JP2005508318A5 - - Google Patents
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- Publication number
- JP2005508318A5 JP2005508318A5 JP2003528493A JP2003528493A JP2005508318A5 JP 2005508318 A5 JP2005508318 A5 JP 2005508318A5 JP 2003528493 A JP2003528493 A JP 2003528493A JP 2003528493 A JP2003528493 A JP 2003528493A JP 2005508318 A5 JP2005508318 A5 JP 2005508318A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- aryl
- compound
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*c1c(*)c(*c2c(*)c(*)c(*C(*)(*)C(O)=O)c(S)c2*)c(*)c(*)c1**[Al] Chemical compound C*c1c(*)c(*c2c(*)c(*)c(*C(*)(*)C(O)=O)c(S)c2*)c(*)c(*)c1**[Al] 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32255601P | 2001-09-14 | 2001-09-14 | |
| US33543401P | 2001-11-30 | 2001-11-30 | |
| US37862702P | 2002-05-07 | 2002-05-07 | |
| US38683302P | 2002-06-06 | 2002-06-06 | |
| PCT/US2002/029232 WO2003024395A2 (en) | 2001-09-14 | 2002-09-13 | Linked biaryl compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508318A JP2005508318A (ja) | 2005-03-31 |
| JP2005508318A5 true JP2005508318A5 (enExample) | 2006-01-05 |
| JP4269052B2 JP4269052B2 (ja) | 2009-05-27 |
Family
ID=27502245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528493A Expired - Fee Related JP4269052B2 (ja) | 2001-09-14 | 2002-09-13 | 連結ビアリール化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6869975B2 (enExample) |
| EP (1) | EP1435946B8 (enExample) |
| JP (1) | JP4269052B2 (enExample) |
| KR (1) | KR20040063897A (enExample) |
| CN (1) | CN1585638A (enExample) |
| AU (1) | AU2002336532C1 (enExample) |
| BR (1) | BR0212512A (enExample) |
| CA (1) | CA2460313C (enExample) |
| ES (1) | ES2443642T3 (enExample) |
| IL (1) | IL160845A0 (enExample) |
| MX (1) | MXPA04002330A (enExample) |
| NZ (1) | NZ531917A (enExample) |
| WO (1) | WO2003024395A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US6869975B2 (en) | 2001-09-14 | 2005-03-22 | Tularik Inc. | Linked biaryl compounds |
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| JP2007525165A (ja) | 2003-03-07 | 2007-09-06 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | タイプ1ライアノジン受容体に基づく方法 |
| CA2521175A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| US20100267778A1 (en) * | 2003-08-04 | 2010-10-21 | Shinya Kusuda | Diphenyl ether compound, process for producing the same, and use |
| US8710045B2 (en) * | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| US7968723B2 (en) * | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
| EP1745014B1 (en) * | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
| ATE475642T1 (de) * | 2004-05-05 | 2010-08-15 | High Point Pharmaceuticals Llc | Phenoxyessigsäurederivate als ppar-agonisten |
| CA2576993C (en) * | 2004-08-12 | 2013-09-24 | Amgen Inc. | Bisaryl-sulfonamides |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| JP2008521831A (ja) * | 2004-11-30 | 2008-06-26 | プレキシコン,インコーポレーテッド | Ppar活性化合物 |
| AU2005311925A1 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR PPAR active compounds |
| WO2006076706A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| FR2880886B1 (fr) * | 2005-01-14 | 2007-04-06 | Merck Sante Soc Par Actions Si | Derives de l'acide 6-phenylhex-5-enoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
| WO2006084033A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| DE102005020230A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
| DE102005020229A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
| US20090118337A1 (en) * | 2005-06-03 | 2009-05-07 | Davis Pamela B | Methods and compositions for treating inflammation |
| AU2006265172B2 (en) * | 2005-06-30 | 2011-09-15 | Vtv Therapeutics Llc | Phenoxy acetic acids as PPAR delta activators |
