TW201613902A - Difluoropyrrolidines as orexin receptor modulators - Google Patents
Difluoropyrrolidines as orexin receptor modulatorsInfo
- Publication number
- TW201613902A TW201613902A TW104126419A TW104126419A TW201613902A TW 201613902 A TW201613902 A TW 201613902A TW 104126419 A TW104126419 A TW 104126419A TW 104126419 A TW104126419 A TW 104126419A TW 201613902 A TW201613902 A TW 201613902A
- Authority
- TW
- Taiwan
- Prior art keywords
- disorder
- difluoropyrrolidines
- receptor modulators
- orexin receptor
- methods
- Prior art date
Links
- VWIGHVNBZXTEFC-UHFFFAOYSA-N 1,2-difluoropyrrolidine Chemical class FC1CCCN1F VWIGHVNBZXTEFC-UHFFFAOYSA-N 0.000 title abstract 2
- 108050000742 Orexin Receptor Proteins 0.000 title 1
- 102000008834 Orexin receptor Human genes 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
- 208000012672 seasonal affective disease Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462037024P | 2014-08-13 | 2014-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201613902A true TW201613902A (en) | 2016-04-16 |
Family
ID=55304607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104126419A TW201613902A (en) | 2014-08-13 | 2015-08-13 | Difluoropyrrolidines as orexin receptor modulators |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10221170B2 (enExample) |
| EP (1) | EP3180332B1 (enExample) |
| JP (1) | JP6663909B2 (enExample) |
| AR (1) | AR101558A1 (enExample) |
| ES (1) | ES2901418T3 (enExample) |
| TW (1) | TW201613902A (enExample) |
| UY (1) | UY36272A (enExample) |
| WO (1) | WO2016025669A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3093291T3 (da) | 2009-10-23 | 2019-07-29 | Janssen Pharmaceutica Nv | Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer |
| PL3414241T3 (pl) | 2016-02-12 | 2022-10-03 | Astrazeneca Ab | Piperydyny podstawione halo jako modulatory receptora oreksyny |
| IL288321B2 (en) | 2016-03-10 | 2025-08-01 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| CN106278918B (zh) * | 2016-08-12 | 2018-05-11 | 合肥久诺医药科技有限公司 | 一种溴芬酸钠杂质标准品2-氨基-3-(4-溴苯甲酰基)苯甲酸的合成方法 |
| JP6957598B2 (ja) | 2017-03-08 | 2021-11-02 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| JP7012703B2 (ja) * | 2017-03-08 | 2022-02-14 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| EP3663281B1 (en) * | 2017-08-03 | 2022-12-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| PE20200935A1 (es) | 2017-08-03 | 2020-09-17 | Takeda Pharmaceuticals Co | Compuestos derivados de 2-((bifenil)pirrolidin o piperidin) sulfonamida o carboxamida agonistas de receptores de orexina 2 |
| JP6874217B2 (ja) * | 2017-09-28 | 2021-05-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なｎ−（２，２−ジフルオロエチル）−ｎ−［（ピリミジニルアミノ）プロパニル］アリールカルボキサミド |
| US11655241B2 (en) | 2018-06-29 | 2023-05-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP7339250B2 (ja) | 2018-06-29 | 2023-09-05 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| WO2020122093A1 (ja) | 2018-12-12 | 2020-06-18 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2020122092A1 (ja) | 2018-12-12 | 2020-06-18 | 武田薬品工業株式会社 | 複素環化合物 |
| TWI841671B (zh) | 2019-01-24 | 2024-05-11 | 日商第一三共股份有限公司 | 具有取代基之脲化合物 |
| EP3917616B1 (en) | 2019-01-31 | 2025-06-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds and use thereof |
| US11286781B2 (en) | 2020-01-17 | 2022-03-29 | Raytheon Technologies Corporation | Multi-disk bladed rotor assembly for rotational equipment |
| US11339673B2 (en) | 2020-01-17 | 2022-05-24 | Raytheon Technologies Corporation | Rotor assembly with internal vanes |
| US11401814B2 (en) | 2020-01-17 | 2022-08-02 | Raytheon Technologies Corporation | Rotor assembly with internal vanes |
| US11208892B2 (en) | 2020-01-17 | 2021-12-28 | Raytheon Technologies Corporation | Rotor assembly with multiple rotor disks |
| US11371351B2 (en) | 2020-01-17 | 2022-06-28 | Raytheon Technologies Corporation | Multi-disk bladed rotor assembly for rotational equipment |
| US11434771B2 (en) | 2020-01-17 | 2022-09-06 | Raytheon Technologies Corporation | Rotor blade pair for rotational equipment |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
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| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
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| GB0225944D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
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-
2015
- 2015-08-13 WO PCT/US2015/044974 patent/WO2016025669A1/en not_active Ceased
- 2015-08-13 TW TW104126419A patent/TW201613902A/zh unknown
- 2015-08-13 UY UY0001036272A patent/UY36272A/es not_active Application Discontinuation
- 2015-08-13 JP JP2017506968A patent/JP6663909B2/ja active Active
- 2015-08-13 US US15/503,131 patent/US10221170B2/en active Active
- 2015-08-13 AR ARP150102622A patent/AR101558A1/es unknown
- 2015-08-13 ES ES15832417T patent/ES2901418T3/es active Active
- 2015-08-13 EP EP15832417.8A patent/EP3180332B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| UY36272A (es) | 2016-02-29 |
| ES2901418T3 (es) | 2022-03-22 |
| US20170226103A1 (en) | 2017-08-10 |
| EP3180332B1 (en) | 2021-10-27 |
| WO2016025669A1 (en) | 2016-02-18 |
| JP2017524005A (ja) | 2017-08-24 |
| JP6663909B2 (ja) | 2020-03-13 |
| AR101558A1 (es) | 2016-12-28 |
| US10221170B2 (en) | 2019-03-05 |
| EP3180332A4 (en) | 2018-01-24 |
| EP3180332A1 (en) | 2017-06-21 |
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