|
US4172896A
(en)
|
1978-06-05 |
1979-10-30 |
Dainippon Pharmaceutical Co., Ltd. |
Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
|
|
US5049578A
(en)
|
1990-03-09 |
1991-09-17 |
E. R. Squibb & Sons, Inc. |
1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
|
|
GB9217295D0
(en)
|
1992-08-14 |
1992-09-30 |
Wellcome Found |
Controlled released tablets
|
|
US5541231A
(en)
|
1993-07-30 |
1996-07-30 |
Glaxo Wellcome Inc. |
Stabilized Pharmaceutical
|
|
US5358970A
(en)
|
1993-08-12 |
1994-10-25 |
Burroughs Wellcome Co. |
Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
|
|
GB9315856D0
(en)
|
1993-07-30 |
1993-09-15 |
Wellcome Found |
Stabilized pharmaceutical
|
|
DE69818675T2
(de)
|
1997-07-29 |
2004-07-29 |
Alcon Laboratories, Inc., Fort Worth |
Galaktomannanpolymere und borat enthaltende augenarzneimittel
|
|
JP2002501892A
(ja)
|
1998-01-29 |
2002-01-22 |
セプラコア インコーポレーテッド |
光学的に純粋な(−)−ビュープロピオンの薬学的使用
|
|
JP4633925B2
(ja)
|
1998-05-08 |
2011-02-16 |
スミスクライン ビーチャム ピー エル シー |
フェニル尿素およびフェニルチオ尿素誘導体
|
|
DE60013250T2
(de)
|
1999-02-12 |
2005-09-08 |
Smithkline Beecham P.L.C., Brentford |
Phenylharnstoff- und Phenylthioharnstoffderivate als Orexinrezeptorantagonisten
|
|
WO2000047576A1
(en)
|
1999-02-12 |
2000-08-17 |
Smithkline Beecham Plc |
Cinnamide derivatives as orexin-1 receptors antagonists
|
|
EP1144409B1
(en)
|
1999-02-12 |
2004-11-17 |
SmithKline Beecham plc |
Phenyl urea and phenyl thiourea derivatives
|
|
AU5723500A
(en)
|
1999-05-24 |
2000-12-12 |
Cor Therapeutics, Inc. |
Inhibitors of factor xa
|
|
US8889112B2
(en)
|
1999-09-16 |
2014-11-18 |
Ocularis Pharma, Llc |
Ophthalmic formulations including selective alpha 1 antagonists
|
|
CA2408343A1
(en)
|
2000-05-11 |
2002-11-07 |
Banyu Pharmaceutical Co., Ltd. |
N-acyltetrahydroisoquinoline derivatives
|
|
PT1289955E
(pt)
|
2000-06-16 |
2005-08-31 |
Smithkline Beecham Plc |
Piperidinas para utilizacao como antagonistas dos receptores da orexina
|
|
WO2002044172A1
(en)
|
2000-11-28 |
2002-06-06 |
Smithkline Beecham P.L.C. |
Morpholine derivatives as antagonists of orexin receptors
|
|
WO2002051232A2
(en)
|
2000-12-27 |
2002-07-04 |
Actelion Pharmaceuticals Ltd. |
Novel benzazepines and related heterocyclic derivatives
|
|
JP4309135B2
(ja)
*
|
2001-05-05 |
2009-08-05 |
スミスクライン ビーチャム ピー エル シー |
N−アロイルサイクリックアミン
|
|
JP2004534026A
(ja)
|
2001-05-05 |
2004-11-11 |
スミスクライン ビーチャム パブリック リミテッド カンパニー |
オレキシン受容体アンタゴニストとしてのn−アロイルサイクリックアミン誘導体
|
|
GB0115862D0
(en)
|
2001-06-28 |
2001-08-22 |
Smithkline Beecham Plc |
Compounds
|
|
GB0124463D0
(en)
|
2001-10-11 |
2001-12-05 |
Smithkline Beecham Plc |
Compounds
|
|
GB0126292D0
(en)
|
2001-11-01 |
2002-01-02 |
Smithkline Beecham Plc |
Compounds
|
|
GB0127145D0
(en)
|
2001-11-10 |
2002-01-02 |
Smithkline Beecham |
Compounds
|
|
GB0130341D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
GB0130393D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
