JP2017505329A5 - - Google Patents
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- Publication number
- JP2017505329A5 JP2017505329A5 JP2016550633A JP2016550633A JP2017505329A5 JP 2017505329 A5 JP2017505329 A5 JP 2017505329A5 JP 2016550633 A JP2016550633 A JP 2016550633A JP 2016550633 A JP2016550633 A JP 2016550633A JP 2017505329 A5 JP2017505329 A5 JP 2017505329A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- formula
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000003839 salts Chemical class 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000011976 maleic acid Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 230000013632 homeostatic process Effects 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 230000036244 malformation Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1402071.3 | 2014-02-07 | ||
| GBGB1402071.3A GB201402071D0 (en) | 2014-02-07 | 2014-02-07 | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| PCT/EP2015/052242 WO2015117981A1 (en) | 2014-02-07 | 2015-02-04 | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020011555A Division JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017505329A JP2017505329A (ja) | 2017-02-16 |
| JP2017505329A5 true JP2017505329A5 (enExample) | 2018-03-15 |
Family
ID=50390572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550633A Pending JP2017505329A (ja) | 2014-02-07 | 2015-02-04 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
| JP2020011555A Pending JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020011555A Pending JP2020097595A (ja) | 2014-02-07 | 2020-01-28 | 炎症性障害の治療のための新規な塩及びその医薬組成物 |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US9382247B2 (enExample) |
| EP (2) | EP3842432A1 (enExample) |
| JP (2) | JP2017505329A (enExample) |
| KR (1) | KR102478614B1 (enExample) |
| CN (2) | CN105960407A (enExample) |
| AR (1) | AR099307A1 (enExample) |
| AU (4) | AU2015215045B2 (enExample) |
| CA (1) | CA2938219C (enExample) |
| CY (1) | CY1124349T1 (enExample) |
| DK (1) | DK3102575T3 (enExample) |
| EA (2) | EA201990330A1 (enExample) |
| ES (1) | ES2853375T3 (enExample) |
| GB (1) | GB201402071D0 (enExample) |
| HR (1) | HRP20210194T1 (enExample) |
| HU (1) | HUE053309T2 (enExample) |
| IL (1) | IL246833B (enExample) |
| LT (1) | LT3102575T (enExample) |
| MX (2) | MX395415B (enExample) |
| NZ (1) | NZ722603A (enExample) |
| PL (1) | PL3102575T3 (enExample) |
| PT (1) | PT3102575T (enExample) |
| RS (1) | RS61450B1 (enExample) |
| SG (2) | SG11201606433PA (enExample) |
| SI (1) | SI3102575T1 (enExample) |
| SM (1) | SMT202100060T1 (enExample) |
| TW (2) | TWI792593B (enExample) |
| UY (1) | UY35984A (enExample) |
| WO (1) | WO2015117981A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201402070D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| RS64677B1 (sr) * | 2015-04-13 | 2023-11-30 | Galapagos Nv | Metode lečenja kardiovaskularnih poremećaja |
| CN107531694A (zh) * | 2015-04-13 | 2018-01-02 | 加拉帕戈斯股份有限公司 | 用于治疗炎性疾病的方法 |
| CA2988593C (en) | 2015-06-16 | 2023-10-24 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| CN105198878B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物f晶型及其制备方法 |
| CN105111206B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物e晶型及其制备方法 |
| CN105198880B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物a晶型及其制备方法 |
| CN105198877B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物g晶型及其制备方法 |
| CN105111207B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物d晶型及其制备方法 |
| CN105198876B (zh) * | 2015-09-18 | 2017-09-29 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物h晶型及其制备方法 |
| CN105198879B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物c晶型及其制备方法 |
