EA202192389A1 - Новый способ получения филготиниба и его промежуточных соединений - Google Patents

Новый способ получения филготиниба и его промежуточных соединений

Info

Publication number
EA202192389A1
EA202192389A1 EA202192389A EA202192389A EA202192389A1 EA 202192389 A1 EA202192389 A1 EA 202192389A1 EA 202192389 A EA202192389 A EA 202192389A EA 202192389 A EA202192389 A EA 202192389A EA 202192389 A1 EA202192389 A1 EA 202192389A1
Authority
EA
Eurasian Patent Office
Prior art keywords
filgotinib
intermediates
obtaining
new method
avoiding
Prior art date
Application number
EA202192389A
Other languages
English (en)
Inventor
Дхананджай Г. Сате
Ариджит Дас
Бхавеш Патель
Экнат Кширсагар
Дипак Патил
Ашок Матале
Original Assignee
Юникем Лабораторис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юникем Лабораторис Лимитед filed Critical Юникем Лабораторис Лимитед
Publication of EA202192389A1 publication Critical patent/EA202192389A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к новому способу получения филготиниба или его фармацевтически приемлемой соли и его промежуточных соединений, позволяющему избежать использования реакции сочетания Сузуки.
EA202192389A 2019-03-30 2020-03-28 Новый способ получения филготиниба и его промежуточных соединений EA202192389A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201921012919 2019-03-30
PCT/IB2020/052977 WO2020201975A2 (en) 2019-03-30 2020-03-28 Novel process for the preparation of filgotinib and intermediates thereof

Publications (1)

Publication Number Publication Date
EA202192389A1 true EA202192389A1 (ru) 2022-01-21

Family

ID=72666162

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192389A EA202192389A1 (ru) 2019-03-30 2020-03-28 Новый способ получения филготиниба и его промежуточных соединений

Country Status (10)

Country Link
US (1) US20220185810A1 (ru)
EP (1) EP3947381A2 (ru)
JP (1) JP2022527512A (ru)
CN (1) CN113677676A (ru)
AU (1) AU2020251400A1 (ru)
BR (1) BR112021019087A2 (ru)
EA (1) EA202192389A1 (ru)
MX (1) MX2021011548A (ru)
WO (1) WO2020201975A2 (ru)
ZA (1) ZA202107053B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110204542B (zh) * 2019-05-23 2022-05-20 四川伊诺达博医药科技有限公司 一种JAK1抑制剂Filgotinib的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719803D0 (en) * 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
TWI462920B (zh) * 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
SG10201700125VA (en) * 2012-06-22 2017-02-27 Galapagos Nv Aminotriazolopyridine For Use In The Treatment Of Inflammation, And Pharmaceutical Compositions Thereof
AU2016257892A1 (en) * 2015-05-05 2017-11-09 Concert Pharmaceuticals, Inc. Deuterated filgotinib

Also Published As

Publication number Publication date
WO2020201975A2 (en) 2020-10-08
CN113677676A (zh) 2021-11-19
WO2020201975A3 (en) 2020-12-03
BR112021019087A2 (pt) 2021-11-30
US20220185810A1 (en) 2022-06-16
JP2022527512A (ja) 2022-06-02
ZA202107053B (en) 2022-11-30
EP3947381A2 (en) 2022-02-09
AU2020251400A1 (en) 2021-10-07
MX2021011548A (es) 2021-10-22

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