GB0130335D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
RU2005103398A
(ru)
|
2002-07-09 |
2006-06-27 |
Актелион Фармасьютикалз Лтд. (Ch) |
Производные 7,8,9,10-тетрагидро-6h-азепино-, 6,7,8,9-тетрагидропиридо-и 2,3-дигидро-2h-пирроло-[2,1-b]-хиназолинона
|
|
WO2004026866A1
(en)
|
2002-09-18 |
2004-04-01 |
Glaxo Group Limited |
N-aroyl cyclic amines as orexin receptor antagonists
|
|
AU2003294671A1
(en)
|
2002-10-11 |
2004-05-04 |
Actelion Pharmaceuticals Ltd. |
Sulfonylamino-acetic derivatives and their use as orexin receptor antagonists
|
|
GB0225884D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0225938D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0225944D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
US6951882B2
(en)
|
2002-12-12 |
2005-10-04 |
Janssen Pharmaceutica N.V. |
Substituted 4-phenyl-[1,3]-dioxanes
|
|
ATE435210T1
(de)
|
2003-03-26 |
2009-07-15 |
Actelion Pharmaceuticals Ltd |
Tetrahydroisochinolylacetamidderivate zur verwendung als orexinrezeptorantagonisten
|
|
CA2520839A1
(en)
|
2003-04-28 |
2004-11-11 |
Actelion Pharmaceuticals Ltd |
Quinoxalinone-3- one derivatives as orexin receptor antagonists
|
|
US6933289B2
(en)
|
2003-07-01 |
2005-08-23 |
Allergan, Inc. |
Inhibition of irritating side effects associated with use of a topical ophthalmic medication
|
|
ES2332049T5
(es)
|
2003-08-07 |
2014-03-27 |
Allergan, Inc. |
Composiciones de administración de sustancias terapéuticas en los ojos
|
|
US20050059744A1
(en)
|
2003-09-12 |
2005-03-17 |
Allergan, Inc. |
Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
|
|
HUP0304101A3
(en)
|
2003-12-22 |
2008-10-28 |
Sanofi Aventis |
Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
|
HUP0400405A3
(en)
|
2004-02-10 |
2009-03-30 |
Sanofi Synthelabo |
Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
|
HRP20150371T1
(hr)
|
2004-03-01 |
2015-05-08 |
Actelion Pharmaceuticals Ltd. |
Supstituirani derivati 1,2,3,4-tetrahidroizokinolina
|
|
WO2006067224A2
(en)
|
2004-12-23 |
2006-06-29 |
Biovitrum Ab (Publ) |
Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists
|
|
CA2603766A1
(en)
|
2005-04-12 |
2006-10-19 |
Merck & Co., Inc. |
Amidopropoxyphenyl orexin receptor antagonists
|
|
JP2008541698A
(ja)
|
2005-05-03 |
2008-11-27 |
アンサンブル ディスカバリー コーポレイション |
核酸検出のためのターンオーバープローブおよびその使用
|
|
EP1888563A1
(en)
|
2005-05-23 |
2008-02-20 |
Merck & Co., Inc. |
Proline bis-amide orexin receptor antagonists
|
|
AU2006278575A1
(en)
|
2005-08-04 |
2007-02-15 |
Merck & Co., Inc. |
Aminoethane sulfonamide orexin receptor antagonists
|
|
CA2620124A1
(en)
|
2005-08-26 |
2007-03-01 |
Merck And Co., Inc. |
Diazaspirodecane orexin receptor antagonists
|
|
JP2009516742A
(ja)
|
2005-11-22 |
2009-04-23 |
メルク エンド カムパニー インコーポレーテッド |
インドールオレキシン受容体アンタゴニスト
|
|
CN101009515A
(zh)
|
2006-01-24 |
2007-08-01 |
华为技术有限公司 |
通信终端设备管理方法及通信终端
|
|
TW200800020A
(en)
|
2006-01-26 |