| JPWO2007013694A1 (ja) * | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| JP2009509932A (ja) * | 2005-09-07 | 2009-03-12 | プレキシコン,インコーポレーテッド | Ppar活性化合物 |
| KR20080042170A (ko) * | 2005-09-07 | 2008-05-14 | 플렉시콘, 인코퍼레이티드 | Ppar 활성 화합물 |
| US20070072904A1 (en) * | 2005-09-07 | 2007-03-29 | Jack Lin | PPAR active compounds |
| NZ568488A (en) | 2005-12-22 | 2011-07-29 | High Point Pharmaceuticals Llc | Phenoxy acetic acids as PPAR delta activators |
| PL1976828T3 (pl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4 |
| CA2645719A1 (en) * | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
| CA2669138A1 (en) * | 2006-11-09 | 2008-12-04 | University Of Maryland, Baltimore | Use of 5,6-dimethylxanthenone-4-acetic acid as an antimicrobial agent |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| CA2708391A1 (en) * | 2007-12-13 | 2009-06-25 | Sri International | Ppar-delta ligands and methods of their use |
| AU2009239430B2 (en) | 2008-04-21 | 2015-01-22 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| AU2011203649A1 (en) * | 2010-01-06 | 2012-06-14 | Brickell Biotech, Inc. | DP2 antagonist and uses thereof |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
| JP6527851B2 (ja) | 2013-03-12 | 2019-06-05 | セルタクシス,インコーポレイテッド | ロイコトリエンa4加水分解酵素を阻害する方法 |
| EP2968264A4 (en) | 2013-03-14 | 2016-11-02 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
| AU2014239567B2 (en) | 2013-03-14 | 2017-12-14 | Celtaxsys, Inc. | Inhibitors of leukotriene A4 hydrolase |
| AU2014239585B2 (en) | 2013-03-14 | 2019-04-04 | Celtaxsys, Inc. | Inhibitors of leukotriene A4 hydrolase |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| CA3102077A1 (en) | 2018-05-31 | 2019-12-05 | Sanjeev AHUJA | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN113912547B (zh) | 2020-07-10 | 2024-04-30 | 成都凡诺西生物医药科技有限公司 | 取代苯丙咪唑类衍生物及其应用 |
| JP2023534835A (ja) | 2020-07-22 | 2023-08-14 | レネオ ファーマシューティカルズ,インク. | 結晶性pparデルタアゴニスト |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3038934A (en) * | 1959-03-17 | 1962-06-12 | Smith Kline French Lab | Iodinated 4-(4'-alkoxyphenoxy)phenylpropionic acids |
| US4443536A (en) * | 1981-08-25 | 1984-04-17 | Eastman Kodak Company | Nondiffusible photographic couplers and photographic elements and processes employing same |
| US4466902A (en) * | 1982-01-31 | 1984-08-21 | Ipposha Oil Industries, Co., Ltd. | Rust inhibitor |
| EP0359169B1 (en) * | 1988-09-14 | 1995-07-26 | Eastman Kodak Company | Photographic recording material comprising magenta coupler and a chalcogenazolium salt |
| CA2194169A1 (en) | 1994-07-01 | 1996-01-18 | Ronald M. Evans | Mammalian peroxisome proliferator-activated receptors and uses thereof |
| US5847008A (en) | 1996-02-02 | 1998-12-08 | Merck & Co., Inc. | Method of treating diabetes and related disease states |
| WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| JP2002503202A (ja) | 1996-02-02 | 2002-01-29 | メルク エンド カンパニー インコーポレーテッド | 抗糖尿病薬 |
| CA2245524A1 (en) | 1996-02-02 | 1997-08-07 | Wei Han | Antidiabetic agents |
| ATE236137T1 (de) | 1996-02-02 | 2003-04-15 | Merck & Co Inc | Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit |
| US5859051A (en) | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| US6090839A (en) | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
| DE69810606T2 (de) * | 1997-03-27 | 2003-10-09 | Taisho Pharmaceutical Co., Ltd. | 2-phenoxyanilinderivate |
| ES2320181T3 (es) | 1997-07-24 | 2009-05-19 | Astellas Pharma Inc. | Composiciones farmaceuticas que tienen un efecto reductor del colesterol. |
| CN1284080A (zh) | 1997-12-23 | 2001-02-14 | 联邦科学和工业研究组织 | 硼化合物 |
| US6583157B2 (en) * | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| EP1053227B1 (en) | 1998-01-29 | 2008-11-05 | Amgen Inc. | Ppar-gamma modulators |
