B2 (en) | 2011-10-11 | 2016-08-16 | Enzo Life Sciences, Inc. | Fluorescent dyes |
| WO2013101935A1 (en) | 2011-12-27 | 2013-07-04 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
| WO2013101783A2 (en) | 2011-12-30 | 2013-07-04 | Bio-Rad Laboratories, Inc. | Methods and compositions for performing nucleic acid amplification reactions |
| CN108611398A (zh) | 2012-01-13 | 2018-10-02 | Data生物有限公司 | 通过新一代测序进行基因分型 |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| EP2880186B1 (en) | 2012-08-03 | 2019-02-06 | University Of Washington Through Its Center For Commercialization | Compositions and methods for improving nanopore sequencing |
| EP2943593B1 (en) | 2013-01-08 | 2019-04-24 | Enzo Biochem, Inc. | Diagnosis and treatment of herpesvirus saimiri associated diseases |
| US9617607B2 (en) | 2013-01-08 | 2017-04-11 | Enzo Biochem, Inc. | Diagnosis and treatment of viral diseases |
| BR112015021788B1 (pt) | 2013-03-08 | 2023-02-28 | Oxford Nanopore Technologies Plc | Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| EP3587592A1 (en) | 2013-03-15 | 2020-01-01 | Theranos IP Company, LLC | Nucleic acid amplification |
| BR112015023398A8 (pt) | 2013-03-15 | 2022-08-23 | Theranos Inc | Métodos para amplificar ácidos nucléicos |
| US20140302504A1 (en) | 2013-03-15 | 2014-10-09 | Theranos, Inc. | Nucleic Acid Amplification |
| US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| KR20160053979A (ko) | 2013-09-06 | 2016-05-13 | 테라노스, 인코포레이티드 | 전염성 질환의 검출을 위한 시스템 및 방법 |
| AU2015208919B9 (en) | 2014-01-22 | 2021-04-01 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| WO2015166275A1 (en) | 2014-05-02 | 2015-11-05 | Oxford Nanopore Technologies Limited | Mutant pores |
| EP3151965B1 (en) | 2014-06-04 | 2021-02-24 | Edan Instruments, Inc. | Sample collection and analysis devices |
| CN106661600B (zh) | 2014-07-16 | 2021-04-06 | 唐恩生物科技股份有限公司 | 用于扩增核酸样品的等温方法 |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| CA2961209A1 (en) * | 2014-09-17 | 2016-03-24 | Theranos, Inc. | Diagnostic methods and compositions |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| WO2016073353A1 (en) | 2014-11-03 | 2016-05-12 | Tangen Biosciences, Inc. | Apparatus and method for cell, spore, or virus capture and disruption |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| CN109072295B (zh) | 2015-12-08 | 2022-05-31 | 鲁汶大学研究与发展中心 | 修饰的纳米孔,包含其的组合物及其应用 |
| WO2017142825A2 (en) * | 2016-02-18 | 2017-08-24 | Merck Sharp & Dohme Corp. | N3-substituted iminopyrimidinones as antimalarial agents |
| WO2017149316A1 (en) | 2016-03-02 | 2017-09-08 | Oxford Nanopore Technologies Limited | Mutant pore |
| CN118326018B (zh) | 2016-04-06 | 2025-11-07 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| CN109477133B (zh) | 2016-06-09 | 2023-04-11 | 加利福尼亚大学董事会 | 用于纸基免疫测定的生物标志物浓缩和信号放大以及用于提取、浓缩和扩增dna的单一平台 |
| US10822648B1 (en) | 2016-07-29 | 2020-11-03 | Labrador Diagnostics Llc | Hybrid multi-step nucleic acid amplification |
| DK3565905T4 (da) | 2017-01-04 | 2025-09-01 | Mgi Tech Co Ltd | Nukleinsyresekvensering ved hjælp af affinitetsreagenser |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| EP3642363B1 (en) | 2017-06-20 | 2025-12-24 | Bio-Rad Laboratories, Inc. | Mda using bead oligonucleotide |
| AU2018294660B2 (en) | 2017-06-30 | 2022-05-19 | Oxford Nanopore Technologies Plc | Novel protein pores |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE265429C (enExample) | 1911-12-15 | 1913-10-10 | ||
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US5241060A (en) | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
| US5260433A (en) | 1982-06-23 | 1993-11-09 | Enzo Diagnostics, Inc. | Saccharide specific binding system labeled nucleotides |
| US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