2008-01-01 |
Basf Ag |
Methods to use 3-pyridyl derivatives as pesticides
|
|
FR2896798A1
(fr)
|
2006-01-27 |
2007-08-03 |
Sanofi Aventis Sa |
Derives de sulfonamides, leur preparation et leur application en therapeutique
|
|
FR2896799B1
(fr)
|
2006-02-02 |
2008-03-28 |
Sanofi Aventis Sa |
Derives de sulfonamides, leur preparation et leur application en therapeutique
|
|
WO2007126934A2
(en)
|
2006-03-29 |
2007-11-08 |
Merck & Co., Inc. |
Amidoethylthioether orexin receptor antagonists
|
|
EP2007717A1
(en)
|
2006-04-11 |
2008-12-31 |
Actelion Pharmaceuticals Ltd. |
Novel sulfonamide compounds
|
|
CA2647077A1
(en)
|
2006-04-26 |
2007-11-01 |
Actelion Pharmaceuticals Ltd |
Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
|
|
WO2007143813A1
(en)
|
2006-06-16 |
2007-12-21 |
Husky Injection Molding Systems Ltd. |
Preventative maintenance update system
|
|
EP2049529B1
(en)
|
2006-07-14 |
2010-08-11 |
Merck Sharp & Dohme Corp. |
Substituted diazepan orexin receptor antagonists
|
|
US8618102B2
(en)
|
2006-07-14 |
2013-12-31 |
Merck Sharp & Dohme Corp. |
Bridged diazepan orexin receptor antagonists
|
|
AU2007272795A1
(en)
|
2006-07-14 |
2008-01-17 |
Merck & Co., Inc. |
2-substituted proline bis-amide orexin receptor antagonists
|
|
PL2069332T3
(pl)
|
2006-08-15 |
2011-07-29 |
Actelion Pharmaceuticals Ltd |
Związki azetydynowe jako antagoniści receptorów oreksynowych
|
|
CA2659352A1
(en)
|
2006-08-28 |
2008-03-06 |
Actelion Pharmaceuticals Ltd |
1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives as orexin receptor antagonists
|
|
EP2079690B1
(en)
|
2006-09-29 |
2010-09-15 |
Actelion Pharmaceuticals Ltd. |
3-aza-bicyclo[3.1.0]hexane derivatives
|
|
WO2008065626A2
(en)
|
2006-12-01 |
2008-06-05 |
Actelion Pharmaceuticals Ltd |
3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors
|
|
PE20081229A1
(es)
|
2006-12-01 |
2008-08-28 |
Merck & Co Inc |
Antagonistas de receptor de orexina de diazepam sustituido
|
|
RU2009127842A
(ru)
|
2006-12-22 |
2011-01-27 |
Актелион Фармасьютиклз Лтд (Ch) |
ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРОИМИДАЗО[1.5-а]ПИРАЗИНА
|
|
CL2007003827A1
(es)
|
2006-12-28 |
2008-09-26 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
|
|
WO2008087611A2
(en)
|
2007-01-19 |
2008-07-24 |
Actelion Pharmaceuticals Ltd |
Pyrrolidine- and piperidine- bis-amide derivatives
|
|
US8410142B2
(en)
|
2007-03-02 |
2013-04-02 |
Merck Sharp & Dohme Corp. |
Bipyridine carboxamide orexin receptor antagonists
|
|
BRPI0808348A2
(pt)
|
2007-03-05 |
2014-07-15 |
Hoffmann La Roche |
Aminoamidas como antagonistas de orexina
|
|
DE602008006368D1
(de)
|
2007-03-15 |
2011-06-01 |
Hoffmann La Roche |
Malonamide als orexin-antagonisten
|
|
CL2008000836A1
(es)
|
2007-03-26 |
2008-11-07 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
|
|
CN101646668A
(zh)
|
2007-04-04 |
2010-02-10 |
弗·哈夫曼-拉罗切有限公司 |
作为食欲肽拮抗剂的杂环类
|
|
US20100222328A1