| CA2337098C (en) * | 1998-07-24 | 2008-08-05 | Teijin Limited | Anthranilic acid derivatives |
| JP2003500432A (ja) | 1999-06-01 | 2003-01-07 | ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター | ジフェニルエーテル誘導体を用いて脱毛症を処置する方法 |
| ATE333448T1 (de) | 1999-06-18 | 2006-08-15 | Merck & Co Inc | Arylthiazolidinedione und aryloxa zolidinedion- derivate |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| CN1171872C (zh) | 1999-06-30 | 2004-10-20 | 图拉列克股份有限公司 | 调节PPARγ活性的化合物 |
| AU7073400A (en) | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| ATE260912T1 (de) | 1999-09-08 | 2004-03-15 | Glaxo Group Ltd | Oxazol ppar antagonisten |
| WO2001060807A1 (en) | 2000-02-18 | 2001-08-23 | Merck & Co. Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| JP2001354671A (ja) | 2000-04-14 | 2001-12-25 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| WO2001082916A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Combination therapeutic compositions and methods of use |
| US20020028826A1 (en) | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| US20020013334A1 (en) | 2000-06-15 | 2002-01-31 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| EP1296967B1 (en) | 2000-06-28 | 2006-05-31 | Amgen Inc. | Benzothiazolyl ppar-gamma modulators |
| CA2415742A1 (en) | 2000-07-25 | 2002-01-31 | Merck & Co., Inc. | N-substituted indoles useful in the treatment of diabetes |
| EP1310494B1 (en) | 2000-08-11 | 2012-01-25 | Nippon Chemiphar Co., Ltd. | PPAR (delta) ACTIVATORS |
| GB0024362D0 (en) | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| GB0024361D0 (en) | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| EP1357914A2 (en) | 2001-02-02 | 2003-11-05 | SmithKline Beecham Corporation | Treatment of ppar mediated diseases |
| JP4499357B2 (ja) * | 2001-02-14 | 2010-07-07 | カロ・バイオ・アー・ベー | 糖質コルチコイド受容体調節剤 |
| US6777442B2 (en) * | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
| WO2002076957A1 (en) | 2001-03-23 | 2002-10-03 | Nippon Chemiphar Co.,Ltd. | Activator for peroxisome proliferator-activated receptor |
| US7279593B2 (en) * | 2001-08-24 | 2007-10-09 | Karo Bio Ab | Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders |
| US6869975B2 (en) * | 2001-09-14 | 2005-03-22 | Tularik Inc. | Linked biaryl compounds |
| CA2461212C (en) * | 2001-09-27 | 2010-08-17 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same |
| EP1471049A4 (en) * | 2002-01-30 | 2006-08-16 | Kissei Pharmaceutical | NEW THYROIDIAN HORMONE RECEPTOR LIGAND, MEDICINAL PREPARATIONS CONTAINING THE SAME AND USE THEREOF |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
-
2002
- 2002-09-13 US US10/244,063 patent/US6869975B2/en not_active Expired - Fee Related
- 2002-09-13 CA CA2460313A patent/CA2460313C/en not_active Expired - Fee Related
- 2002-09-13 BR BR0212512-9A patent/BR0212512A/pt not_active IP Right Cessation
- 2002-09-13 JP JP2003528493A patent/JP4269052B2/ja not_active Expired - Fee Related
- 2002-09-13 ES ES02773386.4T patent/ES2443642T3/es not_active Expired - Lifetime
- 2002-09-13 IL IL16084502A patent/IL160845A0/xx unknown
- 2002-09-13 WO PCT/US2002/029232 patent/WO2003024395A2/en not_active Ceased
- 2002-09-13 CN CNA028223241A patent/CN1585638A/zh active Pending
- 2002-09-13 KR KR10-2004-7003851A patent/KR20040063897A/ko not_active Withdrawn
- 2002-09-13 EP EP02773386.4A patent/EP1435946B8/en not_active Expired - Lifetime
- 2002-09-13 AU AU2002336532A patent/AU2002336532C1/en not_active Ceased
- 2002-09-13 NZ NZ531917A patent/NZ531917A/en unknown
- 2002-09-13 MX MXPA04002330A patent/MXPA04002330A/es active IP Right Grant
-
2004
- 2004-08-20 US US10/939,918 patent/US7645779B2/en not_active Expired - Fee Related
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