JP2010515709A5 - - Google Patents

Download PDF

Info

Publication number
JP2010515709A5
JP2010515709A5 JP2009545192A JP2009545192A JP2010515709A5 JP 2010515709 A5 JP2010515709 A5 JP 2010515709A5 JP 2009545192 A JP2009545192 A JP 2009545192A JP 2009545192 A JP2009545192 A JP 2009545192A JP 2010515709 A5 JP2010515709 A5 JP 2010515709A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
antibody
dose
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009545192A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010515709A (ja
JP5478261B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/050306 external-priority patent/WO2008084106A1/en
Publication of JP2010515709A publication Critical patent/JP2010515709A/ja
Publication of JP2010515709A5 publication Critical patent/JP2010515709A5/ja
Application granted granted Critical
Publication of JP5478261B2 publication Critical patent/JP5478261B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009545192A 2007-01-11 2008-01-11 抗kir抗体、製剤、およびその使用 Expired - Fee Related JP5478261B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87996407P 2007-01-11 2007-01-11
US60/879,964 2007-01-11
US91152707P 2007-04-13 2007-04-13
US60/911,527 2007-04-13
PCT/EP2008/050306 WO2008084106A1 (en) 2007-01-11 2008-01-11 Anti-kir antibodies, formulations, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013213757A Division JP6223771B2 (ja) 2007-01-11 2013-10-11 抗kir抗体、製剤、およびその使用

Publications (3)

Publication Number Publication Date
JP2010515709A JP2010515709A (ja) 2010-05-13
JP2010515709A5 true JP2010515709A5 (OSRAM) 2011-03-03
JP5478261B2 JP5478261B2 (ja) 2014-04-23

Family

ID=39144327

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009545192A Expired - Fee Related JP5478261B2 (ja) 2007-01-11 2008-01-11 抗kir抗体、製剤、およびその使用
JP2013213757A Expired - Fee Related JP6223771B2 (ja) 2007-01-11 2013-10-11 抗kir抗体、製剤、およびその使用
JP2015227492A Pending JP2016104728A (ja) 2007-01-11 2015-11-20 抗kir抗体、製剤、およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013213757A Expired - Fee Related JP6223771B2 (ja) 2007-01-11 2013-10-11 抗kir抗体、製剤、およびその使用
JP2015227492A Pending JP2016104728A (ja) 2007-01-11 2015-11-20 抗kir抗体、製剤、およびその使用

Country Status (8)