(en)
|
2007-05-14 |
2010-09-02 |
Hamed Aissaoui |
2-cyclopropyl-thiazole derivatives
|
|
AU2008255005B2
(en)
|
2007-05-18 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
OXO bridged diazepan orexin receptor antagonists
|
|
US8030495B2
(en)
|
2007-05-23 |
2011-10-04 |
Coleman Paul J |
Cyclopropyl pyrrolidine orexin receptor antagonists
|
|
HRP20120240T1
(hr)
|
2007-05-23 |
2012-04-30 |
Merck Sharp & Dohme Corp. |
Piridil piperidin antagonisti receptora za oreksin
|
|
CA2691373A1
(en)
|
2007-07-03 |
2009-01-08 |
Actelion Pharmaceuticals Ltd |
3-aza-bicyclo[3.3.0]octane compounds
|
|
NZ583487A
(en)
|
2007-07-27 |
2011-09-30 |
Actelion Pharmaceuticals Ltd |
2-aza-bicyclo[3.3.0]octane derivatives
|
|
ATE493386T1
(de)
|
2007-07-27 |
2011-01-15 |
Actelion Pharmaceuticals Ltd |
Trans-3-aza-bicyclo-ä3.1.0ü-hexan-derivate
|
|
AU2008281876A1
(en)
|
2007-08-02 |
2009-02-05 |
F. Hoffmann-La Roche Ag |
Monoamide derivatives as orexin receptor antagonists
|
|
US8003797B2
(en)
|
2007-08-09 |
2011-08-23 |
Merck Sharp & Dohme Corp. |
Pyridine carboxamide orexin receptor antagonists
|
|
BRPI0814149A2
(pt)
|
2007-08-10 |
2011-09-13 |
Cortex Pharma Inc |
composto, composição farmacêutica, métodos de tratamento e uso do composto
|
|
CA2694993A1
(en)
|
2007-08-15 |
2009-02-19 |
Actelion Pharmaceuticals Ltd |
1,2-diamido-ethylene derivatives
|
|
EP2207778A2
(en)
|
2007-09-24 |
2010-07-21 |
Actelion Pharmaceuticals Ltd. |
Pyrrolidines and piperidines as orexin receptor antagonists
|
|
US8362009B2
(en)
|
2007-10-29 |
2013-01-29 |
Merck Sharp & Dohme Corp. |
Substituted diazepan orexin receptor antagonists
|
|
EP2231155A4
(en)
|
2007-12-18 |
2011-09-14 |
Concert Pharmaceuticals Inc |
Tetrahydroisoquinoline DERIVATIVES
|
|
CA2705411A1
(en)
|
2007-12-21 |
2009-07-02 |
F. Hoffmann-La Roche Ag |
Heteroaryl derivatives as orexin receptor antagonists
|
|
KR101178658B1
(ko)
|
2008-01-21 |
2012-08-30 |
에프. 호프만-라 로슈 아게 |
오렉신 길항제로서의 설폰아마이드
|
|
CN101918361B
(zh)
|
2008-02-12 |
2014-05-28 |
弗·哈夫曼-拉罗切有限公司 |
哌啶磺酰胺衍生物
|
|
NZ588080A
(en)
|
2008-02-21 |
2012-04-27 |
Actelion Pharmaceuticals Ltd |
2-Aza-bicyclo[2.2.1]heptane derivatives
|
|
GB0806536D0
(en)
|
2008-04-10 |
2008-05-14 |
Glaxo Group Ltd |
Novel compounds
|
|
JP2011522878A
(ja)
|
2008-06-11 |
2011-08-04 |
アクテリオン ファーマシューティカルズ リミテッド |
オレキシン受容体拮抗薬としてのテトラゾール化合物
|
|
CN102066325A
(zh)
|
2008-06-16 |
2011-05-18 |
弗·哈夫曼-拉罗切有限公司 |
作为食欲肽受体拮抗剂的杂芳族单酰胺类
|
|
US20110105514A1
(en)
|
2008-06-25 |
2011-05-05 |
Hamed Aissaoui |
5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
|
|
CA2729985A1
(en)
|
2008-07-07 |
2010-01-14 |
Actelion Pharmaceuticals Ltd |
Thiazolidine compounds as orexin receptor antagonists
|
|
CN102083820B
(zh)
|
2008-07-29 |
2013-07-17 |
弗·哈夫曼-拉罗切有限公司 |
作为食欲肽拮抗剂的吡咯烷-3-基甲基-胺
|
|
AR072899A1
(es)
|
2008-08-07 |
2010-09-29 |
Merck Sharp & Dohme |
Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad.
