EP3416647A4 - N3-substituted iminopyrimidinones as antimalarial agents - Google Patents

N3-substituted iminopyrimidinones as antimalarial agents Download PDF

Info

Publication number
EP3416647A4
EP3416647A4 EP17753680.2A EP17753680A EP3416647A4 EP 3416647 A4 EP3416647 A4 EP 3416647A4 EP 17753680 A EP17753680 A EP 17753680A EP 3416647 A4 EP3416647 A4 EP 3416647A4
Authority
EP
European Patent Office
Prior art keywords
iminopyrimidinones
substituted
antimalarial agents
antimalarial
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17753680.2A
Other languages
German (de)
French (fr)
Other versions
EP3416647A2 (en
Inventor
Tanweer A. KHAN
Jared N. Cumming
David B. Olsen
Justin A. BODDEY
Alan F. COWMAN
Brad E. SLEEBS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Walter and Eliza Hall Institute of Medical Research
Merck Sharp and Dohme LLC
Original Assignee
Walter and Eliza Hall Institute of Medical Research
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter and Eliza Hall Institute of Medical Research, Merck Sharp and Dohme LLC filed Critical Walter and Eliza Hall Institute of Medical Research
Publication of EP3416647A2 publication Critical patent/EP3416647A2/en
Publication of EP3416647A4 publication Critical patent/EP3416647A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP17753680.2A 2016-02-18 2017-02-13 N3-substituted iminopyrimidinones as antimalarial agents Withdrawn EP3416647A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662296823P 2016-02-18 2016-02-18
PCT/US2017/017603 WO2017142825A2 (en) 2016-02-18 2017-02-13 N3-substituted iminopyrimidinones as antimalarial agents

Publications (2)

Publication Number Publication Date
EP3416647A2 EP3416647A2 (en) 2018-12-26
EP3416647A4 true EP3416647A4 (en) 2019-10-23

Family

ID=59625369

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17753680.2A Withdrawn EP3416647A4 (en) 2016-02-18 2017-02-13 N3-substituted iminopyrimidinones as antimalarial agents

Country Status (3)

Country Link
US (1) US11766435B2 (en)
EP (1) EP3416647A4 (en)
WO (1) WO2017142825A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201805816D0 (en) * 2018-04-06 2018-05-23 Ucb Biopharma Sprl Therapeutic agents
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
GB201906804D0 (en) 2019-05-14 2019-06-26 Ucb Biopharma Sprl Therapeutic agents
WO2021026884A1 (en) * 2019-08-15 2021-02-18 Merck Sharp & Dohme Corp. Antimalarial agents
WO2021032687A1 (en) 2019-08-19 2021-02-25 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues
WO2021097676A1 (en) * 2019-11-19 2021-05-27 Merck Sharp & Dohme Corp. Antimalarial agents
WO2021155612A1 (en) * 2020-02-09 2021-08-12 Merck Sharp & Dohme Corp. Antimalarial agents
GB202010606D0 (en) 2020-07-10 2020-08-26 Ucb Biopharma Sprl Therapeutic agents
WO2023102747A1 (en) * 2021-12-07 2023-06-15 Merck Sharp & Dohme Llc Antimalarial agents
WO2022169790A1 (en) * 2021-02-05 2022-08-11 Merck Sharp & Dohme Llc Chemovaccination against plasmodium infection with selective plasmepsin x inhibitors
WO2023152042A1 (en) 2022-02-08 2023-08-17 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008103351A2 (en) * 2007-02-23 2008-08-28 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2013142396A1 (en) * 2012-03-23 2013-09-26 Merck Sharp & Dohme Corp. N3-substituted iminopyrimidinones as renin inhibitors, compositions, and their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US7579353B2 (en) 2005-03-04 2009-08-25 Glaxo Group Limited Pyridinone derivatives against malaria
US7759354B2 (en) 2005-06-14 2010-07-20 Schering Corporation Bicyclic guanidine derivatives as asparyl protease inhibitors, compositions, and uses thereof
CN101193892A (en) 2005-06-14 2008-06-04 先灵公司 Macrocyclic heterocyclic aspartyl protease inhibitors
AR061264A1 (en) 2006-06-12 2008-08-13 Schering Corp ASPARTILE-PROTEASES INHIBITORS DERIVED FROM PYRIMIDINE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES TO TREAT COGNITIVE OR NEURODEGENERATIVE DISEASES, AND AS HIV VIRUS INHIBITORS.
WO2014160775A1 (en) 2013-03-26 2014-10-02 Saint Louis University Compositions and methods for the treatment of malaria

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008103351A2 (en) * 2007-02-23 2008-08-28 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2013142396A1 (en) * 2012-03-23 2013-09-26 Merck Sharp & Dohme Corp. N3-substituted iminopyrimidinones as renin inhibitors, compositions, and their use

Also Published As

Publication number Publication date
US11766435B2 (en) 2023-09-26
EP3416647A2 (en) 2018-12-26
WO2017142825A2 (en) 2017-08-24
WO2017142825A3 (en) 2017-09-21
US20200230140A1 (en) 2020-07-23

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