MX2020007091A - Proceso para la preparacion de crisaborola y sus intermediarios. - Google Patents

Proceso para la preparacion de crisaborola y sus intermediarios.

Info

Publication number
MX2020007091A
MX2020007091A MX2020007091A MX2020007091A MX2020007091A MX 2020007091 A MX2020007091 A MX 2020007091A MX 2020007091 A MX2020007091 A MX 2020007091A MX 2020007091 A MX2020007091 A MX 2020007091A MX 2020007091 A MX2020007091 A MX 2020007091A
Authority
MX
Mexico
Prior art keywords
preparation
crisaborole
intermediates
present
provides
Prior art date
Application number
MX2020007091A
Other languages
English (en)
Inventor
Rupa Sudhir Merchant
Aditya Sudhir Merchant
Piyushkumar Bhikhalal Limbad
Akshay Madhubhai Pansuriya
Bhavin Madhavjibhai Vavaiya
Jasmin Jaysukhlal Faldu
Original Assignee
Halcyon Labs Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halcyon Labs Private Ltd filed Critical Halcyon Labs Private Ltd
Publication of MX2020007091A publication Critical patent/MX2020007091A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un proceso novedoso y mejorado para la preparación de Crisaborola de Fórmula (I) y sus sales farmacéuticamente aceptables. La presente invención también proporciona intermediarios novedosos y procesos para la preparación de intermediarios utilizados en la preparación de Crisaborola. La presente invención proporciona además un proceso mejorado para la preparación de Crisaborola y sales farmacéuticamente aceptables de la misma, el cual es comercial e industrialmente escalable.
MX2020007091A 2018-01-09 2019-01-01 Proceso para la preparacion de crisaborola y sus intermediarios. MX2020007091A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201821000974 2018-01-09
PCT/IN2019/050002 WO2019138422A1 (en) 2018-01-09 2019-01-01 Process for the preparation of crisaborole and its intermediates

Publications (1)

Publication Number Publication Date
MX2020007091A true MX2020007091A (es) 2020-09-22

Family

ID=67218916

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007091A MX2020007091A (es) 2018-01-09 2019-01-01 Proceso para la preparacion de crisaborola y sus intermediarios.

Country Status (9)

Country Link
US (2) US11014944B2 (es)
EP (1) EP3737685B1 (es)
JP (1) JP7296401B2 (es)
BR (1) BR112020013794B1 (es)
CA (1) CA3087139A1 (es)
ES (1) ES2949908T3 (es)
MX (1) MX2020007091A (es)
PL (1) PL3737685T3 (es)
WO (1) WO2019138422A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11014944B2 (en) * 2018-01-09 2021-05-25 Halcyon Labs Private Limited Process for the preparation of crisaborole and its intermediates
CN114716349A (zh) * 2022-04-29 2022-07-08 武汉绿合医药科技有限公司 一种克立硼罗杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2540966T3 (es) 2005-02-16 2015-07-15 Anacor Pharmaceuticals, Inc. Compuestos biocidas de boronoftalida
DK2719388T3 (da) * 2006-02-16 2019-05-13 Anacor Pharmaceuticals Inc Borholdige små molekyler som antiinflammatoriske midler
US20150065524A1 (en) 2011-08-11 2015-03-05 Intellikine Llc Kinase inhibitor polymorphs
LT3030519T (lt) 2013-08-09 2022-04-11 Glaxosmithkline Intellectual Property (No. 2) Limited Tricikliniai benzoksaborolo junginiai ir jų naudojimas
EP3383363B1 (en) 2015-11-30 2021-01-06 Anacor Pharmaceuticals, Inc. Topical pharmaceutical formulations for treating inflammatory-related conditions
BR112018073017B1 (pt) * 2016-05-09 2022-06-14 Anacor Pharmaceuticals, Inc Forma cristalina i de crisaborol na forma livre, método de preparação e uso da mesma
CN106928264A (zh) 2017-04-12 2017-07-07 湖南中智优库科技有限公司 一种crisaborole的合成方法
US10329311B1 (en) * 2017-12-21 2019-06-25 Olon S.P.A. Process for the preparation of crisaborole
US11014944B2 (en) * 2018-01-09 2021-05-25 Halcyon Labs Private Limited Process for the preparation of crisaborole and its intermediates

Also Published As

Publication number Publication date
ES2949908T3 (es) 2023-10-03
EP3737685A4 (en) 2021-07-28
EP3737685B1 (en) 2023-03-29
US11014944B2 (en) 2021-05-25
CA3087139A1 (en) 2019-07-18
US11708382B2 (en) 2023-07-25
JP2021509685A (ja) 2021-04-01
PL3737685T3 (pl) 2023-10-02
EP3737685A1 (en) 2020-11-18
JP7296401B2 (ja) 2023-06-22
WO2019138422A1 (en) 2019-07-18
US20210246150A1 (en) 2021-08-12
BR112020013794B1 (pt) 2023-05-02
BR112020013794A2 (pt) 2020-12-01
US20210070778A1 (en) 2021-03-11

Similar Documents

Publication Publication Date Title
MX2019012942A (es) Compuestos de imidazo-piperidina fusionada como inhibidores de jak.
MX2021008965A (es) Proceso para preparar un agonista dual de gip/glp1.
MX2021008002A (es) Sales nuevas y forma polimorfica del acido bempedoico.
IN2014CH00247A (es)
PH12019502093A1 (en) Novel ester compounds, method for the production thereof and use thereof
MX2022006783A (es) Nuevos derivados de metilquinazolinona.
MX2019013816A (es) Compuesto usado como regulador de la autofagia, metodo de preparacion y sus usos.
MX2018009503A (es) Sal de trifluoroacetato de agonista de tlr7 y forma cristalina b de la misma, metodos de preparacion y usos.
PH12019500569A1 (en) Blood-brain barrier-penetrant dopamine-b-hydroxylase inhibitors
MY193239A (en) Novel b-lactamase inhibitors
MX2018008966A (es) Procesos mejorados para la preparacion de osimertinib (azd9291) o una sal del mismo y "azd9291 anilina" o una sal del mismo.
IN2013MU03862A (es)
MX2020007091A (es) Proceso para la preparacion de crisaborola y sus intermediarios.
MX2016016050A (es) Procesos para la preparacion de analogos de oxitocina.
PH12018502246A1 (en) Substituted fused pyrimidinone compounds
PH12021550452A1 (en) Methods of treating mycobacterial infections using tetracycline compounds
MX2022002017A (es) Metodo para producir derivado de heterociclideno acetamida.
MX2018014759A (es) Sal farmaceuticamente aceptable como inhibidor del canal de potasio medular externo renal.
MX2021009261A (es) Compuesto de fluorovinilbenzamida como inmunomodulador pd-l1.
WO2020003272A8 (en) An improved process for the preparation of venetoclax
MX2018015990A (es) Compuestos terapeuticos.
MX2021011548A (es) Proceso novedoso para la preparacion de filgotinib e intermediarios del mismo.
MX2021006498A (es) Proceso para la preparacion de un dinucleotido ciclico.
MX2021006692A (es) Proceso mejorado para preparar ozanimod.
WO2016079757A3 (en) NOVEL PROCESSES FOR THE PREPARATION OF SUBSTITUTED 5-HYDROXYMETHYL-OXAZOLIDINE-2-ONE