|
|
EP2161266A1
(en)
|
2008-08-22 |
2010-03-10 |
EVOTEC Neurosciences GmbH |
Benzofuran derivatives as orexin receptor antagonists
|
|
WO2010038200A1
(en)
|
2008-10-01 |
2010-04-08 |
Actelion Pharmaceuticals Ltd |
Oxazolidine compounds as orexin receptor antagonists
|
|
AU2009305005A1
(en)
|
2008-10-14 |
2010-04-22 |
Actelion Pharmaceuticals Ltd |
Phenethylamide derivatives and their heterocyclic analogues
|
|
WO2010048010A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted piperidine orexin receptor antagonists
|
|
WO2010048017A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
Disubstituted azepan orexin receptor antagonists
|
|
WO2010048013A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted morpholine orexin receptor antagonists
|
|
US8357700B2
(en)
|
2008-10-21 |
2013-01-22 |
Merck Sharp & Dohme Corp. |
2,3-disubstituted piperidine orexin receptor antagonists
|
|
JP2012506375A
(ja)
|
2008-10-21 |
2012-03-15 |
メルク・シャープ・エンド・ドーム・コーポレイション |
2,5−二置換ピペリジンオレキシン受容体アンタゴニスト
|
|
CA2739919A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,4-disubstituted pyrrolidine orexin receptor antagonists
|
|
US8703770B2
(en)
|
2008-10-30 |
2014-04-22 |
Merck Sharp & Dohme Corp. |
Pyridazine carboxamide orexin receptor antagonists
|
|
CN102272103B
(zh)
|
2008-10-30 |
2015-10-21 |
默沙东公司 |
异烟酰胺食欲素受体拮抗剂
|
|
EP2349262B1
(en)
|
2008-10-30 |
2014-06-25 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted phenyl carboxamide orexin receptor antagonists
|
|
EP2358711A1
(en)
|
2008-11-26 |
2011-08-24 |
Glaxo Group Limited |
Piperidine derivatives useful as orexin receptor antagonists
|
|
WO2010060471A1
(en)
|
2008-11-26 |
2010-06-03 |
Glaxo Group Limited |
Piperidine derivatives useful as orexin receptor antagonists
|
|
JP2012509912A
(ja)
|
2008-11-26 |
2012-04-26 |
グラクソ グループ リミテッド |
新規の化合物
|
|
UY32277A
(es)
|
2008-12-02 |
2010-05-31 |
Glaxo Group Ltd |
Derivados de n-{[1r,4s,6r)-3-(2-piridinilcarbonil)-3-azabiciclo[4.1.0-il}metil}-2heteroarilamina y uso de los mismos
|
|
BRPI0922353A2
(pt)
|
2008-12-02 |
2018-06-05 |
Glaxo Group Ltd |
Derivados de n-{[(1r,4s, 6r-3- (2-piridinilcarbonil) - 3azabiciclo [4.1.0] hept-4-il] metil}-2-heteroarilamina e usos dos mesmos
|
|
JP2010155827A
(ja)
|
2008-12-04 |
2010-07-15 |
Takeda Chem Ind Ltd |
スピロ環化合物
|
|
GB0823467D0
(en)
|
2008-12-23 |
2009-01-28 |
Glaxo Group Ltd |
Novel Compounds
|
|
WO2010086366A1
(en)
|
2009-01-30 |
2010-08-05 |
Novartis Ag |
4-aryl-butane-1,3-diamides
|
|
EP2421850A1
(en)
|
2009-04-24 |
2012-02-29 |
Glaxo Group Limited |
3 -azabicyclo [4.1.0]heptanes used as orexin antagonists
|
|
US20120101106A1
(en)
|
2009-07-09 |
2012-04-26 |
Mercer Swati P |
Tetrahydronapthyridine Orexin Receptor Antagonists
|
|
EP2275421A1
(en)
|
2009-07-15 |
2011-01-19 |
Rottapharm S.p.A. |
Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
|
|
WO2011016234A1
(en)
|
2009-08-04 |
2011-02-10 |
Raqualia Pharma Inc. |
Picolinamide derivatives as ttx-s blockers
|
|
JP2013502448A
(ja)
|
2009-08-24 |
2013-01-24 |
グラクソ グループ リミテッド |
オレキシンアンタゴニストとして用いられるピペリジン誘導体
|
|
EP2470523A1
(en)
|
2009-08-24 |
2012-07-04 |
Glaxo Group Limited |
5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder
|
|
WO2011050200A1
(en)
|
2009-10-23 |
2011-04-28 |
Janssen Pharmaceutica Nv |
Fused heterocyclic compounds as orexin receptor modulators
|
|
DK3093291T3
(da)
|
2009-10-23 |
2019-07-29 |
Janssen Pharmaceutica Nv |
Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer
|
|
JP5848251B2
(ja)
|
2009-10-23 |
2016-01-27 |
ヤンセン ファーマシューティカ エヌ.ベー. |
オレキシン受容体調節因子としての縮合複素環式化合物
|
|
US20120196901A1
(en)
|
2009-10-29 |