| CN105218539B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物b晶型及其制备方法 |
| US20170174788A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders |
| WO2017106564A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
| WO2017106568A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a bromodomain inhibitor for treating cancer |
| CN105669669A (zh) * | 2016-03-04 | 2016-06-15 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物的a晶型、b晶型、d晶型、g晶型和m晶型及其制备方法 |
| KR20180120273A (ko) | 2016-03-21 | 2018-11-05 | 크리스탈 파마테크 씨오., 엘티디. | Jak 관련 질병 예방 또는 치료용 약물의 염산 결정성 형태 및 이의 제조 방법 |
| EP3495364A4 (en) * | 2016-08-03 | 2019-09-04 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | NOVEL CRYSTAL FORM OF A JAK1 SELECTIVE INHIBITOR AND MANUFACTURING METHOD AND APPLICATION THEREOF |
| CA3043396A1 (en) | 2016-11-10 | 2018-05-17 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory diseases |
| GB201702603D0 (en) | 2017-02-17 | 2017-04-05 | Galápagos Nv | Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| JOP20180018A1 (ar) * | 2017-03-14 | 2019-01-30 | Gilead Sciences Inc | تركيبات صيدلية تتضمن مثبط jak |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
| US10815227B2 (en) | 2018-08-27 | 2020-10-27 | Cadila Healthcare Limited | Processes for the preparation of filgotinib |
| US11882438B2 (en) * | 2018-10-29 | 2024-01-23 | Zorday IP, LLC | Network-enabled electronic cigarette |
| WO2020177705A1 (zh) * | 2019-03-05 | 2020-09-10 | 苏州科睿思制药有限公司 | Filgotinib的马来酸盐晶型CSI及其制备方法和用途 |
| BR112021019087A2 (pt) * | 2019-03-30 | 2021-11-30 | Unichem Lab Ltd | Novo processo para a preparação de filgotinibe e intermediários do mesmo |
| WO2021044327A1 (en) * | 2019-09-03 | 2021-03-11 | Dr. Reddy's Laboratories Limited | Solid forms of filgotinib maleate and processes thereof |
| CN114075188A (zh) * | 2020-08-11 | 2022-02-22 | 南京柯菲平盛辉制药有限公司 | 芳香杂环酰胺类化合物及其制备方法和医药用途 |
| AU2021397808A1 (en) * | 2020-12-09 | 2023-07-06 | Servatus Ltd | Combination therapy for inflammatory disorders of the joints |
| CN113773322B (zh) * | 2021-11-10 | 2022-02-11 | 奥锐特药业(天津)有限公司 | 一种Filgotinib的制备方法 |
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| JP2549632B2 (ja) * | 1986-08-20 | 1996-10-30 | 三井石油化学工業株式会社 | オレフインの重合方法 |
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| JPWO2002087620A1 (ja) | 2001-04-27 | 2004-08-12 | 中外製薬株式会社 | 軟骨形成促進剤 |
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| DE602004001676T2 (de) | 2003-02-14 | 2007-08-30 | Pfizer Products Inc., Groton | Triazolo-Pyridine als entzündungshemmende Verbindungen |
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| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010186A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010013768A1 (ja) * | 2008-07-31 | 2010-02-04 | 第一三共株式会社 | チアゾリジンジオン化合物の結晶及びその製造方法 |
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| TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
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| CN102146082A (zh) * | 2010-02-04 | 2011-08-10 | 江苏恒瑞医药股份有限公司 | 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 |
| JP2013049632A (ja) * | 2011-08-30 | 2013-03-14 | Kowa Co | ベンゾチアジン化合物のモノマレイン酸塩を有効成分とするアレルギー疾患の予防及び／又は治療剤 |
| SA112330992B1 (ar) * | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
| US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| MA37775A1 (fr) | 2012-06-22 | 2017-04-28 | Galapagos Nv | Aminotriazolopyridine pour l'utilisation dans le traitement de l'inflammation, et compositions pharmaceutiques associées |
| GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| RS64677B1 (sr) | 2015-04-13 | 2023-11-30 | Galapagos Nv | Metode lečenja kardiovaskularnih poremećaja |
| CN107531694A (zh) | 2015-04-13 | 2018-01-02 | 加拉帕戈斯股份有限公司 | 用于治疗炎性疾病的方法 |