Country Link
US (3) US20100189723A1 (OSRAM)
EP (2) EP2109460B1 (OSRAM)
JP (3) JP5478261B2 (OSRAM)
CN (2) CN105037549B (OSRAM)
AU (1) AU2008204433B2 (OSRAM)
CA (1) CA2675291C (OSRAM)
ES (2) ES2579768T3 (OSRAM)
WO (1) WO2008084106A1 (OSRAM)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060079180A (ko) 2003-07-02 2006-07-05 노보 노르디스크 에이/에스 Nk 세포 활성을 조절하기 위한 조성물 및 방법
US20090191213A9 (en) * 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
US20090196850A1 (en) * 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
EP2367553B1 (en) * 2008-12-05 2017-05-03 Novo Nordisk A/S Combination therapy to enhance nk cell mediated cytotoxicity
EP3604510B1 (en) 2009-03-30 2025-03-26 Alexion Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
WO2011008885A1 (en) * 2009-07-15 2011-01-20 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
EP3514170A1 (en) * 2010-10-22 2019-07-24 Dana-Farber Cancer Institute, Inc. Discovery of regulatory t cells programmed to suppress an immune response
US9844593B2 (en) * 2010-11-22 2017-12-19 Innate Pharma Sa Methods for treatment of recurrent hematological malignancies
KR20120093002A (ko) 2011-02-14 2012-08-22 (주)에이티젠 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트
US9067997B2 (en) * 2011-05-25 2015-06-30 Innate Pharma Sa Anti-KIR antibodies for the treatment of inflammatory and autoimmune disorders
AU2013327116C1 (en) * 2012-10-02 2018-08-30 Bristol-Myers Squibb Company Combination of anti-KIR antibodies and anti-PD-1 antibodies to treat cancer
CA2906101A1 (en) * 2013-03-15 2014-09-18 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
WO2015069785A1 (en) 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma
US11639384B2 (en) 2014-10-28 2023-05-02 University Children's Hospital Tübingen Treatment of pediatric BCP-ALL patients with an anti-KIR antibody
NZ735820A (en) 2015-04-17 2025-02-28 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
DE112016002056T5 (de) 2015-05-06 2018-02-08 Snipr Technologies Limited Verändern mikrobieller Populationen und Modifizieren von Mikrobiomen
CN111234027A (zh) 2015-05-21 2020-06-05 哈普恩治疗公司 三特异性结合蛋白质及使用方法
CA2986705A1 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. A cxcr4 inhibitor and a pdi antagonist for use in treating cancer
CN108884159A (zh) 2015-11-07 2018-11-23 茂体外尔公司 用于癌症治疗的包含肿瘤抑制基因治疗和免疫检查点阻断的组合物
JP2018536404A (ja) 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Cho細胞において産生したポリペプチドの品質特性を操作する方法
BR112018017195A2 (pt) * 2016-02-24 2019-01-02 Children's Hospital Of Eastern Ontario Research Institute Inc. terapia de combinação de smc para o tratamento do câncer
HRP20240617T1 (hr) 2016-05-20 2024-07-19 Biohaven Therapeutics Ltd. Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
EP3518946A4 (en) 2016-09-27 2020-09-09 Board of Regents, The University of Texas System METHODS TO IMPROVE IMMUNE CHECKPOINT BLOCKING TREATMENT BY MODULATING THE MICROBIOME
JP7041136B2 (ja) 2016-10-12 2022-03-23 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム Tusc2免疫療法のための方法および組成物
EP3551226A1 (en) 2016-12-12 2019-10-16 MultiVir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
KR20250036268A (ko) 2017-03-31 2025-03-13 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
CA3063359A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
UA129446C2 (uk) 2017-10-13 2025-04-30 Гарпун Терап'Ютікс, Інк. Триспецифічні білки і способи їх застосування
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
JP2020536894A (ja) 2017-10-15 2020-12-17 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 腫瘍処置法
AU2019322487B2 (en) 2018-03-19 2024-04-18 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer
JP7351845B2 (ja) 2018-03-23 2023-09-27 ブリストル-マイヤーズ スクイブ カンパニー Micaおよび/またはmicbに対する抗体ならびにそれらの使用
EP4066851A1 (en) 2018-03-25 2022-10-05 SNIPR Biome ApS. Treating & preventing microbial infections
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
KR20200139724A (ko) 2018-03-30 2020-12-14 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
KR20210035805A (ko) 2018-06-15 2021-04-01 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (en) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
CN113166762B (zh) 2018-12-21 2025-01-14 瓦莱里奥治疗公司 新的偶联核酸分子及其用途
MX2021009851A (es) 2019-02-18 2021-09-10 Lilly Co Eli Formulacion de anticuerpos terapeuticos.
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
US20220363760A1 (en) 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
JP2022534982A (ja) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 細胞局在化シグネチャーおよびその使用
WO2020243570A1 (en) 2019-05-30 2020-12-03 Bristol-Myers Squibb Company Cell localization signature and combination therapy
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
AR122644A1 (es) 2020-06-19 2022-09-28 Onxeo Nuevas moléculas de ácido nucleico conjugado y sus usos
US20230355804A1 (en) 2020-06-29 2023-11-09 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
MX2023000197A (es) 2020-07-07 2023-02-22 BioNTech SE Arn terapeutico para el cancer positivo para vph.
EP4204453A1 (en) 2020-08-31 2023-07-05 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
US20220233689A1 (en) 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Methods of treating tumors
RS66849B1 (sr) 2020-12-28 2025-06-30 Bristol Myers Squibb Co Kompozicije antitela i postupci njihove upotrebe
MX2023009100A (es) 2021-02-03 2023-09-25 Mozart Therapeutics Inc Agentes aglutinantes y métodos para usar los mismos.
CA3214085A1 (en) 2021-03-31 2022-10-06 Darby Rye Schmidt Thanotransmission polypeptides and their use in treating cancer
US20240376224A1 (en) 2021-04-02 2024-11-14 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
KR20240026507A (ko) 2021-06-29 2024-02-28 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
CA3225254A1 (en) 2021-07-13 2023-01-19 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
IL313439A (en) 2021-12-16 2024-08-01 Valerio Therapeutics New conjugated nucleic acid molecules and their uses
KR20240159621A (ko) 2022-03-18 2024-11-05 브리스톨-마이어스 스큅 컴퍼니 폴리펩티드를 단리하는 방법
AU2023281061A1 (en) 2022-06-02 2024-12-05 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
AU2023393653A1 (en) 2022-12-14 2025-05-22 Astellas Pharma Europe Bv Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
WO2024151687A1 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
WO2025038763A1 (en) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Ceramic hydroxyapatite chromatography flow through method
WO2025121445A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025120866A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025120867A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2186455A1 (en) * 1994-03-29 1995-10-05 Raymond John Owens Antibodies against e-selectin
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US20010046496A1 (en) * 2000-04-14 2001-11-29 Brettman Lee R. Method of administering an antibody
AR035119A1 (es) * 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
WO2003054517A2 (en) 2001-12-19 2003-07-03 Biogen Idec Ma Inc. Methods for detecting half-antibodies using chip-based gel electrophoresis
EP1481010A2 (en) 2002-02-28 2004-12-01 Eli Lilly And Company Anti-interleukin-1 beta analogs
US20040152632A1 (en) * 2002-11-06 2004-08-05 Wyeth Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome
US20090191213A9 (en) * 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
KR20060079180A (ko) * 2003-07-02 2006-07-05 노보 노르디스크 에이/에스 Nk 세포 활성을 조절하기 위한 조성물 및 방법
CN1852924A (zh) * 2003-07-02 2006-10-25 依奈特制药公司 Pan-kir2dl nk-受体的抗体及其在诊断及治疗中的应用
EP3476861A1 (en) 2004-01-07 2019-05-01 Novartis Vaccines and Diagnostics, Inc. M-csf-specific monoclonal antibody and uses thereof
NZ584288A (en) * 2004-02-06 2011-10-28 Elan Pharm Inc Methods and compositions for treating tumors and metastatic disease
DK2287195T3 (da) * 2004-07-01 2019-08-19 Innate Pharma Pan-kir2dl nk-receptor-antistoffer og anvendelse heraf i diagnostik og terapi
WO2006050073A2 (en) * 2004-10-29 2006-05-11 Fargo Electronics, Inc. Credential production using a secured consumable supply
PL1836225T3 (pl) * 2005-01-06 2012-05-31 Novo Nordisk As Czynniki wiążące kir i sposoby ich stosowania
CA2607475A1 (en) * 2005-04-22 2006-11-02 Genentech, Inc. Method for treating dementia or alzheimer's disease with a cd20 antibody
EP2367553B1 (en) * 2008-12-05 2017-05-03 Novo Nordisk A/S Combination therapy to enhance nk cell mediated cytotoxicity
US9067997B2 (en) * 2011-05-25 2015-06-30 Innate Pharma Sa Anti-KIR antibodies for the treatment of inflammatory and autoimmune disorders

