BR112021019087A2 - Novo processo para a preparação de filgotinibe e intermediários do mesmo - Google Patents

Novo processo para a preparação de filgotinibe e intermediários do mesmo

Info

Publication number
BR112021019087A2
BR112021019087A2 BR112021019087A BR112021019087A BR112021019087A2 BR 112021019087 A2 BR112021019087 A2 BR 112021019087A2 BR 112021019087 A BR112021019087 A BR 112021019087A BR 112021019087 A BR112021019087 A BR 112021019087A BR 112021019087 A2 BR112021019087 A2 BR 112021019087A2
Authority
BR
Brazil
Prior art keywords
filgotinib
intermediates
preparation
new process
pharmaceutically acceptable
Prior art date
Application number
BR112021019087A
Other languages
English (en)
Inventor
Arijit Das
Ashok Matale
Bhavesh Patel
G Sathe Dhananjay
Dipak Patil
Eknath Kshirsagar
Original Assignee
Unichem Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unichem Lab Ltd filed Critical Unichem Lab Ltd
Publication of BR112021019087A2 publication Critical patent/BR112021019087A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

novo processo para a preparação de filgotinibe e intermediários do mesmo. a presente invenção se refere a um novo processo para a preparação de filgotinibe ou um sal farmaceuticamente aceitável e intermediários do mesmo que evitam a reação de acoplamento de suzuki.
BR112021019087A 2019-03-30 2020-03-28 Novo processo para a preparação de filgotinibe e intermediários do mesmo BR112021019087A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201921012919 2019-03-30
PCT/IB2020/052977 WO2020201975A2 (en) 2019-03-30 2020-03-28 Novel process for the preparation of filgotinib and intermediates thereof

Publications (1)

Publication Number Publication Date
BR112021019087A2 true BR112021019087A2 (pt) 2021-11-30

Family

ID=72666162

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021019087A BR112021019087A2 (pt) 2019-03-30 2020-03-28 Novo processo para a preparação de filgotinibe e intermediários do mesmo

Country Status (10)

Country Link
US (1) US20220185810A1 (pt)
EP (1) EP3947381A4 (pt)
JP (1) JP2022527512A (pt)
CN (1) CN113677676A (pt)
AU (1) AU2020251400A1 (pt)
BR (1) BR112021019087A2 (pt)
EA (1) EA202192389A1 (pt)
MX (1) MX2021011548A (pt)
WO (1) WO2020201975A2 (pt)
ZA (1) ZA202107053B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110204542B (zh) * 2019-05-23 2022-05-20 四川伊诺达博医药科技有限公司 一种JAK1抑制剂Filgotinib的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719803D0 (en) * 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
TWI462920B (zh) * 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
ES2685985T3 (es) * 2012-06-22 2018-10-15 Galapagos Nv Aminotriazolopiridina para su uso en el tratamiento de la inflamación, y composiciones farmacéuticas de la misma
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
AU2016257892A1 (en) * 2015-05-05 2017-11-09 Concert Pharmaceuticals, Inc. Deuterated filgotinib

Also Published As

Publication number Publication date
EA202192389A1 (ru) 2022-01-21
EP3947381A4 (en) 2024-07-24
WO2020201975A3 (en) 2020-12-03
MX2021011548A (es) 2021-10-22
WO2020201975A2 (en) 2020-10-08
CN113677676A (zh) 2021-11-19
JP2022527512A (ja) 2022-06-02
ZA202107053B (en) 2022-11-30
US20220185810A1 (en) 2022-06-16
EP3947381A2 (en) 2022-02-09
AU2020251400A1 (en) 2021-10-07

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]