| US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US5360523A (en) | 1984-03-29 | 1994-11-01 | Li-Cor, Inc. | DNA sequencing |
| US4729947A (en) | 1984-03-29 | 1988-03-08 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
| US5346603A (en) | 1984-03-29 | 1994-09-13 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
| US5230781A (en) | 1984-03-29 | 1993-07-27 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes |
| US4749647A (en) * | 1984-06-22 | 1988-06-07 | Genetic Systems Corporation | Polymerization-induced separation assay using recognition pairs |
| GB8421967D0 (en) * | 1984-08-30 | 1984-10-03 | Hickory Springs Mfg Co | Polyurethane foams |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5093232A (en) * | 1985-12-11 | 1992-03-03 | Chiron Corporation | Nucleic acid probes |
| JP3293820B2 (ja) | 1985-12-13 | 2002-06-17 | エンゾ− バイオケム インコ−ポレイテツド | 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物 |
| CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
| US5047519A (en) * | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5032570A (en) | 1987-08-04 | 1991-07-16 | Hitachi Metals, Ltd. | Method for producing ceramic superconducting material using intermediate products |
| DD265429A1 (de) * | 1987-09-30 | 1989-03-01 | Adl Inst Phytopathologie | Verfahren zur nichtradioaktiven markierung von polynukleotiden |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US5260428A (en) * | 1988-07-11 | 1993-11-09 | Boehringer Mannheim Gmbh | Agent for the detection of substances with hydrolase activity |
| US5508178A (en) | 1989-01-19 | 1996-04-16 | Rose; Samuel | Nucleic acid amplification using single primer |
| US5503975A (en) * | 1989-03-01 | 1996-04-02 | City Of Hope | Mechanism based inhibitors of DNA methyltransferase |
| JPH0750041Y2 (ja) | 1990-01-17 | 1995-11-15 | 大同特殊鋼株式会社 | 連続鋳造設備におけるタンディッシュ交換装置 |
| WO1992000989A1 (en) | 1990-07-10 | 1992-01-23 | Imperial Chemical Industries Plc | Non-isotopic nucleic acid labelling method |
| US5595891A (en) | 1990-07-19 | 1997-01-21 | Behringwerke Ag | Method for producing a polynucleotide for use in single primer amplification |
| US5439793A (en) | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
| US5518900A (en) * | 1993-01-15 | 1996-05-21 | Molecular Tool, Inc. | Method for generating single-stranded DNA molecules |
| US5569582A (en) * | 1991-07-15 | 1996-10-29 | Institute Of Molecular Biology & Technology | Rapid amplification and detection of nucleic acids |
| US5714323A (en) * | 1991-08-30 | 1998-02-03 | The University Of Medecine And Dentistry Of New Jersey | Over expression of single-stranded molecules |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5612199A (en) | 1991-10-11 | 1997-03-18 | Behringwerke Ag | Method for producing a polynucleotide for use in single primer amplification |
| WO1993009245A1 (en) * | 1991-10-31 | 1993-05-13 | University Of Pittsburgh | Reverse dot blot hybridization using tandem head-to-tail monomers containing probes synthesized by staggered complementary primers |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| ZA929351B (en) * | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| FR2687679B1 (fr) * | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | Oligothionucleotides. |
| US5462854A (en) | 1993-04-19 | 1995-10-31 | Beckman Instruments, Inc. | Inverse linkage oligonucleotides for chemical and enzymatic processes |
| US5470723A (en) | 1993-05-05 | 1995-11-28 | Becton, Dickinson And Company | Detection of mycobacteria by multiplex nucleic acid amplification |
| EP0785996A1 (en) | 1993-07-13 | 1997-07-30 | Abbott Laboratories | Nucleotide sequences and process for amplifying and detection of hepatitis b virus |
| CA2105364A1 (en) * | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| DE4331670A1 (de) * | 1993-09-17 | 1995-03-23 | Hoechst Ag | Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung |
