MX2021006498A - Proceso para la preparacion de un dinucleotido ciclico. - Google Patents

Proceso para la preparacion de un dinucleotido ciclico.

Info

Publication number
MX2021006498A
MX2021006498A MX2021006498A MX2021006498A MX2021006498A MX 2021006498 A MX2021006498 A MX 2021006498A MX 2021006498 A MX2021006498 A MX 2021006498A MX 2021006498 A MX2021006498 A MX 2021006498A MX 2021006498 A MX2021006498 A MX 2021006498A
Authority
MX
Mexico
Prior art keywords
preparation
cyclic dinucleotide
dinucleotide
cyclic
involving
Prior art date
Application number
MX2021006498A
Other languages
English (en)
Inventor
Benjamin M Cohen
Chao Hang
Amanda J Rogers
Daniel S Treitler
Bin Zheng
Adam Joseph Freitag
Michael Anthony Schmidt
Changxia Yuan
Jason J Zhu
Geoffrey Eugene Purdum
Miao Yu
Edmonds Melda Sezen
Siwei Guo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2021006498A publication Critical patent/MX2021006498A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invención se refiere en general a procesos mejorados para la preparación de un dinucleótido cíclico que es útil como un agonista de STING de la siguiente fórmula (I), (ver Fórmula) que involucran el uso de los compuestos A y B: (ver Fórmulas).
MX2021006498A 2018-12-04 2019-12-03 Proceso para la preparacion de un dinucleotido ciclico. MX2021006498A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862775094P 2018-12-04 2018-12-04
PCT/US2019/064137 WO2020117739A1 (en) 2018-12-04 2019-12-03 Process for the preparation of a cyclic dinucleotide

Publications (1)

Publication Number Publication Date
MX2021006498A true MX2021006498A (es) 2021-07-06

Family

ID=69024628

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021006498A MX2021006498A (es) 2018-12-04 2019-12-03 Proceso para la preparacion de un dinucleotido ciclico.

Country Status (13)

Country Link
US (1) US20220064205A1 (es)
EP (1) EP3891160A1 (es)
JP (1) JP2022513712A (es)
KR (1) KR20210099065A (es)
CN (1) CN113166184B (es)
AU (1) AU2019391012A1 (es)
BR (1) BR112021010466A2 (es)
CA (1) CA3122027A1 (es)
EA (1) EA202191565A1 (es)
IL (1) IL283633A (es)
MX (1) MX2021006498A (es)
SG (1) SG11202105807XA (es)
WO (1) WO2020117739A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253766A (zh) * 2023-03-27 2023-06-13 瑞阳（上海）新药研发有限公司 一种环二核苷酸2’,3’-cGAMP的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY194058A (en) * 2016-01-11 2022-11-10 Innate Tumor Immunity Inc Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
WO2019200273A1 (en) * 2018-04-13 2019-10-17 Bristol-Myers Squibb Company Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Also Published As

Publication number Publication date
EP3891160A1 (en) 2021-10-13
JP2022513712A (ja) 2022-02-09
CN113166184B (zh) 2024-06-18
SG11202105807XA (en) 2021-06-29
CA3122027A1 (en) 2020-06-11
EA202191565A1 (ru) 2021-12-02
AU2019391012A1 (en) 2021-07-22
US20220064205A1 (en) 2022-03-03
BR112021010466A2 (pt) 2021-08-24
KR20210099065A (ko) 2021-08-11
CN113166184A (zh) 2021-07-23
IL283633A (en) 2021-07-29
WO2020117739A1 (en) 2020-06-11

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