TW201613902A - Difluoropyrrolidines as orexin receptor modulators - Google Patents
Difluoropyrrolidines as orexin receptor modulatorsInfo
- Publication number
- TW201613902A TW201613902A TW104126419A TW104126419A TW201613902A TW 201613902 A TW201613902 A TW 201613902A TW 104126419 A TW104126419 A TW 104126419A TW 104126419 A TW104126419 A TW 104126419A TW 201613902 A TW201613902 A TW 201613902A
- Authority
- TW
- Taiwan
- Prior art keywords
- disorder
- difluoropyrrolidines
- receptor modulators
- orexin receptor
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462037024P | 2014-08-13 | 2014-08-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201613902A true TW201613902A (en) | 2016-04-16 |
Family
ID=55304607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW104126419A TW201613902A (en) | 2014-08-13 | 2015-08-13 | Difluoropyrrolidines as orexin receptor modulators |
Country Status (8)
Country | Link |
---|---|
US (1) | US10221170B2 (zh) |
EP (1) | EP3180332B1 (zh) |
JP (1) | JP6663909B2 (zh) |
AR (1) | AR101558A1 (zh) |
ES (1) | ES2901418T3 (zh) |
TW (1) | TW201613902A (zh) |
UY (1) | UY36272A (zh) |
WO (1) | WO2016025669A1 (zh) |
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MX2012004753A (es) | 2009-10-23 | 2012-09-07 | Janssen Pharmaceutica Nv | Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina. |
US10894789B2 (en) | 2016-02-12 | 2021-01-19 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
MA43817B1 (fr) | 2016-03-10 | 2022-04-29 | Janssen Pharmaceutica Nv | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
CN106278918B (zh) * | 2016-08-12 | 2018-05-11 | 合肥久诺医药科技有限公司 | 一种溴芬酸钠杂质标准品2-氨基-3-(4-溴苯甲酰基)苯甲酸的合成方法 |
US11059780B2 (en) | 2017-03-08 | 2021-07-13 | Takeda Pharmaceutical Company Limited | Substituted pyrrolidine compound and use thereof |
WO2018164192A1 (ja) * | 2017-03-08 | 2018-09-13 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
MY202221A (en) | 2017-08-03 | 2024-04-17 | Takeda Pharmaceuticals Co | Heterocyclic compound and use thereof |
US11319286B2 (en) | 2017-08-03 | 2022-05-03 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
US11324724B2 (en) * | 2017-09-28 | 2022-05-10 | Boehringer Ingelheim International Gmbh | N-(2,2-difluoroethyl)-N-[(pyrimidinylamino)propanyl]arylcarboxamides |
EP3816153B1 (en) | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
TWI841671B (zh) | 2019-01-24 | 2024-05-11 | 日商第一三共股份有限公司 | 具有取代基之脲化合物 |
TWI832962B (zh) | 2019-01-31 | 2024-02-21 | 日商武田藥品工業股份有限公司 | 雜環化合物及其用途 |
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- 2015-08-13 JP JP2017506968A patent/JP6663909B2/ja active Active
- 2015-08-13 AR ARP150102622A patent/AR101558A1/es unknown
- 2015-08-13 UY UY0001036272A patent/UY36272A/es not_active Application Discontinuation
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UY36272A (es) | 2016-02-29 |
WO2016025669A1 (en) | 2016-02-18 |
EP3180332A4 (en) | 2018-01-24 |
EP3180332A1 (en) | 2017-06-21 |
US20170226103A1 (en) | 2017-08-10 |
US10221170B2 (en) | 2019-03-05 |
ES2901418T3 (es) | 2022-03-22 |
EP3180332B1 (en) | 2021-10-27 |
AR101558A1 (es) | 2016-12-28 |
JP6663909B2 (ja) | 2020-03-13 |
JP2017524005A (ja) | 2017-08-24 |
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