| WO2017106564A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
| JOP20180018A1 (ar) | 2017-03-14 | 2019-01-30 | Gilead Sciences Inc | تركيبات صيدلية تتضمن مثبط jak |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
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2014
- 2014-02-07 GB GBGB1402071.3A patent/GB201402071D0/en not_active Ceased
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2015
- 2015-02-04 SM SM20210060T patent/SMT202100060T1/it unknown
- 2015-02-04 US US14/614,396 patent/US9382247B2/en active Active
- 2015-02-04 CA CA2938219A patent/CA2938219C/en active Active
- 2015-02-04 RS RS20210134A patent/RS61450B1/sr unknown
- 2015-02-04 HU HUE15704974A patent/HUE053309T2/hu unknown
- 2015-02-04 CN CN201580006893.3A patent/CN105960407A/zh active Pending
- 2015-02-04 SG SG11201606433PA patent/SG11201606433PA/en unknown
- 2015-02-04 NZ NZ722603A patent/NZ722603A/en unknown
- 2015-02-04 JP JP2016550633A patent/JP2017505329A/ja active Pending
- 2015-02-04 HR HRP20210194TT patent/HRP20210194T1/hr unknown
- 2015-02-04 CN CN202010324636.7A patent/CN111499630A/zh active Pending
- 2015-02-04 PL PL15704974T patent/PL3102575T3/pl unknown
- 2015-02-04 EP EP20211405.4A patent/EP3842432A1/en not_active Withdrawn
- 2015-02-04 DK DK15704974.3T patent/DK3102575T3/da active
- 2015-02-04 MX MX2020003368A patent/MX395415B/es unknown
- 2015-02-04 PT PT157049743T patent/PT3102575T/pt unknown
- 2015-02-04 IL IL246833A patent/IL246833B/en unknown
- 2015-02-04 WO PCT/EP2015/052242 patent/WO2015117981A1/en not_active Ceased
- 2015-02-04 AU AU2015215045A patent/AU2015215045B2/en active Active
- 2015-02-04 EA EA201990330A patent/EA201990330A1/ru unknown
- 2015-02-04 KR KR1020167023807A patent/KR102478614B1/ko active Active
- 2015-02-04 LT LTEP15704974.3T patent/LT3102575T/lt unknown
- 2015-02-04 SI SI201531491T patent/SI3102575T1/sl unknown
- 2015-02-04 SG SG10202013187PA patent/SG10202013187PA/en unknown
- 2015-02-04 MX MX2016010068A patent/MX376000B/es active IP Right Grant
- 2015-02-04 EP EP15704974.3A patent/EP3102575B1/en active Active
- 2015-02-04 ES ES15704974T patent/ES2853375T3/es active Active
- 2015-02-04 EA EA201691584A patent/EA032596B1/ru unknown
- 2015-02-06 AR ARP150100351A patent/AR099307A1/es unknown
- 2015-02-06 UY UY0001035984A patent/UY35984A/es not_active Application Discontinuation
- 2015-02-06 TW TW110136599A patent/TWI792593B/zh active
- 2015-02-06 TW TW104104160A patent/TWI767878B/zh active
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2016
- 2016-07-01 US US15/200,228 patent/US20160376269A1/en not_active Abandoned
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2017
- 2017-07-10 US US15/645,308 patent/US10708263B2/en active Active
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2019
- 2019-04-08 AU AU2019202441A patent/AU2019202441B2/en active Active
- 2019-09-30 US US16/588,207 patent/US10919890B2/en active Active
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2020
- 2020-01-28 JP JP2020011555A patent/JP2020097595A/ja active Pending
- 2020-10-26 AU AU2020260391A patent/AU2020260391B2/en active Active
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2021
- 2021-01-08 US US17/144,788 patent/US11667633B2/en active Active
- 2021-02-01 CY CY20211100080T patent/CY1124349T1/el unknown
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2022
- 2022-09-23 AU AU2022235624A patent/AU2022235624B2/en active Active
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2023
- 2023-04-25 US US18/306,867 patent/US12234235B2/en active Active
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2025
- 2025-01-22 US US19/033,986 patent/US20250289816A1/en active Pending
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