JP2017506227A5 - - Google Patents
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- JP2017506227A5 JP2017506227A5 JP2016549715A JP2016549715A JP2017506227A5 JP 2017506227 A5 JP2017506227 A5 JP 2017506227A5 JP 2016549715 A JP2016549715 A JP 2016549715A JP 2016549715 A JP2016549715 A JP 2016549715A JP 2017506227 A5 JP2017506227 A5 JP 2017506227A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- medicament
- pembrolizumab
- dose
- axitinib
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 229960002621 pembrolizumab Drugs 0.000 claims 11
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical group CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 229960003005 axitinib Drugs 0.000 claims 9
- 108091008605 VEGF receptors Proteins 0.000 claims 5
- 229940124674 VEGF-R inhibitor Drugs 0.000 claims 5
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 5
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 5
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 3
- 229940124060 PD-1 antagonist Drugs 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 2
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 1
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 210000003989 endothelium vascular Anatomy 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000002991 immunohistochemical analysis Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019170177A JP6894952B2 (ja) | 2014-02-04 | 2019-09-19 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461935809P | 2014-02-04 | 2014-02-04 | |
| US61/935,809 | 2014-02-04 | ||
| PCT/US2015/014212 WO2015119930A1 (en) | 2014-02-04 | 2015-02-03 | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170177A Division JP6894952B2 (ja) | 2014-02-04 | 2019-09-19 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506227A JP2017506227A (ja) | 2017-03-02 |
| JP2017506227A5 true JP2017506227A5 (OSRAM) | 2018-03-15 |
| JP6591428B2 JP6591428B2 (ja) | 2019-10-16 |
Family
ID=52463238
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549715A Active JP6591428B2 (ja) | 2014-02-04 | 2015-02-03 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
| JP2019170177A Active JP6894952B2 (ja) | 2014-02-04 | 2019-09-19 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
| JP2021093346A Pending JP2021130709A (ja) | 2014-02-04 | 2021-06-03 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019170177A Active JP6894952B2 (ja) | 2014-02-04 | 2019-09-19 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
| JP2021093346A Pending JP2021130709A (ja) | 2014-02-04 | 2021-06-03 | 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10570202B2 (OSRAM) |
| EP (3) | EP3102605B1 (OSRAM) |
| JP (3) | JP6591428B2 (OSRAM) |
| KR (3) | KR20250109796A (OSRAM) |
| CN (2) | CN105960415A (OSRAM) |
| AU (1) | AU2015214390B2 (OSRAM) |
| BR (1) | BR112016017256A2 (OSRAM) |
| CA (2) | CA3210360A1 (OSRAM) |
| CY (2) | CY1121374T1 (OSRAM) |
| DK (1) | DK3102605T3 (OSRAM) |
| EA (1) | EA201691376A1 (OSRAM) |
| ES (2) | ES2710211T3 (OSRAM) |
| HU (2) | HUE057205T2 (OSRAM) |
| IL (2) | IL311399A (OSRAM) |
| MX (1) | MX386604B (OSRAM) |
| PL (2) | PL3102605T3 (OSRAM) |
| PT (2) | PT3498734T (OSRAM) |
| SG (2) | SG11201605824XA (OSRAM) |
| SI (2) | SI3498734T1 (OSRAM) |
| TR (1) | TR201901507T4 (OSRAM) |
| TW (1) | TWI663983B (OSRAM) |
| WO (1) | WO2015119930A1 (OSRAM) |
Families Citing this family (91)
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| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
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| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| AU2015214390B2 (en) * | 2014-02-04 | 2020-05-07 | Merck Sharp & Dohme LLC. | Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer |
| TW201613635A (en) | 2014-02-04 | 2016-04-16 | Pfizer | Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer |
| EP3114144A1 (en) * | 2014-03-05 | 2017-01-11 | Bristol-Myers Squibb Company | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
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| MY193229A (en) | 2015-06-16 | 2022-09-26 | Merck Patent GmbH | Pd-l1 antagonist combination treatments |
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