Similar Documents

Publication Publication Date Title
JP2010515709A5 (OSRAM)
JP5046922B2 (ja) 少なくとも一つのピロロベンゾジアゼピン誘導体とフルダラビンとを含有する治療用組成物
US7618992B2 (en) Method of treating cancer by co-administration of anticancer agents
US11220548B2 (en) Treatment of C1013G/CXCR4-associated Waldenstrom's macroglobulinemia with an anti-CXCR4 antibody
JP2019506403A5 (OSRAM)
JP2017506227A5 (OSRAM)
US12447150B2 (en) Treatment of cancer by combination of immune checkpoint inhibitor and folfirinox therapy
JP2019511565A (ja) ツカレゾールまたはそのアナログを含む組成物
WO2014142220A1 (ja) 抗腫瘍剤
WO2016204193A1 (ja) 抗がん剤
TW201107327A (en) Therapeutic combination comprising a PLK1 inhibitor and an antineoplastic agent
WO2019072220A1 (zh) Pd-1抗体和表观遗传调节剂联合在制备治疗肿瘤的药物中的用途
TW201127384A (en) Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent
Chen et al. TAS-102 an emerging oral fluoropyrimidine
JP2021073203A (ja) Her2陽性転移性乳癌の治療方法
EP3646869B1 (en) Chemotherapy for cancer using azabicyclo compound
KR20140144213A (ko) 3제를 조합한 신규 항종양제
JP2016104703A (ja) 抗腫瘍剤
JP2021508699A (ja) トリプルネガティブ乳がんを処置するためのpd−1抗体及びアパチニブの併用処置の使用
RU2774721C2 (ru) Применение комбинированного лечения на основе антитела к PD-1 и апатиниба для лечения трижды негативного рака молочной железы
Roccaro et al. Advances in the treatment of monoclonal gammopaties: The emerging role of targeted therapy in plasma cell dyscrasias
JP2025185043A (ja) 癌を治療するための免疫調節剤と組み合わせた低酸素活性化型プロドラッグの投与
Garriga European Hematology Association-17th Annual Congress, Amsterdam, The Netherlands-June 14-17, 2012
MARKMAN TAREK MEKHAIL, MD, MSc, FRCSI, FRCSED, RONY ABOU-JAWDE, MD, AND MAURIE MARKMAN, MD
Mekhail et al. Principles of Medical Management