2012-08-02 |
Merck Sharp & Dohme Corp. |
Tertiary amide orexin receptor antagonists
|
|
EP2504316A1
(en)
|
2009-11-23 |
2012-10-03 |
MSD Oss B.V. |
Heterocylic compounds as antagonists of the orexin receptors
|
|
WO2011073316A1
(en)
|
2009-12-18 |
2011-06-23 |
Novartis Ag |
4-aryl-butane-1,3-diamides
|
|
WO2011076744A1
(en)
|
2009-12-21 |
2011-06-30 |
Novartis Ag |
Disubstituted heteroaryl-fused pyridines
|
|
US8530648B2
(en)
|
2009-12-21 |
2013-09-10 |
Novartis Ag |
Diaza-spiro[5.5]undecanes
|
|
WO2011138266A1
(en)
|
2010-05-03 |
2011-11-10 |
Evotec Ag |
Indolizine and imidazopyridine derivatives as orexin receptor antagonists
|
|
WO2011138265A2
(en)
|
2010-05-03 |
2011-11-10 |
Evotec Ag |
Indole and indazole derivatives as orexin receptor antagonists
|
|
SG191103A1
(en)
|
2010-12-17 |
2013-08-30 |
Taisho Pharmaceutical Co Ltd |
Pyrazole derivative
|
|
US20120165331A1
(en)
|
2010-12-22 |
2012-06-28 |
Sangamesh Badiger |
Di/tri-aza-spiro-C9-C11alkanes
|
|
WO2012085852A1
(en)
|
2010-12-22 |
2012-06-28 |
Actelion Pharmaceuticals Ltd |
3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
|
|
US20120165339A1
(en)
|
2010-12-22 |
2012-06-28 |
Eisai R&D Management Co., Ltd. |
Cyclopropane derivatives
|
|
WO2012089607A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
|
|
WO2012089606A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
|
|
WO2012110986A1
(en)
|
2011-02-18 |
2012-08-23 |
Actelion Pharmaceuticals Ltd |
Novel pyrazole and imidazole derivatives useful as orexin antagonists
|
|
WO2012114252A1
(en)
|
2011-02-21 |
2012-08-30 |
Actelion Pharmaceuticals Ltd |
Novel indole and pyrrolopyridine amides
|
|
US9586962B2
(en)
|
2011-04-20 |
2017-03-07 |
Janssen Pharmaceutica Nv |
Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
|
|
EP2708537A4
(en)
|
2011-05-10 |
2014-10-01 |
Taisho Pharmaceutical Co Ltd |
HETEROAROMATIC RING DERIVATIVE
|
|
EP2730573A4
(en)
|
2011-07-05 |
2014-12-03 |
Taisho Pharmaceutical Co Ltd |
METHYLPIPERIDINDERIVAT
|
|
WO2013050938A1
(en)
|
2011-10-04 |
2013-04-11 |
Actelion Pharmaceuticals Ltd |
3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
US9029364B2
(en)
|
2011-10-21 |
2015-05-12 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted thiomorpholine orexin receptor antagonists
|
|
US8940898B2
(en)
|
2011-10-25 |
2015-01-27 |
Merck Sharp & Dohme Corp. |
Piperidinyl alkyne orexin receptor antagonists
|
|
WO2013062858A1
(en)
|
2011-10-25 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Isoxazolopyridine orexin receptor antagonists
|
|
SG11201401665WA
(en)
|
2011-11-08 |
2014-09-26 |
Actelion Pharmaceuticals Ltd |
2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives as orexin receptor antagonists
|
|
ITMI20112329A1
(it)
|
2011-12-21 |
2013-06-22 |
Rottapharm Spa |
Nuovi derivati spiro amminici
|
|
US9440982B2
(en)
|
2012-02-07 |
2016-09-13 |
Eolas Therapeutics, Inc. |
Substituted prolines/piperidines as orexin receptor antagonists
|
|
EP2811997B1
(en)
|
2012-02-07 |
2018-04-11 |
Eolas Therapeutics Inc. |
Substituted prolines/piperidines as orexin receptor antagonists
|
|
RU2617696C2
(ru)
|
2012-02-17 |
2017-04-26 |
ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД |
Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2
|
|
ITMI20120322A1
(it)
*
|
2012-03-01 |
2013-09-02 |
Rottapharm Spa |
Composti di 4,4-difluoro piperidina
|
|
ITMI20120424A1
(it)
|
2012-03-19 |
2013-09-20 |
Rottapharm Spa |
Composti chimici
|
|
TW201613891A
(en)
|
2014-02-12 |
2016-04-16 |
Eolas Therapeutics Inc |
Substituted prolines / piperidines as orexin receptor antagonists
|