| US5470184A (en) * | 1994-01-14 | 1995-11-28 | Chandler; Charles W. | Screw hole plug |
| US5462584A (en) * | 1994-03-21 | 1995-10-31 | Gas Research Institute | Process for dehydrating natural gas |
| FR2721945B1 (fr) | 1994-07-04 | 1996-10-18 | David Fabrice | Accroissement genique, un procede d'amplicication genique isotherme et ses applications |
| FR2726277B1 (fr) * | 1994-10-28 | 1996-12-27 | Bio Merieux | Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin |
| US5665545A (en) * | 1994-11-28 | 1997-09-09 | Akzo Nobel N.V. | Terminal repeat amplification method |
| US5798276A (en) * | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| WO1997004131A1 (en) * | 1995-07-21 | 1997-02-06 | Forsyth Dental Infirmary For Children | Single primer amplification of polynucleotide hairpins |
| US6114150A (en) | 1995-11-29 | 2000-09-05 | Yale University | Amplification of nucleic acids |
| GB9609441D0 (en) * | 1996-05-04 | 1996-07-10 | Zeneca Ltd | Process |
| US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
| JPH10312826A (ja) | 1997-03-10 | 1998-11-24 | Sanyo Electric Co Ltd | 非水電解質電池及びその充電方法 |
| EP0973788A1 (en) | 1997-04-02 | 2000-01-26 | Amersham Pharmacia Biotech UK Limited | Tricyclic base analogues |
| GB9717061D0 (en) | 1997-08-13 | 1997-10-15 | Tepnel Medical Ltd | Amplification of nucleic acids |
| US6087099A (en) * | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| GB9810865D0 (en) * | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Nucleic acid sequence identification |
| US5991238A (en) | 1998-06-09 | 1999-11-23 | Western Atlas International, Inc. | Weighted backus filter method of combining dual sensor traces |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6743605B1 (en) * | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
| ES2393056T3 (es) * | 1998-11-09 | 2012-12-18 | Eiken Kagaku Kabushiki Kaisha | Procedimiento de síntesis de ácido nucleico |
| US6114123A (en) * | 1999-06-14 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Lipocalin family protein |
| CN1415020A (zh) * | 1999-11-08 | 2003-04-30 | 荣研化学株式会社 | 检测突变和/或多态性的方法 |
| KR100612551B1 (ko) | 1999-11-08 | 2006-08-11 | 에이켄 카가꾸 가부시끼가이샤 | 핵산의 합성방법 |
-
1998
- 1998-06-24 US US09/104,067 patent/US6743605B1/en not_active Expired - Lifetime
-
1999
- 1999-06-14 IL IL13047799A patent/IL130477A/en not_active IP Right Cessation
- 1999-06-15 CA CA002273064A patent/CA2273064C/en not_active Expired - Lifetime
- 1999-06-24 EP EP99112181A patent/EP0971039B1/en not_active Expired - Lifetime
- 1999-06-24 DE DE69943292T patent/DE69943292D1/de not_active Expired - Lifetime
- 1999-06-24 JP JP11179056A patent/JP2000037194A/ja not_active Withdrawn
- 1999-11-12 US US09/439,594 patent/US6764821B1/en not_active Expired - Lifetime
-
2002
- 2002-11-22 US US10/303,152 patent/US20050260573A1/en not_active Abandoned
- 2002-11-22 US US10/304,035 patent/US7485417B2/en not_active Expired - Fee Related
- 2002-11-22 US US10/302,362 patent/US7264930B2/en not_active Expired - Lifetime
- 2002-11-27 US US10/307,108 patent/US8133989B2/en not_active Expired - Fee Related
- 2002-11-27 US US10/305,690 patent/US7468245B2/en not_active Expired - Fee Related
- 2002-11-27 US US10/305,664 patent/US7713691B2/en not_active Expired - Lifetime
- 2002-11-29 US US10/306,990 patent/US20030165938A1/en not_active Abandoned
-
2003
- 2003-12-24 JP JP2003428482A patent/JP4493330B2/ja not_active Expired - Lifetime
-
2005
- 2005-04-18 JP JP2005120409A patent/JP4675141B2/ja not_active Expired - Lifetime
-
2007
- 2007-10-26 US US11/925,556 patent/US8288092B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/925,730 patent/US8486633B2/en not_active Expired - Fee Related
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